The DOI matches its Crossref record; 77 of the 79 references it cites were found in a registry or an index.
RNA Binding to CBP Stimulates Histone Acetylation and Transcription
Open accessAbstract
CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expression in multicellular organisms. Active enhancers produce bi-directional enhancer RNAs (eRNAs) and display CBP/p300-dependent histone acetylation. Here, we demonstrate that CBP binds directly to RNAs in vivo and in vitro. RNAs bound to CBP in vivo include a large number of eRNAs. Using steady-state histone acetyltransferase (HAT) assays, we show that an RNA binding region in the HAT domain of CBP-a regulatory motif unique to CBP/p300-allows RNA to stimulate CBP's HAT activity. At enhancers where CBP interacts with eRNAs, stimulation manifests in RNA-dependent changes in the histone acetylation mediated by CBP, such as H3K27ac, and by corresponding changes in gene expression. By interacting directly with CBP, eRNAs contribute to the unique chromatin structure at active enhancers, which, in turn, is required for regulation of target genes.
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“In this sense, enhancers have been related to p300/CBP, as coactivators have been found as a component in the chromatin.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [77]
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“Specific expression profiles have pointed towards increasing levels of monomethylation in the case of H3 and repressing levels of H3K4me3 marks.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [77]
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Histone H3K27ac separates active from poised enhancers and predicts developmental state
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Metadata
- Authors
- Bose, D. A., Donahue, G., Reinberg, D., Shiekhattar, R., Bonasio, R., & Berger, S. L.
- Affiliations
- University of Pennsylvania (US)
- New York University (US)
- University of Miami (US)
- Corresponding author
- Berger, Shelley L.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 168
- Issue
- 1-2
- Pages
- 135-149.e22
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5325706
- OpenAlex
- W2578822114
- Cited by
- 426
- References
- 79
- Citations by year
- 2026: 25 · 2025: 32 · 2024: 55 · 2023: 38 · 2022: 51 · 2021: 66 · 2020: 57 · 2019: 37 · 2018: 42 · 2017: 22
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 CA078831)
- NIH Innovator Award (DP2MH107055)
- Searle Scholars Program (15-SSP-102)
- March of Dimes Foundation (1-FY-15-344)
- W.W. Smith Charitable Trust (C1404)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- CBP, P300, RNA binding, enhancer RNA, histone acetylation, histone acetyltransferase activity, H3K27ac, transcriptional coactivator, gene expression regulation
- MeSH terms
- Acetylation, Animals, Cell Line, Enhancer Elements, Genetic, Fibroblasts, Histones, RNA, Untranslated, p300-CBP Transcription Factors, Mice, Histone Acetyltransferases
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