N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Open accessAbstract
A new layer of transcriptional control: N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m 6 A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m 6 A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. Science , this issue p. 580
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Some m6A-modified chromatin-associated RNAs can bind directly to DNA to regulate chromatin state and downstream transcription.
“Some m6A-modified chromatin-associated RNAs can bind directly to DNA to regulate chromatin state and downstream transcription (Liu et al., 2020).”
From METTL3 uncouples chromatin accessibility from transcription during retinal development (2025) · cites this paper as Liu et al., 2020
The paper's Abstract reports that m6A-modified chromosome-associated regulatory RNAs affect chromatin state and downstream transcription. It does not establish the claim that these RNAs bind directly to DNA; the passages on chromatin-associated RNAs and recruited proteins do not demonstrate direct RNA–DNA binding. (LLM, conf=0.86)
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Self-citation
- Authors
- Liu, J., Dou, X., Chen, C., Chen, C., Liu, C., Xu, M. M., Zhao, S., Shen, B., Gao, Y., Han, D., & He, C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Tongji University (CN)
- Center for Life Sciences (CN)
- Chinese Academy of Sciences (CN)
- State Key Laboratory of Reproductive Medicine (CN)
- Corresponding author
- Liu, Jun
- Dou, Xiaoyang
- Chen, Chuanyuan
- Gao, Yawei
- Han, Dali
- He, Chuan
- ORCID
- Venue
- Science
- Published
- 2020-01-31
- Volume
- 367
- Issue
- 6477
- Pages
- 580-586
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7213019
- OpenAlex
- W2999012956
- Cited by
- 709
- References
- 11
- Citations by year
- 2026: 83 · 2025: 126 · 2024: 114 · 2023: 113 · 2022: 104 · 2021: 121 · 2020: 47 · 2018: 1
- FWCI
- 32.12
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (CHE-1048528)
- National Institutes of Health (HG008935, ES030546)
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- N6-methyladenosine, m6A RNA methylation, chromatin accessibility, chromatin state, transcriptional regulation, mammalian cells
- MeSH terms
- Adenosine, Animals, Chromatin, Enhancer Elements, Genetic, Methylation, Methyltransferases, Promoter Regions, Genetic, RNA, Messenger, Transcription, Genetic, RNA, Nuclear, Mice, Knockout, Mice, Embryonic Stem Cells
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