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Cited by 267

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

Open access
Bei, Fengfeng, Lee, Henry Hing Cheong, Liu, Xuefeng, Gunner, Georgia, Jin, Hai, Ma, Long, Wang, Chen, Hou, lijun, Hensch, Takao K., Frank, Eric, Sanes, Joshua R., Chen, Chinfei, Fagiolini, Michela, He, Zhigang·2016·Cell
DOI 10.1016/j.cell.2015.11.036
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Abstract

Although a number of repair strategies have been shown to promote axon outgrowth following neuronal injury in the mammalian central nervous system, it remains unclear whether regenerated axons establish functional synapses and support behavior. Here, in both juvenile and adult mice, we show that either PTEN and SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of retinal axons and formation of functional synapses in the superior colliculus (SC), but not significant recovery of visual function. Further analyses suggest that regenerated axons fail to conduct action potentials from the eye to the SC due to lack of myelination. Consistent with this idea, administration of voltage-gated potassium channel blockers restores conduction and results in increased visual acuity. Thus, enhancing both regeneration and conduction effectively improves function after optic nerve injury.

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Crossref · 10.1016/j.cell.2015.11.036

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Metadata

Authors
Bei, F., Lee, H. H. C., Liu, X., Gunner, G., Jin, H., Ma, L., Wang, C., Hou, L., Hensch, T. K., Frank, E., Sanes, J. R., Chen, C., Fagiolini, M., & He, Z.
Venue
Cell
Publisher
Elsevier BV
Published
2016-01
Volume
164
Issue
1-2
Pages
219-232
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2015.11.036
OpenAlex
W2234093367
Cited by
267
References
9
FWCI
15.15
Type
journal article
Language
en
Open access
bronze

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