Cited by 736Lipid metabolism and biosynthesisDiet and metabolism studiesCancer, Lipids, and Metabolism

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

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McGarry, J D, Mannaerts, G P, Foster, D W·1977·Journal of Clinical Investigation

Abstract

Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.

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  • ACC2, CPT1A, acetyl-CoA, and malonyl-CoA are important players in memory T cell formation.

    “Some important players to consider in this regard include acetyl-CoA carboxylase (ACC2) (21), the mitochondrial lipid transporter CPT1A (13, 22), and metabolites such as acetyl-CoA and malonyl-CoA (23).”

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Research works printed but not linked: 1

  1. Cook, G. A., M. R. Lakshmanan, and R. L. Veech. 1977. The effect of glucagon on hepatic malonyl-CoA concen- tration and on lipid synthesis. Fed. Proc. 36: 672.

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Authors
McGarry, J. D., Mannaerts, G. P., & Foster, D. W.
Affiliations
University of Texas Health Science Center at Dallas (US)
Venue
Journal of Clinical Investigation
Published
1977-07-01
Volume
60
Issue
1
Pages
265-270
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2126909426
Cited by
736
References
15
Citations by year
2026: 14 · 2025: 15 · 2024: 22 · 2023: 22 · 2022: 38 · 2021: 18 · 2020: 26 · 2019: 17 · 2018: 29 · 2017: 23 · 2016: 24 · 2015: 14 · 2014: 21 · 2013: 18 · 2012: 19
FWCI
9.19
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fogarty International Center
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
malonyl-CoA, hepatic fatty acid oxidation, ketogenesis, oleic acid, octanoic acid, ketone bodies, fasting, liver mitochondria, fatty acid synthesis
MeSH terms
Animals, Caprylates, Carnitine, Coenzyme A, Fatty Acids, Ketone Bodies, Liver, Male, Malonates, Mitochondria, Liver, Models, Biological, Oleic Acids, Oxidation-Reduction, Rats

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