The Roles of Type I Interferon in Bacterial Infection

Boxx, Gayle M.; Cheng, Genhong

doi:10.1016/j.chom.2016.05.016

Cited by 335interferon and immune responsesImmune Response and InflammationAntimicrobial Peptides and Activities

The Roles of Type I Interferon in Bacterial Infection

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Boxx, Gayle M., Cheng, Genhong·2016·Cell Host & Microbe

DOI 10.1016/j.chom.2016.05.016PMC PMC5847370

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Abstract

Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the induction of a potent antiviral gene program essential for host defense against viruses. They also modulate innate and adaptive immune responses. However, the role of type I IFNs in host defense against bacterial infections is enigmatic. Depending on the bacterium, they exert seemingly opposite and capricious functions. In this review, we summarize the effect of type I IFNs on specific bacterial infections and highlight the effector mechanisms regulated by type I IFNs in an attempt to elucidate new avenues to understanding their role.

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The TII response is also induced by bacterial, parasitic, and fungal infections.
“this response is also induced by bacterial, parasitic (43), and fungal infections (30, 44 – 48).”
From Overlooked Candida glabrata petites are echinocandin tolerant, induce host inflammatory responses, and display poor in vivo fitness (2023) · cites this paper as [43]
The “Pathways of recognition and response” section states that bacterial components induce type I interferons, supporting the bacterial part of the claim. Our copy does not establish that parasitic or fungal infections induce this response; searches for those infections found no relevant passage. No page numbers are available in the indexed copy. (LLM, conf=0.87)
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Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
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Faecal microbiota transplant ameliorates gut dysbiosis and cognitive deficits in Huntington’s disease mice
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Overlooked Candida glabrata petites are echinocandin tolerant, induce host inflammatory responses, and display poor in vivo fitness
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“Although classically associated with viral infection, this response is also induced by bacterial, parasitic (43), and fungal infections (30, 44–48).”
Background
Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion
Riedelberger, M., Penninger, P., Tscherner, M., Hadriga, B., Brunnhofer, C., Jenull, S., Stoiber, A., Bourgeois, C., Petryshyn, A., Glaser, W., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101121 · Cited by 23 · see citing works

Authors: Boxx, G. M., & Cheng, G.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Cheng, Genhong
ORCID: Boxx, Gayle M.
Cheng, Genhong
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2016-06
Volume: 19
Issue: 6
Pages: 760-769
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2016.05.016
PMC: PMC5847370
OpenAlex: W2418688677
Cited by: 335
References: 100
Citations by year: 2026: 24 · 2025: 36 · 2024: 38 · 2023: 39 · 2022: 38 · 2021: 46 · 2020: 45 · 2019: 32 · 2018: 19 · 2017: 13 · 2016: 5
FWCI: 2.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI069120, R01AI056154, R01AI078389)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords: type I interferon, bacterial infection, host defense, innate immunity, effector mechanisms, host-pathogen interaction
MeSH terms: Animals, Anti-Inflammatory Agents, Bacterial Infections, Humans, Immunity, Innate, Interferon Type I, Interferon-gamma, Signal Transduction, Cytokines, Antimicrobial Cationic Peptides, Adaptive Immunity

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The Roles of Type I Interferon in Bacterial Infection

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