The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mitochondrial Priming by CD28
Open accessAbstract
SUMMARY T cell receptor (TCR) signaling without CD28 can elicit primary effector T cells, but memory T cells generated during this process are anergic, failing to respond to secondary antigen exposure. We show that upon T cell activation, CD28 transiently promotes expression of carnitine palmitoyltransferase 1a (Cpt1a), an enzyme that facilitates mitochondrial FAO, before the first cell division, coinciding with mitochondrial elongation and enhanced spare respiratory capacity (SRC). microRNA-33 (miR33), a target of thioredoxin-interacting protein (TXNIP), attenuates Cpt1a expression in the absence of CD28, resulting in cells that thereafter are metabolically compromised during reactivation or periods of increased bioenergetic demand. Early CD28-dependent mitochondrial engagement is needed for T cells to remodel cristae, develop SRC, and rapidly produce cytokines upon restimulation – cardinal features of protective memory T cells. Our data show that initial CD28 signals during T cell activation prime mitochondria with latent metabolic capacity essential for future T cell responses.
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Self-citationThioredoxin-interacting protein links oxidative stress to inflammasome activation
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Self-citationThe CD28 Signaling Pathway Regulates Glucose Metabolism
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Self-citationMetabolic Regulation of T Lymphocytes
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Metadata
- Authors
- Klein Geltink, R. I., O’Sullivan, D., Corrado, M., Bremser, A., Buck, M. D., Buescher, J. M., Firat, E., Zhu, X., Niedermann, G., Caputa, G., Kelly, B., Warthorst, U., Rensing-Ehl, A., Kyle, R. L., Vandersarren, L., Curtis, J. D., Patterson, A. E., Lawless, S., Grzes, K., Qiu, J., Sanin, D. E., Kretz, O., Huber, T. B., Janssens, S., Lambrecht, B. N., Rambold, A. S., Pearce, E. J., & Pearce, E. L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 171
- Issue
- 2
- Pages
- 385-397.e11
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2755712391
- Cited by
- 295
- References
- 16
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Klein Geltink, R. I., O’Sullivan, D., Corrado, M., Bremser, A., Buck, M. D., Buescher, J. M., Firat, E., Zhu, X., Niedermann, G., Caputa, G., Kelly, B., Warthorst, U., Rensing-Ehl, A., Kyle, R. L., Vandersarren, L., Curtis, J. D., Patterson, A. E., Lawless, S., Grzes, K., . . . Pearce, E. L. (2017). Mitochondrial Priming by CD28. Cell. https://doi.org/10.1016/j.cell.2017.08.018
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
