Highly Conserved Protective Epitopes on Influenza B Viruses

Dreyfus, Cyrille; Laursen, Nick S.; Kwaks, Ted; Zuijdgeest, David; Khayat, Reza; Ekiert, Damian C.; Lee, Jeong Hyun; Metlagel, Zoltan; Bujny, Miriam V.; Jongeneelen, Mandy; van der Vlugt, Remko; Lamrani, Mohammed; Korse, Hans J. W. M.; Geelen, Eric; Sahin, Özcan; Sieuwerts, Martijn; Brakenhoff, Just P. J.; Vogels, Ronald; Li, Olive T. W.; Poon, Leo L. M.; Peiris, Malik; Koudstaal, Wouter; Ward, Andrew B.; Wilson, Ian A.; Goudsmit, Jaap; Friesen, Robert H. E.

doi:10.1126/science.1222908

Cited by 866

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Highly Conserved Protective Epitopes on Influenza B Viruses

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Dreyfus, Cyrille, Laursen, Nick S., Kwaks, Ted, Zuijdgeest, David, Khayat, Reza, Ekiert, Damian C., Lee, Jeong Hyun, Metlagel, Zoltan, Bujny, Miriam V., Jongeneelen, Mandy, van der Vlugt, Remko, Lamrani, Mohammed, Korse, Hans J. W. M., Geelen, Eric, Sahin, Özcan, Sieuwerts, Martijn, Brakenhoff, Just P. J., Vogels, Ronald, Li, Olive T. W., Poon, Leo L. M., Peiris, Malik, Koudstaal, Wouter, Ward, Andrew B., Wilson, Ian A., Goudsmit, Jaap, Friesen, Robert H. E.·2012·Science

DOI 10.1126/science.1222908

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Abstract

Influenza Antibodies, Part B: With its ability to reassort in animal hosts like pigs and birds, and to cause pandemics, influenza A viruses are often in the spotlight. However, a substantial portion of the annual flu burden is also the result of influenza B virus, which is a single influenza type that is characterized by two antigenically and genetically distinct lineages. Dreyfus et al. (p. 1343 , published online 9 August) identify three monoclonal human antibodies that are able to protect against lethal infection with both lineages of influenza B virus in mice. Two antibodies, which bind to distinct regions of the viral hemagluttinin (HA) molecule, neutralize multiple strains from both lineages of influenza B virus, whereas the third antibody binds to the stem region of HA and is able to neutralize both influenza A and B strains. The structural data from these antibodies bound to HA, together with already known antibodies targeting influenza A, may provide clues for designing a universal vaccine to protect against both influenza virus types.

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Authors: Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M., van der Vlugt, R., Lamrani, M., Korse, H. J. W. M., Geelen, E., Sahin, Ö., Sieuwerts, M., Brakenhoff, J. P. J., Vogels, R., Li, O. T. W., Poon, L. L. M., Peiris, M., Koudstaal, W., Ward, A. B., Wilson, I. A., Goudsmit, J., & Friesen, R. H. E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-09-14
Volume: 337
Issue: 6100
Pages: 1343-1348
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1222908
OpenAlex: W2163135112
Cited by: 866
References: 8
FWCI: 34.90
Type: journal article
Language: en
Open access: green

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This page: CoChat. (2026). Citation check: Highly Conserved Protective Epitopes on Influenza B Viruses. https://app.cochat.ai/papers/10.1126/science.1222908
The paper: Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M., van der Vlugt, R., Lamrani, M., Korse, H. J. W. M., Geelen, E., Sahin, Ö., Sieuwerts, M., Brakenhoff, J. P. J., Vogels, R., Li, O. T. W., . . . Friesen, R. H. E. (2012). Highly Conserved Protective Epitopes on Influenza B Viruses. Science. https://doi.org/10.1126/science.1222908

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Highly Conserved Protective Epitopes on Influenza B Viruses

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