Type I Interferon Responses Drive Intrahepatic T Cells to Promote Metabolic Syndrome
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Obesity-related insulin resistance correlates with type I interferon–driven activation and expansion of intrahepatic T cells. See the related Focus by Ma et al .
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The NASH T cell response is characterized by an enrichment for cytotoxic CD8+ T, TH1 differentiated CD4+ T and NKT cell populations.
“The NASH T cell response is characterized by an enrichment for cytotoxic CD8+ T, TH1 differentiated CD4+ T and NKT cell populations (18, 121, 131–135).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [132]
These immune shifts drive hepatocyte metabolic dysregulation through IFNγ, TNFα, and IL-17A signaling and production of the lymphotoxin LIGHT.
“These immune shifts drive hepatocyte metabolic dysregulation through IFNγ, TNFα, and IL-17A signaling and production of the lymphotoxin LIGHT (18, 121, 132, 133).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [132]
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- Authors
- Ghazarian, M., Revelo, X. S., Nøhr, M. K., Luck, H., Zeng, K., Lei, H., Tsai, S., Schroer, S. A., Park, Y. J., Chng, M. H. Y., Shen, L., D’Angelo, J. A., Horton, P., Chapman, W. C., Brockmeier, D., Woo, M., Engleman, E. G., Adeyi, O., Hirano, N., Jin, T., Gehring, A. J., Winer, S., & Winer, D. A.
- Affiliations
- University Health Network (CA)
- Stanford Medicine (US)
- Shanghai Jiao Tong University (CN)
- Saint Louis University (US)
- Methodist University Hospital (US)
- Washington University in St. Louis (US)
- Mid-America Transplant Services, St. Louis, MO 63110, USA.
- St. Michael's Hospital (CA)
- Corresponding author
- Ghazarian, Magar
- Revelo, Xavier S.
- Winer, Shawn
- Winer, Daniel A.
- ORCID
- Ghazarian, Magar
- Revelo, Xavier S.
- Nøhr, Mark K.
- Luck, Helen
- Lei, Helena
- Tsai, Sue
- Schroer, Stephanie A.
- Park, Yoo Jin
- Chng, Melissa Hui Yen
- Shen, Lei
- D’Angelo, June Ann
- Horton, Peter
- Chapman, William C.
- Brockmeier, Diane
- Woo, Minna
- Engleman, Edgar G.
- Adeyi, Oyedele
- Hirano, Naoto
- Jin, Tianru
- Gehring, Adam J.
- Winer, Daniel A.
- Venue
- Science Immunology
- Published
- 2017-04-21
- Volume
- 2
- Issue
- 10
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC5447456
- OpenAlex
- W2606788958
- Cited by
- 190
- References
- 61
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 29 · 2023: 28 · 2022: 35 · 2021: 24 · 2020: 20 · 2019: 16 · 2018: 4 · 2017: 8
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Funders
- CIHR (award302510)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- type I interferon, interferon alpha receptor 1, non-alcoholic fatty liver disease, metabolic syndrome, intrahepatic T cells, CD8+ T cells, chimeric mice, liver inflammation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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