The biogenesis and emerging roles of circular RNAs

Circular RNAs are a large class of animal RNAs with regulatory potency

Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990 · see citing works

Natural RNA circles function as efficient microRNA sponges

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985 · see citing works

Circular RNAs are abundant, conserved, and associated with ALU repeats

Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388 · see citing works

circRNA biogenesis competes with pre-mRNA splicing

Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083 · see citing works

Exon-intron circular RNAs regulate transcription in the nucleus

Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905 · see citing works

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

Salzman, J., Gawad, C., Wang, P. L., Lacayo, N. J., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,457 · see citing works

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

Rybak-Wolf, A., Stottmeister, C., Glažar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.027 · Cited by 2,423 · see citing works

Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures

Sanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296 · see citing works

Circular intronic long noncoding RNAs

Zhang, Y., Zhang, X.-O., Chen, T., Xiang, J.-F., Yin, Q.-F., Xing, Y.-H., Zhu, S., Yang, L., & Chen, L.-L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.017 · Cited by 2,221 · see citing works

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

Li, Y., Zheng, Q., Bao, C., Li, S., Guo, W., Zhao, J., Chen, D., Gu, J., He, X., & Huang, S. (2015) · Cell Research · doi:10.1038/cr.2015.82 · Cited by 2,210 · see citing works

The RNA Binding Protein Quaking Regulates Formation of circRNAs

Conn, S. J., Pillman, K. A., Toubia, J., Conn, V. M., Salmanidis, M., Phillips, C. A., Roslan, S., SCHREIBER, A. W., Gregory, P. A., & Goodall, G. J. (2015) · Cell · doi:10.1016/j.cell.2015.02.014 · Cited by 2,187 · see citing works

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132 · see citing works

Complementary Sequence-Mediated Exon Circularization

Zhang, X.-O., Wang, H.-B., Zhang, Y., Lu, X., Chen, L.-L., & Yang, L. (2014) · Cell · doi:10.1016/j.cell.2014.09.001 · Cited by 1,999 · see citing works

Cell-Type Specific Features of Circular RNA Expression

Salzman, J., Chen, R. E., Olsen, M. N., Wang, P. L., & Brown, P. O. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003777 · Cited by 1,955 · see citing works

Expanded identification and characterization of mammalian circular RNAs

Guo, J. U., Agarwal, V., Guo, H., & Bartel, D. P. (2014) · Genome biology · doi:10.1186/s13059-014-0409-z · Cited by 1,578 · see citing works

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391 · see citing works

Mis-splicing yields circular RNA molecules.

Cocquerelle, C., Mascrez, B., Hétuin, D., & Bailleul, B. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.1.7678559 · Cited by 1,197 · see citing works

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., Akbalik, G., Wang, M., Glock, C., Quedenau, C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3975 · Cited by 1,149 · see citing works

Circular transcripts of the testis-determining gene Sry in adult mouse testis

Capel, B., Swain, A., Nicolis, S. K., Hacker, A., Walter, M. A., Koopman, P. A., Goodfellow, P. N., & Lovell-Badge, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90279-y · Cited by 1,100 · see citing works

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

Ivanov, A., Memczak, S., Wyler, E., Torti, F., Porath, H. T., Orejuela, M. R., Piechotta, M., Levanon, E. Y., Landthaler, M., Dieterich, C., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.019 · Cited by 1,092 · see citing works

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

Westholm, J. O., Miura, P., Olson, S., Shenker, S., Joseph, B. J., Sanfilippo, P., Celniker, S., Graveley, B. R., & Lai, E. C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.062 · Cited by 1,001 · see citing works

miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA

Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J., & Kjems, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.359 · Cited by 996 · see citing works

Short intronic repeat sequences facilitate circular RNA productionPreprint

Liang, D., & Wilusz, J. E. (2014) · Genes & Development · doi:10.1101/gad.251926.114 · Cited by 959 · see citing works

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

Burd, C. E., Jeck, W. R., Liu, Y., Sanoff, H. K., Wang, Z., & Sharpless, N. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001233 · Cited by 895 · see citing works

Scrambled exons

Nigro, J. M., Cho, K. R., Fearon, E. R., Kern, S. E., Ruppert, J. M., Oliner, J., Kinzler, K. W., & Vogelstein, B. (1991) · Cell · doi:10.1016/0092-8674(91)90244-s · Cited by 888 · see citing works

SELF-SPLICING OF GROUP I INTRONS

Cech, T. R. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.002551 · Cited by 874 · see citing works

Coupling mRNA processing with transcription in time and space

Bentley, D. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3662 · Cited by 828 · see citing works

Exon Circularization Requires Canonical Splice Signals

Starke, S., Jost, I., Roßbach, O., Schneider, T. P., Schreiner, S., Hung, L.-H., & Bindereif, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.002 · Cited by 768 · see citing works

Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs

Chen, C.-Y., & Sarnow, P. (1995) · Science · doi:10.1126/science.7536344 · Cited by 766 · see citing works

Circular RNA Is Expressed across the Eukaryotic Tree of Life

Wang, P. L., Bao, Y., Yee, M., Barrett, S. P., Hogan, G. J., Olsen, M. N., Dinneny, J. R., Brown, P. O., & Salzman, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090859 · Cited by 754 · see citing works

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

Bachmayr-Heyda, A., Reiner, A. T., Auer, K., Sukhbaatar, N., Aust, S., Bachleitner‐Hofmann, T., Mesteri, I., Grunt, T. W., Zeillinger, R., & Pils, D. (2015) · Scientific Reports · doi:10.1038/srep08057 · Cited by 732 · see citing works

Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

Denzler, R., Agarwal, V., Stefano, J., Bartel, D. P., & Stoffel, M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.045 · Cited by 723 · see citing works

Efficient backsplicing produces translatable circular mRNAs

Wang, Y., & Wang, Z. (2014) · RNA · doi:10.1261/rna.048272.114 · Cited by 665 · see citing works

Widespread intron retention in mammals functionally tunes transcriptomes

Braunschweig, U., Barbosa-Morais, N. L., Pan, Q., Nachman, E. N., Alipanahi, B., Gonatopoulos-Pournatzis, T., Frey, B., Irimia, M., & Blencowe, B. J. (2014) · Genome Research · doi:10.1101/gr.177790.114 · Cited by 664 · see citing works

The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva

Bahn, J. H., Zhang, Q., Li, F., Chan, T.-M., Lin, X., Kim, Y. D., Wong, D. T., & Xiao, X. G. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.230433 · Cited by 658 · see citing works

The hepatitis delta (δ) virus possesses a circular RNA

Kos, A., Dijkema, R., Arnberg, A. C., van der Meide, P. H., & Schellekens, H. (1986) · Nature · doi:10.1038/323558a0 · Cited by 651 · see citing works

Identification and characterization of circular RNAs As a new class of putative biomarkers in human blood

Memczak, S., Papavasileiou, P., Peters, O., & Rajewsky, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141214 · Cited by 639 · see citing works

Circular RNA (circRNA) in Alzheimer’s disease (AD)

Lukiw, W. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00307 · Cited by 636 · see citing works

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development

Szabo, L. A., Morey, R. E., Palpant, N. J., Wang, P. L., Afari, N., Chuan, J., Parast, M. M., Murry, C. E., Laurent, L. C., & Salzman, J. (2015) · Genome biology · doi:10.1186/s13059-015-0690-5 · Cited by 608 · see citing works

Transcriptome-wide discovery of circular RNAs in Archaea

Danan, M., Schwartz, S., Edelheit, S., & Sorek, R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1009 · Cited by 560 · see citing works

Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteinsPreprint

Kramer, M. C., Liang, D., Tatomer, D. C., Gold, B., March, Z. M., Cherry, S. R., & Wilusz, J. E. (2015) · Genes & Development · doi:10.1101/gad.270421.115 · Cited by 494 · see citing works

Circular RNA biogenesis can proceed through an exon-containing lariat precursor

Barrett, S. P., Wang, P. L., & Salzman, J. (2015) · eLife · doi:10.7554/elife.07540 · Cited by 439 · see citing works

Genomewide characterization of non-polyadenylated RNAs

Yang, L. C., Duff, M. O., Graveley, B. R., Carmichael, G., & Chen, L. (2011) · Genome biology · doi:10.1186/gb-2011-12-2-r16 · Cited by 423 · see citing works

Transcriptome-wide investigation of circular RNAs in rice

Lu, T., Cui, L., Zhou, Y., Zhu, C., Fan, D., Gong, H., Zhao, Q., Zhou, C., Zhao, Y., Lu, D., et al. (2015) · RNA · doi:10.1261/rna.052282.115 · Cited by 418 · see citing works

Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos

Fan, X., Zhang, X., Wu, X., Guo, H., Hu, Y., Tang, F., & Huang, Y. (2015) · Genome biology · doi:10.1186/s13059-015-0706-1 · Cited by 416 · see citing works

Exon Skipping Is Correlated with Exon Circularization

Kelly, S. L., Greenman, C., Cook, P. R., & Papantonis, A. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.02.018 · Cited by 374 · see citing works

Splicing with inverted order of exons occurs proximal to large introns.

Cocquerelle, C., Daubersies, P., Majérus, M.-A., Kerckaert, J. P., & Bailleul, B. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05148.x · Cited by 314 · see citing works

tRNA Splicing

Abelson, J. N., Trotta, C. R., & Li, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12685 · Cited by 274 · see citing works

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

Armakola, M., Higgins, M., Figley, M. D., Barmada, S. J., Scarborough, E. A., Diaz, Z., Fang, X., Shorter, J., Krogan, N. J., Finkbeiner, S. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2434 · Cited by 250 · see citing works

Metazoan tRNA introns generate stable circular RNAs in vivo

Lu, Z., Filonov, G. S., Noto, J. J., Schmidt, C. A., Hatkevich, T., Wen, Y., Jaffrey, S. R., & Matera, A. G. (2015) · RNA · doi:10.1261/rna.052944.115 · Cited by 203 · see citing works

The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of tetrahymena

Grabowski, P. J., Zaug, A. J., & Cech, T. R. (1981) · Cell · doi:10.1016/0092-8674(81)90142-2 · Cited by 196 · see citing works

Exon circularization in mammalian nuclear extracts.

Pasman, Z., Been, M. D., & García-Blanco, M. A. (1996) · PubMed · Cited by 185 · see citing works

Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA

Broadbent, K. M., Broadbent, J. C., Ribacke, U., Wirth, D. F., Rinn, J. L., & Sabeti, P. C. (2015) · BMC Genomics · doi:10.1186/s12864-015-1603-4 · Cited by 180 · see citing works

Lariat intronic RNAs in the cytoplasm of Xenopus tropicalis oocytes

Talross, G. J. S., & Gall, J. G. (2014) · RNA · doi:10.1261/rna.045781.114 · Cited by 147 · see citing works

RNomics in Archaea reveals a further link between splicing of archaeal introns and rRNA processing

Tang, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.921 · Cited by 144 · see citing works

Stable intronic sequence RNA (sisRNA), a new class of noncoding RNA from the oocyte nucleus of Xenopus tropicalisPreprint

Gardner, E. J., Nizami, Z. F., Talbot, C. C., & Gall, J. G. (2012) · Genes & Development · doi:10.1101/gad.202184.112 · Cited by 144 · see citing works

Rolling-circle replication of viroids, viroid-like satellite RNAs and hepatitis delta virus: Variations on a theme

Flores, R., Grubb, D., Elleuch, A., Nohales, M. A., Delgado, S., & Gago‐Zachert, S. (2011) · RNA Biology · doi:10.4161/rna.8.2.14238 · Cited by 126 · see citing works

Permuted tRNA Genes Expressed via a Circular RNA Intermediate in Cyanidioschyzon merolae

Soma, A., Onodera, A., Sugahara, J., Kanai, A., Yachie, N., Tomita, M., Kawamura, F., & Sekine, Y. (2007) · Science · doi:10.1126/science.1145718 · Cited by 112 · see citing works

ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner

Chen, T. X., Xiang, J., Zhu, S., Chen, S., Yin, Q.-F., Zhang, X.-O., Zhang, J., Feng, H., Dong, R., Li, X.-J., et al. (2015) · Cell Research · doi:10.1038/cr.2015.24 · Cited by 91 · see citing works

Two reactions of Haloferax volcanii RNA splicing enzymes: Joining of exons and circularization of introns

Salgia, S., SINGH, S. K., Gurha, P., & GUPTA, R. (2003) · RNA · doi:10.1261/rna.2118203 · Cited by 85 · see citing works

Multiple physical forms of excised group II intron RNAs in wheat mitochondria

Li‐Pook‐Than, J., & Bonen, L. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl328 · Cited by 82 · see citing works

Peach latent mosaic viroid is locked by a 2′,5′-phosphodiester bond produced by in vitro self-ligation 1 1Edited by D. E. Draper

Côté, F., & Perreault, J. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1355 · Cited by 45 · see citing works

Excision of the Sinorhizobium meliloti Group II Intron RmInt1 as Circles in Vivo

Molina-Sánchez, M. D., Martínez‐Abarca, F., & Toro, N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602695200 · Cited by 45 · see citing works

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Kopp, F. B., & Mendell, J. T. (2018) · Cell · doi:10.1016/j.cell.2018.01.011 · Cited by 3,522 · see citing works

The Biogenesis, Functions, and Challenges of Circular RNAs

Li, X., Yang, L. C., & Chen, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.034 · Cited by 2,043 · see citing works

Circular RNAs Act as miRNA Sponges

Panda, A. C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_6 · Cited by 1,116 · see citing works

Linking Long Noncoding RNA Localization and Function

Chen, L. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.07.003 · Cited by 1,042 · see citing works

Noncoding RNA:RNA Regulatory Networks in Cancer

Chan, J. J., & Tay, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051310 · Cited by 1,030 · see citing works

Diverse alternative back-splicing and alternative splicing landscape of circular RNAsPreprint

Zhang, X.-O., Dong, R., Zhang, Y., Zhang, J., Luo, Z. D., Zhang, J., Chen, L., & Yang, L. C. (2016) · Genome Research · doi:10.1101/gr.202895.115 · Cited by 1,022 · see citing works

Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance

Li, J., Sun, D., Pu, W., Wang, J., & Peng, Y. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.01.012 · Cited by 797 · see citing works

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

Yu, J., Xu, Q., Wang, Z., Yang, Y., Zhang, L., Ma, J., Sun, S., Yang, F., & Zhou, W. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.01.012 · Cited by 763 · see citing works

Circular RNAs are miRNA sponges and can be used as a new class of biomarker

Kulcheski, F. R., Christoff, A. P., & Margis, R. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.09.011 · Cited by 739 · see citing works

The Biogenesis of Nascent Circular RNAs

Zhang, Y., Xue, W., Li, X., Zhang, J., Chen, S., Zhang, J.-L., Yang, L., & Chen, L.-L. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.058 · Cited by 643 · see citing works

MicroRNAs and complex diseases: from experimental results to computational models

Chen, X., Xie, D., Zhao, Q., & You, Z. (2017) · Briefings in Bioinformatics · doi:10.1093/bib/bbx130 · Cited by 640 · see citing works

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

Qu, L., Yi, Z., Shen, Y., Lin, L., Chen, F., Xu, Y., Wu, Z., Tang, H., Zhang, X., Tian, F., et al. (2021) · doi:10.1101/2021.03.16.435594 · Cited by 636 · see citing works

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

Li, X., Liu, C., Xue, W., Zhang, Y., Jiang, S., Yin, Q.-F., Wei, J., Yao, R.-W., Yang, L. C., & Chen, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.023 · Cited by 629 · see citing works

Identifying and Characterizing circRNA-Protein Interaction

Du, W. W., Zhang, C., Yang, W., Yong, T., Awan, F. M., & Yang, B. B. (2017) · Theranostics · doi:10.7150/thno.21299 · Cited by 615 · see citing works

Advances in COVID-19 mRNA vaccine development

Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Zhang, P., Gao, C., Huang, X., Lu, J., Guo, X.-J., Shi, G., Cai, J., & Ke, A.-W. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01222-5 · Cited by 597 · see citing works

A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation

Conn, V. M., Hugouvieux, V., Nayak, A., Conos, S. A., Capovilla, G., Cildir, G., Jourdain, A., Tergaonkar, V., Schmid, M., Zubieta, C., et al. (2017) · Nature Plants · doi:10.1038/nplants.2017.53 · Cited by 582 · see citing works

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

Park, O. H., Ha, H., Lee, Y., Boo, S. H., Kwon, D. H., Song, H. K., & Kim, Y. K. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.034 · Cited by 574 · see citing works

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01305-4 · Cited by 570 · see citing works

Widespread and Functional RNA Circularization in Localized Prostate Cancer

Chen, S., Huang, V., Xu, X., Livingstone, J., Soares, F., Jeon, J., Zeng, Y., Hua, J. T., Petricca, J., Guo, H., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.025 · Cited by 544 · see citing works

Alternative splicing and cancer: a systematic review

Zhang, Y., Qian, J., Gu, C., & Yang, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00486-7 · Cited by 503 · see citing works

Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus

Shan, K. Y., Liu, C., Liu, B.-H., Chen, X., Dong, R., Liu, X., Zhang, Y., Liu, B., Zhang, S., Wang, J., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.029004 · Cited by 502 · see citing works

Sensing Self and Foreign Circular RNAs by Intron Identity

Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., Iwasaki, A., & Chang, H. Y. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.022 · Cited by 475 · see citing works

Targeting mitochondria-located circrna scar alleviates nash via reducing mros output

Zhao, Q., Liu, J., Deng, H., Ma, R., Liao, J.-Y., Liang, H., Hu, J., Li, J., Guo, Z., Cai, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.009 · Cited by 469 · see citing works

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

Su, M., Xiao, Y., Ma, J., Tang, Y., Tian, B., Zhang, Y., Xu, L., Wu, Z., Yang, D., Zhou, Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1002-6 · Cited by 456 · see citing works

Insights into circular RNA biology

Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2016) · RNA Biology · doi:10.1080/15476286.2016.1271524 · Cited by 454 · see citing works

Deep intronic mutations and human disease

Vaz‐Drago, R., Custódio, N., & Carmo‐Fonseca, M. (2017) · Human Genetics · doi:10.1007/s00439-017-1809-4 · Cited by 448 · see citing works

Molecular Mechanisms Driving mRNA Degradation by m6A Modification

Lee, Y., Choe, J., Park, O. H., & Kim, Y. K. (2020) · Trends in Genetics · doi:10.1016/j.tig.2019.12.007 · Cited by 447 · see citing works

Targeting non-coding RNAs to overcome cancer therapy resistance

Chen, B., Dragomir, M. P., Chen, Y., Li, Q., Horst, D. A., & Călin, G. A. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00975-3 · Cited by 442 · see citing works

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

Liang, D., Tatomer, D. C., Luo, Z., Wu, H., Yang, L. C., Chen, L., Cherry, S. R., & Wilusz, J. E. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.034 · Cited by 435 · see citing works

Recent advances in gastric cancer early diagnosis

Necula, L. G., Matei, L., Dragu, D., Neagu, A. I., Mambet, C., Nedeianu, S., Bleoţu, C., Diaconu, C. C., & Chivu‐Economescu, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i17.2029 · Cited by 432 · see citing works

Cellular origins of dsRNA, their recognition and consequences

Chen, Y. G., & Hur, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00430-1 · Cited by 430 · see citing works

The emerging landscape of circular RNA in life processes

Qu, S., Zhong, Y., Shang, R., Zhang, X., Song, W., Kjems, J., & Li, H. (2016) · RNA Biology · doi:10.1080/15476286.2016.1220473 · Cited by 421 · see citing works

Circular RNAs in Cancer

Bach, D., Lee, S. K., & Sood, A. K. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.02.005 · Cited by 415 · see citing works

Long non-coding RNA: Classification, biogenesis and functions in blood cells

Dahariya, S., Paddibhatla, I., Kumar, S., Raghuwanshi, S., Pallepati, A., & Gutti, R. K. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.04.011 · Cited by 414 · see citing works

The bioinformatics toolbox for circRNA discovery and analysis

Chen, L., Wang, C., Sun, H., Wang, J., Liang, Y., Wang, Y., & Wong, G. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa001 · Cited by 394 · see citing works

PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial–Mesenchymal Transition

Chen, X., Chen, R.-X., Wei, W.-S., Li, Y.-H., Feng, Z.-H., Tan, L., Chen, J.-W., Yuan, G., Chen, S.-L., Guo, S., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1270 · Cited by 383 · see citing works

Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression

Wang, L., Long, H., Zheng, Q., Bo, X., Xiao, X., & Li, B. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1046-7 · Cited by 379 · see citing works

The Diversity of Long Noncoding RNAs and Their Generation

Wu, H., Yang, L. C., & Chen, L. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.05.004 · Cited by 378 · see citing works

CircRNA inhibits DNA damage repair by interacting with host gene

Xu, X., Zhang, J., Tian, Y., Gao, Y., Dong, X., Chen, W., Yuan, X., Yin, W., Xǔ, J., Chen, K., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01246-x · Cited by 365 · see citing works

Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment

Tahamtan, A., Teymoori‐Rad, M., Nakstad, B., & Salimi, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01377 · Cited by 355 · see citing works

Review on circular RNAs and new insights into their roles in cancer

Tang, X., Ren, H., Guo, M., Qian, J., Yang, Y., & Gu, C. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.018 · Cited by 353 · see citing works

A comprehensive overview and evaluation of circular RNA detection tools

Zeng, X., Lin, W., Guo, M., & Zou, Q. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005420 · Cited by 345 · see citing works

Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Meng, J., Chen, S., Han, J., Qian, B., Wang, X., Zhong, W., Qin, Y., Zhang, H., Gao, W.-F., Lei, Y.-Y., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3009 · Cited by 337 · see citing works

Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

Liu, Z., Zhou, Y., Liang, G., Ling, Y., Tan, W., Tan, L., Andrews, R., Zhong, W., Zhang, X., Song, E., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1287-1 · Cited by 336 · see citing works

CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway

Huang, G., Liang, M., Liu, H., Huang, J., Li, P., Wang, C., Zhang, Y., Lin, Y., & Jiang, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03276-1 · Cited by 325 · see citing works

Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer

Chen, X., Mao, R., Su, W., Yang, X., Geng, Q., Guo, C., Wang, Z., Wang, J., Kresty, L. A., Beer, D. G., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1634945 · Cited by 322 · see citing works

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

Cheng, J., Meng, J., Zhu, L., & Peng, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01189-3 · Cited by 317 · see citing works

Lessons from non-canonical splicing

Sibley, C. R., Blázquez, L., & Ule, J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.46 · Cited by 312 · see citing works

Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN

Lu, Q., Liu, T., Feng, H., Yang, R., Zhao, X., Chen, W., Jiang, B., Qin, H., Guo, X., Liu, M., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1040-0 · Cited by 312 · see citing works

Splicing regulation by long noncoding RNAs

Romero-Barrios, N., Legascue, M. F., Benhamed, M., Ariel, F., & Crespi, M. D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky095 · Cited by 305 · see citing works

Biogenesis and Regulatory Roles of Circular RNAs

Yang, L. C., Wilusz, J. E., & Chen, L. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-125117 · Cited by 303 · see citing works

Epigenetic Modifications in Cardiovascular Aging and Diseases

Zhang, W., Song, M., Qu, J. T., & Liu, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312497 · Cited by 291 · see citing works

Circular RNAs in immune responses and immune diseases

Chen, X., Yang, T., Wang, W., Xi, W., Zhang, T., Li, Q., Yang, A., & Wang, T. (2019) · Theranostics · doi:10.7150/thno.29678 · Cited by 291 · see citing works

The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma

Qiu, M., Xia, W., Chen, R., Wang, S., Xu, Y., Ma, Z., Xu, W., Zhang, E., Wang, J., Tian, F., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2808 · Cited by 285 · see citing works

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion

Xia, P., Wang, S., Ye, B., Du, Y., Li, C., Xiong, Z., Qu, Y., & Fan, Z. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.016 · Cited by 279 · see citing works

The emerging functions and roles of circular RNAs in cancer

Qu, S., Liu, Z., Yang, X., Zhou, J., Yu, H., Zhang, R., & Li, H. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.022 · Cited by 278 · see citing works

CIRCpedia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison

Dong, R., Ma, X.-K., Li, G., & Yang, L. C. (2018) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.08.001 · Cited by 275 · see citing works

Global circular RNA expression profile of human gastric cancer and its clinical significance

Shao, Y., Li, J., Lu, R., Li, T., Yang, Y., Xiao, B., & Guo, J. (2017) · Cancer Medicine · doi:10.1002/cam4.1055 · Cited by 268 · see citing works

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Xue, C., Li, G., Lü, J., & Li, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00788-w · Cited by 264 · see citing works

IRES-mediated cap-independent translation, a path leading to hidden proteome

Yang, Y., & Wang, Z. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz091 · Cited by 260 · see citing works

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1

Panda, A. C., Grammatikakis, I., Kim, K. M., De, S., Martindale, J. L., Munk, R. B., Yang, X., Abdelmohsen, K., & Gorospe, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1201 · Cited by 254 · see citing works

Circular RNA CDR1as regulates osteoblastic differentiation of periodontal ligament stem cells via the miR-7/GDF5/SMAD and p38 MAPK signaling pathway

Li, X., Zheng, Y., Zheng, Y., Huang, Y., Zhang, Y., Jia, L., & Li, W. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0976-0 · Cited by 254 · see citing works

Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction

Liu, C., Yao, M.-D., Li, C., Shan, K. Y., Yang, H., Wang, J., Liu, B., Li, X., Yao, J., Jiang, Q. L., et al. (2017) · Theranostics · doi:10.7150/thno.19353 · Cited by 252 · see citing works

Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis

Hu, Z., Zhou, S., Li, J., Zhou, Z., Wang, P., Xin, H., Mao, L., Luo, C., Yu, S., Huang, X., et al. (2019) · Hepatology · doi:10.1002/hep.31068 · Cited by 252 · see citing works

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop

Zhao, W., Cui, Y., Liu, L., Qi, X., Liu, J., Ma, S., Hu, X. T., Zhang, Z., Wang, Y., Li, H., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0423-5 · Cited by 251 · see citing works

Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies

Li, H., Peng, K., Yang, K., Ma, W., Qi, S., Yu, X., He, J., Lin, X., & Yu, G. (2022) · Theranostics · doi:10.7150/thno.77350 · Cited by 245 · see citing works

circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression

Sun, Y., Wang, W., Zeng, Z., Chen, T.-Q., Han, C., Pan, Q., Huang, W., Fang, K., Sun, L.-Y., Zhou, Y.-F., et al. (2019) · Blood · doi:10.1182/blood.2019000802 · Cited by 244 · see citing works

Selective release of circRNAs in platelet‐derived extracellular vesicles

Preußer, C., Hung, L.-H., Schneider, T. P., Schreiner, S., Hardt, M., Moebus, A., Santoso, S., & Bindereif, A. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1424473 · Cited by 239 · see citing works

The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p

Wei, S.-L., Zheng, Y., Jiang, Y., Li, X., Geng, J., Shen, Y., Qin, L., Wang, X., Zhao, C., Chen, Y., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.05.032 · Cited by 236 · see citing works

Pervasive translation of circular RNAs driven by short IRES-like elements

Fan, X., Yang, Y., Chen, C., & Wang, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-31327-y · Cited by 235 · see citing works

A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p

Li, M., Ding, W., Tariq, M., Chang, W., Zhang, X., Xu, W., Hou, L., Wang, Y., & Wang, J. (2018) · Theranostics · doi:10.7150/thno.27285 · Cited by 234 · see citing works

EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1–2 signaling

Wei, Y., Lu, C., Zhou, P., Zhao, L., Lyu, X., Yin, J., Shi, Z., & You, Y. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa214 · Cited by 233 · see citing works

CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer

Yang, H., Li, X., Meng, Q., Sun, H., Wu, S., Hu, W., Liu, G., Li, X., Yang, Y., & Chen, R. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1139-3 · Cited by 231 · see citing works

Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

Huang, X., Zhang, P., Wei, C., Peng, R., Lu, J., Gao, C., Cai, J.-B., Yang, X., Fan, J., Ke, A., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01213-6 · Cited by 223 · see citing works

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3

Zhu, P., Zhu, X., Wu, J., He, L., Lu, T., Wang, Y., Liu, B., Ye, B., Sun, L., Fan, D., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0297-6 · Cited by 217 · see citing works

Increased complexity of circRNA expression during species evolution

Dong, R., Ma, X.-K., Chen, L., & Yang, L. C. (2016) · RNA Biology · doi:10.1080/15476286.2016.1269999 · Cited by 216 · see citing works

CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth

Xu, L., Feng, X., Hao, X., Wang, P., Zhang, Y., Zheng, X., Li, L., Ren, S., Zhang, M., & Xu, M. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1041-2 · Cited by 215 · see citing works

Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation

Liu, X., Abraham, J. M., Cheng, Y., Wang, Z., Wang, Z., Zhang, G., Ashktorab, H., Smoot, D. T., Cole, R. N., Boronina, T. N., et al. (2018) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2018.09.010 · Cited by 212 · see citing works

The emerging role of circular RNAs in transcriptome regulation

Huang, S., Yang, B., Chen, B. J., Bliim, N., Ueberham, U., Arendt, T., & Janitz, M. (2017) · Genomics · doi:10.1016/j.ygeno.2017.06.005 · Cited by 207 · see citing works

m6A-dependent biogenesis of circular RNAs in male germ cells

Tang, C., Xie, Y., Yu, T., Liu, N., Wang, Z., Woolsey, R. J., Tang, Y., Zhang, X., Qin, W., Zhang, Y., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0279-8 · Cited by 207 · see citing works

Noncoding RNAs in Alzheimer's disease

Idda, M. L., Munk, R. B., Abdelmohsen, K., & Gorospe, M. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1463 · Cited by 206 · see citing works

Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit

Ma, C., Wang, X., Yang, F., Zang, Y., Liu, J., Wang, X., Xu, X., Li, W., Jia, J., & Liu, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01268-5 · Cited by 206 · see citing works

How to stomach an epigenetic insult: the gastric cancer epigenome

Padmanabhan, N., Ushijima, T., & Tan, P. B. O. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.53 · Cited by 205 · see citing works

Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity

Wang, M., Yu, F., Wu, W., Zhang, Y., Chang, W., Ponnusamy, M., Wang, K., & Li, P. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.22531 · Cited by 203 · see citing works

High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs

Panda, A. C., De, S., Grammatikakis, I., Munk, R. B., Yang, X., Piao, Y., Dudekula, D. B., Abdelmohsen, K., & Gorospe, M. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx297 · Cited by 199 · see citing works

Circular RNAs in Cardiovascular Disease: An Overview

Fan, X., Weng, X., Zhao, Y., Chen, W., Gan, T., & Xu, D. (2017) · BioMed Research International · doi:10.1155/2017/5135781 · Cited by 196 · see citing works

Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer

Yang, F., Liu, D., Guo, J., Ge, N., Zhu, P., Liu, X., Wang, S., Wang, G., & Sun, S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i47.8345 · Cited by 196 · see citing works

New Blood Biomarkers for the Diagnosis of AFP-Negative Hepatocellular Carcinoma

Wang, T., & Zhang, K.-H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01316 · Cited by 195 · see citing works

The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation

Chen, L.-Y., Wang, L. Y., Ren, Y.-X., Pang, Z., Liu, Y., Sun, X.-D., Tu, J., Zhi, Z., Yan, Q., Sun, L., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01272-9 · Cited by 195 · see citing works

MicroRNA Biomarkers and Platelet Reactivity

Sunderland, N. P., Skroblin, P., Barwari, T., Huntley, R. P., Lu, R., Joshi, A., Lovering, R. C., & Mayr, M. (2017) · Circulation Research · doi:10.1161/circresaha.116.309303 · Cited by 193 · see citing works

Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer

Tan, S., Gou, Q., Pu, W., Guo, C., Yang, Y., Wu, K., Liu, Y., Liu, L., Wei, Y.-Q., & Peng, Y. (2018) · Cell Research · doi:10.1038/s41422-018-0033-7 · Cited by 192 · see citing works

Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR

Liu, H., Lan, T., Li, H., Xu, L., Chen, X., Liao, H., Chen, X., Du, J., Cai, Y., Wang, J., et al. (2020) · Theranostics · doi:10.7150/thno.53227 · Cited by 191 · see citing works

circRNA-miRNA-mRNA in breast cancer

Zhang, M., Bai, X., Zeng, X., Liu, J., Liu, F., & Zhang, Z. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.09.013 · Cited by 191 · see citing works

Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy

Zhang, S., Chen, X., Li, C., Li, X., Liu, C., Liu, B.-H., Shan, K. Y., Jiang, Q. L., Zhao, C., & Yan, B. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22698 · Cited by 188 · see citing works

Circ2Disease: a manually curated database of experimentally validated circRNAs in human disease

Yao, D., Zhang, L., Zheng, M., Sun, X., Lü, Y., & Liu, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-29360-3 · Cited by 188 · see citing works

STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

Sadrkhanloo, M., Entezari, M., Orouei, S., Ghollasi, M., Fathi, N., Rezaei, S., Hejazi, E. S., Kakavand, A., Saebfar, H., Hashemi, M., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106311 · Cited by 188 · see citing works

Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

Liu, X., Wang, X., Li, J., Hu, S., Deng, Y., Yin, H., Bao, X., Zhang, Q. C., Wang, G., Wang, B., et al. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1631-9 · Cited by 186 · see citing works

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

Nicolet, B. P., Engels, S., Aglialoro, F., van den Akker, E., Lindern, M. V., & Wolkers, M. C. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky721 · Cited by 184 · see citing works

The expanding regulatory mechanisms and cellular functions of circular RNAs

Chen, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0243-y · Cited by 1,714 · see citing works

The Biogenesis, Functions, and Challenges of Circular RNAs

Li, X., Yang, L. C., & Chen, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.034 · Cited by 2,043 · see citing works

The emerging roles and functions of circular RNAs and their generation

Yu, C., & Kuo, H. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0523-z · Cited by 431 · see citing works

Biogenesis and Regulatory Roles of Circular RNAs

Yang, L. C., Wilusz, J. E., & Chen, L. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-125117 · Cited by 303 · see citing works

Features and biomedical relevance of circular RNA biogenesis

Wang, X., & Shan, G. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.11.001 · Cited by 15 · see citing works