The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
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A. muciniphilia has also been found to be enriched in mice fed a ketogenic diet, exhibiting gut-brain functions including conferring seizure protection in two preclinical models for refractory epilepsy.
“A. muciniphilia has also been found to be enriched in mice fed a ketogenic diet, exhibiting gut-brain functions including conferring seizure protection in two preclinical models for refractory epilepsy [66].”
From The athletic gut microbiota (2020) · cites this paper as [66]
A ketogenic diet alters gut microbiota composition, leading to an increase in Akkermansia abundance.
“a ketogenic diet alters gut microbiota composition leading to an increase in Akkermansia abundance.”
From The athletic gut microbiota (2020) · cites this paper as [66]
Akkermansia fed to mice has a positive impact on reducing seizures, providing a potential mechanism for the neuroprotective effects of a ketogenic diet.
“Akkermansia fed to mice has a positive impact on reducing seizures, providing a potential mechanism for the observed neuroprotective effects of a ketogenic diet [66, 202].”
From The athletic gut microbiota (2020) · cites this paper as [66]
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- Authors
- Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y.
- Corresponding author
- Hsiao, Elaine Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 174
- Issue
- 2
- Pages
- 497
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4249493171
- Cited by
- 224
- References
- 0
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 30 · 2023: 43 · 2022: 42 · 2021: 23 · 2020: 24 · 2019: 19 · 2018: 5
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- Funders
- National Institutes of Health (DP5OD017924)
- National Institute of Mental Health (F31MH090749)
- National Institute of General Medical Sciences (T32GM065823)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- gut microbiota, ketogenic diet, epilepsy, antiseizure effects, Akkermansia muciniphila, GABA/glutamate ratio, hippocampus, seizure susceptibility
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