Cited by 447Genomics and Chromatin DynamicsCancer-related molecular mechanisms researchChromatin Remodeling and Cancer

The DOI matches its Crossref record; 77 of the 79 references it cites were found in a registry or an index.

RNA Binding to CBP Stimulates Histone Acetylation and Transcription

Open access

Bose, Daniel A., Donahue, Greg, Reinberg, Danny, Shiekhattar, Ramin, Bonasio, Roberto, Berger, Shelley L.·2017·Cell

DOI 10.1016/j.cell.2016.12.020PMC PMC5325706

Open this paper in CoChat — free account

Abstract

CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expression in multicellular organisms. Active enhancers produce bi-directional enhancer RNAs (eRNAs) and display CBP/p300-dependent histone acetylation. Here, we demonstrate that CBP binds directly to RNAs in vivo and in vitro. RNAs bound to CBP in vivo include a large number of eRNAs. Using steady-state histone acetyltransferase (HAT) assays, we show that an RNA binding region in the HAT domain of CBP-a regulatory motif unique to CBP/p300-allows RNA to stimulate CBP's HAT activity. At enhancers where CBP interacts with eRNAs, stimulation manifests in RNA-dependent changes in the histone acetylation mediated by CBP, such as H3K27ac, and by corresponding changes in gene expression. By interacting directly with CBP, eRNAs contribute to the unique chromatin structure at active enhancers, which, in turn, is required for regulation of target genes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2016.12.020

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Fitting a mixture model by expectation maximization to discover motifs in biopolymers.
Bailey, T. L., & Elkan, C. (1994) · PubMed · Cited by 4,982
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873
Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450

Flagged first, then by citations

Show all 79 references

2 of the 79 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 447

Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Chen, J., Caviness, P. C., Zhao, H., Belcher, B., Wankhade, U. D., Shankar, K., Blackburn, M. L., & Lazarenko, O. P. (2022) · Epigenetics · doi:10.1080/15592294.2022.2111759 · Cited by 15
Mechanisms of Histone Modifications
Vanzan, L., Sklias, A., Bošković, M., Herceg, Z., Murr, R., & Suter, D. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00019-0 · Cited by 17
An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions
(2025) · doi:10.1038/s41467-025-57671-3 · Cited by 15
CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma
Yan, X., Kang, D.-Z., Lin, Y., Qi, S., & Jiang, C. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-021-00797-w · Cited by 15
Transcription levels of a noncoding RNA orchestrate opposing regulatory and cell fate outcomes in yeast
Moretto, F., Wood, N. E., Chia, M., Li, C., Luscombe, N. M., & van Werven, F. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108643 · Cited by 14
H3K27ac-activated lncRNA KTN1-AS1 aggravates tumor progression by miR-505-3p/ZNF326 axis in ovarian cancer
Xie, X., Wen, Q., Yang, X., Chen, W., Liu, Y., Liu, W., Zhang, T., Xu, C., & Shi, K. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-443 · Cited by 15
Molecular Basis of the Function of Transcriptional Enhancers
Ibragimov, A. N., Bylino, O. V., & Shidlovskii, Y. V. (2020) · Cells · doi:10.3390/cells9071620 · Cited by 15
Cisinteractions in theIrf8locus regulate stage-dependent enhancer activationPreprint
Liu, T., Ou, F., Belk, J. A., Bagadia, P., Anderson, D. A., Durai, V., Yao, W., Satpathy, A. T., Murphy, T. L., & MURPHY, K. M. M. (2023) · Genes & Development · doi:10.1101/gad.350339.122 · Cited by 13
Genome organization and botanical diversity
Paterson, A. H., & Queitsch, C. (2024) · The Plant Cell · doi:10.1093/plcell/koae045 · Cited by 14
High frequency of intron retention and clustered H3K4me3-marked nucleosomes in short first introns of human long non-coding RNAs
Dey, P., & Mattick, J. S. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00419-2 · Cited by 13
Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer
Lewis, M. W., Wiśniewska, K., King, C. M., Li, S., Coffey, A. R., Kelly, M. R., Regner, M. J., & Franco, H. L. (2022) · Cancers · doi:10.3390/cancers14071852 · Cited by 14
Enhancers are genes that express organizational RNAs
Mattick, J. S. (2023) · Frontiers in RNA Research · doi:10.3389/frnar.2023.1194526 · Cited by 10
Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase
Johnson, H. M., Noon-Song, E. N., & Ahmed, C. M. I. (2019) · Mediators of Inflammation · doi:10.1155/2019/4143604 · Cited by 13
Noncoding RNAs Set the Stage for RNA Polymerase II Transcription
Studniarek, C., Egloff, S., & Murphy, S. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.09.013 · Cited by 14
High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity
He, K.-Y., Zhao, A., Guo, J.-R., Wu, D., Liu, H., Gao, F., Liu, M., Yang, J.-Y., Lei, X., Li, J.-Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60221-6 · Cited by 13
Super-enhancers: drivers of cells’ identities and cells’ debacles
Lavaud, M., Tesfaye, R. A., Lassous, L., Royer, B. B.-L., Baud’huin, M., Verrecchia, F., Lamoureux, F., Georges, S., & Ory, B. (2024) · Epigenomics · doi:10.2217/epi-2023-0409 · Cited by 15
CRED9: a differentially expressed elncRNA regulates expression of transcription factor CEBPA
Setten, R. L., Chomchan, P., Epps, E. W., Burnett, J. C., & Rossi, J. J. (2021) · RNA · doi:10.1261/rna.078752.121 · Cited by 12
Epigenome Interactions with Patterned Neuronal Activity
Belgrad, J., & Fields, R. D. (2018) · The Neuroscientist · doi:10.1177/1073858418760744 · Cited by 14
Heat shock protein 27 inhibits HMGB1 translocation by regulating CBP acetyltransferase activity and ubiquitination
Bi, X., Xu, M., Li, J., Huang, T. H., Jiang, B., Shen, L., Luo, L., Liu, S., & Yin, Z. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.02.008 · Cited by 12
NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA
Amin, R., Ha, N., Qiu, T., Holewinski, R. J., Lam, K. C., Lopès, A., Liu, H., Tran, A. D., Lee, M. P., Andrésson, Þ., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.11.010 · Cited by 12
Deciphering the regulatory landscape of enhancer RNAs in health and disease
Wang, Q., ten Dijke, P., & Fan, C. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02436-z · Cited by 15
Deregulation of enhancer structure, function, and dynamics in acute lymphoblastic leukemia
Belver, L., Alberó, R., & Ferrando, A. A. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.03.005 · Cited by 13
Heterogeneity among enhancer RNAs: origins, consequences and perspectives
Syed, K. M., & Hon, C.-C. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200064 · Cited by 13
Enhancer-Mediated Formation of Nuclear Transcription Initiation Domains
Gibbons, M. D., Fang, Y., Spicola, A. P., Linzer, N., Jones, S. M., Johnson, B. R., Li, L., Xie, M., & Bungert, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169290 · Cited by 12
The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus
Suzuki, A., Minamide, R., & Iwata, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32888-z · Cited by 12
Enhancer rewiring in tumors: an opportunity for therapeutic intervention
Richart, L., Bidard, F., & Margueron, R. (2021) · Oncogene · doi:10.1038/s41388-021-01793-7 · Cited by 12
GWAS-associated variants, non-genetic factors, and transient transcriptome in multiple sclerosis etiopathogenesis: A colocalization analysis
Bellucci, G., Umeton, R., Bigi, R., Romano, S., Buscarinu, M. C., Reniè, R., Rinaldi, V., Umeton, R. P., Morena, E., Romano, C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-022-11444-w · Cited by 13
Challenges in the Structural–Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools
Bekesi, A., Abdellaoui, S., Holroyd, N., Delm, W. V., Pardon, E., Pauwels, J., Gevaert, K., Steyaert, J., Derveaux, S., Borysik, A. J., et al. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.09.032 · Cited by 11
A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons
Brookes, E., Cruz, B. M. D. L., Boulasiki, P., Au, H. Y. A., Varsally, W., Barrington, C., Hadjur, S., & Riccio, A. (2022) · iScience · doi:10.1016/j.isci.2022.105695 · Cited by 13
Enhancer RNA Expression in Response to Glucocorticoid Treatment in Murine Macrophages
Greulich, F., Bielefeld, K. A., Scheundel, R., Mechtidou, A., Strickland, B. A., & Uhlenhaut, N. H. (2021) · Cells · doi:10.3390/cells11010028 · Cited by 11
Enhancer RNA AL928768.3 from the IGH Locus Regulates MYC Expression and Controls the Proliferation and Chemoresistance of Burkitt Lymphoma Cells with IGH/MYC Translocation
Stasevich, E. M., Uvarova, A. N., Murashko, M. M., Khabusheva, E., Sheetikov, S. A., Prassolov, V., Kuprash, D. V., Демин, Д. Э., & Schwartz, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094624 · Cited by 10
Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation
Kaypee, S., Sahadevan, S. A., Sudarshan, D., Sinha, S. H., Patil, S., Senapati, P., Kodaganur, G. S., Mohiyuddin, A., Dasgupta, D., & Kundu, T. K. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.05.003 · Cited by 10
Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
Wang, X., Kutschat, A. P., Aggrey-Fynn, J. E., Hamdan, F. H., Graham, R. P., Wixom, A. Q., Souto, Y., Ladigan‐Badura, S., Yonkus, J. A., Abdelrahman, A. M., et al. (2023) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0916 · Cited by 8
A transcription coupling model for how enhancers communicate with their target genes
Altendorfer, E., Mundlos, S., & Mayer, A. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01523-7 · Cited by 10
HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7
Hsieh, F., Ji, F., Damle, M., Sadreyev, R. I., & Kingston, R. E. (2021) · Life Science Alliance · doi:10.26508/lsa.202101127 · Cited by 9
Long non-coding RNAs as emerging regulators of miRNAs and epigenetics in diabetes-related chronic kidney disease
Shelke, V., Kale, A., Sankrityayan, H., Anders, H., & Gaikwad, A. B. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.2023580 · Cited by 9
Coregulators Reside within Drosophila Ecdysone-Inducible Loci before and after Ecdysone Treatment
Краснов, А. Н., Evdokimova, A. A., Mazina, M. Y., Erokhin, M., Chetverina, D., & Vorobyeva, N. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411844 · Cited by 9
Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ -Globin Gene Expression
Shen, Y., Bassett, M., Gurumurthy, A., Nar, R., Knudson, I. J., Guy, C. R., Perez, A., Mellen, R. W., Ikeda, M., Hossain, M. A., et al. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00197-18 · Cited by 9
Cruciform Formable Sequences within Pou5f1 Enhancer Are Indispensable for Mouse ES Cell Integrity
Yamamoto, Y., Miura, O., & Ohyama, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073399 · Cited by 8
Does the stapes reflex remain the same after Bell's palsy?
Ardıç, F. N., Topaloğlu, İ., Öncel, S., Ardıç, F. N., & Uğuz, M. Z. (1997) · PubMed · Cited by 9
Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification
Yin, X., Li, J., Zhao, J., Zheng, W., Zhang, A., & Ma, J. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01773-0 · Cited by 9
Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs
Chen, W., Wang, Z., Wang, Y., Lin, J., Chen, S., Chen, H., Ma, X., Zou, X., Li, X., Qin, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202411974 · Cited by 8
Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p–CUEDC2 Axis
Zhang, Z., Yu, T., Li, H., Du, L., Jin, Z., Peng, X., Yan, Y., Zhou, J., & Gu, J. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04206-22 · Cited by 8
3D genome organization and its study in livestock breeding
Cheng, J., Cao, X., Wang, S., Zhang, J., Yue, B., Zhang, X., Huang, Y., Lan, X., Ren, G., & Chen, H. (2023) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2023.04.007 · Cited by 9
Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites
Giorgio, E. D., Benetti, R., Kerschbamer, E., Xodo, L. E., & Brancolini, C. (2023) · International review of cytology · doi:10.1016/bs.ircmb.2023.03.013 · Cited by 9
An Emerging Role for Enhancer RNAs in Brain Disorders
Patel, A., & Dharap, A. A. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08776-3 · Cited by 9
Uncovering the functions and mechanisms of regulatory elements-associated non-coding RNAs
Fosseprez, O., & Cuvier, O. (2024) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2024.195059 · Cited by 6
tRF-21LeuTAA Promotes Oxidative Stress by Altering Glutathione Metabolic Enzymes to Support Prostate Cancer Progression
Guo, X., Zhong, J., Qian, J., Pan, X., Zhang, X., Chen, X., Zeng, H., Chen, N., Nie, L., Yu, T., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-0273 · Cited by 7
Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective
Pande, A., Makałowski, W., Brosius, J., & Raabe, C. A. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa026 · Cited by 7
Stress and its effects across generations
Engmann, O., & Mansuy, I. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00018-5 · Cited by 7
Transcriptional Regulation of RUNX1: An Informatics Analysis
Thomas, A., Marsman, J., Antony, J., Schierding, W. S., O'Sullivan, J. M., & Horsfield, J. A. (2021) · Genes · doi:10.3390/genes12081175 · Cited by 8
Dynamic interaction of MYC enhancer RNA with YEATS2 protein regulates MYC gene transcription in pancreatic cancer
Roy, J., Kumar, A., Chakravarty, S., Biswas, N. K., Goswami, S., & Mazumder, A. (2025) · EMBO Reports · doi:10.1038/s44319-025-00446-0 · Cited by 6
Out of the dark: the emerging roles of lncRNAs in pain
Habib, A. M., Cox, J. J., & Okorokov, A. L. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.04.009 · Cited by 6
eRNA-IDO: A One-stop Platform for Identification, Interactome Discovery, and Functional Annotation of Enhancer RNAs
Zhang, Y., Gong, L., Ding, R., Chen, W., Rong, H., Li, Y., Shameem, F., Ali, K. A., Li, L., & Liao, Q. (2024) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzae059 · Cited by 6
Identification of enhancer RNA AC005515.1 as a novel biomarker for prognosis in esophageal cancer and predictors of immunotherapy response
Jia, L., Chen, J., Zhao, J., & Yang, J. (2023) · Translational Cancer Research · doi:10.21037/tcr-23-777 · Cited by 6
Enhancing Gonadotrope Gene Expression Through Regulatory lncRNAs
Refael, T., & Melamed, P. (2021) · Endocrinology · doi:10.1210/endocr/bqab116 · Cited by 6
Multifaceted regulation of enhancers in cancer
Xiao, Q., Xiao, Y., Li, L., Chen, M., & Wu, M. (2022) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2022.194839 · Cited by 6
The TAZ2 domain of CBP/p300 directs acetylation towards H3K27 within chromatinPreprint
Sheahan, T. W., Major, V., Webb, K. M., Bryan, E., & Voigt, P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.21.214338 · Cited by 6
Chromatin regulation of neuronal activity-dependent gene programs in circuit formation and plasticity
Pumo, G., & Rijli, F. M. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103024 · Cited by 5
The PURB–HOTAIR complex regulates p53-dependent promoter-specific transcriptional activation
Xia, Z., Kon, N., Su, Z., Yi, J., Xu, H. Z., Zhou, H., Zhang, Z., & Gu, W. J. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01597-3 · Cited by 5
RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription
Budinich, K. A., Yao, X., Gong, C., Song, L., Wang, X., Lee, M. C., Mathias, K. M., Li, Q., Tang, S., Liu, Y., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.05.024 · Cited by 5
Interplay between NRF2 post-translational modifications and protein-protein interactions: Perspectives from emerging structural and functional evidence
Ozleyen, A., Kulabas, S. S., Novak, M. J., Cichoń, M., Heras, C. M. D. L., Honda, T., Doveston, R. G., Dinkova‐Kostova, A. T., Grochot‐Przeczek, A., & Tumer, T. B. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110847 · Cited by 5
LINC00887 Acts as an Enhancer RNA to Promote Medullary Thyroid Carcinoma Progression by Binding with FOXQ1
Liu, D., Wang, W., Wu, Y., Qiu, Y., & Zhang, L. (2023) · Current Cancer Drug Targets · doi:10.2174/0115680096258716231026063704 · Cited by 5
Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases
He, Y., Cai, Y., Cao, Y., Wang, Y., Wang, J., & Ding, H. (2025) · Biomedicines · doi:10.3390/biomedicines13010117 · Cited by 5
Kat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway
Liu, Z., Qiu, L., Zhang, Y., Zhao, G., Sun, X., & Luo, W. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02519-y · Cited by 5
Emerging Role of Enhancer RNAs as Potential Diagnostic and Prognostic Biomarkers in Cancer
Panahi-Moghadam, S., Hassani, S., Farivar, S., & Vakhshiteh, F. (2022) · Non-Coding RNA · doi:10.3390/ncrna8050066 · Cited by 5
CBP-IDRs regulate acetylation and gene expression
Gelder, K. L., Carruthers, N. A., Gilbert, G., Harrison, L. J., Evans, B. V., Evans, T. I., Ball, S. S., Dunning, M., Craggs, T. D., Twelvetrees, A. E., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117109 · Cited by 5
Self-citation
The Estrogen-Regulated Transcriptome: Rapid, Robust, Extensive, and Transient
Vasquez, Y. M., & Kraus, W. L. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-99350-8_5 · Cited by 5
ELOVL2-AS1 inhibits migration of triple negative breast cancer
Zhu, M., Zhang, J., Li, G., & Liu, Z. (2022) · PeerJ · doi:10.7717/peerj.13264 · Cited by 5
Enhancer RNAs are necessary and sufficient for activity-dependent neuronal gene transcriptionPreprint
Carullo, N. V. N., Simon, R. C., Salisbury, A. J., Revanna, J. S., Bunner, K. D., Savell, K. E., Sultan, F. A., Ca, G., & Day, J. (2019) · IUScholarWorks Open (Indiana University) · doi:10.1101/270967 · Cited by 6
Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELFPreprint
Gorbovytska, V., Kim, S.-K., Kuybu, F., Götze, M., Um, D., Kang, K., Pittroff, A., Schneider, L.-M., Leitner, A., Kim, T.-K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.25.441328 · Cited by 5
Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci
Betti, M. J., Lin, P., Aldrich, M. C., & Gamazon, E. R. (2025) · Nature Communications · doi:10.1038/s41467-025-58023-x · Cited by 6
CRISPR-epigenetic crosstalk: From bidirectional regulation to therapeutic potential
Wei, Y., Sun, J. Y., & Zhu, R. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.10.031 · Cited by 5
An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs
Yu, X., Song, X., Schäfer, R. A., Meng, Q., Tiek, D. M., Wu, R., He, Q. Q., Walker, M. N., Cao, Q., Yang, R., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01924-w · Cited by 4
The untold story between enhancers and skeletal muscle development
Zhang, Y., Lü, D., Yu-wen, L. I. U., Yi, G., & Tang, Z. (2020) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(20)63235-x · Cited by 4
Neuronal RNA processing: cross-talk between transcriptional regulation and RNA-binding proteins
Ozbulut, H. C., & Hilgers, V. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1426410 · Cited by 4
Discovery of Klf2 interactors in mouse embryonic stem cells by immunoprecipitation-mass spectrometry utilizing exogenously expressed bait
Seo, L., Kim, Y., Kim, H., Hyun, K., Kim, J., & Lee, J. E. (2021) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2021.140672 · Cited by 4
H3K27ac-activated LncRNA NUTM2A-AS1 Facilitated the Progression of Colorectal Cancer Cells via MicroRNA-126-5p/FAM3C Axis
Lin, H., Hu, S., Li, Y., Li, S., Teng, D., Yang, Y., Liu, B., & Du, X. (2024) · Current Cancer Drug Targets · doi:10.2174/0115680096277956240119065938 · Cited by 4
Cut from the same cloth: RNAs transcribed from regulatory elements
Stasevich, E. M., Simonova, A. V., Bogomolova, E. A., Murashko, M. M., Uvarova, A. N., Zheremyan, E. A., Korneev, K. V., Schwartz, A. M., Kuprash, D. V., & Демин, Д. Э. (2024) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2024.195049 · Cited by 4
Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway
Chen, Y., Tan, F., Fang, Q., Zhang, L., Liao, J., Shen, P., Qian, Y., Wen, M., Song, R., Fu, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202500895 · Cited by 4
Prospects for Epigenetic Targeted Therapies of Bone and Soft-Tissue Sarcomas
Wang, J., Elkrief, A., Guo, W., Shukla, N. N., Gounder, M. M., & Ladanyi, M. (2021) · Sarcoma · doi:10.1155/2021/5575444 · Cited by 4
Non-coding RNAs
Kasprzyk, M. E., Kazimierska, M., Sura, W., Dzikiewicz‐Krawczyk, A., & Podralska, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90406-3.00010-5 · Cited by 6
Identification and characterization of transcribed enhancers during cerebellar development through enhancer RNA analysis
Ramirez, M., Robert, R., Yeung, J., Wu, J., Abdalla-Wyse, A., & Goldowitz, D. (2023) · BMC Genomics · doi:10.1186/s12864-023-09368-4 · Cited by 4
Nuclear RNA: a transcription-dependent regulator of chromatin structure
Stocks, J., & Gilbert, N. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230787 · Cited by 6
Efficient AuPd@GO-based electrochemical nanoprobe for sensitive detection of histone acetylase activity and its inhibitor
Liu, Q., Yang, L., She, Y., & Hu, Y. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-02112-6 · Cited by 4
Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets?
Hanly, D. J., Esteller, M., & Berdasco, M. (2019) · Topics in medicinal chemistry · doi:10.1007/7355_2019_83 · Cited by 4
The epipliancy journey: Tumor initiation at the mercy of identity crisis and epigenetic drift
Benhassoun, R., Morel, A., Jacquot, V., Puisieux, A., & Ouzounova, M. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189307 · Cited by 4
Advances in research on the molecular mechanisms of miRNAs in radiation responses
Yang, X., Hu, W., & Zhou, G. (2025) · Radiation Medicine and Protection · doi:10.1016/j.radmp.2025.06.002 · Cited by 3
Enhancer Trajectories in Lineage Commitment: Regulatory Logic of States and Cooperation
Oh, M., Jeong, S., Kang, K., & Kim, S.-K. (2026) · Biomolecules · doi:10.3390/biom16010087 · Cited by 5
Emerging roles of circular RNAs and enhancer RNAs: new insights into the development and management of neurodegenerative disorders
Ziaei, A., Kargar, M., Shirvani-Farsani, Z., & MehrabMohseni, M. (2026) · Biomarker Research · doi:10.1186/s40364-025-00886-9 · Cited by 4
Emerging insights into enhancer RNAs: biogenesis, function, mechanism, and disease implication
Qiu, M., Yu, X., Liu, H., Tao, Y., Huang, C., Xi, Y., & Liao, Q. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf700 · Cited by 4
Enhancer in cancer pathogenesis and treatment
Sun, Z., Fan, J., Dang, Y., & Zhao, Y. (2023) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2022-0313 · Cited by 4
DNA regulatory element cooperation and competition in transcription
Lee, H., Friedman, M. J., Kim, S. B., & Oh, S. (2024) · BMB Reports · doi:10.5483/bmbrep.2024-0069 · Cited by 4
Introductory Chapter: Current Studies in Transcriptional Control System; Toward the Establishment of Therapies against Human Diseases
Uchiumi, F. (2018) · InTech eBooks · doi:10.5772/intechopen.71701 · Cited by 3
Rapid induction of expression by LPS is accompanied by favorable chromatin and rapid binding of c-Jun
Maurer, K., Ramen, S., Shi, L., Song, L., & Sullivan, K. E. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.02.002 · Cited by 3
The Complexity of the Mammalian Transcriptome
Salama, S. R. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-92034-0_2 · Cited by 3
A novel enhancer that regulates Bdnf expression in developing neuronsPreprint
Brookes, E., Au, H. Y. A., Varsally, W., Barrington, C., Hadjur, S., & Riccio, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.18.469096 · Cited by 3
IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitisPreprint
Liu, X., Zhou, F., Wang, W., Chen, G., Zhang, Q. C., Lv, R., Zhao, Z., Li, X., Yu, Q., Meves, J. M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-249849/v1 · Cited by 3
Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progressionPreprint
Amin, R., Ha, N., Qiu, T., Holewinski, R. J., Lam, K. C., Lopès, A., Liu, H., Tran, A. D., Lee, M. P., Gamage, S. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.24.577116 · Cited by 3
The long non-coding RNA NEAT1 regulates the transcriptional landscape of cardiomyocytesPreprint
Pant, P., Sivakumar, P., Nanda, D., Ram, N. S., Dhandapany, P. S., Thum, T., & Kumarswamy, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.27.600932 · Cited by 3

Authors: Bose, D. A., Donahue, G., Reinberg, D., Shiekhattar, R., Bonasio, R., & Berger, S. L.
Affiliations: University of Pennsylvania (US)
New York University (US)
University of Miami (US)
Corresponding author: Berger, Shelley L.
ORCID: Bose, Daniel A.
Donahue, Greg
Reinberg, Danny
Shiekhattar, Ramin
Bonasio, Roberto
Berger, Shelley L.
Venue: Cell
Publisher: Elsevier BV
Published: 2017-01
Volume: 168
Issue: 1-2
Pages: 135-149.e22
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2016.12.020
PMC: PMC5325706
OpenAlex: W2578822114
Cited by: 426
References: 79
Citations by year: 2026: 25 · 2025: 32 · 2024: 55 · 2023: 38 · 2022: 51 · 2021: 66 · 2020: 57 · 2019: 37 · 2018: 42 · 2017: 22
FWCI: 17.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 377 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01 CA078831)
NIH Innovator Award (DP2MH107055)
Searle Scholars Program (15-SSP-102)
March of Dimes Foundation (1-FY-15-344)
W.W. Smith Charitable Trust (C1404)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: CBP, P300, RNA binding, enhancer RNA, histone acetylation, histone acetyltransferase activity, H3K27ac, transcriptional coactivator, gene expression regulation
MeSH terms: Acetylation, Animals, Cell Line, Enhancer Elements, Genetic, Fibroblasts, Histones, RNA, Untranslated, p300-CBP Transcription Factors, Mice, Histone Acetyltransferases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

RNA Binding to CBP Stimulates Histone Acetylation and Transcription

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks