Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678 · see citing works

Full-length RNA-seq from single cells using Smart-seq2

Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

Molecular Architecture of the Mouse Nervous System

Zeisel, A., Hochgerner, H., Lönnerberg, P., Johnsson, A., Memic, F., van der Zwan, J., Häring, M., Braun, E., Borm, L. E., La Manno, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.021 · Cited by 2,995 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

IL-6 as a keystone cytokine in health and disease

Hunter, C. A., & Jones, S. A. (2015) · Nature Immunology · doi:10.1038/ni.3153 · Cited by 2,511 · see citing works

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,859 · see citing works

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841 · see citing works

Impaired immune and acute-phase responses in interleukin-6-deficient mice

Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · see citing works

Bile acid metabolites control TH17 and Treg cell differentiation

Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1785-z · Cited by 1,457 · see citing works

Peripheral education of the immune system by colonic commensal microbiota

Lathrop, S. K., Bloom, S. M., Rao, S. M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D. A., Stappenbeck, T. S., & Hsieh, C.-S. (2011) · Nature · doi:10.1038/nature10434 · Cited by 1,034 · see citing works

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

Song, X., Sun, X., Oh, S. F., Wu, M., Zhang, Y., Zheng, W., Geva-Zatorsky, N., Jupp, R., Mathis, D., Benoist, C., et al. (2020) · Nature · doi:10.1038/s41586-019-1865-0 · Cited by 1,024 · see citing works

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007 · see citing works

Bacteria activate sensory neurons that modulate pain and inflammation

Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949 · see citing works

Individual intestinal symbionts induce a distinct population of RORγ ⁺ regulatory T cells

Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879 · see citing works

The microbiota regulates type 2 immunity through RORγt ⁺ T cells

Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863 · see citing works

The enteric nervous system and gastrointestinal innervation: integrated local and central control

Furness, J. B., Callaghan, B. P., Rivera, L. R., & Cho, H.-J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_3 · Cited by 827 · see citing works

Mining the Human Gut Microbiota for Immunomodulatory Organisms

Geva-Zatorsky, N., Sefik, E., Kua, L., Pasman, L., Tan, T. G., Ortiz-Lopez, A., Yanortsang, T. B., Yang, L., Jupp, R., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.01.022 · Cited by 762 · see citing works

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K. D., Berres, M., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.050 · Cited by 727 · see citing works

A weaning reaction to microbiota is required for resistance to immunopathologies in the adult

Al Nabhani, Z., Dulauroy, S., Marques, R., Cousu, C., Al Bounny, S., Déjardin, F., Sparwasser, T., Bérard, M., Cerf-Bensussan, N., & Eberl, G. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.014 · Cited by 679 · see citing works

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

Gabanyi, I., Muller, P. A., Feighery, L. M., Oliveira, T. Y., Costa‐Pinto, F. A., & Mucida, D. (2016) · Cell · doi:10.1016/j.cell.2015.12.023 · Cited by 658 · see citing works

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Wallrapp, A., Riesenfeld, S. J., Burkett, P. R., Abdulnour, R.-E. E., Nyman, J., Dionne, D. A., Hofree, M., Cuoco, M. S., Rodman, C., Farouq, D., et al. (2017) · Nature · doi:10.1038/nature24029 · Cited by 641 · see citing works

Interleukin-33 in tissue homeostasis, injury, and inflammation

Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638 · see citing works

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainPreprint

Zhu, Y., Romero‐Ortega, M. I., Ghosh, P., Ye, Z., Charnay, P., Rushing, E. J., Marth, J. D., & Parada, L. F. (2001) · Genes & Development · doi:10.1101/gad.862101 · Cited by 606 · see citing works

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

Cardoso, V., Chesné, J., Ribeiro, H., García-Cassani, B., Carvalho, T., Bouchery, T., Shah, K., Barbosa-Morais, N. L., Harris, N., & Veiga-Fernandes, H. (2017) · Nature · doi:10.1038/nature23469 · Cited by 592 · see citing works

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

Drokhlyansky, E., Smillie, C. S., Wittenberghe, N. V., Ericsson, M., Griffin, G. K., Eraslan, G., Dionne, D. A., Cuoco, M. S., Goder-Reiser, M. N., Sharova, T. Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.003 · Cited by 585 · see citing works

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

Schepper, S. D., Verheijden, S., Aguilera‐Lizarraga, J., Viola, M. F., Boesmans, W., Stakenborg, N., Voytyuk, I., Schmidt, I., Boeckx, B., de Casterlé, I. D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.048 · Cited by 578 · see citing works

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Klose, C. S. N., Mahlakõiv, T., Moeller, J. B., Rankin, L. C., Flamar, A.-L., Kabata, H., Monticelli, L. A., Moriyama, S., Putzel, G., Rakhilin, N., et al. (2017) · Nature · doi:10.1038/nature23676 · Cited by 570 · see citing works

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556 · see citing works

The gut as a sensory organ

Furness, J. B., Rivera, L. R., Cho, H., Bravo, D. M., & Callaghan, B. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.180 · Cited by 549 · see citing works

Tissue Tregs

Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536 · see citing works

Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt + Cells

Eberl, G., & Littman, D. R. (2004) · Science · doi:10.1126/science.1096472 · Cited by 514 · see citing works

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

Kuswanto, W. F., Burzyn, D., Panduro, M., Wang, K. K., Jang, Y. C., Wagers, A. J., Benoist, C. O., & Mathis, D. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.009 · Cited by 509 · see citing works

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Xu, M., Pokrovskii, M., Ding, Y., Yi, R., Au, C., Harrison, O. J., Galan, C., Belkaid, Y., Bonneau, R., & Littman, D. R. (2018) · Nature · doi:10.1038/nature25500 · Cited by 498 · see citing works

Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials

Gadient, R. A., & Otten, U. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00021-x · Cited by 481 · see citing works

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Meseguer, V., Alpizar, Y. A., Luis, E., Tajada, S., Denlinger, B., Fajardo, O., Manenschijn, J.-A., Fernández-Peña, C., Talavera, A., Kichko, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms4125 · Cited by 479 · see citing works

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

Yoo, B. B., & Mazmanian, S. K. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.011 · Cited by 479 · see citing works

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

Pinho-Ribeiro, F. A., Baddal, B., Haarsma, R., O’Seaghdha, M., Yang, N. J., Blake, K. J., Portley, M. K., Verri, W. A., Jr., Dale, J. B., Wessels, M. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.006 · Cited by 437 · see citing works

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

Yang, B.-H., Hagemann, S., Mamareli, P., Lauer, U., Hoffmann, U., Beckstette, M., Föhse, L., Prinz, I., Pezoldt, J., Suerbaum, S., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.74 · Cited by 435 · see citing works

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

Ibiza, S., García-Cassani, B., Ribeiro, H., Carvalho, T., Almeida, L., Marques, R., Misic, A. M., Bartow‐McKenney, C., Larson, D. M., Pavan, W. J., et al. (2016) · Nature · doi:10.1038/nature18644 · Cited by 362 · see citing works

Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

Lai, N. Y., Musser, M. A., Pinho-Ribeiro, F. A., Baral, P., Jacobson, A. R., Ma, P., Potts, D. E., Chen, Z., Paik, D., Soualhi, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.014 · Cited by 349 · see citing works

Sympathetic neurons can produce and respond to interleukin 6.

März, P., Cheng, J. G., Gadient, R., Patterson, P. H., Stoyan, T., Otten, U., & Rose-John, S. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.6.3251 · Cited by 346 · see citing works

Single-molecule transcript counting of stem-cell markers in the mouse intestine

Itzkovitz, S., Lyubimova, A., Blat, I. C., Maynard, M. A., van Es, J. H., Lees, J. A., Jacks, T., Clevers, H. C., & van Oudenaarden, A. (2011) · Nature Cell Biology · doi:10.1038/ncb2384 · Cited by 340 · see citing works

Differential expression of α-CGRP and β-CGRP by primary sensory neurons and enteric autonomic neurons of the rat

Mulderry, P. K., Ghatki, M. A., Spokks, R. A., Jonhs, P. M., Pierson, A. M., Hamid, Q. A., Kanse, S. M., Amara, S. G., Burrik, J. M., Legon, S., et al. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90018-8 · Cited by 333 · see citing works

Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE

Liu, Y., Teige, I., Birnir, B., & Issazadeh‐Navikas, S. (2006) · Nature Medicine · doi:10.1038/nm1402 · Cited by 302 · see citing works

Neuro-Immune Interactions at Barrier Surfaces

Veiga‐Fernandes, H., & Mucida, D. (2016) · Cell · doi:10.1016/j.cell.2016.04.041 · Cited by 290 · see citing works

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

Teratani, T., Mikami, Y., Nakamoto, N., Suzuki, T., Harada, Y., Okabayashi, K., Hagihara, Y., Taniki, N., Kohno, K., Shibata, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2425-3 · Cited by 268 · see citing works

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

Wallrapp, A., Burkett, P. R., Riesenfeld, S. J., Kim, S.-J., Christian, E., Abdulnour, R.-E. E., Thakore, P. I., Schnell, A., Lambden, C. D., Herbst, R. H., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.005 · Cited by 265 · see citing works

Chemical coding of neurons in the myenteric plexus and external muscle of the small and large intestine of the mouse

Sang, Q., & Young, H. M. (1996) · Cell and Tissue Research · doi:10.1007/s004410050565 · Cited by 262 · see citing works

Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut

Joseph, N. M., He, S., Quintana, E., Kim, Y.-G., Núñez, G., & Morrison, S. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58186 · Cited by 256 · see citing works

IL-6 regulation of synaptic function in the CNS

Gruol, D. L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.023 · Cited by 254 · see citing works

An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk

Yissachar, N., Zhou, Y., Ung, L., Lai, N. Y., Mohan, J. F., Ehrlicher, A., Weitz, D. A., Kasper, D. L., Chiu, I. M., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.009 · Cited by 242 · see citing works

Cell surface polysaccharides of <i>Bifidobacterium bifidum</i> induce the generation of Foxp3 ⁺ regulatory T cells

Verma, R., Lee, C., Jeun, E.-J., Yi, J., Kim, K. S., Ghosh, A., Byun, S., Lee, C.-G., Kang, H.-J., Kim, G.-C., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat6975 · Cited by 242 · see citing works

Neuroimmune circuits in inter-organ communication

Huh, J. R., & Veiga‐Fernandes, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0247-z · Cited by 216 · see citing works

IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

Peine, C., Marek, R. M., & Löhning, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.007 · Cited by 180 · see citing works

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells

Ye, J., Qiu, J., Bostick, J. W., Ueda, A., Schjerven, H., Li, S., Jobin, C., Chen, Z. E., & Zhou, L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.114 · Cited by 180 · see citing works

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

Neumann, C., Blume, J., Roy, U., Teh, P. P., Vasanthakumar, A., Beller, A. V., Liao, Y., Heinrich, F., Arenzana, T. L., Hackney, J. A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0316-2 · Cited by 179 · see citing works

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

Ramanan, D., Sefik, E., Galván-Peña, S., Wu, M., Yang, L., Yang, Z., Kostic, A. D., Golovkina, T. V., Kasper, D. L., Mathis, D. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.030 · Cited by 173 · see citing works

Bacterial Signaling to the Nervous System through Toxins and Metabolites

Yang, N. J., & Chiu, I. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.12.023 · Cited by 165 · see citing works

Interleukin-6 mRNA expression by cortical neurons in culture: Evidence for neuronal sources of interleukin-6 production in the brain

Ringheim, G. E., Burgher, K. L., & Heroux, J. A. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00134-4 · Cited by 158 · see citing works

Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery

Nutsch, K., Chai, J. N., Ai, T. L., Russler-Germain, E. V., Feehley, T., Nagler‐Anderson, C., & Hsieh, C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.092 · Cited by 146 · see citing works

RET Is Dispensable for Maintenance of Midbrain Dopaminergic Neurons in Adult Mice

Jain, S. R., Golden, J. P., Wozniak, D. F., Pehek, E. A., Johnson, E. M., & Milbrandt, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1876-06.2006 · Cited by 106 · see citing works

Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior

Quintana, A., Erta, M., Ferrer, B., Comes, G., Giralt, M., & Hidalgo, J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.10.011 · Cited by 104 · see citing works

TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP

de Jong, P. R., Takahashi, N., Peiris, M., Bertin, S., Lee, J., Gareau, M. G., Paniagua, A., Harris, A. R., Herdman, D. S., Corr, M., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.82 · Cited by 88 · see citing works

Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract

Margolis, K. G., Gershon, M. D., & Bogunovic, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.05.003 · Cited by 86 · see citing works

Advances in Enteric Neurobiology: The “Brain” in the Gut in Health and Disease

Kulkarni, S., Ganz, J., Bayrer, J. R., Becker, L. S., Bogunovic, M., & Rao, M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1663-18.2018 · Cited by 83 · see citing works

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

Pratama, A., Schnell, A., Mathis, D. J., & Benoist, C. O. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190428 · Cited by 70 · see citing works

Vasoactive Intestinal Polypeptide Promotes Intestinal Barrier Homeostasis and Protection Against Colitis in Mice

Wu, X., Conlin, V. S., Morampudi, V., Ryz, N. R., Nasser, Y., Bhinder, G., Bergstrom, K., Yu, H. B., Waterhouse, C. C. M., Buchan, A. M. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125225 · Cited by 69 · see citing works

Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice

He, Z., Chen, L., Souto, F. O., Canasto‐Chibuque, C., Bongers, G., Deshpande, M., Harpaz, N., Ko, H. M., Kelley, K. A., Furtado, G. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05716-z · Cited by 68 · see citing works

Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes

Wheaton, J. D., Yeh, C., & Ciofani, M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701134 · Cited by 67 · see citing works

Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis

Engel, M. A., Khalil, M., Siklosi, N., Mueller–Tribbensee, S. M., Neuhuber, W., Neurath, M. F., Becker, C., & Reeh, P. W. (2011) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.08.030 · Cited by 54 · see citing works

Protective Roles of α-Calcitonin and β-Calcitonin Gene-Related Peptide in Spontaneous and Experimentally Induced Colitis

Thompson, B. J., Washington, M. K., Kurre, U., Singh, M., Rula, E. Y., & Emeson, R. B. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9848-7 · Cited by 38 · see citing works

Mouse Enteric Neuronal Cell Culture

Zhang, Y., & Hu, W. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-640-5_6 · Cited by 30 · see citing works

Signaling inflammation across the gut-brain axis

Agirman, G., Yu, K. B., & Hsiao, E. Y. (2021) · Science · doi:10.1126/science.abi6087 · Cited by 846 · see citing works

The enteric nervous system

Sharkey, K. A., & Mawe, G. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00018.2022 · Cited by 423 · see citing works

Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease

Bairamian, D., Sha, S., Rolhion, N., Sokol, H., Dorothée, G., Lemere, C. A., & Krantic, S. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00522-2 · Cited by 318 · see citing works

Somatosensory and autonomic neuronal regulation of the immune response

Udit, S., Blake, K. J., & Chiu, I. M. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00555-4 · Cited by 238 · see citing works

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 188 · see citing works

Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system

Mi, B.-B., Xiong, Y., Knoedler, S. A., Alfertshofer, M. G., Panayi, A. C., Wang, H., Lin, S.-E., Li, G., & Liu, G. (2024) · Bone Research · doi:10.1038/s41413-024-00346-4 · Cited by 138 · see citing works

Enteric neuroimmune interactions coordinate intestinal responses in health and disease

Wang, H., Foong, J. P. P., Harris, N. L., & Bornstein, J. C. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00443-1 · Cited by 128 · see citing works

Regulatory T cells in the face of the intestinal microbiota

Ramanan, D., Pratama, A., Zhu, Y., Venezia, O., Sassone-Corsi, M., Chowdhary, K., Galván-Peña, S., Sefik, E., Brown, C., Gélineau, A., et al. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00890-w · Cited by 126 · see citing works

T Cell Responses to the Microbiota

Ivanov, I. I., Tuganbaev, T., Skelly, A. N., & Honda, K. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-011829 · Cited by 128 · see citing works

Role of IL-6 in the commitment of T cell subsets

Korn, T., & Hiltensperger, M. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155654 · Cited by 125 · see citing works

A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut

Zhu, Y., Meerschaert, K. A., Galván-Peña, S., Bin, N., Yang, D., Basu, H., Kawamoto, R., Shalaby, A., Liberles, S. D., Mathis, D. J., et al. (2024) · Science · doi:10.1126/science.adk1679 · Cited by 120 · see citing works

Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation

Selck, C., & Dominguez‐Villar, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.661875 · Cited by 106 · see citing works

Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease

Gao, H., Sun, M., Ai, L., Gu, Q., Kang, D., Feng, Z., Li, X., Wang, X., Chen, L., Hong, Y., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2467235 · Cited by 113 · see citing works

The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease?

Parodi, B., & de Rosbo, N. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718220 · Cited by 105 · see citing works

Neuroimmune Interactions in the Intestine

Wallrapp, A., & Chiu, I. M. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-042929 · Cited by 91 · see citing works

Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction

Sun, M., Mao, S., Wu, C., Zhao, X., Guo, C., Hu, J., Xu, S., Zheng, F., Zhu, G., Tao, H., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.065390 · Cited by 82 · see citing works

Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy

Bhattacharjee, A., Burr, A. B. P., Overacre-Delgoffe, A. E., Tometich, J. T., Yang, D., Huckestein, B. R., Linehan, J. L., Spencer, S. P., Hall, J. A., Harrison, O. J., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.07.005 · Cited by 75 · see citing works

Exploration on neurobiological mechanisms of the central–peripheral–central closed-loop rehabilitation

Jia, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.982881 · Cited by 73 · see citing works

Dietary tryptophan deficiency promotes gut RORγt+ Treg cells at the expense of Gata3+ Treg cells and alters commensal microbiota metabolism

Rankin, L. C., Kaiser, K. A., Santos, K. D. L., Park, H., Uhlemann, A., Gray, D. H. D., & Arpaia, N. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112135 · Cited by 63 · see citing works

The role of cellular and molecular neuroimmune crosstalk in gut immunity

Yang, D., Almanzar, N., & Chiu, I. M. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01054-5 · Cited by 60 · see citing works

The lung-gut crosstalk in respiratory and inflammatory bowel disease

Du, B., Fu, Y., Han, Y., Sun, Q., Xu, J., Yang, Y., & Rong, R. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1218565 · Cited by 52 · see citing works

Treg cell: Critical Role of Regulatory T-cells in Depression.

Gao, X., Tang, Y.-R., Kong, L.-L., Fan, Y., Wang, C.-X., & Wang, R. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106893 · Cited by 48 · see citing works

Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification

Huang, M., Ji, Q., Huang, H., Wang, X., & Wang, L. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2486519 · Cited by 53 · see citing works

Vagus nerve-mediated intestinal immune regulation: therapeutic implications of inflammatory bowel diseases

Mikami, Y., Tsunoda, J., Kiyohara, H., Taniki, N., Teratani, T., & Kanai∥, T. (2021) · International Immunology · doi:10.1093/intimm/dxab039 · Cited by 50 · see citing works

Immunological regulation of skeletal muscle adaptation to exercise

Langston, P. K., & Mathis, D. J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.001 · Cited by 52 · see citing works

Stability and plasticity of regulatory T cells in health and disease

Contreras-Castillo, E., García-Rasilla, V. Y., García-Patiño, M. G., & Licona-Limón, P. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae049 · Cited by 46 · see citing works

Phenotypic and Functional Diversity in Regulatory T Cells

Sjaastad, L. E., Owen, D. L., Tracy, S. I., & Farrar, M. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.715901 · Cited by 44 · see citing works

Environmental perception and control of gastrointestinal immunity by the enteric nervous system

Schneider, K. M., Kim, J., Bahnsen, K., Heuckeroth, R. O., & Thaiss, C. A. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.09.005 · Cited by 42 · see citing works

Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms

Ciorba, M. A., Konnikova, L., Hirota, S. A., Lucchetta, E. M., Turner, J. R., Slavin, A., Johnson, K., Condray, C. D., Hong, S., Cressall, B. K., et al. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae081 · Cited by 44 · see citing works

Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis

Liu, N., He, J., Yang, Y., Wang, Y., Zhang, L., Xiao, Z., Xiong, Z., Zhong, S., Xu, Y., Gu, Y., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02081-2 · Cited by 42 · see citing works

Vagal pathway activation links chronic stress to decline in intestinal stem cell function

Zhang, G., Lian, Y., Li, Q., Zhou, S., Zhang, L., Chen, L., Tang, J., Liu, H., Li, N., Pan‐Hammarström, Q., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.02.016 · Cited by 41 · see citing works

TREGking From Gut to Brain: The Control of Regulatory T Cells Along the Gut-Brain Axis

Choi, J., Kim, B., Akuzum, B., Chang, L., Lee, J., & Kwon, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.916066 · Cited by 36 · see citing works

Bacterial and Viral Co-Infection in the Intestine: Competition Scenario and Their Effect on Host Immunity

Lian, S., Liu, J., Wu, Y., Xia, P., & Zhu, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042311 · Cited by 33 · see citing works

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

Ramanan, D., Chowdhary, K., Candéias, S. M., Sassone‐Corsi, M., Gélineau, A., Mathis, D. J., & Benoist, C. O. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311566120 · Cited by 32 · see citing works

Current status and future directions in food protein–induced enterocolitis syndrome: An NIAID workshop report of the June 22, 2022, virtual meeting

Nowak-Wegrzyn, A. H., Sicherer, S. H., Akin, C., Anvari, S., Bartnikas, L. M., Berin, M. C., Bingemann, T. A., Boyd, S. D., Brown-Whitehorn, T. F., Bunyavanich, S., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.10.022 · Cited by 31 · see citing works

The gut-immune-brain axis in neurodevelopment and neurological disorders

Park, J. C., & Im, S. (2022) · Microbiome Research Reports · doi:10.20517/mrr.2022.11 · Cited by 32 · see citing works

The crosstalk between enteric nervous system and immune system in intestinal development, homeostasis and diseases

Wang, X., Ding, C., & Li, H. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2376-0 · Cited by 29 · see citing works

The gut–organ axis: Clinical aspects and immune mechanisms

Fukasawa, N., Tsunoda, J., Sunaga, S., Kiyohara, H., Nakamoto, N., Teratani, T., Mikami, Y., & Kanai∥, T. (2025) · Allergology International · doi:10.1016/j.alit.2025.01.004 · Cited by 32 · see citing works

Interplay between Microbiota and γδ T Cells: Insights into Immune Homeostasis and Neuro-Immune Interactions

Mohamed, A. A. A., al-Ramadi, B. K., & Fernández-Cabezudo, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031747 · Cited by 28 · see citing works

Role of the microbiota in inflammation-related related psychiatric disorders

Zhou, L., Wu, Q. J., Jiang, L., Rao, J., Gao, J., Zhao, F., & Wang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1613027 · Cited by 30 · see citing works

Neonatal development of intestinal neuroimmune interactions

Schill, E. M., Floyd, A. N., & Newberry, R. D. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.10.002 · Cited by 27 · see citing works

Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota

Zhai, J., Li, Y., Liu, J., & Dai, C. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70329 · Cited by 30 · see citing works

Recent advances in understanding the roles of the enteric nervous system

Chanpong, A., Borrelli, O., & Thapar, N. (2022) · Faculty Reviews · doi:10.12703/r/11-7 · Cited by 27 · see citing works

Enteric neuro-immune interactions in intestinal health and disease

van Baarle, L., Stakenborg, M., & Matteoli, G. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101819 · Cited by 25 · see citing works

Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology

Sunaga, S., Tsunoda, J., Teratani, T., Mikami, Y., & Kanai∥, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.867351 · Cited by 26 · see citing works

Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination

Mukherjee, S., Chakraborty, S., Basak, U., Pati, S., Dutta, A., Dutta, S., Roy, D., Banerjee, S., Ray, A., Sa, G., et al. (2023) · Discover Oncology · doi:10.1007/s12672-023-00787-z · Cited by 23 · see citing works

Diversity, development and immunoregulation of enteric neurons

Marklund, U. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00553-y · Cited by 21 · see citing works

Perioperative neurocognitive disorders: Advances in molecular mechanisms and bioactive molecules

Mao, L., Wang, L., Huang, Z., Switzer, J. A., Hess, D. C., & Zhang, Q. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102885 · Cited by 21 · see citing works

The Imperative for Innovative Enteric Nervous System–Intestinal Organoid Co-Culture Models: Transforming GI Disease Modeling and Treatment

Llorente, C. (2024) · Cells · doi:10.3390/cells13100820 · Cited by 18 · see citing works

Neuroimmune Circuits in Allergic Diseases

Cai, H., Zhu, X., & Sokol, C. L. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082423-032154 · Cited by 19 · see citing works

Regulatory T cells in neurological disorders and tissue regeneration: Mechanisms of action and therapeutic potentials

Jie, J., Yao, X., Deng, H., Zhou, Y., Jiang, X., DAI, X. H., Yang, Y., & Yang, P. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01363 · Cited by 18 · see citing works

Immunomodulatory Effects of Ganoderma lucidum Bioactive Compounds on Gut–Brain and Gut–Liver Axis Disorders

Zhao, L., Geng, Z., Wang, Y., Wen, J., & Liu, D. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47100842 · Cited by 18 · see citing works

Neuro-immune-metabolism: The tripod system of homeostasis

Deshpande, D., Fuchs, L., & Klose, C. S. N. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.10.001 · Cited by 19 · see citing works

The role of IL-23/IL-17 axis in ischemic stroke from the perspective of gut-brain axis

Jiang, Y., Dai, Y., Liu, Z., Liao, Y., Sun, S., Kong, X., Hu, J., & Tang, Y. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109505 · Cited by 18 · see citing works

Navigating the blurred path of mixed neuroimmune signaling

Gupta, S., Viotti, A., Eichwald, T., Roger, A., Kaufmann, E., Othman, R., Ghasemlou, N., Rafei, M., Foster, S. L., & Talbot, S. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.02.006 · Cited by 19 · see citing works

Systematic Insights into the Relationship between the Microbiota–Gut–Brain Axis and Stroke with the Focus on Tryptophan Metabolism

Shen, X., & Mu, X. (2024) · Metabolites · doi:10.3390/metabo14080399 · Cited by 18 · see citing works

Tissue-Specific Contributions to Control of T Cell Immunity

Poholek, A. C. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2000103 · Cited by 18 · see citing works

A Pumpless, High‐Throughput Microphysiological System to Mimic Enteric Innervation of Duodenal Epithelium and the Impact on Barrier Function

Kaiser, K. N., Snyder, J. R., Koppes, R. A., & Koppes, A. N. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202409718 · Cited by 17 · see citing works

Molecular profiling of enteric nervous system cell lineages

Obata, Y., Castaño, Á., Fallesen, T. L., Bon‐Frauches, A. C., Boeing, S., Huseynova, A., McCallum, S. E., Lasrado, R., Heanue, T. A., & Pachnis, V. (2022) · Nature Protocols · doi:10.1038/s41596-022-00697-4 · Cited by 17 · see citing works

Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia

Wood, L. B., & Singer, A. C. (2025) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110122-120158 · Cited by 16 · see citing works

Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival

Miao, X., Jiang, Y., Kong, D., Wu, Z., Liu, H., Ye, X., & Gong, W. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00794-22 · Cited by 16 · see citing works

Intestinal IL-17 family orchestrates microbiota-driven histone deacetylation and promotes Treg differentiation to mediate the alleviation of asthma by Ma-Xing-Shi-Gan decoction

Hong, Y., Cui, J., Xu, G., Li, N., & Peng, G. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156656 · Cited by 15 · see citing works

A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation

Forster, P. M., Jakob, M. O., Yusuf, D., Bubeck, M., Limberger, H., Luo, Y., Thieme, P., Polici, A., Sterczyk, N., Boulekou, S., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.02.018 · Cited by 15 · see citing works

Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells

Schroeter, C. B., Huntemann, N., Böck, S., Nelke, C., Kremer, D., Pfeffer, K., Meuth, S. G., & Ruck, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.747143 · Cited by 15 · see citing works

Effect and Mechanism of Sodium Butyrate on Neuronal Recovery and Prognosis in Diabetic Stroke

Li, T., Zhao, D.-M., Wei, Y., Li, J.-B., Li, X., Wan, Q., Zhang, X., Liu, X.-N., Yang, W., & Li, W. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10071-0 · Cited by 14 · see citing works

Pathogenic mechanisms in the evolution of food allergy

Martínez‐Blanco, M., Mukhatayev, Z., & Chatila, T. A. (2024) · Immunological Reviews · doi:10.1111/imr.13398 · Cited by 13 · see citing works

Patchouli alcohol improved diarrhea-predominant irritable bowel syndrome by regulating excitatory neurotransmission in the myenteric plexus of rats

Tan, B., Liao, L., Huang, Z., Lu, Y.-L., Lin, Y., Pei, Y., Yi, S.-L., Huang, C., Cao, H., & Tan, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.943119 · Cited by 13 · see citing works

T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota

Souza, P., Keenan, C. M., Wallace, L. E., Habibyan, Y. B., Davoli-Ferreira, M., Ohland, C., Vicentini, F., McCoy, K. D., & Sharkey, K. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2442528 · Cited by 12 · see citing works

Insight Into Regulatory T Cells in Sepsis-Associated Encephalopathy

Gao, Y.-L., Liu, Y.-C., Zhang, X., Shou, S.-T., & Chai, Y.-F. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.830784 · Cited by 11 · see citing works

Preoperative inflammatory markers in pediatric appendicitis: associations with disease severity, postoperative recovery, pain, and surgical outcomes

Li, X., Gong, S., Ding, Y., Chen, Y., & Yu, Z. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05941-w · Cited by 11 · see citing works

Localization and movement of Tregs in gastrointestinal tract: a systematic review

Harada, Y., Miyamoto, K., Chida, A., Tojo, A. O., Yoshimatsu, Y., Kudo, Y., & Sujino, T. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00232-8 · Cited by 11 · see citing works

Intestinal factors promoting the development of RORγt+ cells and oral tolerance

López‐Fandiño, R., Molina, E., & Lozano‐Ojalvo, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294292 · Cited by 11 · see citing works

Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts

Sassone‐Corsi, M., Azriel, S., Simon, A., Ramanan, D., Ortiz-Lopez, A., Chen, F., Yissachar, N., Mathis, D. J., & Benoist, C. O. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209624119 · Cited by 10 · see citing works

Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation

Li, Y., Yang, S.-Y., Zhang, Y.-R., & Wang, Y. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.04.001 · Cited by 10 · see citing works

Neuroimmune Crossroads: The Interplay of the Enteric Nervous System and Intestinal Macrophages in Gut Homeostasis and Disease

Lou, M., Heuckeroth, R. O., & Tjaden, N. E. B. (2024) · Biomolecules · doi:10.3390/biom14091103 · Cited by 10 · see citing works

Neuro-immune cell interactions in the regulation of intestinal immune homeostasis

Hou, X., & Artis, D. (2024) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000001065 · Cited by 10 · see citing works

Gut neuropeptide involvement in Parkinson’s disease

Templeton, H., Tobet, S. A., & Schwerdtfeger, L. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2024 · Cited by 9 · see citing works

The Role of the Gut-Brain Axis in Diseases

Chen, J. W., Xu, Y., & Cao, P. (2025) · Physiology · doi:10.1152/physiol.00016.2025 · Cited by 9 · see citing works

The environmental pollutant 3-methyl-4-nitrophenol reduces the regulatory T cells in the intestine

Hu, S., Liu, H., Tao, S., Wang, Y., Wang, S., Liao, Y., Zheng, P., & Yang, P. (2022) · Toxicology · doi:10.1016/j.tox.2022.153356 · Cited by 9 · see citing works

Neuroimmune crosstalk in the gut and liver

Teratani, T., Mikami, Y., & Kanai∥, T. (2022) · International Immunology · doi:10.1093/intimm/dxac033 · Cited by 9 · see citing works

Serine, glutamate, and proline in a high‐fat diet exacerbated metabolite reduction‐induced memory and cognitive decline

Zhang, M., Shan, K., Song, S., Bai, J., Jiang, P., Zhao, D., Ke, W., Zhou, G., & Li, C. (2023) · Food Frontiers · doi:10.1002/fft2.239 · Cited by 9 · see citing works

Neonatal Meningitis-Causing Escherichia coli Induces Microglia Activation which Acts as a Double-Edged Sword in Bacterial Meningitis

Su, Y., Ma, G., Zheng, Y., Qin, J., Li, X., Ge, Q., Sun, H., & Liu, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129915 · Cited by 8 · see citing works

Vancomycin-induced gut microbial dysbiosis alters enteric neuron–macrophage interactions during a critical period of postnatal development

Schill, E. M., Joyce, E. L., Floyd, A. N., Udayan, S., Rusconi, B. A., Gaddipati, S., Barrios, B. E., John, V., Kaye, M. E., Kulkarni, D. H., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1268909 · Cited by 8 · see citing works

The role of reactive enteric glia‐macrophage interactions in acute and chronic inflammation

Schneider, R., Schneider, L. H., Hamza, E., Leven, P., & Wehner, S. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14947 · Cited by 8 · see citing works

Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn’s disease severity

Ragab, M., Schlichting, H., Hicken, M., Mester, P., Hirose, M., de Almeida, L. N., Christiansen, L., Ibrahim, S. M., Tews, H. C., Divanovic, S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-63730-4 · Cited by 8 · see citing works

Association of Chronic Inflammation-Associated Cancer With Cytokines

Nakase, H., & Shimomori, Y. (2025) · Cureus · doi:10.7759/cureus.92239 · Cited by 7 · see citing works

Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis

Naim, G., Romano-Zadaka, H., Amidror, S., Levy, D. J., Cohen, A., Sochen, C., Gilberg, H., Farah, N., Rudenko, V., Yarden‐Rabinowitz, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64995-7 · Cited by 8 · see citing works

Tissue Regulatory T Cells

Feuerer, M., Gray, D. H. D., Rankin, L. C., Schmidleithner, L. M., & Liston, A. (2026) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082924-092651 · Cited by 7 · see citing works

Intratracheal Transplantation of Mesenchymal Stem Cells Attenuates Hyperoxia-Induced Microbial Dysbiosis in the Lungs, Brain, and Gut in Newborn Rats

Ahn, S. Y., Sung, D. K., Chang, Y. S., & Park, W. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126601 · Cited by 7 · see citing works

Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance

Chen, K., Tang, L., & Nong, X. (2023) · Inflammation Research · doi:10.1007/s00011-023-01729-9 · Cited by 7 · see citing works

Development of a non-invasive bioassay for adiponectin target engagement in mice

Tang, J., Lei, Y., Pignalosa, A., Hsu, H. H., Sater, A. A. A., & Sweeney, G. (2024) · iScience · doi:10.1016/j.isci.2024.110994 · Cited by 6 · see citing works

The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection

Costa, D. V. D. S., Thomasi, B. B. D. M., Brito, G. A. D. C., Gulbransen, B. D., & Warren, C. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01071-x · Cited by 6 · see citing works

IL-6–Mediated Neurogenic Inflammation Regulated by the Dorsal Root Ganglion Macrophages Exacerbates Imiquimod-Induced Psoriasis-Like Skin Lesions in Mice

Jiang, J., Liu, X., Zhang, Y., Kong, Y., Luo, Q., Hou, Y., Li, L., Liu, S., Tao, Q., Lin, S., et al. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.07.018 · Cited by 6 · see citing works

Silibinin-derived microbiota enrich (R)-2,3-dihydroxy-isovalerate and ameliorate colitis via the GAT-3/RARβ/RORγt axis

Yan, B., Zheng, X., Lu, D., Li, T., Chen, X., Shao, Z., & Fu, T. (2025) · The ISME Journal · doi:10.1093/ismejo/wraf175 · Cited by 6 · see citing works

Fecal metabolomics in Crohn's disease reveal N-Acetylglutamine as a Th17/Treg modulator.

Han, M., Dong, X.-T., Zhao, R., Hu, X., Li, D., Yan, X., Liu, Y.-D., Du, Q.-P., & Li, M.-R. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.11.012 · Cited by 6 · see citing works

The role of gut microbiota in neuropathic pain: insights into immune mechanisms

Gong, Z., Zou, J., Fang, Y., Li, J., Luo, Y., Xue, Q., Yu, B., Hua, B., & Liu, Z. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02260-4 · Cited by 6 · see citing works

Regulation of Host Immunity by the Gut Microbiota

Partney, H., & Yissachar, N. (2022) · Progress in inflammation research · doi:10.1007/978-3-030-91051-8_4 · Cited by 6 · see citing works

Linking the gut microbiome to microglial activation in opioid use disorder

Antoine, D., Venigalla, G., Truitt, B., & Roy, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1050661 · Cited by 6 · see citing works

Cascading catalytic nanozyme enhance ferroptosis-mediated chemoimmunotherapy via the cGAS-STING and IL-6/STAT3 pathways

Zhao, Y., Zhang, G., Yu, F., Bai, F., Ai, C., Zhou, D., Zhou, D., Xu, X., Liu, H., Duan, J., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161354 · Cited by 5 · see citing works

Tissue-resident regulatory T cells: modulators of local immunity

Shi, Y., Wang, L., Bao, C., Wang, G., & Sun, Z. (2026) · Trends in Immunology · doi:10.1016/j.it.2025.12.001 · Cited by 5 · see citing works

A neu(ronal) player joins the T regulatory game

Larsen, S. B., & Naik, S. (2021) · Immunity · doi:10.1016/j.immuni.2021.02.016

T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota

Souza, P., Keenan, C. M., Wallace, L. E., Habibyan, Y. B., Davoli-Ferreira, M., Ohland, C., Vicentini, F., McCoy, K. D., & Sharkey, K. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2442528 · Cited by 12 · see citing works

Regulatory T cells are induced by gut microbiota through differentially regulating costimulatory molecules of enteric glial cells

Yang, J., Zeng, Q., Zou, M., Nie, J., & Gan, H. (2026) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2025 · Cited by 2 · see citing works

Controlling the frontier: Regulatory T-cells and intestinal homeostasis

Bollrath, J., & Powrie, F. M. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.002 · Cited by 85 · see citing works

Mapping neuroimmune interactions in the gut

Ray, K. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00982-5 · Cited by 1 · see citing works