Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns

Cited by (582)

Items 101–200 of 582

1. The Human Islet: Mini-Organ With Mega-Impact
   John T. Walker, Diane C. Saunders, Marcela Briššová, Alvin C. Powers · 2021 · Endocrine Reviews
2. scDFC: A deep fusion clustering method for single-cell RNA-seq data
   Dayu Hu, Ke Liang, Sihang Zhou, Wenxuan Tu, Meng Liu, Xinwang Liu · 2023 · Briefings in Bioinformatics
3. Biology-inspired data-driven quality control for scientific discovery in single-cell transcriptomics
   Ayshwarya Subramanian, Mikhail Alperovich, Yiming Yang, Bo Li · 2022 · Genome biology
4. Insights Into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy
   Sijie Fang, Yazhuo Huang, Ningjian Wang, Shuo Zhang, Sisi Zhong, Yinwei Li, Jing Ping Sun, Xingtong Liu, Yang Wang, Ping Gu et al. · 2018 · The Journal of Clinical Endocrinology & Metabolism
5. A single-cell transcriptomic atlas of primate pancreatic islet aging
   Jingyi Li, Yuxuan Zheng, Pengze Yan, Moshi Song, Si Wang, Liang Sun, Zunpeng Liu, Shuai Ma, Juan Carlos Izpisúa Belmonte, Piu Chan et al. · 2020 · National Science Review
6. The pancreatic β-cell in ageing: Implications in age-related diabetes
   Eva Tudurí, Sergi Soriano, Lucía Almagro, Eduard Montanya, Paloma Alonso‐Magdalena, Ángel Nadal, Iván Quesada · 2022 · Ageing Research Reviews
7. Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis
   Jérôme Bourgault, Erik Abner, Hasanga D. Manikpurage, Natàlia Pujol‐Gualdo, Triin Laisk, Émilie Gobeil, Éloi Gagnon, Arnaud S. Girard, Patricia L. Mitchell, Sébastien Thériault et al. · 2023 · Gastroenterology
8. Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation
   Shufen Zheng, Philip S. Tsao, Cuiping Pan · 2024 · Nature Communications
9. Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes
   Mario A Miranda, Juan F Macias-Velasco, Heather A. Lawson · 2021 · American Journal of Physiology-Endocrinology and Metabolism
10. Systems approaches to investigate the role of NF-κB signaling in aging
    Masatoshi Haga, Mariko Okada · 2022 · Biochemical Journal
11. Senescence Alters PPARγ (Peroxisome Proliferator–Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation
    Anaïs Briot, Pauline Decaunes, Fanny Volat, Chloé Belles, Muriel Coupaye, Séverine Ledoux, Anne Bouloumié · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
12. Quantitative mapping of human hair greying and reversal in relation to life stress
    Ayelet M Rosenberg, Shannon Rausser, Junting Ren, Eugene V. Mosharov, Gabriel Sturm, Robert Todd Ogden, Purvi R. Patel, Rajesh Kumar Soni, Clay Lacefield, Desmond John Tobin et al. · 2021 · eLife
13. A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas
    H. Efsun Arda, Jennifer Tsai, Yenny Rosli, Paul G. Giresi, Rita Bottino, William James Greenleaf, Howard Y. Chang, Seung K. Kim · 2018 · Cell Systems
14. SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans
    Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao Khanh Lai, Davide Brusa, Birgit Stierstorfer et al. · 2020 · Molecular Metabolism
15. Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation
    Vidhi Chandra, Le Li, Olivereen Le Roux, Yu Zhang, Rian M. Howell, Dhwani N. Rupani, Seyda Baydogan, Haiyan D Miller, Erick Marcelo Riquelme, Joseph F. Petrosino et al. · 2023 · Cancer Cell
16. The potential of erythrocytes as cellular aging models
    Lars Kaestner, Giampaolo Minetti · 2017 · Cell Death and Differentiation
17. Sex differences in islet stress responses support female β cell resilience
    George P. Brownrigg, Yi Han Xia, Chieh Min Jamie Chu, Su Wang, Charlotte F. Chao, Jiashuo Aaron Zhang, Søs Skovsø, Evgeniy Panzhinskiy, Xiaoke Hu, James D. Johnson et al. · 2023 · Molecular Metabolism
18. Heterogeneity and transcriptome changes of human CD8+ T cells across nine decades of life
    Jian Lü, Raheel Ahmad, Thomas B. V. Nguyen, Jeffrey Cifello, Humza Hemani, Jiangyuan Li, Jinguo Chen, Siyi Li, Jing Wang, Achouak Achour et al. · 2022 · Nature Communications
19. Regulation and mechanism of Astragalus polysaccharide on ameliorating aging in Drosophila melanogaster
    Xu Li, Shipei Yang, Shuwei Wang, Yan Shi, Yuting Dai, Xueyan Zhang, Yongqi Liu, Yaqiong Guo, Jianzheng He, Minghui Xiu · 2023 · International Journal of Biological Macromolecules
20. Cell Type Purification by Single-Cell Transcriptome-Trained Sorting
    Chloé S. Baron, Aditya Barve, Mauro J. Muraro, Reinier van der Linden, Gitanjali Dharmadhikari, Anna Lyubimova, Eelco J.P. de Koning, Alexander van Oudenaarden · 2019 · Cell
21. Profiling DNA break sites and transcriptional changes in response to contextual fear learning
    Stott, Ryan T., Kritsky, Oleg, Tsai, Li-Huei · 2021 · PLOS ONE
22. Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles
    Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa M. Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcı́a-Ocaña, Geming Lu · 2023 · Genome Medicine
23. The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans
    Felicia Gerst, Benjamin Assad Jaghutriz, Harald Staiger, Anke M. Schulte, Estela Lorza‐Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz et al. · 2018 · The Journal of Clinical Endocrinology & Metabolism
24. Brain Somatic Mutation in Aging and Alzheimer's Disease
    Michael B. Miller, Hannah Reed, Christopher A. Walsh · 2021 · Annual Review of Genomics and Human Genetics
25. A transcriptional cross species map of pancreatic islet cells
    Sophie Tritschler, Moritz Thomas, Anika Böttcher, Barbara Ludwig, Janine Schmid, Undine Schubert, Elisabeth Kemter, Eckhard Wolf, Heiko Lickert, Fabian Joachim Theis · 2022 · Molecular Metabolism
26. Epigenetic dosage identifies two major and functionally distinct β cell subtypes
    Erez Dror, Luca Fagnocchi, Vanessa Wegert, Stefanos Apostle, Brooke Grimaldi, Tim Gruber, Ilaria Panzeri, Steffen Heyne, Kira Daniela Höffler, Victor Kreiner et al. · 2023 · Cell Metabolism
27. Somatic mutations in neurons during aging and neurodegeneration
    Bert M. Verheijen, Marc Vermulst, Fred W. van Leeuwen · 2018 · Acta Neuropathologica
28. Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity
    Hamit İzgi, DingDing Han, Ulas Isildak, Shuyun Huang, Ece Kocabiyik, Philipp Khaitovich, Mehmet Somel, Handan Melike Dönertaş · 2022 · eLife
29. Single-cell RNA-seq data semi-supervised clustering and annotation via structural regularized domain adaptation
    Liang Chen, Qiuyan He, Yuyao Zhai, Minghua Deng · 2020 · Bioinformatics
30. Temporal changes in the gene expression heterogeneity during brain development and aging
    Işıldak, Ulaş, Somel, Mehmet, Thornton, Janet M., Dönertaş, Handan Melike · 2020 · Scientific Reports
31. Making use of noise in biological systems
    Yaron Ilan · 2023 · Progress in Biophysics and Molecular Biology
32. Noise-driven cellular heterogeneity in circadian periodicity
    Yan Li, Yongli Shan, Ravi V. Desai, Kimberly H. Cox, Leor S. Weinberger, Joseph S. Takahashi · 2020 · Proceedings of the National Academy of Sciences
33. IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration
    Omid Omrani, Anna Křepelová, Seyed Mohammad Mahdi Rasa, Dovydas Širvinskas, Jing Nan Lu, Francesco Annunziata, George B. Garside, Seerat Bajwa, Susanne Reinhardt, Lisa Adam et al. · 2023 · Nature Communications
34. Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies
    Jeeyeon Cha, Cristina Aguayo‐Mazzucato, Peter J. Thompson · 2023 · Frontiers in Endocrinology
35. Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia
    Yang Li, Chuhan Li, Qin Zhou, Xingyuan Liu, Yulong Qiao, Ting Xie, Hao Sun, Michael Tim‐Yun Ong, Huating Wang · 2025 · Nature Communications
36. Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets
    Brenda Marquina-Sanchez, Nikolaus Fortelny, Matthias Farlik, Andhira Vieira, Patrick Collombat, Christoph Bock, Stefan Kubicek · 2020 · Genome biology
37. Single-Cell RNA Sequencing and Assay for Transposase-Accessible Chromatin Using Sequencing Reveals Cellular and Molecular Dynamics of Aortic Aging in Mice
    Xie, Wenhui, Ke, Yilang, You, Qinyi, Li, Jing, Chen, Lu, Li, Dang, Fang, Jun, Chen, Xiaofeng, Zhou, Yuanyuan, Chen, Liangwan et al. · 2022 · Arteriosclerosis, Thrombosis, and Vascular Biology
38. Single-cell transcriptomic and genomic changes in the ageing human brain
    Ailsa M. Jeffries, Tianxiong Yu, Jennifer S. Ziegenfuss, Allie K. Tolles, Christina E. Baer, Cesar Bautista Sotelo, Yerin Kim, Zhiping Weng, Michael A. Lodato · 2025 · Nature
39. Basic and translational aging research in China: present and future
    Major Program Expert Group, Xiaojuan He, Moshi Song, Jing Tao Qu, Yansu Guo, Heqi Cao, Ruijuan Sun, Guang‐Hui Liu, Yong Shen · 2019 · Protein & Cell
40. psupertime: supervised pseudotime analysis for time-series single-cell RNA-seq data
    Will Macnair, Revant Gupta, Manfred Claassen · 2022 · Bioinformatics
41. Integrating Deep Supervised, Self-Supervised and Unsupervised Learning for Single-Cell RNA-seq Clustering and Annotation
    Liang Chen, Yuyao Zhai, Qiuyan He, Weinan Wang, Minghua Deng · 2020 · Genes
42. Age-related loss of gene-to-gene transcriptional coordination among single cells
    Orr Levy, Guy Amit, Dana Ben Porath, Tom Snir, Sol Efroni, Peter J. Castaldi, Yang‐Yu Liu, Haim Yosef Cohen, Amir Bashan · 2020 · Nature Metabolism
43. The aging transcriptome: read between the lines
    Anabel Pérez‐Gómez, Joel N. Buxbaum, Michael Petrascheck · 2020 · Current Opinion in Neurobiology
44. Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage
    Mayur Doke, Silvia Álvarez-Cubela, Dagmar Klein, Isabella Altilio, Joseph Schulz, Luciana Mateus Gonçalves, Joana Almaça, Christopher A. Fraker, Alberto Pugliese, Camillo Ricordi et al. · 2023 · Cell Metabolism
45. The RNA world of human ageing
    Juan Carlos Gómez-Verján, Edgar Ricardo Vázquez-Martínez, Nadia Alejandra Rivero-Segura, Raúl Hernán Medina-Campos · 2018 · Human Genetics
46. Single-cell genomics to understand disease pathogenesis
    Seitaro Nomura · 2020 · Journal of Human Genetics
47. SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells
    Romina J. Bevacqua, Jonathan Y. Lam, Heshan S. Peiris, Robert L. Whitener, Seokho Kim, Xueying Gu, Mollie S. H. Friedlander, Seung K. Kim · 2021 · Genes & Development
48. Long-Term High-Fat High-Fructose Diet Induces Type 2 Diabetes in Rats through Oxidative Stress
    Yue Zhao, Qingyu Wang, Lv-Tao Zeng, Jing-Jing Wang, Zhen Liu, Guoqing Fan, Jin Li, Jian‐Ping Cai · 2022 · Nutrients
49. Gene regulatory networks in disease and ageing
    Paula Unger Avila, Tsimafei Padvitski, Ana Carolina Leote, He Chen, Julio Sáez-Rodríguez, Martin Kann, Andreas Beyer · 2024 · Nature Reviews Nephrology
50. Multi-level remodeling of transcriptional landscapes in aging and longevity
    Rochelle W. Lai, Ryan J. Lu, Prakroothi S. Danthi, Juan I. Bravo, Alexandre Goumba, Nirmal Kumar Sampathkumar, Bérénice Anath Benayoun · 2019 · BMB Reports
51. The widespread increase in inter-individual variability of gene expression in the human brain with age
    Veronika R. Kedlian, Handan Melike Dönertaş, Janet M. Thornton · 2019 · Aging
52. Differentiation reveals latent features of aging and an energy barrier in murine myogenesis
    Kimmel, Jacob C., Yi, Nelda, Roy, Margaret, Hendrickson, David G., Kelley, David R. · 2021 · Cell Reports
53. Sex Differences in the Molecular Programs of Pancreatic Cells Contribute to the Differential Risks of Type 2 Diabetes
    Hyo Jeong Yong, Maria Pilar Toledo, Richard S. Nowakowski, Yue Julia Wang · 2022 · Endocrinology
54. Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression
    Anna Billeschou, Christian Dall Johansen, Jens Bager Christensen, Sasha A. S. Kjeldsen, Katrine Douglas Galsgaard, Marie Winther‐Sørensen, Reza Serizawa, Mads Hornum, Esteban Porrini, Jens Pedersen et al. · 2022 · Communications Biology
55. Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice
    Cristiane dos Santos, Amanda Cambraia, Shristi Shrestha, Melanie Cutler, Matthew A. Cottam, Guy A Perkins, Varda Lev‐Ram, Birbickram Roy, Christopher Acree, Keun-young Kim A et al. · 2024 · Nature Communications
56. Pitx2 maintains mitochondrial function during regeneration to prevent myocardial fat deposition
    Lele Li, Ge Tao, Matthew C. Hill, Min Zhang, Yuka Morikawa, James F. Martin · 2018 · Development
57. Largest GWAS (N=1,126,563) of Alzheimer’s Disease Implicates Microglia and Immune Cells
    Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Arvid Rongve, Sigrid Børte, Bendik Slagsvold Winsvold, Ole Kristian Drange, Amy E. Martinsen et al. · 2020 · medRxiv
58. Lack of evidence for increased transcriptional noise in aged tissues
    Olga Ibáñez-Solé, Alex M. Ascensión, Marcos Jesus Araúzo-Bravo, Ander Izeta · 2022 · eLife
59. The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases
    Muhammad Ajmal Shah, Hafiza Ishmal Faheem, Ayesha Hamid, Rimsha Yousaf, Muhammad Haris, Uzma Saleem, Ghulam Mujtaba Shah, Reem Hasaballah Alhasani, Norah Ayidh Althobaiti, Ifat Alsharif et al. · 2023 · Medicinal Research Reviews
60. Low-Density Lipoprotein Cholesterol Is Associated With Insulin Secretion
    Corinna Dannecker, Robert J. Wagner, Andreas Peter, Julia Hummel, Andreas Vosseler, Hans‐Ulrich Häring, Andreas Fritsche, Andreas L. Birkenfeld, Norbert Stefan, Martin Heni · 2021 · The Journal of Clinical Endocrinology & Metabolism
61. Theaflavin-regulated Imd condensates control Drosophila intestinal homeostasis and aging
    Qingshuang Cai, Shanming Ji, Mengwan Li, Sen Zheng, Xiuhong Zhou, Huimin Guo, Siyu Deng, Junyan Zhu, Daxiang Li, Zhongwen Xie · 2021 · iScience
62. MitoTrace: A Computational Framework for Analyzing Mitochondrial Variation in Single-Cell RNA Sequencing Data
    Mingqiang Wang, Wankun Deng, David C. Samuels, Zhongming Zhao, Lukas Mikolaj Simon · 2023 · Genes
63. Pancreatic Progenitors: There and Back Again
    Juan Domínguez‐Bendala, Mirza Muhammad Fahd Qadir, Ricardo Luis Pastori · 2018 · Trends in Endocrinology and Metabolism
64. Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell
    Amparo Pascual‐Ahuir, Josep Fita‐Torró, Markus Proft · 2020 · International Journal of Molecular Sciences
65. Highly Multiplexed Single‐Cell Protein Profiling with Large‐Scale Convertible DNA‐Antibody Barcoded Arrays
    Peng Zhao, Sirsendu Bhowmick, Jian-Chao Yu, Jun Wang · 2018 · Advanced Science
66. Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
    Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni · 2021 · Genome Medicine
67. Lessons from single-cell RNA sequencing of human islets
    Mtakai Ngara, Nils Wierup · 2022 · Diabetologia
68. The origins and functional effects of postzygotic mutations throughout the human life span
    Nicole B. Rockweiler, Avinash Ramu, Liina Nagirnaja, Winghing Wong, Michiel J. Noordam, Casey W. Drubin, Ni Huang, Brian Miller, Ellen Z. Todres, Katinka A. Vigh‐Conrad et al. · 2023 · Science
69. Decoding Aging Hallmarks at the Single-Cell Level
    Shuai Ma, Xu Chi, Yusheng Cai, Zhejun Ji, Si Wang, Jie Ren, Guang‐Hui Liu · 2023 · Annual Review of Biomedical Data Science
70. Neural cell state shifts and fate loss in ageing and age-related diseases
    Larissa Traxler, Raffaella Lucciola, Joseph R. Herdy, Jeffrey R. Jones, Jérôme Mertens, Fred H. Gage · 2023 · Nature Reviews Neurology
71. Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris
    Nicholas Schaum, Jim Karkanias, Norma F Neff, Andrew P. May, Stephen R. Quake, Tony Wyss‐Coray, Spyros Darmanis, Joshua Batson, Olga Borisovna Botvinnik, Michelle B. Chen et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
72. Sfaira accelerates data and model reuse in single cell genomics
    Fischer, David S., Dony, Leander, König, Martin, Moeed, Abdul, Zappia, Luke, Heumos, Lukas, Tritschler, Sophie, Holmberg, Olle, Aliee, Hananeh, Theis, Fabian J. · 2021 · Genome Biology
73. Advances in drug discovery for human beta cell regeneration
    Esra Karaköse, Courtney A. Ackeifi, Peng Wang, Andrew F. Stewart · 2018 · Diabetologia
74. Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
    Lu Cui, Ignacio Moraga, Tristan Lerbs, Camille Van Neste, Stephan Wilmes, Naotaka Tsutsumi, Aaron C. Trotman-Grant, Milica Gakovic, Sarah Andrews, Jason R. Gotlib et al. · 2020 · Proceedings of the National Academy of Sciences
75. Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research
    Mollie S. H. Friedlander, Vy Nguyen, Seung K. Kim, Romina J. Bevacqua · 2021 · Diabetes
76. Genetic cartography of longevity in humans and mice: Current landscape and horizons
    Michael Hook, Suheeta Roy, Evan G. Williams, Maroun S. Bou Sleiman, Khyobeni Mozhui, James F. Nelson, Lu Lu, Johan H. Auwerx, Robert W. Williams · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
77. Single-Cell RNA Sequencing-Based Computational Analysis to Describe Disease Heterogeneity
    Tao Zeng, Hao Dai · 2019 · Frontiers in Genetics
78. Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
    Rezwana Ahmed, Yasukazu Nakahata, Kazuyuki Shinohara, Yasumasa Bessho · 2021 · Frontiers in Neuroscience
79. Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
    Sandrina Martens, Katarina Coolens, Mathias Van Bulck, Tatjana Arsenijevic, Joan Casamitjana, Angel Fernandez Ruiz, Abdessamad El Kaoutari, Jaime Martínez de Villarreal, Hediel Madhloum, Farzad Esni et al. · 2021 · Gut
80. Single‐cell RNA ‐seq reveals early heterogeneity during aging in yeast
    Yi Zhang, Yuchen Sang, Yuchen Sang, Shengxian Jin, Xuezheng Wang, Gajendra Kumar Azad, Mark A. McCormick, Brian Keith Kennedy, Qing Li, Jianbin Wang et al. · 2022 · Aging Cell
81. CellVoyager: AI CompBio agent generates new insights by autonomously analyzing biological data
    Samuel Alber, Bowen Chen, Eric Sun, Alina Isakova, Aaron J. Wilk, James Zou · 2026 · Nature Methods
82. Tissue aging: the integration of collective and variant responses of cells to entropic forces over time
    Michael E. Todhunter, Rosalyn W. Sayaman, Masaru Miyano, Mark A. LaBarge · 2018 · Current Opinion in Cell Biology
83. The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis
    Richard K.P. Benninger, Craig Dorrell, David J. Hodson, Guy A. Rutter · 2018 · Current Diabetes Reports
84. Ageing and sources of transcriptional heterogeneity
    Chrysa Nikopoulou, Swati Parekh, Peter Tessarz · 2019 · Biological Chemistry
85. Transcriptomic Analysis of Cellular Senescence: One Step Closer to Senescence Atlas
    Sohee Kim, Chuna Kim · 2021 · Molecules and Cells
86. Genetic regulation of RNA splicing in human pancreatic islets
    Goutham Atla, Sílvia Bonàs‐Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, Javier García-Hurtado, Ignasi Morán, Miriam Cnop, Lena Eliasson, Jonathan L.S. Esguerra et al. · 2022 · Genome biology
87. LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells
    Federica Cuozzo, Katrina Viloria, Ali H. Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Jason Tong, Zicong Jiao, Adam Boufersaoui, Bryan P. Marzullo, Daniel B. Rosoff et al. · 2024 · Cell Reports
88. Unraveling aging from transcriptomics
    Yuanfang Huang, Shouxuan Zhu, Shuai Yao, Haotian Zhai, Chenyang Liu, Jing‐Dong J. Han · 2024 · Trends in Genetics
89. Nuclear organization and regulation of the differentiated state
    Eliya Bitman-Lotan, Amir Orian · 2021 · Cellular and Molecular Life Sciences
90. scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies
    Peilin Jia, Ruifeng Hu, Fangfang Yan, Yulin Dai, Zhongming Zhao · 2022 · Genome biology
91. Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes
    Rebecca Craig‐Schapiro, Ge Li, Kevin Chen, Jesús M. Gómez-Salinero, Ryan Nachman, Aleksandra Kopacz, Ryan P. Schreiner, Xiaojuan Chen, Qiao Zhou, Shahin Rafii et al. · 2025 · Nature Communications
92. The Systems Biology of Single-Cell Aging
    Ruijie Song, Ethan A. Sarnoski, Murat Açar · 2018 · iScience
93. Emerging roles of olfactory receptors in glucose metabolism
    Zhao Yang, Jie Cheng, Pan Shang, Jin‐Peng Sun, Xiao Yu · 2022 · Trends in Cell Biology
94. The diagnostic value and pathogenetic role of lncRNA-ATB in patients with osteoarthritis
    Xiliang Dang, Liping Lian, Dongsheng Wu · 2018 · Cellular & Molecular Biology Letters
95. Somatic mutations in aging and disease
    Peijun Ren, Jie Zhang, Jan Vijg · 2024 · GeroScience
96. Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
    Chu, Liu-Xi, Wang, Wen-Jia, Gu, Xin-Pei, Wu, Ping, Gao, Chen, Zhang, Quan, Wu, Jia, Jiang, Da-Wei, Huang, Jun-Qing, Ying, Xin-Wang et al. · 2024 · Military Medical Research
97. Understanding generation and regeneration of pancreatic β cells from a single-cell perspective
    Xin‐Xin Yu, Cheng‐Ran Xu · 2020 · Development
98. CSEA-DB: an omnibus for human complex trait and cell type associations
    Yulin Dai, Ruifeng Hu, Astrid Marilyn Manuel, Andi Liu, Peilin Jia, Zhongming Zhao · 2020 · Nucleic Acids Research
99. Age or lifestyle-induced accumulation of genotoxicity is associated with a length-dependent decrease in gene expression
    Olga Ibáñez-Solé, Irantzu Barrio, Ander Izeta · 2023 · iScience
100. Beta Cell Therapies for Preventing Type 1 Diabetes: From Bench to Bedside
     Gabriel M. Brawerman, Peter J. Thompson · 2020 · Biomolecules