The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation
Open accessAbstract
Nociceptor sensory neurons protect organisms from dangers by eliciting pain and driving avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly clear that active crosstalk occurs between nociceptor neurons and the immune system to regulate pain, host defense, and inflammatory diseases. Immune cells at peripheral nerve terminals and within the spinal cord release mediators that modulate mechanical and thermal sensitivity. In turn, nociceptor neurons release neuropeptides and neurotransmitters from nerve terminals that regulate vascular, innate, and adaptive immune cell responses. Therefore, the dialogue between nociceptor neurons and the immune system is a fundamental aspect of inflammation, both acute and chronic. A better understanding of these interactions could produce approaches to treat chronic pain and inflammatory diseases.
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Citations
Cites
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Pro-resolving lipid mediators are leads for resolution physiology
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Mast cells, versatile gatekeepers of pain
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Cited by
Molecular and functional neuroscience in immunity
Pavlov, V. A., Chavan, S. S., & Tracey, K. J. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053158 · Cited by 444
Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection
Pinho-Ribeiro, F. A., Baddal, B., Haarsma, R., O’Seaghdha, M., Yang, N. J., Blake, K. J., Portley, M., Verri, W. A., Dale, J. B., Wessels, M. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.006 · Cited by 435
Self-citationNeuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
Therapeutic options for targeting inflammatory osteoarthritis pain
Conaghan, P. G., Cook, A. D., Hamilton, J. A., & Tak, P. P. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0221-y · Cited by 405
Insular cortex neurons encode and retrieve specific immune responses
Koren, T., Yifa, R., Amer, M., Krot, M., Boshnak, N., Ben-Shaanan, T. L., Azulay-Debby, H., Zalayat, I., Avishai, E., Hajjo, H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.013 · Cited by 334
Metadata
- Authors
- Pinho-Ribeiro, F. A., Verri, W. A., & Chiu, I. M.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 38
- Issue
- 1
- Pages
- 5-19
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2535664532
- Cited by
- 1,027
- References
- 6
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
