The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
Open accessAbstract
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when compared to other anti-stem antibodies. MEDI8852 is effective in mice and ferrets with a therapeutic window superior to that of oseltamivir. Crystallographic analysis of Fab alone or in complex with H5 or H7 HA proteins reveals that MEDI8852 binds through a coordinated movement of CDRs to a highly conserved epitope encompassing a hydrophobic groove in the fusion domain and a large portion of the fusion peptide, distinguishing it from other structurally characterized cross-reactive antibodies. The unprecedented breadth and potency of neutralization by MEDI8852 support its development as immunotherapy for influenza virus-infected humans.
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Cites
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Self-citationNew World Bats Harbor Diverse Influenza A Viruses
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Highly Conserved Protective Epitopes on Influenza B Viruses
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Self-citationVaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses
Joyce, M. G., Wheatley, A. K., Thomas, P. V., Chuang, G.-Y., Soto, C., Bailer, R. T., Druz, A., Georgiev, I. S., Gillespie, R. A., Kanekiyo, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.043 · Cited by 333
Learning the language of viral evolution and escape
Hie, B., Zhong, E. D., Berger, B., & Bryson, B. (2021) · Science · doi:10.1126/science.abd7331 · Cited by 361
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Antibodies to combat viral infections: development strategies and progress
Pantaleo, G., Correia, B., Fenwick, C., Joo, V. S., & Perez, L. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00495-3 · Cited by 279
Metadata
- Authors
- Kallewaard, N. L., Corti, D., Collins, P. J., Neu, U., McAuliffe, J. M., Benjamin, E., Wachter-Rosati, L., Palmer-Hill, F. J., Yuan, A. Q., Walker, P. A., Vorlaender, M. K., Bianchi, S., Guarino, B., De Marco, A., Vanzetta, F., Agatic, G., Foglierini, M., Pinna, D., Fernandez-Rodriguez, B., Fruehwirth, A., Silacci, C., Ogrodowicz, R. W., Martin, S. R., Sallusto, F., Suzich, J. A., Lanzavecchia, A., Zhu, Q., Gamblin, S. J., & Skehel, J. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 166
- Issue
- 3
- Pages
- 596-608
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2491163602
- Cited by
- 426
- References
- 32
- FWCI
- 33.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kallewaard, N. L., Corti, D., Collins, P. J., Neu, U., McAuliffe, J. M., Benjamin, E., Wachter-Rosati, L., Palmer-Hill, F. J., Yuan, A. Q., Walker, P. A., Vorlaender, M. K., Bianchi, S., Guarino, B., De Marco, A., Vanzetta, F., Agatic, G., Foglierini, M., Pinna, D., Fernandez-Rodriguez, B., . . . Skehel, J. J. (2016). Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes. Cell. https://doi.org/10.1016/j.cell.2016.05.073
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
