Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns

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  1. Progress in Discovering Transcriptional Noise in Aging
    Josh Bartz, Hannim Jung, Karen R. Wasiluk, Lei Justan Zhang, Xiao Dong · 2023 · International Journal of Molecular Sciences
  2. Smurfness‐based two‐phase model of ageing helps deconvolve the ageing transcriptional signature
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  3. Machine learning based classification of cells into chronological stages using single-cell transcriptomics
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  5. Misexpression of genes lacking CpG islands drives degenerative changes during aging
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  7. Pancreatic Organoids for Regenerative Medicine and Cancer Research
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  8. A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions
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    Paul V. Sabatini, Thilo Speckmann, Cuilan Nian, Maria M. Glavas, Chi Kin Wong, Ji Soo Yoon, Tatsuya Kin, Andrew M. James Shapiro, William T. Gibson, C. Bruce Verchere et al. · 2018 · Cell Reports
  10. A complex auxiliary: IL-17/Th17 signaling during type 1 diabetes progression
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  11. Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis
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  12. Overview of Transcriptomic Research on Type 2 Diabetes: Challenges and Perspectives
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  13. Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations
    Kasit Chatsirisupachai, João Pedro de Magalhães · 2024 · Ageing Research Reviews
  14. Insights From Single Cell RNA Sequencing Into the Immunology of Type 1 Diabetes- Cell Phenotypes and Antigen Specificity
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  15. Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetes
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  16. Pancreatic islet cell type–specific transcriptomic changes during pregnancy and postpartum
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  17. Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species
    Alistair P. Green, Florian Klimm, Aidan S. Marshall, Rein Leetmaa, Juvid Aryaman, Aurora Gómez-Durán, Patrick Francis Chinnery, Nick S. Jones · 2025 · Nature Communications
  18. Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans
    Jiaxi Song, Qicheng Ni, Jiajun Sun, Jing Xie, Jianmin Liu, Guang Ning, Weiqing Wang, Qidi Wang · 2022 · The Journal of Clinical Endocrinology & Metabolism
  19. Deciphering Immune Landscape Remodeling Unravels the Underlying Mechanism for Synchronized Muscle and Bone Aging
    Pengbin Yin, Ming Chen, Man Rao, Yuan Lin, Mingming Zhang, Ren Xu, Xueda Hu, Ruijing Chen, Wei Chai, Xiang Huang et al. · 2023 · Advanced Science
  20. Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells
    Huijuan Hua, Yaqi Wang, Xiaofeng Wang, Shusen Wang, Yunlu Zhou, Yinan Liu, Zhen Liang, Huixia Ren, Sufang Lu, Shuangshuang Wu et al. · 2024 · Cell stem cell
  21. CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type
    Junil Kim, Diana E. Stanescu, Kyoung‐Jae Won · 2018 · Nucleic Acids Research
  22. Models of Gastroenteropancreatic Neuroendocrine Neoplasms: Current Status and Future Directions
    Katharina M Detjen, Linda Hammerich, Burcin Özdirik, Münevver Demir, Bertram Wiedenmann, Frank Tacke, Henning Jann, Christoph Roderburg · 2020 · Neuroendocrinology
  23. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland
    Qiaoran Wang, Xuebao Wang, Beibei Liu, Shuai Ma, Feng Zhang, Shuhui Sun, Yaobin Jing, Yanling Fan, Yingjie Ding, Muzhao Xiong et al. · 2024 · Nature Aging
  24. Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion
    Satsuki Miyazaki, Fumi Tashiro, Takashi Tsuchiya, Kazuki Sasaki, Jun‐ichi Miyazaki · 2021 · Scientific Reports
  25. Atlas of transcriptionally active transposable elements in human adult tissues
    Gireesh K. Bogu, Ferrán Reverter, Marc A. Martı́-Renom, Michael P. Snyder, Roderic Guigó · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Loss of coordination between basic cellular processes in human aging
    Ana Carolina Leote, Francisco José Calheiros Craveiro Lopes, Andreas Beyer · 2024 · Nature Aging
  27. Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice
    Elizabeth R. De Leon, Jacqueline A. Brinkman, Rachel J. Fenske, Trillian Gregg, Brian Schmidt, Dawn S. Sherman, Nicole E. Richardson, Darby C. Peter, Michelle E. Kimple, Dudley W. Lamming et al. · 2018 · Scientific Reports
  28. FIRM: Flexible integration of single-cell RNA-sequencing data for large-scale multi-tissue cell atlas datasets
    Jingsi Ming, Zhixiang Lin, Jia Zhao, Xiang Wan, Camille Ezran, Shixuan Liu, Can Yang, Angela Ruohao Wu · 2022 · Briefings in Bioinformatics
  29. Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility
    Rosalyn W. Sayaman, Masaru Miyano, Eric G Carlson, Parijat Senapati, Arrianna Zirbes, Sundus Shalabi, Michael E. Todhunter, Victoria E Seewaldt, Susan L. Neuhausen, Martha R. Stampfer et al. · 2024 · eLife
  30. Cell-to-cell variation in gene expression and the aging process
    Alexander Mendenhall, George M. Martin, Matt R. Kaeberlein, Rozalyn M. Anderson · 2021 · GeroScience
  31. Small things matter: Lack of extraislet β cells in type 1 diabetes
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  32. Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas
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  33. Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes
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  34. Senescence: a double-edged sword in beta-cell health and failure?
    Sneha S. Varghese, Sangeeta Dhawan · 2023 · Frontiers in Endocrinology
  35. Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI
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  36. Human neurons to model aging: A dish best served old
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  37. Northstar enables automatic classification of known and novel cell types from tumor samples
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  38. Tissue‐disruption‐induced cellular stochasticity and epigenetic drift: Common origins of aging and cancer?
    Jean‐Pascal Capp, Frédéric Thomas A · 2020 · BioEssays
  39. Data Denoising and Post-Denoising Corrections in Single Cell RNA Sequencing
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  40. The Immune System as a Therapeutic Target for Alzheimer’s Disease
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  41. The human α cell in health and disease
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  42. Measuring cell-to-cell expression variability in single-cell RNA-sequencing data: a comparative analysis and applications to B cell aging
    Huiwen Zheng, Jan Vijg, Atefeh Taherian Fard, Jessica C. Mar · 2023 · Genome biology
  43. Cellular senescence: from homeostasis to pathological implications and therapeutic strategies
    Chunhong Li, Yixiao Yuan, YingDong Jia, Qiang Zhou, Qiang Wang, Xiulin Jiang · 2025 · Frontiers in Immunology
  44. Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis
    Frederico C. Kiffer, Tyler C. Alexander, Julie E. Anderson, Thomas R. Groves, Taylor McElroy, Jing Wang, Vijayalakshmi Sridharan, Michael Bauer, Marjan Boerma, Antiño R. Allen · 2020 · Frontiers in Behavioral Neuroscience
  45. Exploring Additional Valuable Information From Single-Cell RNA-Seq Data
    Yunjin Li, Qiyue Xu, Duojiao Wu, Geng Chen · 2020 · Frontiers in Cell and Developmental Biology
  46. Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging
    Zhenguo Wang, Zhe Yi Li, Hongyu Liu, Chenghua Yang, Xin Li · 2025 · Nature Aging
  47. Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures
    Mingyu Xia, Feng Zhang, Jiaoyao Ma, Yunjie Li, Gaogan Jia, Mingxuan Wu, Yiyun Lou, Yaoqian Liu, Lingjie Li, Huawei Li et al. · 2025 · Cell Reports
  48. Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges
    Srishti Banerjee, Sandipan Ray · 2022 · Progress in Neurobiology
  49. Epigenetics as a mediator of genetic risk in osteoarthritis: role during development, homeostasis, aging, and disease progression
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  50. A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging
    Hao Jia, Yuan Chang, Yulin Chen, Xiao Chen, Hang Zhang, Xiumeng Hua, Mengda Xu, Yixuan Sheng, Ningning Zhang, Hao Cui et al. · 2024 · Communications Biology
  51. Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors
    Esra Karaköse, Xuedi Wang, Peng Wang, Saul Carcamo, Deniz Demircioğlu, Luca Lambertini, Olivia Wood, Randy B. Kang, Geming Lu, Donald K. Scott et al. · 2024 · Cell Reports Medicine
  52. Single-cell RNA sequencing for engineering and studying human islets
    Punn Augsornworawat, Jeffrey R. Millman · 2020 · Current Opinion in Biomedical Engineering
  53. Notable challenges posed by long-read sequencing for the study of transcriptional diversity and genome annotation
    Carolina Monzó, Adam Frankish, Ana Conesa · 2025 · Genome Research
  54. scGAD: a new task and end-to-end framework for generalized cell type annotation and discovery
    Yuyao Zhai, Liang Chen, Minghua Deng · 2023 · Briefings in Bioinformatics
  55. A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-Cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data
    Su Wang, Stéphane Flibotte, Joan Camuñas-Soler, Patrick E. MacDonald, James D. Johnson · 2021 · Canadian Journal of Diabetes
  56. A Transcriptionally Distinct Subpopulation of Healthy Acinar Cells Exhibit Features of Pancreatic Progenitors and PDAC
    Vishaka Gopalan, Arashdeep Singh, Farid Rashidi Mehrabadi, Li Wang, Eytan Ruppin, H. Efsun Arda, Sridhar S. Hannenhalli · 2021 · Cancer Research
  57. psupertime: supervised pseudotime inference for single cell RNA-seq data with sequential labels
    Will Macnair, Manfred Claassen · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  58. A cellular identity crisis? Plasticity changes during aging and rejuvenation
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  59. Single‐Cell and Spatial Multiomics: Applications for Diseases
    Wentao Li, Chao Chen, Xin Zhu, Chenping Zhang · 2025 · MedComm
  60. Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation
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  61. Transcriptional dynamics of induced pluripotent stem cell differentiation into β cells reveals full endodermal commitment and homology with human islets
    Silvia Pellegrini, Raniero Chimienti, Giulia Maria Scotti, Francesca Giannese, Dejan Lazarević, Fabio Manenti, Gaia Poggi, Marta Tiffany Lombardo, Alessandro Cospito, Rita Nano et al. · 2020 · Cytotherapy
  62. Single-cell analysis reveals androgen receptor regulates the ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate cancer progression
    Lingling Hu, Xin Chen, Nitin P. Narwade, Michelle Gek Liang Lim, Zikai Chen, Chandana Tennakoon, Peiyong Guan, Un In Chan, Zuxianglan Zhao, Mokan Deng et al. · 2021 · Oncogene
  63. Healthy skeletal muscle aging: The role of satellite cells, somatic mutations and exercise
    Irene Franco, Rodrigo Fernandez‐Gonzalo, Peter Vrtačnik, Tommy R. Lundberg, Maria Eriksson, Thomas P. Gustafsson · 2019 · International review of cytology
  64. Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells
    Emily Marques, Emily Formato, Wenle Liang, Emily Leonard, Alicia R. Timme‐Laragy · 2021 · Journal of Diabetes
  65. A Single-Cell Survey of Cellular Heterogeneity in Human Great Saphenous Veins
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  66. It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease
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  67. Single-cell metabolic profiling of primary human hepatocytes shows heterogenous responses to drug metabolism
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  68. Apolipoprotein L genes are novel mediators of inflammation in beta cells
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  69. Methylation entropy landscape of Chinese long‐lived individuals reveals lower epigenetic noise related to human healthy aging
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  70. Investigation of human aging at the single-cell level
    Yunjin Li, Qixia Wang, Yuan Xuan, Jian Zhao, Jin Li, Yuncai Tian, Geng Chen, Fei Tan · 2024 · Ageing Research Reviews
  71. Somatic mutations – Evolution within the individual
    Satoshi Oota · 2019 · Methods
  72. Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain
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  73. Polyploidisation pleiotropically buffers ageing in hepatocytes
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  74. scCobra allows contrastive cell embedding learning with domain adaptation for single cell data integration and harmonization
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  75. Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma
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  76. Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas
    Junqiang Wang, Ruoshi Yuan, Xiaomei Zhu, Ping Ao · 2020 · Scientific Reports
  77. Advances of single-cell genomics and epigenomics in human disease: where are we now?
    Rizqah Kamies, Celia Pilar Martinez‐Jimenez · 2020 · Mammalian Genome
  78. Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific
    Rafael Arrojo e Drigo, Galina A. Erikson, Swati Tyagi, Juliana S. Capitanio, James G. Lyon, Aliya F Spigelman, Austin Bautista, Jocelyn E. Manning Fox, Max Shokhirev, Patrick E. MacDonald et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Targeting individual cells by barcode in pooled sequence libraries
    Ranu, Navpreet, Villani, Alexandra-Chloé, Hacohen, Nir, Blainey, Paul C · 2019 · Nucleic Acids Research
  80. Stem/progenitor cells in normal physiology and disease of the pancreas
    Mario Enrique Alvarèz Fallas, Sergio Pedraza‐Arévalo, Ana-Maria Cujba, Teodora Manea, Christopher Lambert, Rosario Morrugares, Rocı́o Sancho · 2021 · Molecular and Cellular Endocrinology
  81. Transcriptomic reprogramming for neuronal age reversal
    Alexandru M. Pleşa, Michael Shadpour, Edward S. Boyden, George McDonald Church · 2023 · Human Genetics
  82. De novo identification of expressed cancer somatic mutations from single-cell RNA sequencing data
    Tianyun Zhang, Hanying Jia, Tairan Song, Lin Lv, D. Gulhan, Haishuai Wang, Wei Guo, Ruibin Xi, Hongshan Guo, Ning Shen · 2023 · Genome Medicine
  83. Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis
    Jin Wang, Shiyi Wen, Minqi Chen, Jiayi Xie, Xinhua Lou, Haihan Zhao, Yanming Chen, Meng Liang Zhao, Guojun Shi · 2024 · Communications Biology
  84. Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system
    Shugo Sasaki, Michelle Y. Y. Lee, Yuka Wakabayashi, Luka Suzuki, Helena K. Winata, Miwa Himuro, Taka‐aki Matsuoka, Iichiro Shimomura, Hirotaka Watada, Francis C. Lynn et al. · 2022 · Diabetologia
  85. Discovering Cellular Mitochondrial Heteroplasmy Heterogeneity with Single Cell RNA and ATAC Sequencing
    Aidan S. Marshall, Nick S. Jones · 2021 · Biology
  86. Quantification of Age-Related Decline in Transcriptional Homeostasis
    Krishan Gupta, Princey Yadav, Sidrah Maryam, Gaurav Ahuja, Debarka Sengupta · 2021 · Journal of Molecular Biology
  87. Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
    Ruben De Man, John E. McDonough, Taylor Sterling Adams, Fadi Nikola, Reina Rangel, Sabina Anderson, Edward P. Manning, Juan Cala-García, B.J. Moss, Alan Waich et al. · 2026 · Nature Communications
  88. Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production
    Daniel Oropeza, Pedro Luis Herrera · 2023 · Trends in Cell Biology
  89. Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis
    Xiao‐Tong Mao, Sheng-Han Mao, Lei Wang, Hui Jiang, Shun‐Jiang Deng, Yuanchen Wang, Jun Ye, Zhao‐Shen Li, Wen‐Bin Zou, Zhuan Liao · 2022 · Genes
  90. Single-Cell Transcriptome Analysis Revealed Heterogeneity of Fibroblast and Cellular Senescence in Aging Penile Corpus Cavernosum
    Qiwei Liu, Yulong Song, Yubin Cui, Cheng Hu, Yun Luo, Daoyuan Hu, Hua Wang, Ke Li, Jun Chen, Hengjun Xiao · 2021 · SSRN Electronic Journal
  91. Transcriptional Noise and Somatic Mutations in the Aging Pancreas
    Avital Swisa, Klaus H. Kaestner, Yuval Dor · 2017 · Cell Metabolism
  92. Complex Genetics in Pancreatitis
    Mitchell A. Ellison, Daniel M. Spagnolo, Celeste A. Shelton, Ekatarina Orlova, Jessica LaRusch, David Clement Whitcomb, Mark E. Haupt · 2020 · Pancreas
  93. SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation
    Kouminin Kanwore, Xiaoxiao Guo, Abiola Abdulrahman Ayanlaja, Piniel Alphayo Kambey, Iqra Nadeem, Dianshuai Gao · 2021 · Molecular Neurobiology
  94. A murine aging cell atlas reveals cell identity and tissue-specific trajectories of aging
    2019
  95. A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular Programs
    Ruben De Man, John E. McDonough, Taylor Sterling Adams, Edward P. Manning, Greg Myers, Robin Vos, Laurens Joseph Ceulemans, Lieven Dupont, Bart M. Vanaudenaerde, Wim A Wuyts et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  96. TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic Pancreatitis
    N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Köhn‐Gaone, Vincent M. Williams, Marco Falasca, John Kevin Olynyk, Grant A. Ramm, Janina E. E. Tirnitz‐Parker · 2023 · Cancers
  97. Continually adapting pre-trained language model to universal annotation of single-cell RNA-seq data
    Hui Song Wan, Musu Yuan, Yiwei Fu, Minghua Deng · 2024 · Briefings in Bioinformatics
  98. RadiationGeneSigDB : a database of oxic and hypoxic radiation response gene signatures and their utility in pre-clinical research
    Venkata SK. Manem, Andrew Dhawan · 2019 · British Journal of Radiology
  99. scDA: Single cell discriminant analysis for single-cell RNA sequencing data
    Qianqian Shi, Xinxing Li, Qirui Peng, Chuanchao Zhang, Luonan Chen · 2021 · Computational and Structural Biotechnology Journal
  100. Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement
    Roy A Goode, Julia M. Hum, Michael A. Kalwat · 2022 · Endocrinology