The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications
Open accessAbstract
Gliomas are complex and heterogeneous brain tumors with poor prognosis. Glioma cells can communicate with their surroundings to create a tumor-permissive microenvironment. Exosomes represent a new means of intercellular communication by delivering various bioactive molecules, including proteins, lipids and nucleic acids, and participate in tumor initiation and progression. Noncoding RNAs (ncRNAs) including microRNA, long-noncoding RNA, and circular RNA, account for a large portion of human transcriptome and play important roles in various pathophysiological processes, especially in cancers. In addition, ncRNAs can be selectively packaged, secreted and transferred between cells in exosomes and modulate numerous hallmarks of glioma, such as proliferation, invasion, angiogenesis, immune-escape, and treatment resistance. Hence, the strategies of specifically targeting exosomal ncRNAs could be attractive therapeutic options. Exosomes are able to cross the blood brain barrier (BBB), and are readily accessible in nearly all types of human biofluids, which make them the promising biomarkers for gliomas. Additionally, given the biocompatibility of exosomes, they can be engineered to deliver therapeutic factors, such as RNA, proteins and drugs, to target cells for therapeutic applications. Here, we reviewed current research on the roles of exosomal ncRNAs in glioma progression. We also discussed their potential clinical applications as novel biomarkers and therapeutics.
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Cites
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Cited by
Li, Y., He, X., Li, Q., Lai, H., Zhang, H., Hu, Z., Li, Y., & Huang, S. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.10.002 · Cited by 197
Zhong, L., Wang, J., Wang, P., Liu, X., Liu, P., Cheng, X., Cao, L., Wu, H., Chen, J., & Zhou, L. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03409-1 · Cited by 110
Filannino, F. M., Panaro, M. A., Benameur, T., Pizzolorusso, I., & Porro, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031629 · Cited by 60
Noncoding RNAs involved in the STAT3 pathway in glioma
Bian, Z., Ji, W., Xu, B., Huo, Z., Huang, H., Huang, J., Jiao, J., Shao, J., & Zhang, X. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02144-y · Cited by 28
Metadata
- Authors
- Cheng, J., Meng, J., Zhu, L., & Peng, Y.
- Venue
- Molecular Cancer
- Published
- 2020-03-25
- Volume
- 19
- Issue
- 1
- Pages
- 66-66
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W3013918681
- Cited by
- 319
- References
- 115
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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