Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Open accessPublished version of a preprint
Abstract
Antibodies predating infection: Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that in a cohort of 350 SARS-CoV-2–uninfected individuals, a small proportion had circulating immunoglobulin G (IgG) antibodies that could cross-react with the S2 subunit of the SARS-CoV-2 spike protein (see the Perspective by Guthmiller and Wilson). By contrast, COVID-19 patients generated IgA, IgG, and IgM antibodies that recognized both the S1 and S2 subunits. The anti-S2 antibodies from SARS-CoV-2–uninfected patients showed specific neutralizing activity against both SARS-CoV-2 and SARS-CoV-2 S pseudotypes. A much higher percentage of SARS-CoV-2–uninfected children and adolescents were positive for these antibodies compared with adults. This pattern may be due to the fact that children and adolescents generally have higher hCoV infection rates and a more diverse antibody repertoire, which may explain the age distribution of COVID-19 susceptibility. Science , this issue p. 1339 ; see also p. 1272
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The S2 domain of SARS-CoV-2 spike is more conserved with other coronaviruses.
“the S2 domain of SARS-CoV-2 spike is more conserved with other coronaviruses”
From mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern (2021) · cites this paper as [41]
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- Authors
- Ng, K. W., Faulkner, N., Cornish, G. H., Rosa, A., Harvey, R., Hussain, S., Ulferts, R., Earl, C., Wrobel, A. G., Benton, D. J., Roustan, C., Bolland, W., Thompson, R., Agua-Doce, A., Hobson, P., Heaney, J., Rickman, H., Paraskevopoulou, S., Houlihan, C. F., Thomson, K., Sanchez, E., Shin, G. Y., Spyer, M. J., Joshi, D., O’Reilly, N., Walker, P. A., Kjaer, S., Riddell, A., Moore, C., Jebson, B. R., Wilkinson, M., Marshall, L. R., Rosser, E. C., Radziszewska, A., Peckham, H., Ciurtin, C., Wedderburn, L. R., Beale, R., Swanton, C., Gandhi, S., Stockinger, B., McCauley, J., Gamblin, S. J., McCoy, L. E., Cherepanov, P., Nastouli, E., & Kassiotis, G.
- Affiliations
- The Francis Crick Institute (GB)
- Structural Biology STP, The Francis Crick Institute, London NW1 1AT, UK.
- Flow Cytometry STP, The Francis Crick Institute, London NW1 1AT, UK.
- University College London Hospitals NHS Foundation Trust (GB)
- University Hospital of Wales (GB)
- Great Ormond Street Hospital (GB)
- Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- Corresponding author
- McCoy, Laura E.
- Nastouli, Eleni
- Kassiotis, George
- ORCID
- Ng, Kevin W.
- Faulkner, Nikhil
- Cornish, Georgina H.
- Rosa, Annachiara
- Harvey, Ruth
- Hussain, Saira
- Ulferts, Rachel
- Earl, Christopher
- Wrobel, Antoni G.
- Benton, Donald J.
- Roustan, Chloe
- Bolland, William
- Thompson, Rachael
- Agua-Doce, Ana
- Hobson, Philip
- Rickman, Hannah
- Houlihan, Catherine F.
- Thomson, Kirsty
- Shin, Gee Yen
- Spyer, Moira J.
- Joshi, Dhira
- O’Reilly, Nicola
- Walker, Philip A.
- Kjaer, Svend
- Riddell, Andrew
- Moore, Catherine
- Jebson, Bethany R.
- Wilkinson, Meredyth
- Marshall, Lucy R.
- Rosser, Elizabeth C.
- Radziszewska, Anna
- Peckham, Hannah
- Ciurtin, Coziana
- Wedderburn, Lucy R.
- Beale, Rupert
- Swanton, Charles
- Gandhi, Sonia
- Stockinger, Brigitta
- McCauley, John
- Gamblin, Steve J.
- McCoy, Laura E.
- Cherepanov, Peter
- Nastouli, Eleni
- Kassiotis, George
- Venue
- Science
- Published
- 2020-12-11
- Volume
- 370
- Issue
- 6522
- Pages
- 1339-1343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7857411
- OpenAlex
- W3096867322
- Cited by
- 886
- References
- 38
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- 24.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
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- Locations
- Science (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (102898/B/13/Z)
- Francis Crick Institute (10169, 10827, 10015, 10078, 10030, 10099, 10013, 10061, 10006, 10159)
- Cancer Research UK
- National Institute for Health and Care Research (NIHR-INF-1079, COVID-19, NF-SI-0616-10099, ACF-2018-20-002)
- Università degli Studi di Trento
- University College London Hospitals NHS Foundation Trust
- Versus Arthritis (21593, 22203, 21552)
- Medical Research Council (MR/M004600/1, MR/R013926/1, MR/N003322/1, MR/R008698/1, COVID-19)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-CoV-2, pre-existing immunity, humoral immunity, spike protein, S2 subunit, S1 subunit, neutralizing antibodies, IgG, IgM, IgA, children and adolescents, zoonotic coronaviruses, COVID-19 pandemic
- MeSH terms
- COVID-19, SARS-CoV-2, Viral Zoonoses, Adult, Aged, Aged, 80 and over, Amino Acid Sequence, Animals, Antibodies, Viral, Female, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Male, Middle Aged, Epitope Mapping, Young Adult, Immunity, Humoral, HEK293 Cells, Spike Glycoprotein, Coronavirus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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