Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976 · see citing works

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,027 · see citing works

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947 · see citing works

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888 · see citing works

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658 · see citing works

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576 · see citing works

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329 · see citing works

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · see citing works

Systemic Lupus Erythematosus

Tsokos, G. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100359 · Cited by 2,747 · see citing works

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., & Chen, Z. J. (2012) · Science · doi:10.1126/science.1229963 · Cited by 2,574 · see citing works

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562 · see citing works

5'-Triphosphate RNA Is the Ligand for RIG-I

Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science · doi:10.1126/science.1132505 · Cited by 2,474 · see citing works

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401 · see citing works

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates

Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210 · see citing works

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182 · see citing works

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y.-T., Grishin, N. V., et al. (2015) · Science · doi:10.1126/science.aaa2630 · Cited by 1,927 · see citing works

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.017 · Cited by 1,917 · see citing works

Recognition of single-stranded RNA viruses by Toll-like receptor 7

Lund, J. M., Alexopoulou, L., Sato, A., Karow, M. L., Adams, N. C., Gale, N. W., Iwasaki, A., & Flavell, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400937101 · Cited by 1,854 · see citing works

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849 · see citing works

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works

cGAS surveillance of micronuclei links genome instability to innate immunity

Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752 · see citing works

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., et al. (2007) · Nature · doi:10.1038/nature06013 · Cited by 1,704 · see citing works

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Gack, M. U., Shin, Y. C., Joo, C.-H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z. J., Inoue, S., et al. (2007) · Nature · doi:10.1038/nature05732 · Cited by 1,683 · see citing works

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643 · see citing works

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

Bauer, S., Kirschning, C. J., Häcker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H., & Lipford, G. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161293498 · Cited by 1,527 · see citing works

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,514 · see citing works

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Harding, S. M., Benci, J. L., Irianto, J., Discher, D. E., Minn, A. J., & Greenberg, R. A. (2017) · Nature · doi:10.1038/nature23470 · Cited by 1,508 · see citing works

Activated STING in a Vascular and Pulmonary Syndrome

Liu, Y., de Jesus, A. A., Marrero, B., Yang, D., RAMSEY, S. E., Sanchez, G. A. M., Tenbrock, K., Wittkowski, H., Jones, O. Y., Kuehn, H. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312625 · Cited by 1,415 · see citing works

Cell Type-Specific Involvement of RIG-I in Antiviral Response

Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.010 · Cited by 1,368 · see citing works

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,274 · see citing works

Toll-Like Receptor Signaling Pathways

Barton, G. M., & Medzhitov, R. M. (2003) · Science · doi:10.1126/science.1085536 · Cited by 1,270 · see citing works

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,208 · see citing works

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185 · see citing works

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

Zhang, S., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero, P. J., Segal, D. M., Sancho‐Shimizu, V., Lorenzo, L., Puel, A., et al. (2007) · Science · doi:10.1126/science.1139522 · Cited by 1,165 · see citing works

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

Gitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R. A., Diamond, M., & Colonna, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603082103 · Cited by 1,156 · see citing works

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1244040 · Cited by 1,097 · see citing works

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

Christensen, S. R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R. A., & Shlomchik, M. J. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.013 · Cited by 1,090 · see citing works

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

Loo, Y.-M., Fornek, J., Crochet, N., Bajwa, G., Perwitasari, O., Martinez-Sobrido, L., Akira, S., Gill, M. A., García-Sastre, A., Katze, M. G., et al. (2008) · Journal of Virology · doi:10.1128/jvi.01080-07 · Cited by 1,071 · see citing works

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T., Sato, S., Ishii, K. J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., et al. (2004) · Nature Immunology · doi:10.1038/ni1118 · Cited by 1,038 · see citing works

Biochemistry of mammalian peroxisomes revisited

Wanders, R. J. A., & Waterham, H. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133329 · Cited by 995 · see citing works

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1240933 · Cited by 986 · see citing works

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

Barrat, F. J., Meeker, T., Gregorio, J. D., Chan, J. H., Uematsu, S., Akira, S., Chang, B., Duramad, O., & Coffman, R. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050914 · Cited by 932 · see citing works

Toll-like receptor 3 promotes cross-priming to virus-infected cells

Schulz, O., Diebold, S. S., Chen, M., Näslund, T. I., Nolte, M. A., Alexopoulou, L., Azuma, Y., Flavell, R. A., Liljeström, P., & Sousa, C. R. E. (2005) · Nature · doi:10.1038/nature03326 · Cited by 919 · see citing works

Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I

Sumpter, R., Loo, Y., Foy, E. M., Li, K., Yoneyama, M., Fujita, T., Lemon, S. M., & Gale, M. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.2689-2699.2005 · Cited by 900 · see citing works

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892 · see citing works

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

Zhang, Z., Yuan, B., Bao, M., Lu, N., Kim, T., & Liu, Y. (2011) · Nature Immunology · doi:10.1038/ni.2091 · Cited by 874 · see citing works

Peroxisomes are signaling platforms for antiviral innate immunity

Dixit, E., Boulant, S., Zhang, Y.-J., Lee, A. S., Odendall, C., Shum, B. O. V., Hacohen, N., Chen, Z.-J. J., Whelan, S. P. J., Fransen, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.04.018 · Cited by 848 · see citing works

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

Liu, L., Botos, I., Wang, Y., Leonard, J. N., Shiloach, J., Segal, D. M., & Davies, D. R. (2008) · Science · doi:10.1126/science.1155406 · Cited by 733 · see citing works

A cell biological view of Toll-like receptor function: regulation through compartmentalization

Barton, G. M., & Kagan, J. C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2587 · Cited by 713 · see citing works

Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells

Matsumoto, M., Funami, K., Tanabe, M., Oshiumi, H., Shingai, M., Seto, Y., Yamamoto, A., & Seya, T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3154 · Cited by 708 · see citing works

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

Kim, Y., Brinkmann, M. M., Paquet, M.-È., & Ploegh, H. L. (2008) · Nature · doi:10.1038/nature06726 · Cited by 699 · see citing works

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

Kowalinski, E., Lunardi, T., McCarthy, A. A., Louber, J., Brunel, J., Grigorov, B., Gerlier, D., & Cusack, S. (2011) · Cell · doi:10.1016/j.cell.2011.09.039 · Cited by 688 · see citing works

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

Konno, H., Konno, K., & Barber, G. N. (2013) · Cell · doi:10.1016/j.cell.2013.09.049 · Cited by 676 · see citing works

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

Barton, G. M., Kagan, J. C., & Medzhitov, R. M. (2005) · Nature Immunology · doi:10.1038/ni1280 · Cited by 669 · see citing works

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

Ablasser, A., Schmid-Burgk, J. L., Hemmerling, I., Horvath, G. L., Schmidt, T., Latz, E., & Hornung, V. (2013) · Nature · doi:10.1038/nature12640 · Cited by 649 · see citing works

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

Dobbs, N., Burnaevskiy, N., Chen, D., Gonugunta, V. K., Alto, N. M., & Yan, N. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.001 · Cited by 633 · see citing works

Post-Translational Modification Control of Innate Immunity

Liu, J., Qian, C., & Cao, X. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.020 · Cited by 632 · see citing works

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., & Chen, Z. J. (2010) · Cell · doi:10.1016/j.cell.2010.03.029 · Cited by 613 · see citing works

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

Gao, P., Ascano, M., Zillinger, T., Wang, W., Dai, P., Serganov, A. A., Gaffney, B. L., Shuman, S., Jones, R. A., Deng, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.07.023 · Cited by 595 · see citing works

Nucleic acid recognition by the innate immune system

Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577 · see citing works

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Feixia Chu, C., Walz, T., & Hur, S. (2012) · Cell · doi:10.1016/j.cell.2012.11.048 · Cited by 572 · see citing works

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

Andreeva, L., Hiller, B., Kostrewa, D., Lässig, C., de Oliveira Mann, C. C., Jan Drexler, D., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., et al. (2017) · Nature · doi:10.1038/nature23890 · Cited by 511 · see citing works

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

Marchi, S., Patergnani, S., & Pinton, P. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.10.015 · Cited by 506 · see citing works

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

Tsuchida, T., Zou, J. P., Saitoh, T., Kumar, H., Abe, T., Matsuura, Y., Kawai, T., & Akira, S. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.013 · Cited by 488 · see citing works

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

Zhong, B., Zhang, L., Lei, C., Li, Y., Mao, A., Yang, Y. F., Wang, Y., Zhang, X., & Shu, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.008 · Cited by 478 · see citing works

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

Park, B., Brinkmann, M. M., Spooner, E., Lee, C. C., Kim, Y., & Ploegh, H. L. (2008) · Nature Immunology · doi:10.1038/ni.1669 · Cited by 478 · see citing works

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

Arimoto, K., Takahashi, H., Hishiki, T., Konishi, H., Fujita, T., & Shimotohno, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611551104 · Cited by 472 · see citing works

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

York, A. G., Williams, K. J., Argus, J. P., Zhou, Q., Brar, G., Vergnes, L., Gray, E. E., Zhen, A., Wu, N. C., Yamada, D. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.045 · Cited by 449 · see citing works

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

Jiang, F., Ramanathan, A., Miller, M. T., Tang, G., Gale, M., Patel, S. S., & Marcotrigiano, J. (2011) · Nature · doi:10.1038/nature10537 · Cited by 429 · see citing works

Viral RNA detection by RIG-I-like receptors

Yoneyama, M., Onomoto, K., Jogi, M., Akaboshi, T., & Fujita, T. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.12.012 · Cited by 422 · see citing works

Structural Insights into RNA Recognition by RIG-I

Luo, D., Ding, S. C., Vela, A., Kohlway, A. S., Lindenbach, B. D., & Pyle, A. M. (2011) · Cell · doi:10.1016/j.cell.2011.09.023 · Cited by 420 · see citing works

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

Bernard, J. J., Cowing-Zitron, C., Nakatsuji, T., Muehleisen, B., Muto, J., Borkowski, A. W., Martinez, L., Greidinger, E. L., Yu, B., & Gallo, R. L. (2012) · Nature Medicine · doi:10.1038/nm.2861 · Cited by 408 · see citing works

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

Zhang, J., Hu, M., Wang, Y., & Shu, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.362608 · Cited by 390 · see citing works

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

Osorio, F., & Sousa, C. R. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.001 · Cited by 388 · see citing works

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

Kranzusch, P. J., Lee, A. S.-Y., Berger, J. M., & Doudna, J. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.008 · Cited by 385 · see citing works

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

Gray, E. E., Treuting, P. M., Woodward, J. J., & Stetson, D. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500969 · Cited by 384 · see citing works

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

Hu, M., Yang, Q., Xie, X., Liao, C.-Y., Lin, H., Liu, T., Yin, L., & Shu, H. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.014 · Cited by 376 · see citing works

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

Wang, Q., Liu, X., Cui, Y., Tang, Y., Chen, W., Li, S., Yu, H., Pan, Y., & Wang, C. (2014) · Immunity · doi:10.1016/j.immuni.2014.11.011 · Cited by 363 · see citing works

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

Mankan, A. K., Schmidt, T., Chauhan, D., Goldeck, M., Höning, K., Gaidt, M. M., Kubarenko, A. V., Andreeva, L., Hopfner, K., & Hornung, V. (2014) · The EMBO Journal · doi:10.15252/embj.201488726 · Cited by 359 · see citing works

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

Liu, S., Chen, J., Cai, X., Wu, J., Chen, X., Wu, Y.-T., Sun, L., & Chen, Z. J. (2013) · eLife · doi:10.7554/elife.00785 · Cited by 354 · see citing works

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Lafaille, F. G., Pessach, I. M., Zhang, S., Ciancanelli, M. J., Casadio, M., Abhyankar, A., Ying, S., Keros, S., Goldstein, P. A., Mostoslavsky, G., et al. (2012) · Nature · doi:10.1038/nature11583 · Cited by 341 · see citing works

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Almine, J. F., O'Hare, C., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., Connolly, D. J., Taylor, J., Kelsall, I. R., Bowie, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14392 · Cited by 341 · see citing works

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

Kondo, T., Kobayashi, J., Saitoh, T., Maruyama, K., Ishii, K. J., Barber, G. N., Komatsu, K., Akira, S., & Kawai, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222694110 · Cited by 338 · see citing works

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J. R., Ueberheide, B. M., Lamming, D. W., Chen, Z. J., Horng, T., Yeretssian, G., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.034 · Cited by 329 · see citing works

Transmission of innate immune signaling by packaging of cGAMP in viral particles

Gentili, M., Kowal, J., Tkach, M., Satoh, T., Lahaye, X., Conrad, C., Boyron, M., Lombard, B., Durand, S., Kroemer, G., et al. (2015) · Science · doi:10.1126/science.aab3628 · Cited by 322 · see citing works

RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection

Nasirudeen, A. M. A., Wong, H. H., Thien, P., Xu, S., Lam, K., & Liu, D. X. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000926 · Cited by 314 · see citing works

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-β Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

Higgs, R., Gabhann, J. N., Larbi, N. B., Breen, E. P., Fitzgerald, K. A., & Jefferies, C. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1780 · Cited by 310 · see citing works

Localisation and trafficking of Toll-like receptors: an important mode of regulation

McGettrick, A. F., & O'Neill, L. A. J. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.12.002 · Cited by 308 · see citing works

cGAS is activated by DNA in a length‐dependent manner

Luecke, S., Holleufer, A., Christensen, M. H., Jønsson, K. L., Boni, G. A., Sørensen, L. K., Johannsen, M., Jakobsen, M. R., Hartmann, R., & Paludan, S. R. (2017) · EMBO Reports · doi:10.15252/embr.201744017 · Cited by 308 · see citing works

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

Wies, E., Wang, M. K., Maharaj, N. P., Chen, K., Zhou, S., Finberg, R. W., & Gack, M. U. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.018 · Cited by 306 · see citing works

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

Cui, J., Li, Y., Zhu, L., Liu, D., Songyang, Z., Wang, H. Y., & Wang, R. (2012) · Nature Immunology · doi:10.1038/ni.2239 · Cited by 301 · see citing works

The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation

Haas, T. L., Metzger, J., Schmitz, F., Heit, A., Müller, T. R., Latz, E., & Wagner, H. (2008) · Immunity · doi:10.1016/j.immuni.2008.01.013 · Cited by 298 · see citing works

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

Jønsson, K. L., Laustsen, A., Krapp, C., Skipper, K. A., Thavachelvam, K., Hotter, D., Egedal, J. H., Kjølby, M., Mohammadi, P., Prabakaran, T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14391 · Cited by 279 · see citing works

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Herzner, A., Hagmann, C. A., Goldeck, M., Wolter, S., Kübler, K., Wittmann, S., Gramberg, T., Andreeva, L., Hopfner, K., Mertens, C., et al. (2015) · Nature Immunology · doi:10.1038/ni.3267 · Cited by 255 · see citing works

Viruses transfer the antiviral second messenger cGAMP between cells

Bridgeman, A., Maelfait, J., Davenne, T., Partridge, T., Peng, Y., Mayer, A., Dong, T., Kaever, V., Borrow, P., & Rehwinkel, J. (2015) · Science · doi:10.1126/science.aab3632 · Cited by 253 · see citing works

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

Holm, C. K., Jensen, S. B., Jakobsen, M. R., Cheshenko, N., Horan, K., Moeller, H. B., Gonzalez‐Dosal, R., Rasmussen, S. B., Christensen, M. H., Yarovinsky, T. O., et al. (2012) · Nature Immunology · doi:10.1038/ni.2350 · Cited by 247 · see citing works

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

Luo, W., Li, S., Li, C., Lian, H., Yang, Q., Zhong, B., & Shu, H. (2016) · Nature Immunology · doi:10.1038/ni.3510 · Cited by 247 · see citing works

Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction

An, J., Woodward, J. J., Sasaki, T., Minie, M., & Elkon, K. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402793 · Cited by 243 · see citing works

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response

Morchikh, M., Cribier, A., Raffel, R., Amraoui, S., Cau, J., Séverac, D., Dubois, E., Schwartz, O., Bennasser, Y., & Benkirane, M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.020 · Cited by 236 · see citing works

Dengue virus activates cGAS through the release of mitochondrial DNA

Sun, B., Sundström, K. B., Chew, J. J., Bist, P., Gan, E. S., Tan, H. C., Goh, K. C., Chawla, T., Tang, C. K., & Ooi, E. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-03932-1 · Cited by 225 · see citing works

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

Brunette, R. L., Young, J. M., Whitley, D. G., Brodsky, I. E., Malik, H. S., & Stetson, D. B. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121960 · Cited by 223 · see citing works

Modulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK

Guo, B., & Cheng, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700017200 · Cited by 221 · see citing works

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

Xia, P., Ye, B., Wang, S., Zhu, X., Du, Y., Xiong, Z., Tian, Y., & Fan, Z. (2016) · Nature Immunology · doi:10.1038/ni.3356 · Cited by 220 · see citing works

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

Seo, G. J., Yang, A., Tan, B., Kim, S., Liang, Q., Choi, Y., Yuan, W., Feng, P., Park, H.-S., & Jung, J. U. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.007 · Cited by 210 · see citing works

RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms

Qin, Y., Zhou, M., Hu, M., Hu, Y.-H., Zhang, J., Guo, L., Zhong, B., & Shu, H. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004358 · Cited by 203 · see citing works

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1

Yoh, S. M., Schneider, M., Seifried, J., Soonthornvacharin, S., Akleh, R. E., Olivieri, K. C., Jesus, P. D. D., Ruan, C., de Castro, E., Ruiz, P. A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.050 · Cited by 200 · see citing works

The tumor suppressor PTEN has a critical role in antiviral innate immunity

Li, S., Zhu, M., Pan, R., Fang, T., Cao, Y., Chen, S., Zhao, X., Lei, C., Guo, L., Chen, Y. Z., et al. (2015) · Nature Immunology · doi:10.1038/ni.3311 · Cited by 195 · see citing works

Type I interferonopathies: Mendelian type I interferon up-regulation

Crow, Y. J. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.10.005 · Cited by 189 · see citing works

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

Wang, P., Zhao, W., Zhao, K., Zhang, L., & Gao, C. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004726 · Cited by 184 · see citing works

Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent

Triantafilou, K., Orthopoulos, G., Vakakis, E., Ahmed, M. A. E., Golenbock, D. T., Lepper, P. M., & Triantafilou, M. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00537.x · Cited by 183 · see citing works

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

Garcia-Cattaneo, A., Gobert, F.-X., Müller, M., Toscano, F., Flores, M., Lescure, A., Nery, E. D., & Benaroch, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115091109 · Cited by 183 · see citing works

Antiviral responses induced by the TLR3 pathway

Matsumoto, M., Oshiumi, H., & Seya, T. (2011) · Reviews in Medical Virology · doi:10.1002/rmv.680 · Cited by 182 · see citing works

Glycogen Synthase Kinase 3β Regulates IRF3 Transcription Factor-Mediated Antiviral Response via Activation of the Kinase TBK1

Lei, C., Zhong, B., Zhang, Y., Zhang, J., Wang, S., & Shu, H. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.021 · Cited by 180 · see citing works

Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6

Li, S., Zheng, H., Mao, A., Zhong, B., Li, Y., Liu, Y., Gao, Y., Ran, Y., Tien, P., & Shu, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074971 · Cited by 179 · see citing works

TLR3 immunity to infection in mice and humans

Zhang, S., Casadio, M., Ciancanelli, M. J., de Diego, R. P., Sancho‐Shimizu, V., Abel, L., & Casanova, J. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.11.001 · Cited by 179 · see citing works

Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants

Dubensky, T. W., Kanne, D. B., & Leong, M. L. L. (2013) · Therapeutic Advances in Vaccines · doi:10.1177/2051013613501988 · Cited by 175 · see citing works

Suppression of systemic autoimmunity by the innate immune adaptor STING

Sharma, S., Campbell, A. M., Chan, J., Schattgen, S., Orlowski, G. M., Nayar, R., Huyler, A. H., Nündel, K., Mohan, C., Berg, L. J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420217112 · Cited by 172 · see citing works

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

Wang, Q., Huang, L., Hong, Z., Lv, Z., Mao, Z., Tang, Y., Kong, X., Li, S., Cui, Y., Liu, H., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006264 · Cited by 167 · see citing works

Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection

Harrison, C. J., Jenski, L. J., Voychehovski, T., & Bernstein, D. I. (1988) · Antiviral Research · doi:10.1016/0166-3542(88)90032-0 · Cited by 154 · see citing works

TLR9 and STING agonists synergistically induce innate and adaptive type‐II IFN

Temizoz, B., Kuroda, E., Ohata, K., Jounai, N., Ozasa, K., Kobiyama, K., Aoshi, T., & Ishii, K. J. (2014) · European Journal of Immunology · doi:10.1002/eji.201445132 · Cited by 153 · see citing works

The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling

Zhou, Q., Lin, H., Wang, S., Wang, S., Ran, Y., Liu, Y., Ye, W., Xiong, X., Zhong, B., Shu, H., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.006 · Cited by 150 · see citing works

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

Li, Y., Chen, R., Zhou, Q., Xu, Z.-S., Li, C., Wang, S., Mao, A., Zhang, X., He, W.-W., & Shu, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203405109 · Cited by 146 · see citing works

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

Zhang, M., Tian, Y., Wang, R., Gao, D., Zhang, Y., Diao, F., Chen, D., Zhai, Z., & Shu, H. (2008) · Cell Research · doi:10.1038/cr.2008.277 · Cited by 144 · see citing works

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

Uchikawa, E., Lethier, M., Malet, H., Brunel, J., Gerlier, D., & Cusack, S. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.021 · Cited by 143 · see citing works

NAK-Associated Protein 1 Participates in Both the TLR3 and the Cytoplasmic Pathways in Type I IFN Induction

Sasai, M., Shingai, M., Funami, K., Yoneyama, M., Fujita, T., Matsumoto, M., & Seya, T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8676 · Cited by 138 · see citing works

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

Hu, M., Liao, C.-Y., Yang, Q., Xie, X., & Shu, H. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161015 · Cited by 135 · see citing works

Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response

Mao, A., Li, S., Zhong, B., Li, Y., Yan, J., Li, Q., Teng, C., & Shu, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071043 · Cited by 134 · see citing works

HIV-1 Lentiviral Vector Immunogenicity Is Mediated by Toll-Like Receptor 3 (TLR3) and TLR7

Breckpot, K., Escors, D., Vargas, F. A., Lopes, L., Karwacz, K., Lint, S. V., Keyaerts, M., & Collins, M. K. (2010) · Journal of Virology · doi:10.1128/jvi.00014-10 · Cited by 134 · see citing works

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Nguyen, T. A., Smith, B. R. C., Tate, M. D., Belz, G. T., Barrios, M. H., Elgass, K., Weisman, A. S., Baker, P. J., Preston, S., Whitehead, L. W., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.007 · Cited by 130 · see citing works

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

Andrade, W. A., Firon, A., Schmidt, T., Hornung, V., Fitzgerald, K. A., Kurt‐Jones, E. A., Trieu‐Cuot, P., Golenbock, D. T., & Kaminski, P. A. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.06.003 · Cited by 128 · see citing works

A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation

Zhao, J., Zeng, Y. A., Xu, S., Chen, J., Shen, G., Yu, C., Knipe, D. M., Yuan, W., Peng, J., Xu, W., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.10.011 · Cited by 120 · see citing works

Topical Imiquimod

Wagstaff, A. J., & Perry, C. M. (2007) · Drugs · doi:10.2165/00003495-200767150-00006 · Cited by 115 · see citing works

The Toll-like receptor 3:dsRNA signaling complex

Botos, I., Liu, L., Wang, Y., Segal, D. M., & Davies, D. R. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.06.005 · Cited by 111 · see citing works

RNA Recognition via TLR7 and TLR8

Hornung, V., Barchet, W., Schlee, M., & Hartmann, G. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72167-3_4 · Cited by 99 · see citing works

WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-κB activation

Wang, Y., Liu, L., Zhong, B., Liu, T., Li, Y., Yang, Y., Ran, Y., Li, S., Tien, P., & Shu, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908967107 · Cited by 89 · see citing works

SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation

Ran, Y., Liu, T., Zhou, Q., Li, S., Mao, A., Li, Y., Liu, L.-J., Cheng, J., & Shu, H. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr020 · Cited by 87 · see citing works

Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation

Tao, J., Zhang, X., Jin, J., Du, X., Lian, T., Yang, J., Zhou, X., Jiang, Z., & Su, X. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601909 · Cited by 83 · see citing works

Endosomal Localization of TLR8 Confers Distinctive Proteolytic Processing on Human Myeloid Cells

Ishii, N. K., Funami, K., Tatematsu, M., Seya, T., & Matsumoto, M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401375 · Cited by 82 · see citing works

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

Ran, Y., Zhang, J., Liu, L., Pan, Z.-Y., Nie, Y., Zhang, H., & Wang, Y. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv068 · Cited by 80 · see citing works

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling

Tan, P., He, L., Cui, J., Chen, Q., Cao, X., Lin, M., Zhu, Q., Li, Y., Xing, C., Yu, X. H., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.035 · Cited by 78 · see citing works

Activation of the RIG-I Pathway during Influenza Vaccination Enhances the Germinal Center Reaction, Promotes T Follicular Helper Cell Induction, and Provides a Dose-Sparing Effect and Protective Immunity

Kulkarni, R. R., Rasheed, M. A. U., Bhaumik, S. K., Ranjan, P., Cao, W., Davis, C. W., Marisetti, K., Thomas, S., Gangappa, S., Sambhara, S. R., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02273-14 · Cited by 77 · see citing works

Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9

Bauer, S., Pigisch, S., Hangel, D., Kaufmann, A. M., & Hamm, S. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.10.010 · Cited by 74 · see citing works

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

Maschalidi, S., Hässler, S., Blanc, F., Sepulveda, F. E., Tohmé, M., Chignard, M., Endert, P. V., Si‐Tahar, M., Descamps, D., & Manoury, B. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002841 · Cited by 67 · see citing works

DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation

Tai, A., Li, S., Pan, W. D., Tien, P., Zhong, B., Shu, H., & Wu, S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005179 · Cited by 64 · see citing works

Role of human Toll‐like receptors in naturally occurring influenza A infections

Lee, N. L. S., Wong, C. K., Hui, D. S. C., Lee, S. K. W., Wong, R. Y. K., Ngai, K. L. K., Chan, M. C. W., Chu, Y. J., Ho, A. M. ‐., Lui, G. C.-Y., et al. (2013) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12109 · Cited by 64 · see citing works

The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response

Yang, Y., Wang, S., Huang, Z.-F., Zou, H.-M., Yan, B.-R., Luo, W., & Wang, Y. (2016) · Cell Research · doi:10.1038/cr.2016.16 · Cited by 59 · see citing works

Adding to the STING

Shu, H., & Wang, Y. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.002 · Cited by 49 · see citing works

Innate immune sensing of HIV infection

Silvin, A., & Manel, N. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.12.003 · Cited by 43 · see citing works

LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner

Liu, T., Yang, Q., Li, M., Zhong, B., Ran, Y., Liu, L., Yang, Y., Wang, Y., & Shu, H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600212 · Cited by 41 · see citing works

PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation

Yan, B.-R., Zhou, L., Hu, M., Li, M., Lin, H., Yang, Y., Wang, Y., & Shu, H. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006648 · Cited by 39 · see citing works

Cytoplasm-Translocated Ku70/80 Complex Sensing of HBV DNA Induces Hepatitis-Associated Chemokine Secretion

Li, Y., Wu, Y., Zheng, X., Cong, J., Liu, Y., Li, J., Sun, R., Tian, Z., & Wei, H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00569 · Cited by 36 · see citing works

Mitochondria–Endoplasmic Reticulum Contact Sites Mediate Innate Immune Responses

Misawa, T., Takahama, M., & Saitoh, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4567-7_14 · Cited by 32 · see citing works

GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome

Nie, Y., Ran, Y., Zhang, H., Huang, Z.-F., Pan, Z.-Y., Wang, S., & Wang, Y. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006328 · Cited by 30 · see citing works

MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes

Chen, L.-T., Hu, M., Xu, Z.-S., Liu, Y., & Shu, H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600039 · Cited by 28 · see citing works

Toll-Like Receptor Agonists as Adjuvants for HIV Vaccines

Stevceva, L. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797636027 · Cited by 13 · see citing works

Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

Kasravi, M., Ahmadi, A., Babajani, A., Mazloomnejad, R., Hatamnejad, M. R., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00348-z · Cited by 316 · see citing works

Cytosolic DNA sensing by cGAS: regulation, function, and human diseases

Yu, L., & Liu, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00554-y · Cited by 278 · see citing works

Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation

Platanitis, E., & Decker, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02542 · Cited by 251 · see citing works

Mitochondrial DNA-triggered innate immune response: mechanisms and diseases

Hu, M.-M., & Shu, H. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01086-x · Cited by 247 · see citing works

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

Fu, Y.-Z., Wang, S., Zheng, Z.-Q., Huang, Y., Li, W.-W., Xu, Z.-S., & Wang, Y. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00571-x · Cited by 205 · see citing works

Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases

Hu, M., & Shu, H. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-070119-115052 · Cited by 156 · see citing works

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

Zhong, L., Hu, M., Bian, L., Liu, Y., Chen, Q., & Shu, H. (2020) · Cell Discovery · doi:10.1038/s41421-020-0162-2 · Cited by 137 · see citing works

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

Lin, H., Li, S., & Shu, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01751 · Cited by 130 · see citing works

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

Sun, X., Liu, T., Zhao, J., Xia, H., Xie, J., Guo, Y., Zhong, L., Li, M., Yang, Q., Peng, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19941-0 · Cited by 129 · see citing works

Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity

Hu, M., He, W.-R., Gao, P., Yang, Q., He, K. F., Cao, L.-B., Li, S., Feng, Y., & Shu, H. (2019) · Cell Research · doi:10.1038/s41422-018-0136-1 · Cited by 119 · see citing works

KAT5 acetylates cGAS to promote innate immune response to DNA virus

Song, Z.-M., Lin, H., Yi, X.-M., Guo, W., Hu, M., & Shu, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922330117 · Cited by 108 · see citing works

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Schmidt, N., Domingues, P., Gołębiowski, F., Patzina, C., Tatham, M. H., Hay, R. T., & Hale, B. G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907031116 · Cited by 108 · see citing works

African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity

Ran, Y., Li, D., Xiong, M.-G., Liu, H., Feng, T., Shi, Z., Li, Y., Wu, H.-N., Wang, S., Zheng, H., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010270 · Cited by 91 · see citing works

RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA

Zhang, Z.-D., Xiong, T.-C., Yao, S., Wei, M., Chen, M., Lin, D., & Zhong, B. (2020) · Nature Communications · doi:10.1038/s41467-020-19318-3 · Cited by 87 · see citing works

PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response

Xia, T., Yi, X.-M., Wu, X., Shang, J., & Shu, H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906431116 · Cited by 83 · see citing works

USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity

Zhang, Q., Tang, Z., An, R., Ye, L., & Zhong, B. (2020) · Cell Research · doi:10.1038/s41422-020-0341-6 · Cited by 83 · see citing works

RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation

Yang, B., Liu, Y., Cui, Y., Song, D., Zhang, G., Ma, S., Liu, Y., Chen, M., Chen, F., Wang, H., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008387 · Cited by 78 · see citing works

NS1: A Key Protein in the “Game” Between Influenza A Virus and Host in Innate Immunity

Ji, Z., Wang, X., & Liu, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.670177 · Cited by 76 · see citing works

Pattern recognition receptor‐mediated inflammation in diabetic vascular complications

Wang, X., Antony, V., Wang, Y., Wu, G., & Liang, G. (2020) · Medicinal Research Reviews · doi:10.1002/med.21711 · Cited by 73 · see citing works

MAVS integrates glucose metabolism and RIG-I-like receptor signaling

He, Q.-Q., Huang, Y., Nie, L., Ren, S., Xu, G., Deng, F., Cheng, Z., Zuo, Q., Zhang, L., Cai, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41028-9 · Cited by 63 · see citing works

Deciphering the pathways to antiviral innate immunity and inflammation

Yang, Q., & Shu, H. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.11.001 · Cited by 65 · see citing works

cGAS/STING signalling pathway in senescence and oncogenesis

Yu, L., & Liu, P. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.08.007 · Cited by 63 · see citing works

PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA

Liao, C.-Y., Lei, C., & Shu, H. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0462-3 · Cited by 58 · see citing works

VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release

He, W.-R., Cao, L.-B., Yang, Y.-L., Hua, D., Hu, M., & Shu, H. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00673-0 · Cited by 62 · see citing works

Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response

Fu, Y.-Z., Guo, Y., Zou, H.-M., Su, S., Wang, S., Yang, Q., Luo, M., & Wang, Y. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007691 · Cited by 56 · see citing works

USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA

Ye, L., Zhang, Q., Liuyu, T., Xu, Z., Zhang, M., Luo, M., Zeng, W., Zhu, Q., Lin, D., & Zhong, B. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007680 · Cited by 53 · see citing works

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

Li, M., & Shu, H. (2020) · Protein & Cell · doi:10.1007/s13238-020-00729-3 · Cited by 48 · see citing works

The monkeypox virus-host interplays

Yi, X.-M., Lei, Y., Li, M., Zhong, L., & Li, S. (2024) · Cell Insight · doi:10.1016/j.cellin.2024.100185 · Cited by 47 · see citing works

Regulation and function of the cGAS-MITA/STING axis in health and disease

Zhang, Z.-D., & Zhong, B. (2022) · Cell Insight · doi:10.1016/j.cellin.2021.100001 · Cited by 44 · see citing works

Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone

Su, S., Hua, D., Li, J.-P., Zhang, X., Bai, L., Cao, L.-B., Guo, Y., Zhang, M., Dong, J., Liang, X.-W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00981-5 · Cited by 41 · see citing works

Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair

Aditi, A., Downing, S. M., Schreiner, P. A., Kwak, Y. D., Li, Y., Shaw, T. I., Russell, H. R., & McKinnon, P. J. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.040 · Cited by 40 · see citing works

USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA

Zhang, H., Liao, B.-W., Xu, Z.-S., Ran, Y., Wang, D., Yang, Y., Luo, W., & Wang, Y. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008178 · Cited by 37 · see citing works

USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA

Zhang, M., Cai, Z., Zhang, M., Wang, X., Wang, Y., Zhao, F., Zhu, Q., Luo, M., Zhu, Q., Xu, Z., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801447 · Cited by 33 · see citing works

Evasion of host defense by Brucella

Yang, J., Wang, Y., Hou, Y., Sun, M., Xia, T., & Wu, X. G. (2023) · Cell Insight · doi:10.1016/j.cellin.2023.100143 · Cited by 33 · see citing works

Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-κB-Mediated Transcription

Fu, Y.-Z., Su, S., Zou, H.-M., Guo, Y., Wang, S., Li, S., Luo, M., & Wang, Y. (2019) · Journal of Virology · doi:10.1128/jvi.00181-19 · Cited by 33 · see citing works

SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA

Guo, W., Wei, J., Zhong, X., Zang, R., Lian, H., Hu, M., Li, S., Shu, H., & Yang, Q. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0285-2 · Cited by 33 · see citing works

Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review

He, W.-R., Yuan, J., Ma, Y., Zhao, C.-Y., Yang, Z., Zhang, Y., Han, S., Wan, B., & Zhang, G. (2022) · Animals · doi:10.3390/ani12212935 · Cited by 32 · see citing works

Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2

Zhang, Y., Xu, Y., Dai, Y., Li, Z., Wang, J., Ye, Z., Ren, Y., Wang, H., Li, W.-X., Lü, J., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009790 · Cited by 31 · see citing works

Mouse circulating extracellular vesicles contain virus‐derived siRNAs active in antiviral immunity

Zhang, Y., Dai, Y., Wang, J., Xu, Y., Li, Z., Lü, J., Xu, Y., Zhong, J., Ding, S., & Li, Y. (2022) · The EMBO Journal · doi:10.15252/embj.2021109902 · Cited by 31 · see citing works

Aquatic animal viruses mediated immune evasion in their host

Ke, F., & Zhang, Q.-Y. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.12.027 · Cited by 30 · see citing works

Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses

Cai, X., Zhou, Z., Zhu, J., Liu, X., Ouyang, G., Wang, J., Li, Z., Li, X., Zha, H., Zhu, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110920 · Cited by 30 · see citing works

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease

Song, J., Yang, R., Chang, J., Liu, Y., Lu, C.-H., Chen, L., Guo, H., Zhang, Y., Fan, Z., Zhou, J., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01002-5 · Cited by 30 · see citing works

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Wang, H., Zang, C., Ren, M., Shang, M., Wang, Z., Peng, X., Zhang, Q., Wen, X., Xi, Z., & Zhou, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-72393-w · Cited by 29 · see citing works

The molecular mechanisms of extracellular matrix-derived hydrogel therapy in idiopathic pulmonary fibrosis models

Evangelista-Leite, D., Carreira, A. C. O., Nishiyama, M. Y., Gilpin, S. E., & Miglino, M. A. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122338 · Cited by 27 · see citing works

Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity

Zheng, Z.-Q., Fu, Y.-Z., Wang, S., Xu, Z.-S., Zou, H.-M., & Wang, Y. (2022) · Cell Insight · doi:10.1016/j.cellin.2022.100014 · Cited by 25 · see citing works

Multimericity Amplifies the Synergy of BCR and TLR4 for B Cell Activation and Antibody Class Switching

Pone, E. J., Hernandez‐Davies, J. E., Jan, S., Silzel, E. K., Felgner, P. L., & Davies, D. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.882502 · Cited by 27 · see citing works

Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response

Yang, Y.-L., Cao, L.-B., He, W.-R., Zhong, L., Guo, Y., Yang, Q., Shu, H., & Hu, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2207280119 · Cited by 25 · see citing works

Lactiplantibacillus plantarum Strains Modulate Intestinal Innate Immune Response and Increase Resistance to Enterotoxigenic Escherichia coli Infection

Baillo, A. A., Villena, J., Albarracín, L., Tomokiyo, M., Elean, M., Fukuyama, K., Quilodrán-Vega, S., Fadda, S., & Kitazawa, H. (2022) · Microorganisms · doi:10.3390/microorganisms11010063 · Cited by 24 · see citing works

ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response

Zhong, X., Feng, L., Zang, R., Lei, C., Yang, Q., & Shu, H. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008457 · Cited by 24 · see citing works

Chikungunya Virus Vaccines: Platforms, Progress, and Challenges

DeFilippis, V. R. (2019) · Current topics in microbiology and immunology · doi:10.1007/82_2019_175 · Cited by 22 · see citing works

The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response

Li, C., Feng, L., Luo, W., Lei, C., Li, M., & Shu, H. (2021) · Cell Discovery · doi:10.1038/s41421-021-00277-y · Cited by 22 · see citing works

TRAF7 negatively regulates the RLR signaling pathway by facilitating the K48-linked ubiquitination of TBK1

Huang, J., Yang, Y., Chen, T., Wang, D., Li, J., & Xu, L. (2023) · Virologica Sinica · doi:10.1016/j.virs.2023.04.005 · Cited by 18 · see citing works

Estrogen receptor α-mediated signaling inhibits type I interferon response to promote breast carcinogenesis

Cao, L.-B., Ruan, Z.-L., Yang, Y.-L., Zhang, N.-C., Gao, C., Cai, C., Zhang, J., Hu, M.-M., & Shu, H. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad047 · Cited by 17 · see citing works

The Contribution of Viral Proteins to the Synergy of Influenza and Bacterial Co-Infection

Mikušová, M., Tomčíková, K., Briestenská, K., Kostolanský, F., & Varečková, E. (2022) · Viruses · doi:10.3390/v14051064 · Cited by 17 · see citing works

β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response

Guo, Y., Zhang, X., Su, S., Ruan, Z.-L., Hu, M., & Shu, H. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00967-x · Cited by 16 · see citing works

CSK promotes innate immune response to DNA virus by phosphorylating MITA

Gao, P., Hu, M., & Shu, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.069 · Cited by 16 · see citing works

Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways

Deng, Y. L., Wang, Y., Li, L., Miao, E. A., & Liu, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.898724 · Cited by 16 · see citing works

Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition

Liu, Y., Abula, A., Xiao, H., Guo, H., Li, T., Zheng, L., Chen, B., Nguyen, H. C., & Ji, X. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167920 · Cited by 15 · see citing works

Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62

Krause, M., Samolej, J., Yakimovich, A., Kriston-Vizi, J., Huttunen, M., Reyna, S. J. L., Frickel, E., & Mercer, J. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202104129 · Cited by 15 · see citing works

A highly sensitive and versatile fluorescent biosensor for pathogen nucleic acid detection based on toehold-mediated strand displacement initiated primer exchange reaction

Zhang, Y., Li, Z., Su, W., Zhong, G., Zhang, X., Wu, Y. J., Situ, B., Xiao, Y., Yan, X., & Zheng, L. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.340125 · Cited by 15 · see citing works

Porcine sialoadhesin suppresses type I interferon production to support porcine reproductive and respiratory syndrome virus infection

Liu, Y., Li, R., Qiao, S., Chen, X., Deng, R., & Zhang, G. (2020) · Veterinary Research · doi:10.1186/s13567-020-00743-7 · Cited by 14 · see citing works

The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation

Huang, C., Yin, Y., Pan, P., Huang, Y., Chen, S., Chen, J., Wang, J., Xu, G., Tao, X., Xiao, X., et al. (2023) · Viruses · doi:10.3390/v15122304 · Cited by 13 · see citing works

Genome integrity and inflammation in the nervous system

Aditi, A., & McKinnon, P. J. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103406 · Cited by 12 · see citing works

Transcriptome Analysis Identifies Strategies Targeting Immune Response-Related Pathways to Control Enterotoxigenic Escherichia coli Infection in Porcine Intestinal Epithelial Cells

Wu, Q., Cui, D., Chao, X.-Y., Chen, P., Liu, J., Wang, Y., Su, T., Li, M., Xu, R., Zhu, Y., et al. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.677897 · Cited by 12 · see citing works

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Li, W.-W., Fan, X.-X., Zhu, Z., Cao, X.-J., Zhu, Z.-Y., Pei, D.-S., Wang, Y.-Z., Zhang, J.-Y., Wang, Y.-Y., & Zheng, H. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011742 · Cited by 11 · see citing works

Host Factors Modulate Virus-Induced IFN Production via Pattern Recognition Receptors

Wang, J., Dong, Y., Zheng, X., Ma, H., Huang, M., Fu, D., Liu, J., & Yin, Q. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s455035 · Cited by 11 · see citing works

Role of the AIM2 Inflammasome in Cancer: Potential Therapeutic Strategies

Colarusso, C., Terlizzi, M., Caprio, S. D., Falanga, A., D’Andria, E., Bianca, R. D. D. V., & Sorrentino, R. (2025) · Biomedicines · doi:10.3390/biomedicines13020395 · Cited by 10 · see citing works

The cGAS-STING signaling pathway in the regulation of pulmonary infections: a systematic review

Xu, Q., & Zhu, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1628481 · Cited by 10 · see citing works

ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3

Yu, C., Wang, B., Zhu, Y., Zhang, C., Ren, L., Lei, X., Xiang, Z., Zhou, Z. L., Huang, H., Wang, J., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abh0068 · Cited by 10 · see citing works

The influence of extracellular vesicles on tumor evolution and resistance to therapy

Baston, E., García-Agulló, J., & Peinado, H. (2025) · Physiological Reviews · doi:10.1152/physrev.00019.2024 · Cited by 8 · see citing works

The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor

Ren, H., Wang, Y., Li, L., Shi, L.-F., Ma, Y., Fan, J.-H., Pan, X.-Y., Shao, H.-C., Zhang, Y., Han, S., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013319 · Cited by 11 · see citing works

Mitotic inactivation of the cGAS‒MITA/STING pathways

Zhong, L., & Shu, H. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab061 · Cited by 8 · see citing works

Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection

Xu, Y., Yang, Q., Xue, B., Wang, X., Tian, R., Deng, R., Chen, S., Wang, X., Wang, L., Wang, C., et al. (2022) · Journal of Virology · doi:10.1128/jvi.00001-22 · Cited by 8 · see citing works

PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses

Shi, M.-L., Wang, C., Chen, Z., Zhou, Y., Yu, L., Liu, Y., Guo, T., Shang, J., Xu, H., Zhang, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59421-x · Cited by 7 · see citing works

IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner

Gao, M., Qi, Y., & Zhang, J. (2025) · Cell Insight · doi:10.1016/j.cellin.2025.100255 · Cited by 7 · see citing works

Picrasidine S Induces cGAS‐Mediated Cellular Immune Response as a Novel Vaccine Adjuvant

Ding, X., Sun, M., Guo, F., Qian, X., Yuan, H., Lou, W., Wang, Q., Lei, X., & Zeng, W. (2024) · Advanced Science · doi:10.1002/advs.202310108 · Cited by 6 · see citing works

Mycobacterial peptidyl prolyl isomerase A activates STING ‐ TBK1 ‐ IRF3 signaling to promote IFNβ release in macrophages

Sharma, A. K., Mal, S., Sahu, S. K., Bagchi, S., Majumder, D., Chakravorty, D., Saha, S., Kundu, M., & Basu, J. (2024) · FEBS Journal · doi:10.1111/febs.17261 · Cited by 7 · see citing works

SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome

Li, J., Chen, T., Xie, T., Yang, Y., He, T., & Xu, L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.121 · Cited by 7 · see citing works

SIRT2 inhibition enhances mitochondrial apoptosis in Brucella-infected bovine placental trophoblast cells

Zhang, M., Qi, L., Li, J., Yuan, N., Zhai, Y., Hao, M., Zhou, D., Liu, W., Jin, Y., & Wang, A. (2025) · Veterinary Research · doi:10.1186/s13567-025-01518-8 · Cited by 6 · see citing works

Mitochondrial DUT-M potentiates RLR-mediated antiviral signaling by enhancing VISA and TRAF2 association

Weng, G.-X., Ling, T., Hou, W., Li, S.-N., Chen, T., Zhang, Z., Wang, D., & Xu, L. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.01.023 · Cited by 6 · see citing works

RNF138 Downregulates Antiviral Innate Immunity by Inhibiting IRF3 Activation

Zeng, X., Liu, C., Fan, J., Zou, J., Guo, M., & Sun, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216110 · Cited by 6 · see citing works

When ASFV Infection Meets the cGAS‐STING Signaling Pathway

Chen, S., Shang, K., Wei, Y., Chen, J., Yu, Z., He, L., & Ding, K. (2024) · Transboundary and Emerging Diseases · doi:10.1155/2024/6898157 · Cited by 6 · see citing works

Epstein‐Barr virus regulates the life cycle and host cell biology by hijacking post‐translational modification

Zhang, X., Zhang, Y., Liu, W., & Luo, B. (2023) · Reviews in Medical Virology · doi:10.1002/rmv.2447 · Cited by 5 · see citing works

HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I

Yang, Y., Huang, J., Li, S.-N., Li, J., Ling, T., Xie, T., & Xu, L. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.03.002 · Cited by 5 · see citing works

HTATSF1 regulates innate antiviral immune response by orchestrating TRAF3-IRF3 and TRAF6-NF-κB pathways

Zeng, J., Ruan, Z., Zhang, Q., Yi, X.-M., Chen, Y.-D., Hu, M.-M., & Li, S. (2025) · Cell Insight · doi:10.1016/j.cellin.2025.100294 · Cited by 4 · see citing works

ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I

Zhong, N., Wang, C., Weng, G.-X., Ling, T., & Xu, L. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023136 · Cited by 4 · see citing works

The carcinogenic metabolite acetaldehyde impairs cGAS activity to negatively regulate antiviral and antitumor immunity

Zhou, X.-Y., Zhang, N.-C., Zhang, X.-N., Sun, X.-D., Ruan, Z.-L., Yang, Q., Hu, M., & Shu, H. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217615 · Cited by 4 · see citing works

African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination

Zhao, J., Zhang, X., Mou, C., Shi, K., & Chen, Z. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110669 · Cited by 3 · see citing works

NRF1-mediated innate immune response drives inflammaging

Lei, H., Zhao, T., Zhang, J., Long, Y., Chen, Y., Zhu, Y., Meng, Y., Tang, Y., Liu, X., Sun, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66368-6 · Cited by 4 · see citing works

Ctenopharyngodon idella (grass carp) SIRT7 negatively regulates anti-GCRV innate immunity by promoting IRF3 and IRF7 degradation

Bai, Y., Liao, Q., Wang, Z., Zhu, C., Liu, W., Xiao, W., & Liu, X. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742575 · Cited by 3 · see citing works

CHID1 positively regulates RLR antiviral signaling by targeting the RIG‐I/VISA signalosome

Li, S.-N., Ling, T., Yang, Y., Huang, J., & Xu, L. (2019) · Journal of Medical Virology · doi:10.1002/jmv.25508 · Cited by 3 · see citing works

SOX9 negatively regulates the RLR antiviral signaling by targeting MAVS

Jiang, X., & Xu, L. (2022) · Virus Genes · doi:10.1007/s11262-022-01886-9 · Cited by 3 · see citing works

Human-specific activation of the DUX4-SLC34A2 axis by herpesviruses suppresses antiviral innate immunity

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PIASy of orange-spotted grouper (Epinephelus coioides) negatively regulates RLRs-mediated innate antiviral immunity

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PTPN2 modulates antiviral immunity in grouper by promoting TBK1 degradation and suppressing interferon signaling

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Grass carp ( Ctenopharyngodon idella ) SMYD3 negatively regulates antiviral innate immunity by methylating IRF3 and IRF7 during GCRV infection

Wang, Z., Bai, Y., Liu, W., Zhu, C., Sun, X., Deng, H., Shi, S., Xiao, W., & Liu, X. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf311 · Cited by 1 · see citing works

GPAT4 regulates antitumor immune response through activating the mtDNA-cGAS axis in cancer cells

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STRAP upregulates antiviral innate immunity against PRV by targeting TBK1

He, W., Chang, H., Li, C., Wang, C., Li, L., Yang, G., Chen, J., & Liu, H. (2024) · Virology Journal · doi:10.1186/s12985-024-02474-z · Cited by 1 · see citing works

FBXW7 is a multifaceted regulator of the innate immune response to DNA viruses

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Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

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Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

Wu, J., & Chen, Z. J. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120156 · Cited by 1,179 · see citing works

Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid SensorsPreprint

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Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways

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Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases

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