Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364

Salmon provides fast and bias-aware quantification of transcript expression

Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700

Genome engineering using the CRISPR-Cas9 system

Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Law, C. W., Chen, Y., Shi, W., & Smyth, G. K. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r29 · Cited by 6,155

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

Eden, E., Navon, R., Steinfeld, I., Lipson, D., & Yakhini, Z. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-48 · Cited by 3,356

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304

Interferon-stimulated genes: A complex web of host defenses

Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067

Repbase Update, a database of repetitive elements in eukaryotic genomes

Bao, W., Kojima, K. K., & Kohany, O. (2015) · Mobile DNA · doi:10.1186/s13100-015-0041-9 · Cited by 2,942

Regulation of the epigenome through RNA modifications

Patrasso, E. A., Raikundalia, S., & Arango, D. (2023) · Chromosoma · doi:10.1007/s00412-023-00794-7 · Cited by 27

ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways

Vongpipatana, T., Nakahama, T., Shibuya, T., Kato, Y., & Kawahara, Y. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900929 · Cited by 27

Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity

Jarmoskaite, I., & Li, J. B. (2024) · RNA · doi:10.1261/rna.079953.124 · Cited by 26

Retroelement-derived RNA and its role in the brain

Evans, T. A., & Erwin, J. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.11.001 · Cited by 25

Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA

Price, A. M., Steinbock, R. T., Di, C., Hayer, K. E., Li, Y., Herrmann, C., Parenti, N. A., Whelan, J. N., Weiss, S. R., & Weitzman, M. D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab896 · Cited by 25

The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways

Nakahama, T., & Kawahara, Y. (2022) · International Immunology · doi:10.1093/intimm/dxac056 · Cited by 25

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

Hwang, M., Boulanger, J., Howe, J. D., Albecka, A., Pasche, M., Mureşan, L., & Modis, Y. (2019) · FEBS Journal · doi:10.1111/febs.14772 · Cited by 25

15-Deoxy-Δ12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2α and activates the integrated stress response

Tauber, D., & Parker, R. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007138 · Cited by 25

RNA Epigenetics: Fine-Tuning Chromatin Plasticity and Transcriptional Regulation, and the Implications in Human Diseases

Willbanks, A. R., Wood, S., & Cheng, J. X. (2021) · Genes · doi:10.3390/genes12050627 · Cited by 26

Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA

Manjunath, L., Santiago, G., Ortega, P., Sanchez, A., Oh, S., Garcia, A. N., Li, J., Duong, D., Bournique, E., Bouin, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58412-2 · Cited by 24

Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity

Asthana, A., Gaughan, C., Dong, B., Weiss, S. R., & Silverman, R. H. (2021) · mBio · doi:10.1128/mbio.01781-21 · Cited by 24

Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy

Ran, X., Ding, L., Sun, Q.-Y., Yang, H. H., Said, J. W., Lao, Z., Madan, V., Dakle, P., Xiao, J.-F., Loh, X.-Y., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-21-3052 · Cited by 24

Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape

Batjargal, T., Zappa, F., Grant, R. J., Piscopio, R. A., Chialastri, A., Dey, S. S., Acosta‐Alvear, D., & Wilson, M. Z. (2023) · Cell Systems · doi:10.1016/j.cels.2023.06.001 · Cited by 25

Structural Variability in the RLR-MAVS Pathway and Sensitive Detection of Viral RNAs

Jiang, Q. (2018) · Medicinal Chemistry · doi:10.2174/1573406415666181219101613 · Cited by 25

Therapeutic Interventions Targeting Innate Immune Receptors: A Balancing Act

Cao, X., Cordova, A. F., & Li, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00716 · Cited by 24

RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications

Xiang, Y., Chang, H., Leung, P. C. K., Bai, L., & Zhu, Y. (2025) · Human Reproduction Update · doi:10.1093/humupd/dmaf005 · Cited by 23

Inosine and its methyl derivatives: Occurrence, biogenesis, and function in RNA

Dutta, N., Deb, I., Sarzyńska, J., & Lahiri, A. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.01.001 · Cited by 23

Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium

Sáenz, J. B., Vargas, N., Cho, C. J., & Mills, J. C. (2022) · JCI Insight · doi:10.1172/jci.insight.153511 · Cited by 23

Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease

Wang, H., Yin, J. L., Gu, X., Shao, W., Jia, Z., Chen, H., & Xia, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.893204 · Cited by 23

Z-RNA biology: a central role in the innate immune response?

Nichols, P. J., Krall, J. B., Henen, M. A., Vögeli, B., & Vicens, Q. (2023) · RNA · doi:10.1261/rna.079429.122 · Cited by 24

ADAR1-mediated RNA editing promotes B cell lymphomagenesis

Pecori, R., Ren, W., Pirmoradian, M., Wang, X., Liu, D., Berglund, M., Li, W., Tasakis, R. N., Giorgio, S. D., Ye, X., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106864 · Cited by 23

Generation of a new Adar1p150 − / − mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis

Liang, Z., Goradia, A., Walkley, C. R., & Heraud-Farlow, J. E. (2023) · RNA · doi:10.1261/rna.079509.122 · Cited by 23

Structural perspectives on adenosine to inosine RNA editing by ADARs

Fisher, A. J., & Beal, P. A. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102284 · Cited by 23

Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine

Kimura, S., Srisuknimit, V., McCarty, K. L., Dedon, P. C., Kranzusch, P. J., & Waldor, M. K. (2022) · Nature Communications · doi:10.1038/s41467-022-33714-x · Cited by 23

High-throughput mutagenesis reveals unique structural features of human ADAR1

Park, S., Doherty, E. E., Xie, Y., Padyana, A. K., Fang, F., Zhang, Y., Karki, A., Lebrilla, C. B., Siegel, J. B., & Beal, P. A. (2020) · Nature Communications · doi:10.1038/s41467-020-18862-2 · Cited by 24

ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms

Corbet, G. A., Burke, J. M., & Parker, R. (2021) · Journal of Cell Science · doi:10.1242/jcs.258783 · Cited by 23

Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets

Cheng, H., Yu, J. Q., & Wong, C. C. (2024) · Protein & Cell · doi:10.1093/procel/pwae039 · Cited by 23

Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease

Crooke, P. S., Tossberg, J. T., Porter, K. P., & Aune, T. M. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001428 · Cited by 22

Interplays of different types of epitranscriptomic mRNA modifications

Rengaraj, P., Obrdlík, A., Vukić, D., Varadarajan, N. M., Keegan, L. P., Vaňáčová, Š., & O’Connell, M. A. (2021) · RNA Biology · doi:10.1080/15476286.2021.1969113 · Cited by 21

The Landscape of IFN/ISG Signaling in HIV-1-Infected Macrophages and Its Possible Role in the HIV-1 Latency

Rojas, M., Luz‐Crawford, P., Soto‐Rifo, R., Reyes-Cerpa, S., & Toro‐Ascuy, D. (2021) · Cells · doi:10.3390/cells10092378 · Cited by 22

ADAR1 Prevents R-loop Accumulation-Driven ATR Pathway Activation in Ovarian Cancer

Cui, H., Yi, Q., Tian, M., Yang, H., Liang, Y., Huang, J. S., Zeng, Q., Sun, W., Han, J., Guo, J., et al. (2022) · Journal of Cancer · doi:10.7150/jca.72108 · Cited by 21

Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?

Bellingrath, J.-S., McClements, M. E., Fischer, M. D., & MacLaren, R. E. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1092913 · Cited by 21

RNA editing and immune control: from mechanism to therapy

Hu, S.-B., & Li, J. B. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102195 · Cited by 21

EditPredict: Prediction of RNA editable sites with convolutional neural network

Wang, J., Ness, S. A., Brown, R. B., Yu, H., Oyebamiji, O., Jiang, L., Sheng, Q., Samuels, D. C., Zhao, Y., Tang, J., et al. (2021) · Genomics · doi:10.1016/j.ygeno.2021.09.016 · Cited by 20

Deciphering the Biological Significance of ADAR1–Z-RNA Interactions

Nakahama, T., & Kawahara, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111435 · Cited by 20

RNA-Editing Enzyme ADAR1 p150 Isoform Is Critical for Germinal Center B Cell Response

Li, Y., Ruan, G., Chen, W., Huang, H., Zhang, R., Wang, J., Li, Y., Xu, S., & Ou, X. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200149 · Cited by 20

ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit

Riella, C. V., McNulty, M. T., Ribas, G. T., Tattersfield, C. F., Perez-Gill, C., Eichinger, F. H., Kelly, J., Chun, J., Subramanian, B., Guizelini, D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210150119 · Cited by 20

ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus

Yanai, M., Kojima, S., Sakai, M., Komorizono, R., Tomonaga, K., & Makino, A. (2019) · Journal of Virology · doi:10.1128/jvi.01513-19 · Cited by 20

Betacoronavirus-specific alternate splicing

Karlebach, G., Aronow, B. J., Baylin, S. B., Butler, D., Foox, J., Levy, S. A., Meydan, C., Mozsary, C., Saravia-Butler, A., Taylor, D. M., et al. (2022) · Genomics · doi:10.1016/j.ygeno.2022.110270 · Cited by 20

A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion

Diallo, M., Pirotte, S., Hu, Y., Morvan, L., Rakus, K. Ł., Suárez, N. M., PoTsang, L., Saneyoshi, H., Xu, Y., Davison, A. J., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac761 · Cited by 20

Biochemical profiling and structural basis of ADAR1-mediated RNA editing

Deng, X., Sun, L., Zhang, M., Basavaraj, R., Wang, J., Weng, Y.-L., & Gao, Y. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.02.017 · Cited by 19

Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

Li, J. B., & Walkley, C. R. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-025-00830-5 · Cited by 22

Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L

Chitrakar, A., Solorio-Kirpichyan, K., Prangley, E., Rath, S. P., Du, J., & Korennykh, A. V. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102134118 · Cited by 19

Brain Epitranscriptomic Analysis Revealed Altered A-to-I RNA Editing in Septic Patients

Zhang, J.-Q., Pan, J., Wei, Z.-Y., Ren, C., Ru, F.-X., Xia, S.-Y., He, Y.-S., Lin, K., & Chen, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.887001 · Cited by 19

A Dual Role of DDX3X in dsRNA-Derived Innate Immune Signaling

Kwon, J., Choi, H., & Han, C. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.912727 · Cited by 19

Retrotransposon life cycle and its impacts on cellular responses

Luqman-Fatah, A., Nishimori, K., Amano, S., Fumoto, Y., & Miyoshi, T. (2024) · RNA Biology · doi:10.1080/15476286.2024.2409607 · Cited by 20

RNA editing restricts hyperactive ciliary kinases

Li, D., Liu, Y., Yi, P., Zhu, Z., Li, W., Zhang, Q. C., Li, J. B., & Ou, G. (2021) · Science · doi:10.1126/science.abd8971 · Cited by 19

Long noncoding RNA RFPL1S-202 inhibits ovarian cancer progression by downregulating the IFN-β/STAT1 signaling

Liu, S., Chen, X., Huang, K., Xiong, X., Shi, Y., Wang, X., Pan, X., Cong, Y., Sun, Y., Ge, L., et al. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113438 · Cited by 19

RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway

Yang, K., Dong, B., Asthana, A., Silverman, R. H., & Yan, N. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00187-1 · Cited by 18

Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication

Liao, G., Tseng, Y., Tseng, C., Lin, F., Yamada, Y., Liu, H., Kuan, C.-Y., & Hsu, W. (2019) · Journal of Virology · doi:10.1128/jvi.01912-18 · Cited by 18

Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases

Kano, N., Ong, G. H., Ori, D., & Kawai, T. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.910654 · Cited by 20

Human LINE-1 retrotransposons: impacts on the genome and regulation by host factors

Luqman-Fatah, A., & Miyoshi, T. (2022) · Genes & Genetic Systems · doi:10.1266/ggs.22-00038 · Cited by 20

Engineered deaminases as a key component of DNA and RNA editing tools

Budzko, L., Hoffa-Sobiech, K., Jackowiak, P., & Figlerowicz, M. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102062 · Cited by 18

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

Gan, W. L., Ren, X., Ng, V. H. E., Ng, L., Song, Y., Tano, V., Han, J., An, Ö., Xie, J., Ng, B. Y. L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114400 · Cited by 18

Dimerization of ADAR1 modulates site-specificity of RNA editing

Mboukou, A., Rajendra, V., Messmer, S., Mandl, T. C., Catala, M., Tisné, C., Jantsch, M. F., & Barraud, P. (2024) · Nature Communications · doi:10.1038/s41467-024-53777-2 · Cited by 18

The non-coding epitranscriptome in cancer

Miano, V., Codino, A., Pandolfini, L., & Barbieri, I. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab003 · Cited by 18

Marburg and Ebola Virus mRNA 3′ Untranslated Regions Contain Negative Regulators of Translation That Are Modulated by ADAR1 Editing

Khadka, S., Williams, C. G., Gibbons, J. S., & Basler, C. F. (2021) · Journal of Virology · doi:10.1128/jvi.00652-21 · Cited by 18

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

Walkley, C. R., & Kile, B. T. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2160-6 · Cited by 17

Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing

Singh, R., Wu, Y., Herrero del Valle, A., Leigh, K. E., Mong, S., Cheng, M. T. K., Ferguson, B. J., & Modis, Y. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105711 · Cited by 16

Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing

Heruye, S., Myslinski, J., Zeng, C., Zollman, A., Makino, S., Nanamatsu, A., Mir, Q., Janga, S. C., Doud, E. H., Eadon, M. T., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180117 · Cited by 16

The cellular and KSHV A-to-I RNA editome in primary effusion lymphoma and its role in the viral lifecycle

Rajendren, S., Ye, X., Dunker, W., Richardson, A., & Karijolich, J. J. (2023) · Nature Communications · doi:10.1038/s41467-023-37105-8 · Cited by 16

PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5

Song, J., Liu, Y., Yin, Y., Wang, H., Zhang, X., Li, Y., Zhao, X., Zhang, G., Meng, X., Jin, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113388 · Cited by 16

Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and aging

Zhang, W., Huang, C., Yao, H., Yang, S., Jiapaer, Z., Song, J., & Wang, X. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00471-y · Cited by 16

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables

Giacopuzzi, E., Gennarelli, M., Sacco, C., Filippini, A., Mingardi, J., Magri, C., & Barbon, A. (2018) · BMC Genomics · doi:10.1186/s12864-018-5364-8 · Cited by 15

Recognize Yourself—Innate Sensing of Non-LTR Retrotransposons

Lagisquet, J., Zuber, K., & Gramberg, T. (2021) · Viruses · doi:10.3390/v13010094 · Cited by 17

Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo

Ruiz, S. M., Chalk, A. M., Goradia, A., Heraud-Farlow, J. E., & Walkley, C. R. (2023) · NAR Cancer · doi:10.1093/narcan/zcad023 · Cited by 15

Inosine RNA modifications are enriched at the codon wobble position in mouse oocytes and eggs†

Brachova, P., Alvarez, N. S., Hong, X., Gunewardena, S., Vincent, K. A., Latham, K. E., & Christenson, L. K. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz130 · Cited by 18

PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling

Dobrikov, M. I., Dobrikova, E. Y., McKay, Z. P., Kastan, J. P., Brown, M. C., & Gromeier, M. (2022) · mBio · doi:10.1128/mbio.00854-22 · Cited by 14

Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity

Luca, D., Lee, S., Hirota, K., Okabe, Y., Uehori, J., Izawa, K., Lanz, A.-L., Schütte, V., Sivri, B., Tsukamoto, Y., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk0820 · Cited by 14

Transcriptome-wide identification of A-to-I RNA editing sites using ICE-seq

Okada, S., Ueda, H., Noda, Y., & Suzuki, T. (2018) · Methods · doi:10.1016/j.ymeth.2018.12.007 · Cited by 14

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Vuillier, F., Li, Z., Black, I., Cruciani, M., Rubino, E., Michel, F., & Pellegrini, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.939907 · Cited by 14

Roles of Aging, Circular RNAs, and RNA Editing in the Pathogenesis of Amyotrophic Lateral Sclerosis: Potential Biomarkers and Therapeutic Targets

Hosaka, T., Tsuji, H., & Kwak, S. (2023) · Cells · doi:10.3390/cells12101443 · Cited by 14

Zα domain proteins mediate the immune response

Zhong, Y., Zhong, X., Qiao, L., Wu, H., Liu, C., & Zhang, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1241694 · Cited by 14

Spiropyran as a potential molecular diagnostic tool for double-stranded RNA detection

Ali, A. A., Kang, M., Kharbash, R., & Kim, Y. (2019) · BMC Biomedical Engineering · doi:10.1186/s42490-019-0008-x · Cited by 14

Identification of ADAR1i-124: The first effective A-to-I RNA editing inhibitor with promising cancer therapeutic potential

Minakuchi, M., Zhang, H., Cassel, J. A., Shiromoto, Y., Villanueva, J., Skordalakes, E., Salvino, J. M., Li, Q., & Nishikura, K. (2026) · iScience · doi:10.1016/j.isci.2025.114615 · Cited by 13

Differential Structural Features of Two Mutant ADAR1p150 Zα Domains Associated with Aicardi-Goutières Syndrome

Langeberg, C. J., Nichols, P. J., Henen, M. A., Vicens, Q., & Vögeli, B. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168040 · Cited by 13

METTL3 suppresses pancreatic ductal adenocarcinoma progression through activating endogenous dsRNA-induced anti-tumor immunity

Zhu, L., Li, B., Li, R., Hu, L.-P., Zhang, Y., Zhang, Z., Jiang, S., & Zhang, X. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00829-2 · Cited by 13

Signaling plasticity in the integrated stress response

Boone, M., & Zappa, F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1271141 · Cited by 14

Targeting exosomal double-stranded RNA-TLR3 signaling pathway attenuates morphine tolerance and hyperalgesia

Wang, B., Le, D., Liu, J., Zhang, X., Yang, F. N., Lai, G.-R., Zhang, C., Zhao, M.-L., Shen, Y.-P., Liao, P.-S., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101782 · Cited by 13

Epitranscriptomics in atherosclerosis: Unraveling RNA modifications, editing and splicing and their implications in vascular disease

Stopa, V., Dafou, D., Karagianni, K., Nossent, A. Y., Farrugia, R. C., Devaux, Y., & Sopić, M. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107496 · Cited by 13

Ku limits RNA-induced innate immunity to allow Alu expansion in primates

Zhu, Y., Li, A., Maji, S., Lee, B. J., Korn, S. M., Gertie, J. A., Dorrity, T. J., Wang, J., Wang, K. J., Pelletier, A., et al. (2025) · Nature · doi:10.1038/s41586-025-09104-w · Cited by 14

Inflammatory mitochondrial signalling and viral mimicry in cancer

Nesci, S., Marchi, S., Hu, J. K., Marincola, F. M., & Algieri, C. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06931-3 · Cited by 14

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis

Weldy, C. S., Li, Q., Monteiro, J. P., Peters, T. S., Guo, H., Galls, D., Gu, W., Cheng, P. P., Ramste, M. O., Li, D. Y., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00710-5 · Cited by 13

Protective Mechanisms Against DNA Replication Stress in the Nervous System

Charlier, C. F., & Martins, R. A. P. (2020) · Genes · doi:10.3390/genes11070730 · Cited by 16

How Z-DNA/RNA binding proteins shape homeostasis, inflammation, and immunity

KIM, C. S. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.9.141 · Cited by 13

Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation

Song, Y., Hou, G., Diep, J., Ooi, Y. S., Akopyants, N. S., Beverley, S. M., Carette, J. E., Greenberg, H. B., & Ding, S. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1070 · Cited by 15

ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway

Guo, X., Liu, S., Yan, R., Nguyen, V., Zenati, M. S., Billiar, T. R., & Wang, Q. (2021) · Life Science Alliance · doi:10.26508/lsa.202101191 · Cited by 13

Mono a Mano: ZBP1’s Love–Hate Relationship with the Kissing Virus

Herbert, A. G., Fedorov, A., & Poptsova, M. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063079 · Cited by 13

How RNA editing keeps an I on physiology

Goldeck, M., Gopal, A., Jantsch, M. F., Mansouri, H. R., Rajendra, V., & Vesely, C. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2022 · Cited by 13

Z‐nucleic acids: Uncovering the functions from past to present

Tang, Q. (2022) · European Journal of Immunology · doi:10.1002/eji.202249968 · Cited by 13

AZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer

Ghalali, A., Wang, L., Stopsack, K. H., Rice, J. M., Wu, S., Wu, C., Zetter, B. R., & Rogers, M. S. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00845-6 · Cited by 13

Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad

Piazzi, M., Bavelloni, A., Faenza, I., & Blalock, W. L. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118769 · Cited by 13

ZYS-1 is not an ADAR1 inhibitor

Smoak, C. N., Gardner, E. N., Chua, R. N., & Cottrell, K. A. (2025) · RNA · doi:10.1261/rna.080721.125 · Cited by 12

Navigating the brain and aging: exploring the impact of transposable elements from health to disease

Breton, A. L., Bettencourt, M. P., & Gendrel, A.-V. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1357576 · Cited by 12

Making Sense of Intracellular Nucleic Acid Sensing in Type I Interferon Activation in Sjögren’s Syndrome

Huijser, E., & Versnel, M. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030532 · Cited by 12

Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis

Chen, W., Li, Y., Ruan, G., Huang, H., Zhang, R., Wang, J., Ouyang, Y., Li, Y., Xu, S., & Ou, X. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111687 · Cited by 12

The Role of RNA Editing in the Immune Response

Ahmad, S., Mu, X. N., & Hur, S. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0787-9_17 · Cited by 12

A-to-I RNA editing and hematopoiesis

Liang, Z., Walkley, C. R., & Heraud-Farlow, J. E. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104621 · Cited by 11

Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression

Fan, B., Li, Y., Wang, Y., Yang, S., Peng, Q., Qian, J., Wang, C., Zhang, X., Xu, H., Liu, S., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae921 · Cited by 11

RNA editing in disease: mechanisms and therapeutic potential

Tamizkar, K. H., & Jantsch, M. F. (2025) · RNA · doi:10.1261/rna.080331.124 · Cited by 11

The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways

Nakahama, T., & Kawahara, Y. (2022) · International Immunology · doi:10.1093/intimm/dxac056 · Cited by 25

Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs

Yang, S., Deng, P., Zhu, Z., Zhu, J., Wang, G., Zhang, L., Chen, A. F., Wang, T., Sarkar, S. N., Billiar, T. R., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401136 · Cited by 83

ADAR1 is a central regulator of the dsRNA response : from A-to-Z RNA

de Reuver, R. (2024) · Ghent University Academic Bibliography (Ghent University)

ADAR1 , inosine and the immune sensing system: distinguishing self from non‐self

Liddicoat, B., Chalk, A. M., & Walkley, C. R. (2015) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1322 · Cited by 58

The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA

Heraud-Farlow, J. E., & Walkley, C. R. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1416-1 · Cited by 34