The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Functional Classification and Experimental Dissection of Long Noncoding RNAs
Open accessAbstract
Over the last decade, it has been increasingly demonstrated that the genomes of many species are pervasively transcribed, resulting in the production of numerous long noncoding RNAs (lncRNAs). At the same time, it is now appreciated that many types of DNA regulatory elements, such as enhancers and promoters, regularly initiate bidirectional transcription. Thus, discerning functional noncoding transcripts from a vast transcriptome is a paramount priority, and challenge, for the lncRNA field. In this review, we aim to provide a conceptual and experimental framework for classifying and elucidating lncRNA function. We categorize lncRNA loci into those that regulate gene expression in cis versus those that perform functions in trans, and propose an experimental approach to dissect lncRNA activity based on these classifications. These strategies to further understand lncRNAs promise to reveal new and unanticipated biology, with great potential to advance our understanding of normal physiology and disease.
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Cited by
Gene regulation by long non-coding RNAs and its biological functions
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Metadata
- Authors
- Kopp, F., & Mendell, J. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 172
- Issue
- 3
- Pages
- 393-407
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2784570320
- Cited by
- 3,529
- References
- 17
- FWCI
- 110.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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