The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer
Open accessAbstract
SUMMARY Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions while simultaneously inhibiting the development of anti-tumor immune responses. Hostile microenvironmental conditions within tumor masses, such as nutrient deprivation, oxygen limitation, high metabolic demand and oxidative stress disturb the protein folding capacity of the Endoplasmic Reticulum (ER), thereby provoking a cellular state of “ER stress”. Sustained activation of ER stress sensors endows malignant cells with greater tumorigenic, metastatic and drug resistant capacity. Additionally, recent studies have uncovered that ER stress responses further impede the development of protective anti-cancer immunity by manipulating the function of myeloid cells in the tumor microenvironment. Here, we discuss the tumorigenic and immunoregulatory effects of ER stress in cancer, and we explore the concept of targeting ER stress responses to enhance the efficacy of standard chemotherapies and evolving cancer immunotherapies in the clinic.
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Metadata
- Authors
- Cubillos-Ruiz, J. R., Bettigole, S. E., & Glimcher, L. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 168
- Issue
- 4
- Pages
- 692-706
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2586097538
- Cited by
- 895
- References
- 135
- FWCI
- 33.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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