Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

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Items 301–400 of 841

1. Transcriptional profiling aligned with in situ expression image analysis reveals mosaically expressed molecular markers for GABA neuron sub‐groups in the ventral tegmental area
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2. Elucidating the cellular dynamics of the brain with single-cell RNA sequencing
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3. Aromatic l -amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies
   Giada Rossignoli, Karolin Krämer, Eleonora Lugarà, Haya Alrashidi, Simon A. S. Pope, Carmen De La Fuente Barrigon, Katy E Barwick, Giovanni Bisello, Joanne Ng, John Robert Counsell et al. · 2021 · Brain
4. Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting
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5. Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations
   Daniel J. Kramer, Erin E. Aisenberg, Polina Kosillo, Drew Friedmann, David A. Stafford, Angus Yiu-Fai Lee, Liqun Luo, Dirk F. Hockemeyer, John Ngai, Helen S. Bateup · 2021 · Cell Reports
6. Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder
   Fabian M. P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A. S. H. Dalm et al. · 2022 · The Journal of Experimental Medicine
7. Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics
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8. Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model
   Natalia López‐González del Rey, Nagore Hernández-Pinedo, Megan Carrillo, María del Cerro, Noelia Esteban-García, Inés Trigo‐Damas, Mariana H.G. Monje, José Luis Lanciego, Carmen Cavada, Jose Angel Obeso et al. · 2024 · npj Parkinson s Disease
9. scBFA: modeling detection patterns to mitigate technical noise in large-scale single-cell genomics data
   Ruoxin Li, Gerald Quon · 2019 · Genome biology
10. Neuronal replacement: Concepts, achievements, and call for caution
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11. Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing
    Alessandro Fiorenzano, Edoardo Sozzi, Malin Parmar, Petter Storm · 2021 · Cells
12. Recent advances in tissue stem cells
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13. Genetic Insights of Schizophrenia via Single Cell RNA-Sequencing Analyses
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14. APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases
    Perez-Corredor, Paula, Vanderleest, Timothy E., Vacano, Guido N., Sanchez, Justin S., Villalba-Moreno, Nelson D., Marino, Claudia, Krasemann, Susanne, Mendivil-Perez, Miguel A., Aguillón, David, Jiménez-Del-Río, Marlene et al. · 2024 · Frontiers in Molecular Neuroscience
15. Primary cilia promote the differentiation of human neurons through the WNT signaling pathway
    Coschiera, Andrea, Yoshihara, Masahito, Lauter, Gilbert, Ezer, Sini, Pucci, Mariangela, Li, Haonan, Kavšek, Alan, Riedel, Christian G., Kere, Juha, Swoboda, Peter · 2024 · BMC Biology
16. The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation
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17. Integrative analysis of the human brain mural cell transcriptome
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18. The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain
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19. Cell–Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson’s Disease
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20. Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits
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21. Cerebral Organoids as an Experimental Platform for Human Neurogenomics
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22. Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration
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23. Single-cell multimodal transcriptomics to study neuronal diversity in human stem cell-derived brain tissue and organoid models
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24. Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells
    Sarita Panula, Magdalena Kurek, Pankaj Kumar, Halima M. A. Albalushi, Sara Padrell Sánchez, Pauliina Damdimopoulou, Jan I. Olofsson, Outi Hovatta, Fredrik Lanner, Jan‐Bernd Stukenborg · 2019 · Human Reproduction
25. ERICH3: vesicular association and antidepressant treatment response
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26. Single-nucleus transcriptomes reveal evolutionary and functional properties of cell types in the Drosophila accessory gland
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27. HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch–Nyhan disease
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28. Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture in humans
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29. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
    Nora I. Strom, Brad Verhulst, Silviu‐Alin Bacanu, Rosa Cheesman, Kirstin Lee Purves, Hüseyin Gedik, Brittany L. Mitchell, Alex S. F. Kwong, Annika B. Faucon, Kritika Singh et al. · 2024 · medRxiv
30. Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids
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31. Interspecies Organogenesis for Human Transplantation
    Andrew T. Crane, Rajagopal N. Aravalli, Atsushi Asakura, Andrew Walker Grande, Venkatramana Divana Krishna, Daniel F. Carlson, Maxim C.‐J. Cheeran, Georgette Danczyk, James R. Dutton, Perry B. Hackett et al. · 2019 · Cell Transplantation
32. Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity
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33. TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms
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34. Creating Lineage Trajectory Maps Via Integration of Single‐Cell RNA‐Sequencing and Lineage Tracing
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35. LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies
    Martyna M. Grochowska, Ana Carreras Mascaro, Valerie Boumeester, Domenico Natale, Guido J. Breedveld, Hanneke Geut, Wiggert A. van Cappellen, Agnita J.W. Boon, Anneke J.A. Kievit, Esther M. Sammler et al. · 2021 · Acta Neuropathologica
36. Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease
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37. Neurons gating behavior—developmental, molecular and functional features of neurons in the Substantia Nigra pars reticulata
    Juha M. Partanen, Kaia Achim · 2022 · Frontiers in Neuroscience
38. Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system
    Masatoshi Ito, Natsuko Fujii, Saori Kohara, Shuho Hori, Masayuki Tanaka, Christopher Wittwer, Kenta Kikuchi, Takatoshi Iijima, Yu Kakimoto, Kenichi Hirabayashi et al. · 2023 · Journal of Biological Chemistry
39. Distributional coding of associative learning in discrete populations of midbrain dopamine neurons
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40. TARGET-seq: Linking single-cell transcriptomics of human dopaminergic neurons with their target specificity
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41. Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
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42. Mapping of clonal lineages across developmental stages in human neural differentiation
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43. Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration
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44. Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling
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45. Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model
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46. A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
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47. A cluster robustness score for identifying cell subpopulations in single cell gene expression datasets from heterogeneous tissues and tumors
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48. Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
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49. Neuronal differentiation strategies: insights from single-cell sequencing and machine learning
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50. Comprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disorders
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51. Bioengineered models of Parkinson’s disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment
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52. Embryonic development of selectively vulnerable neurons in Parkinson’s disease
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53. Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivo
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54. Cryopreservation of Human Midbrain Dopaminergic Neural Progenitor Cells Poised for Neuronal Differentiation
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55. Single-cell transcriptomic atlas of the human substantia nigra in Parkinson’s disease
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56. The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis
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57. Dopaminergic Perturbation in the Aetiology of Neurodevelopmental Disorders
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58. Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease
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59. Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons
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60. Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation
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61. Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson’s disease patient-derived iPSCs
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62. Single-nucleus transcriptomic analysis reveals the relationship between gene expression in oligodendrocyte lineage and major depressive disorder
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63. Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes
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64. Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease
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65. Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants
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66. The latest role of nerve‐specific splicing factor PTBP1 in the transdifferentiation of glial cells into neurons
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67. Single-cell RNA-sequencing of mammalian brain development: insights and future directions
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68. Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups
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69. Opto-seq reveals input-specific immediate-early gene induction in ventral tegmental area cell types
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70. Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter
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71. Development and Application of High-Throughput Single Cell Lipid Profiling: A Study of SNCA-A53T Human Dopamine Neurons
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72. Defining Specific Cell States of MPTP-Induced Parkinson’s Disease by Single-Nucleus RNA Sequencing
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73. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution
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74. Single-cell RNA sequencing reveals homogeneous transcriptome patterns and low variance in a suspension CHO-K1 and an adherent HEK293FT cell line in culture conditions
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75. A robust and accurate single-cell data trajectory inference method using ensemble pseudotime
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76. Reference-based cell type matching of in situ image-based spatial transcriptomics data on primary visual cortex of mouse brain
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77. Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level
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78. Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
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79. Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI
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80. Comprehensive analysis of retinal development at single cell resolution identifies NFI factors as essential for mitotic exit and specification of late-born cells
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81. Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
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82. Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
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83. Single-cell sequencing of the substantia nigra reveals microglial activation in a model of MPTP
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84. Data Denoising and Post-Denoising Corrections in Single Cell RNA Sequencing
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85. KIT Is Required for Fetal Liver Hematopoiesis
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86. Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons
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87. Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons
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88. scCODE: an R package for data-specific differentially expressed gene detection on single-cell RNA-sequencing data
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89. Unraveling Psychiatric Disorders through Neural Single-Cell Transcriptomics Approaches
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90. Advances in the knowledge and therapeutics of schizophrenia, major depression disorder, and bipolar disorder from human brain organoid research
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91. Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool
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92. Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine–Glutamate Co-release as Future Target in Substance Use Disorder
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93. Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice
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94. Longitudinal single-cell RNA-seq of hESCs-derived retinal organoids
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95. Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson’s Disease Drug Development
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96. Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils
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97. Brain Organoids: Tiny Mirrors of Human Neurodevelopment and Neurological Disorders
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98. Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson’s Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology
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99. Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors
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100. Clinical application of single‐cell RNA sequencing in disease and therapy
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