The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection
Open accessAbstract
SUMMARY The nervous system, the immune system, and microbial pathogens interact closely at barrier tissues. Here we find that a bacterial pathogen, Streptococcus pyogenes, hijacks pain and neuronal regulation of the immune response to promote bacterial survival. Necrotizing fasciitis is a life-threatening soft tissue infection in which “pain is out of proportion” to early physical manifestations. We find that S. pyogenes, the leading cause of necrotizing fasciitis, secretes streptolysin S (SLS) to directly activate nociceptor neurons and produce pain during infection. Nociceptors, in turn, release the neuropeptide calcitonin gene-related peptide (CGRP) into infected tissues, which inhibits the recruitment of neutrophils and opsonophagocytic killing of S. pyogenes. Botulinum neurotoxin A and CGRP antagonism block neuron-mediated suppression of host defense, thereby preventing and treating S. pyogenes necrotizing infection. We conclude that targeting the peripheral nervous system and blocking neuro-immune communication is a promising strategy to treat highly invasive bacterial infections.
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Falanga, V., Isseroff, R. R., Soulika, A. M., Romanelli, M., Margolis, D., Kapp, S., Granick, M., & Harding, K. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00377-3 · Cited by 1,020
Neuromodulation by the immune system: a focus on cytokines
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Therapeutic options for targeting inflammatory osteoarthritis pain
Conaghan, P. G., Cook, A. D., Hamilton, J. A., & Tak, P. P. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0221-y · Cited by 405
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Yan, Y., Ramanan, D., Rozenberg, M., McGovern, K., Rastelli, D., Vijaykumar, B., Yaghi, O., Voisin, T., Mosaheb, M., Chiu, I., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.02.002 · Cited by 165
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Metadata
- Authors
- Pinho-Ribeiro, F. A., Baddal, B., Haarsma, R., O’Seaghdha, M., Yang, N. J., Blake, K. J., Portley, M., Verri, W. A., Dale, J. B., Wessels, M. R., & Chiu, I. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 173
- Issue
- 5
- Pages
- 1083-1097.e22
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2803070334
- Cited by
- 435
- References
- 64
- FWCI
- 36.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pinho-Ribeiro, F. A., Baddal, B., Haarsma, R., O’Seaghdha, M., Yang, N. J., Blake, K. J., Portley, M., Verri, W. A., Dale, J. B., Wessels, M. R., & Chiu, I. M. (2018). Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. https://doi.org/10.1016/j.cell.2018.04.006
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