d-glutamate and Gut Microbiota in Alzheimer’s Disease
Open accessAbstract
Background: An increasing number of studies have shown that the brain–gut–microbiota axis may significantly contribute to Alzheimer’s disease (AD) pathogenesis. Moreover, impaired memory and learning involve the dysfunction neurotransmission of glutamate, the agonist of the N-methyl-d-aspartate receptor and a major excitatory neurotransmitter in the brain. This systematic review aimed to summarize the current cutting-edge research on the gut microbiota and glutamate alterations associated with dementia. Methods: PubMed, the Cochrane Collaboration Central Register of Controlled Clinical Trials, and Cochrane Systematic Reviews were reviewed for all studies on glutamate and gut microbiota in dementia published up until Feb 2020. Results: Several pilot studies have reported alterations of gut microbiota and metabolites in AD patients and other forms of dementia. Gut microbiota including Bacteroides vulgatus and Campylobacter jejuni affect glutamate metabolism and decrease the glutamate metabolite 2-keto-glutaramic acid. Meanwhile, gut bacteria with glutamate racemase including Corynebacterium glutamicum, Brevibacterium lactofermentum, and Brevibacterium avium can convert l-glutamate to d-glutamate. N-methyl-d-aspartate glutamate receptor (NMDAR)-enhancing agents have been found to potentially improve cognition in AD or Parkinson’s disease patients. These findings suggest that d-glutamate (d-form glutamate) metabolized by the gut bacteria may influence the glutamate NMDAR and cognitive function in dementia patients. Conclusions: Gut microbiota and glutamate are potential novel interventions to be developed for dementia. Exploring comprehensive cognitive functions in animal and human trials with glutamate-related NMDAR enhancers are warranted to examine d-glutamate signaling efficacy in gut microbiota in patients with AD and other neurodegenerative dementias.
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Glutamate does not readily cross the blood-brain barrier, which may limit its direct influence on brain glutamate levels.
“glutamate does not readily cross the BBB, which may limit its direct influence on brain glutamate levels.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [541]
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A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,068 · see citing works
Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125 · see citing works
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791 · see citing works
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,644 · see citing works
Glutamate and the pathophysiology of hypoxic–ischemic brain damage
Rothman, S. M., & Olney, J. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190202 · Cited by 2,428 · see citing works
Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,304 · see citing works
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055 · see citing works
Memantine in Moderate-to-Severe Alzheimer's Disease
Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., & Möbius, H. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013128 · Cited by 2,043 · see citing works
Glutamate: A Neurotransmitter in Mammalian Brain
Fonnum, F. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb09689.x · Cited by 2,003 · see citing works
Ionic dependence of glutamate neurotoxicity
Choi, D. W. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00369.1987 · Cited by 1,854 · see citing works
APP Processing and Synaptic Function
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · cited 2× · see citing works
“Finally, these effects may contribute to the inhibition of apoptosis and promotion of cell survival [72,73].”
BackgroundShankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592 · see citing works
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
Liu, R., Hong, J., Xu, X., Feng, Q., Zhang, D., Gu, Y., Shi, J., Zhao, S., Liu, W., Wang, X., et al. (2017) · Nature Medicine · doi:10.1038/nm.4358 · Cited by 1,501 · see citing works
Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · cited 1× · see citing works
“In contrast, adequate NMDAR activation induces adequate increase in postsynaptic Ca2+ and leads to phosphatase-mediated, long-term depression (LTD) [67].”
BackgroundThe Time Course of Glutamate in the Synaptic Cleft
Clements, J. D., Lester, R. A. J., Tong, G., Jahr, C. E., & Westbrook, G. L. (1992) · Science · doi:10.1126/science.1359647 · Cited by 1,089 · see citing works
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y. (2018) · Cell · doi:10.1016/j.cell.2018.04.027 · Cited by 1,057 · see citing works
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works
Role of Glutamate and NMDA Receptors in Alzheimer’s Disease
Wang, R., & Reddy, P. H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160763 · Cited by 1,009 · see citing works
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists
Choi, D. W., Koh, J., & Peters, S. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-01-00185.1988 · Cited by 983 · see citing works
Glutamate receptor function in learning and memory
Riedel, G. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00272-3 · Cited by 964 · see citing works
De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882 · see citing works
Excitatory amino acid receptors and synaptic plasticity
Collingridge, G. L., & Singer, W. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90011-v · Cited by 862 · see citing works
The Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works
Metabolism and role of glutamate in mammalian brain
Erecińska, M., & Silver, I. A. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90013-7 · Cited by 682 · see citing works
The SLC3 and SLC7 families of amino acid transporters
Fotiadis, D., Kanai, Y., & Palacı́n, M. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.007 · Cited by 674 · see citing works
A nomenclature for ligand-gated ion channels
Collingridge, G. L., Olsen, R. W., Peters, J. A., & Spedding, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.063 · Cited by 602 · see citing works
Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows.
Pessione, E. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00086 · Cited by 592 · see citing works
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
Tymianski, M., Charlton, M. P., Carlen, P. L., & Tator, C. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02085.1993 · Cited by 567 · see citing works
Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders
Parsons, M. P., & Raymond, L. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.030 · Cited by 555 · see citing works
Neuropathologic changes in Alzheimer's disease.
Wenk, G. L. (2003) · PubMed · Cited by 554 · see citing works
Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses
Abramov, E., Dolev, I., Fogel, H., Ciccotosto, G. D., Ruff, E., & Slutsky, I. (2009) · Nature Neuroscience · doi:10.1038/nn.2433 · Cited by 499 · see citing works
Excitatory Amino Acid Neurotransmission: NMDA Receptors and Hebb-Type Synaptic Plasticity
Cotman, C. W., & Monaghan, D. T. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.000425 · Cited by 484 · see citing works
Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease
Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476 · see citing works
Danysz, W., & Parsons, C. G. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.938 · Cited by 404 · see citing works
The glial cell glutamate uptake carrier countertransports pH-changing anions
Bouvier, M., Szatkowski, M. S., Amato, A., & Attwell, D. (1992) · Nature · doi:10.1038/360471a0 · Cited by 374 · see citing works
Alberdi, E. M., Sánchez‐Gómez, M. V., Cavaliere, F., Pérez‐Samartín, A., Zugaza, J. L., Trullás, R., Domercq, M., & Matute, C. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.010 · Cited by 364 · see citing works
Intestinal Glutamate Metabolism
Reeds, P. J., Burrin, D. G., Stoll, B., & Jahoor, F. (2000) · Journal of Nutrition · doi:10.1093/jn/130.4.978s · Cited by 350 · see citing works
GABA and Glutamate Transporters in Brain
Zhou, Y., & Danbolt, N. C. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00165 · Cited by 347 · see citing works
LI, S., MALLORY, M., ALFORD, M., TANAKA, S., & MASLIAH, E. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199708000-00008 · Cited by 343 · see citing works
Overview of glutamatergic neurotransmission in the nervous system
Niciu, M. J., Kelmendi, B., & Sanacora, G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.08.008 · Cited by 335 · see citing works
Functional characterization of a potassium-selective prokaryotic glutamate receptor
Chen, G., Cui, C., Mayer, M. L., & Gouaux, E. (1999) · Nature · doi:10.1038/45568 · Cited by 333 · see citing works
Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis
Baj, A., Moro, E., Bistoletti, M., Orlandi, V. T., Crema, F., & Giaroni, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061482 · Cited by 330 · see citing works
The SLC1 high-affinity glutamate and neutral amino acid transporter family
Kanai, Y., Clémençon, B., Simonin, A., Leuenberger, M., Lochner, M., Weisstanner, M., & Hediger, M. A. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.001 · Cited by 329 · see citing works
The blood-brain barrier and glutamate.
Hawkins, R. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462bb · Cited by 294 · see citing works
Metabolic fate and function of dietary glutamate in the gut
Burrin, D. G., & Stoll, B. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462y · Cited by 288 · see citing works
Genchi, G. (2017) · Amino Acids · doi:10.1007/s00726-017-2459-5 · Cited by 288 · see citing works
Human gut microbiota: the links with dementia development
Alkasir, R., Li, J., Li, X., Jin, M., & Zhu, B. (2016) · Protein & Cell · doi:10.1007/s13238-016-0338-6 · Cited by 283 · see citing works
Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease
Schneider, L. S. S. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.69 · Cited by 276 · see citing works
Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1856-5 · Cited by 270 · see citing works
Danysz, W., Parsons, C. G., Möbius, H. J., Stöffler, A., & Quack, G. (2000) · Neurotoxicity Research · doi:10.1007/bf03033787 · Cited by 262 · see citing works
Add-on Treatment of Benzoate for Schizophrenia
Lane, H., Lin, C., Green, M. F., Hellemann, G., Huang, C., Chen, P., Tun, R., Chang, Y.-C., & Tsai, G. E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.2159 · Cited by 229 · see citing works
Self-citationThe Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y. (2018) · Cell · doi:10.1016/j.cell.2018.06.051 · Cited by 224 · see citing works
Amyloid β peptide oligomers directly activate NMDA receptors
Texidó, L., Martı́n-Satué, M., Alberdi, E. M., Solsona, C., & Matute, C. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.02.001 · Cited by 223 · see citing works
Neuronal vs glial glutamate uptake: Resolving the conundrum
Danbolt, N. C., Furness, D. N., & Zhou, Y. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.05.009 · Cited by 214 · see citing works
Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease
Scott, H. A., Gebhardt, F. M., Mitrovic, A. D., Vandenberg, R. J., & Dodd, P. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.008 · Cited by 202 · see citing works
Kirvell, S. L., Esiri, M. M., & Francis, P. T. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03935.x · Cited by 187 · see citing works
Wang, M., Wan, J., Rong, H., He, F., Wang, H., Zhou, J., Cai, C., Wang, Y., Xu, R., Yin, Z., et al. (2019) · mSystems · doi:10.1128/msystems.00321-18 · Cited by 181 · see citing works
Opstvedt, J., Miller, R., Hardy, R. W., & Spinelli, J. (1984) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00124a056 · Cited by 170 · see citing works
Pathogenic microbes, the microbiome, and Alzheimer’s disease (AD)
Hill, J. M., Clément, C., Pogue, A. I., Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00127 · Cited by 169 · see citing works
Selective Cognitive Impairments Associated with NMDA Receptor Blockade in Humans
Rowland, L. M., Astur, R. S., Jung, R. E., Bustillo, J., Lauriello, J., & Yeo, R. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300642 · Cited by 167 · see citing works
Pursuing Human-Relevant Gut Microbiota-Immune Interactions
Spencer, S. P., Fragiadakis, G. K., & Sonnenburg, J. L. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.002 · Cited by 160 · see citing works
Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes Epidemic
Velmurugan, G., Ramprasath, T., Mithieux, G., Swaminathan, K., & Ramasamy, S. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.05.001 · Cited by 159 · see citing works
Udaka, S. (1960) · Journal of Bacteriology · doi:10.1128/jb.79.5.754-755.1960 · Cited by 152 · see citing works
Glutamate signaling in the pathophysiology and therapy of schizophrenia
Lin, C., Lane, H., & Tsai, G. E. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.023 · Cited by 150 · see citing works
Self-citationThe effects of gut microbiota on CNS function in humans
Tillisch, K. (2014) · Gut Microbes · doi:10.4161/gmic.29232 · Cited by 144 · see citing works
Survival Signaling Pathways Activated by NMDA Receptors
Hetman, M., & Kharebava, G. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606777057553 · Cited by 141 · see citing works
Le, W., Colom, L. V., Xie, W., SMITH, R. G., Alexianu, M. E., & Appel, S. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00450-5 · Cited by 138 · see citing works
Pál, B. Z. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2837-5 · Cited by 135 · see citing works
Marcone, G. L., Rosini, E., Crespi, E., & Pollegioni, L. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10264-9 · Cited by 132 · see citing works
Lin, C., Chen, P.-K., Chang, Y., Chuo, L.-J., Chen, Y.-S., Tsai, G. E., & Lane, H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.010 · Cited by 130 · see citing works
Self-citationMcCoy, A. J., Adams, N. E., Hudson, A. O., Gilvarg, C., Leustek, T., & Maurelli, A. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608643103 · Cited by 129 · see citing works
Glutamate and the glutamate receptor system: a target for drug action
Bleich, S., R�mer, K., Wiltfang, J., & Kornhuber, J. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.933 · Cited by 125 · see citing works
Perry, T. L., Yong, V. W., Bergeron, C., Hansen, S., & Jones, K. L. (1987) · Annals of Neurology · doi:10.1002/ana.410210403 · Cited by 121 · see citing works
Gut microbiota of mice putatively modifies amino acid metabolism in the host brain
Kawase, T., Nagasawa, M., Ikeda, H., Yasuo, S., Koga, Y., & Furuse, M. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517000678 · Cited by 119 · see citing works
β-Amyloid Modulation of Synaptic Transmission and Plasticity
Venkitaramani, D. V., Chin, J., Netzer, W. J., Gouras, G. K., Lesné, S., Malinow, R., & Lombroso, P. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3478-07.2007 · Cited by 115 · see citing works
The Roles of Dietary Glutamate in the Intestine
Tomé, D. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000494777 · Cited by 114 · see citing works
A Glutamic Acid-Producing Lactic Acid Bacteria Isolated from Malaysian Fermented Foods
Zareian, M., Ebrahimpour, A., Bakar, F. A., Mohamed, A. K. S., Forghani, B., Ab-Kadir, M. S. B., & Saari, N. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13055482 · Cited by 110 · see citing works
The inhibitory effects of β-amyloid on glutamate and glucose uptakes by cultured astrocytes
Parpura‐Gill, A., Beitz, D. C., & Uemura, E. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00043-7 · Cited by 105 · see citing works
Pro-survival signalling from the NMDA receptor
Hardingham, G. E. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340936 · Cited by 100 · see citing works
Lin, C.-Y., Liang, S.-Y., Chang, Y., Ting, S.-Y., Kao, C.-L., Wu, Y., Tsai, G. E., & Lane, H. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1117654 · Cited by 97 · see citing works
Self-citationOur microbes not only produce antibiotics, they also overproduce amino acids
Sánchez, S., Rodrı́guez-Sanoja, R., Ramos, A., & Demain, A. L. (2017) · The Journal of Antibiotics · doi:10.1038/ja.2017.142 · Cited by 96 · see citing works
Koh, J., & Choi, D. W. (1991) · Brain Research · doi:10.1016/0006-8993(91)91140-v · Cited by 93 · see citing works
Arias, C., Arrieta, I., & Tapia, R. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490410416 · Cited by 93 · see citing works
Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging
Lin, C., Yang, H.-T., Chiu, C.-C., & Lane, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-13951-7 · Cited by 93 · see citing works
Self-citationMonti, B., & Contestabile, A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00189.x · Cited by 92 · see citing works
Substrate selectivity in arginine-dependent acid resistance in enteric bacteria
Tsai, M.-F., & Miller, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301442110 · Cited by 91 · see citing works
Metabolic functions of the human gut microbiota: the role of metalloenzymes
Rajakovich, L. J., & Balskus, E. P. (2018) · Natural Product Reports · doi:10.1039/c8np00074c · Cited by 89 · see citing works
Chromatographic determination of D-amino acids as native constituents of vegetables and fruits
Brückner, H. J., & Westhauser, T. (1994) · Chromatographia · doi:10.1007/bf02278756 · Cited by 83 · see citing works
How Glutamate Is Managed by the Blood–Brain Barrier
Hawkins, R. A., & Vinã, J. R. (2016) · Biology · doi:10.3390/biology5040037 · Cited by 82 · see citing works
Fernández-Tomé, P., Brera, B., Arévalo, M., & CEBALLOS, M. L. D. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.006 · Cited by 79 · see citing works
Lin, C., Yang, H.-T., & Lane, H. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172760 · Cited by 79 · see citing works
Self-citationGlutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition
Palomo-Buitrago, M. E., Sabater, M., Moreno‐Navarrete, J. M., Caballano‐Infantes, E., Arnoriaga‐Rodríguez, M., Coll, C., Ramió, L., Palomino‐Schätzlein, M., Gutiérrez-Carcedo, P., Pérez‐Brocal, V., et al. (2019) · Acta Diabetologica · doi:10.1007/s00592-019-01313-w · Cited by 76 · see citing works
Ye, C., Walsh, D. M., Selkoe, D. J., & Hartley, D. M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.060 · Cited by 75 · see citing works
Jin, D., Miyahara, T., Oe, T., & Toyo’oka, T. (1999) · Analytical Biochemistry · doi:10.1006/abio.1998.3090 · Cited by 75 · see citing works
d-Amino Acids and Lactic Acid Bacteria
Kobayashi, J. (2019) · Microorganisms · doi:10.3390/microorganisms7120690 · Cited by 75 · see citing works
Mutaguchi, Y., Ohmori, T., Akano, H., Doi, K., & Ohshima, T. (2013) · SpringerPlus · doi:10.1186/2193-1801-2-691 · Cited by 73 · see citing works
D-Glutamate is metabolized in the heart mitochondria
Ariyoshi, M., Katane, M., Hamase, K., Miyoshi, Y., Nakane, M., Hoshino, A., Okawa, Y., Mita, Y., Kaimoto, S., Uchihashi, M., et al. (2017) · Scientific Reports · doi:10.1038/srep43911 · Cited by 71 · see citing works
Occurrence of D-amino acids in food
Palla, G., Marchelli, R., Dossena, A., & Casnati, G. (1989) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)91414-6 · Cited by 70 · see citing works
Janeczko, M., Stoll, B., Chang, X., Guan, X., & Burrin, D. G. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2384 · Cited by 64 · see citing works
Domingues, A. M. D. J., Almeida, S., DACRUZESILVA, E., Oliveira, C. R., & Rego, A. C. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.03.001 · Cited by 58 · see citing works
Bai, W., & Zhou, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00400 · Cited by 57 · see citing works
Wong, D. Y., Atiya, S., Fogarty, J., Montero‐Odasso, M., Pasternak, S., Brymer, C., BORRIE, M. J., & Bartha, R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190773 · Cited by 56 · see citing works
Nakayama, Y., Hashimoto, K.-I., Sawada, Y., Sokabe, M., Kawasaki, H., & Martinac, B. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0452-1 · Cited by 49 · see citing works
werf, P. V. D., & Meister, A. (1975) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122884.ch7 · Cited by 47 · see citing works
Reaction Mechanism of Glutamate Racemase, a Pyridoxal Phosphate-Independent Amino Acid Racemase
Choi, S., Esaki, N., Yoshimura, T., & Soda, K. (1992) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123853 · Cited by 47 · see citing works
Bunjapamai, S., Mahoney, R. R., & Fagerson, I. S. (1982) · Journal of Food Science · doi:10.1111/j.1365-2621.1982.tb07654.x · Cited by 46 · see citing works
Kawamoto, E. M., Lepsch, L. B., Cury‐Boaventura, M. F., Munhoz, C. D., Lima, L. S., Yshii, L., Avellar, M. C. W., Curi, R., Mattson, M. P., & Scavone, C. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21548 · Cited by 43 · see citing works
Haÿs, S., Ordonez, J. M., Burrin, D. G., & Sunehag, A. L. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e318123f719 · Cited by 42 · see citing works
Detection of free D ‐amino acids in food by chiral phase capillary gas chromatography
Brückner, H. J., & Hausch, M. (1989) · Journal of High Resolution Chromatography · doi:10.1002/jhrc.1240121012 · Cited by 41 · see citing works
Immunocytochemical visualization of d-glutamate in the rat brain
Mangas, A., Coveñas, R., Bodet, D., Geffard, M., Aguilar, L. A., & Yajeya, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.045 · Cited by 39 · see citing works
Brückner, H. J., & Hausch, M. (1990) · Milk science international/Milchwissenschaft · Cited by 31 · see citing works
Howley, E., Bestwick, M., Fradley, R. L., Harrison, H., Leveridge, M., Okada, K., Fieldhouse, C., Farnaby, W., Canning, H. E., Sykes, A. P., et al. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2367-9 · Cited by 30 · see citing works
van der Stel, A., van Mourik, A., Łaniewski, P., van Putten, J. P. M., Jagusztyn-Krynicka, E. K., & Wösten, M. M. S. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00567 · Cited by 28 · see citing works
Dean, S. F., Whalen, K. L., & Spies, M. A. (2015) · ACS Central Science · doi:10.1021/acscentsci.5b00211 · Cited by 26 · see citing works
Jang, B.-G., In, S., Choi, B., & Kim, M.-J. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000260 · Cited by 24 · see citing works
Ger, M.-F., Rendon, G., Tilson, J. L., & Jakobsson, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012827 · Cited by 23 · see citing works
Glutamate Transporters in the Blood-Brain Barrier
Helms, H. C. C., Nielsen, C. U., Waagepetersen, H. S., & Brodin, B. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-55769-4_15 · Cited by 21 · see citing works
Vijayakumari, A. A., Menon, R. N., Thomas, B., Arun, T. M., Mohanan, N., & Kesavadas, C. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00122-7 · Cited by 20 · see citing works
How Glutamate Is Managed by the Blood-Brain BarrierPreprint
Hawkins, R. A., & Vinã, J. R. (2016) · Preprints.org · doi:10.20944/preprints201609.0077.v1 · Cited by 19 · see citing works
Bertoldi, M., Cellini, B., Paiardini, A., di Salvo, M. L., & BORRIVOLTATTORNI, C. (2003) · Biochemical Journal · doi:10.1042/bj20020875 · Cited by 19 · see citing works
Brain d-amino acids: a novel class of neuromodulators
Mothet, J., & Snyder, S. H. (2012) · Amino Acids · doi:10.1007/s00726-012-1403-y · Cited by 18 · see citing works
Investigation of the Essentiality of Glutamate Racemase in Mycobacterium smegmatis
Li, Y., Mortuza, R., Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2014) · Journal of Bacteriology · doi:10.1128/jb.02090-14 · Cited by 18 · see citing works
Raj, D. S., Langford, M. P., Krueger, S., Shelton, M., & Welbourne, T. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e214 · Cited by 16 · see citing works
Isolation of themurIgene fromBrevibacterium lactofermentumATCC 13869 encoding d-glutamate racemase
Malathi, K. C., Wachi, M., & Nagai, K. (1999) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1999.tb13619.x · Cited by 13 · see citing works
Dyakin, V., Lucas, J. P., Dyakina‐Fagnano, N. V., Posner, E. V., & Vadász, C. (2017) · Neurology and Neuroscience Research · doi:10.24983/scitemed.nnr.2017.00028 · Cited by 12 · see citing works
Böhmer, N., Dautel, A., EISELE, T. A., & Fischer, L. (2012) · Protein Expression and Purification · doi:10.1016/j.pep.2012.11.012 · Cited by 12 · see citing works
Chirality and drugs used to treat psychiatric disorders
Baker, G. B., Prior, T. I., & Coutts, R. T. (2002) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0260 · Cited by 11 · see citing works
Coveñas, R., Mangas, A., Sánchez, M. L., Cadena, D., Husson, M., & Geffard, M. (2018) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2017.0023 · Cited by 8 · see citing works
Malathi, K. C. (1999) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(99)00192-5 · Cited by 2 · see citing works
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Chen, Y., Xu, J., & Chen, Y. (2021) · Nutrients · doi:10.3390/nu13062099 · Cited by 917 · see citing works
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Dicks, L. M. T. (2022) · Microorganisms · doi:10.3390/microorganisms10091838 · Cited by 482 · see citing works
Brain–gut–microbiota axis in depression: A historical overview and future directions
Chang, L., Wei, Y., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.004 · Cited by 395 · see citing works
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
Gut liver brain axis in diseases: the implications for therapeutic interventions
Yan, M., Man, S., Sun, B., Ma, L., Guo, L., Huang, L., & Gao, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01673-4 · Cited by 301 · see citing works
Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor
Wei, Y., Chang, L., & Hashimoto, K. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01121-1 · Cited by 248 · see citing works
Shabbir, U., Arshad, M. S., Sameen, A., & Oh, D.-H. (2021) · Nutrients · doi:10.3390/nu13020690 · Cited by 191 · see citing works
Checa-Ros, A., Jeréz-Calero, A., Molina-Carballo, A., Campoy, C., & Muñoz-Hoyos, A. (2021) · Nutrients · doi:10.3390/nu13010249 · Cited by 164 · see citing works
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Huang, Q., Liao, C., Ge, F., Ao, J., & Liu, T. (2022) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2022.100002 · Cited by 165 · see citing works
Park, S.-H., Lee, J. H., Shin, J., Kim, J.-S., Cha, B., Lee, S., Kwon, K. S., Shin, Y. W., & Choi, S. H. (2021) · Current Medical Research and Opinion · doi:10.1080/03007995.2021.1957807 · Cited by 157 · see citing works
Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2076064 · Cited by 156 · see citing works
Eicher, T. P., & Mohajeri, M. H. (2022) · Nutrients · doi:10.3390/nu14132661 · Cited by 148 · see citing works
Mhanna, A., Martini, N., Hmaydoosh, G., Hamwi, G., Jarjanazi, M., Zaifah, G., Kazzazo, R., Mohamad, A. H., & Alshehabi, Z. (2024) · Medicine · doi:10.1097/md.0000000000037114 · Cited by 144 · see citing works
Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions
Hashimoto, K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02287-6 · Cited by 143 · see citing works
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Muller, E., Shiryan, I., & Borenstein, E. (2024) · Nature Communications · doi:10.1038/s41467-024-46888-3 · Cited by 132 · see citing works
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Munawar, N., Ahsan, K., Muhammad, K., Ahmad, A., Anwar, M. A., Shah, I., Ameri, A. A., & Mughairbi, F. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147671 · Cited by 105 · see citing works
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Mishima, Y., & Ishihara, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228664 · Cited by 89 · see citing works
Pentón-Rol, G., Marín-Prida, J., & McCarty, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210408123807 · Cited by 73 · see citing works
Farmen, K., Tofiño-Vian, M., & Iovino, F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.680858 · Cited by 70 · see citing works
Liu, X., Liu, Y., Liu, J., Zhang, H., Shan, C., Guo, Y., Gong, X., Cui, M., Li, X., & Tang, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382223 · Cited by 69 · see citing works
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Lei, W., Cheng, Y., Liu, X., Gao, J., Zhu, Z., Ding, W., Xu, X., Li, Y., Ling, Z., Jiang, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582119 · Cited by 68 · see citing works
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Fan, Y.-Y., Luo, R.-Y., Wang, M., Yuan, C.-Y., Sun, Y., & Jing, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1446523 · Cited by 69 · see citing works
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Kolobaric, A., Andreescu, C., Jašarević, E., Hong, C. H., Roh, H., Cheong, J. Y., Kim, Y., Shin, T. S., Kang, C. S., Kwon, C. O., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02551-3 · Cited by 62 · see citing works
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Bioque, M., González-Rodríguez, A., García‐Rizo, C., Cobo, J., Monreal, J. A., Usall, J., Soria, V., & Labad, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110130 · Cited by 58 · see citing works
Lin, C., Chen, P.-K., Wang, S., & Lane, H. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.6156 · Cited by 58 · see citing works
Self-citationOshaghi, M., Kourosh‐Arami, M., & Roozbehkia, M. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06413-0 · Cited by 55 · see citing works
Cutuli, D., Decandia, D., Giacovazzo, G., & Coccurello, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914686 · Cited by 58 · see citing works
Ruiz‐González, C., Román, P., Rueda‐Ruzafa, L., Rodríguez-Arrastia, M. J., & Cardona, D. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110189 · Cited by 53 · see citing works
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Jung, Y. H., Chae, C. W., & Han, H. J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01282-3 · Cited by 42 · see citing works
The emerging roles of neuroactive components produced by gut microbiota
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Shiadeh, S. M. J., Chan, W. K., Rasmusson, S., Hassan, N., Joca, S. R. L., Westberg, L., Elfvin, A., Mallard, C. E., & Ardalan, M. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03504-2 · Cited by 49 · see citing works
Lane, H., Tu, C., Lin, W.-C., & Lin, C. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab001 · Cited by 41 · see citing works
Self-citationGut microbiota and its metabolites in Alzheimer’s disease: from pathogenesis to treatment
Zou, X., Zou, G., Zou, X., Wang, K., & Chen, Z. (2024) · PeerJ · doi:10.7717/peerj.17061 · Cited by 40 · see citing works
Dubey, S., & Singh, E. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01173-5 · Cited by 39 · see citing works
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Lu, Y., Yu, X., Wang, Z., Kong, L., Jiang, Z., Shang, R., Zhong, X., Lv, S., Zhang, G., Gao, H., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156012 · Cited by 39 · see citing works
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Gu, X., Zhou, Y., Zhang, Y., Wang, L., Gao, W., Luo, K., Sun, B., Li, T., Wang, H., Si, N., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01587-5 · Cited by 38 · see citing works
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Errico, F., Cuomo, M., Canu, N., Caputo, V., & Usiello, A. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140471 · Cited by 33 · see citing works
Liu, G., Gu, K., Liu, X., Jia, G., Zhao, H. Y., Chen, X., & Wang, J. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112597 · Cited by 36 · see citing works
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Gong, Y., Chen, A., Zhang, G., Shen, Q., Zou, L., Li, J., Miao, Y., & Liu, W. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85259 · Cited by 33 · see citing works
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D-Amino acids from foods and gut microbiota and their effects in health and disease
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Nakayama, Y. (2021) · Microorganisms · doi:10.3390/microorganisms9010201 · Cited by 29 · see citing works
Protective mechanism of Paeonol on central nervous system
Wu, R., Liu, Y., Zhang, F., Dai, S., Xue, X., Peng, C., Li, Y., & Li, Y. (2023) · Phytotherapy Research · doi:10.1002/ptr.8049 · Cited by 28 · see citing works
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Pfaffinger, J. M., Hays, K. E., Seeley, J., Babu, P. R., & Ryznar, R. J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1600148 · Cited by 35 · see citing works
Nuzzo, T., Miroballo, M., Casamassa, A., Mancini, A., Gaetani, L., Nisticò, R., Eusebi, P., Katane, M., Homma, H., Calabresi, P., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140537 · Cited by 28 · see citing works
Lloyd, M. D., Yevglevskis, M., Nathubhai, A., James, T. D., Threadgill, M. D., & Woodman, T. J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00540a · Cited by 27 · see citing works
Meng, Y., & Shen, H.-L. (2022) · Journal of Pain Research · doi:10.2147/jpr.s367982 · Cited by 18 · see citing works
Chakraborty, P., Banerjee, D., Majumder, P., & Sarkar, J. (2024) · Medicine in Microecology · doi:10.1016/j.medmic.2024.100104 · Cited by 27 · see citing works
Shi, L., Feng, Y., Wang, J., Xiao, R., Wang, L., Tian, P., Jin, X., Zhao, J., & Wang, G. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123107 · Cited by 26 · see citing works
Trisal, A., Singh, I., Garg, G., Jorwal, K., & Singh, A. K. (2024) · 3 Biotech · doi:10.1007/s13205-024-04187-0 · Cited by 27 · see citing works
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Liang, Y.-J., Su, Q., Sheng, Z., Weng, Q., Niu, Y., Zhou, H., & Liu, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.830824 · Cited by 25 · see citing works
Lapidot, Y., Reshef, L., Maya, M., Cohen, D., Gophna, U., & Muhsen, K. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00271-6 · Cited by 23 · see citing works
Han, Y., Quan, X., Chuang, Y. C., Liang, Q., Li, Y., Yuan, Z., Bian, Y., Wei, L., Wang, J., & Zhao, Y. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.909 · Cited by 25 · see citing works
Li, H., Huang, Y., Liang, L., Li, H., Li, S., Feng, Y., Feng, S., Wu, K., & Wu, F. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.03.053 · Cited by 25 · see citing works
Singh, S., Singh, P. K., & Kumar, A. (2022) · Infection and Immunity · doi:10.1128/iai.00252-22 · Cited by 23 · see citing works
Liang, J., Wang, Y., Liu, B., Dong, X., Cai, W., Zhang, N., & Zhang, H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14704 · Cited by 27 · see citing works
Zhang, S., Qian, Y., Li, Q., Xu, X., Li, X., Wang, C., Cai, H., Zhu, J., & Yu, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.750704 · Cited by 23 · see citing works
Effects of gut microbiota and probiotics on Alzheimer’s disease
Guo, L., Xu, J., Du, Y., Wu, W., Nie, W., Zhang, D., Luo, Y., Lu, H., Lei, M., Xiao, S., et al. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0203 · Cited by 23 · see citing works
Navalon-Monllor, V., Soriano-Romaní, L., Silva, M., Hazas, M. L. D. L., Hernando-Quintana, N., Suárez-Diéguez, T., Morell, P., & Nieto, J. A. (2023) · Food & Function · doi:10.1039/d3fo01257c · Cited by 23 · see citing works
Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders
Villavicencio-Tejo, F., Olesen, M. A., Navarro, L., Calisto, N., Iribarren, C., GARCÍA, K. P., Corsini, G., & Quintanilla, R. A. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00681-0 · Cited by 23 · see citing works
Kulkarni, R., Kumari, S., Dhapola, R., Sharma, P., Singh, S. K., Medhi, B., & HariKrishnaReddy, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04545-2 · Cited by 23 · see citing works
Exploring the potential of probiotics in Alzheimer's disease and gut dysbiosis
Sowmiya, S., Ls, D., Rajendran, P., Harikrishnan, N., & Ankul Singh, S. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.11.004 · Cited by 22 · see citing works
Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut
Vergroesen, J. E., Jarrar, Z. A., Weiß, S., Frost, F., Ansari, A. S., Nguyen, P., Kraaij, R., Medina‐Gómez, C., Völzke, H., Tost, F., et al. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.2.7 · Cited by 22 · see citing works
Gupta, S., Gupta, A. K., Mehan, S., Khan, Z., Gupta, G. D., & Narula, A. S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.021 · Cited by 21 · see citing works
Bacteria-driven bio-therapy: From fundamental studies to clinical trials
Yu, Y., Lin, S., Chen, Z., Qin, B. Y., He, Z., Cheng, M., Sun, M., & Sun, J. Y. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101731 · Cited by 21 · see citing works
The Gut Microbiome and Alzheimer’s Disease: A Growing Relationship
Zerdan, M. B., Hebbo, E., Hijazi, A., Gemayel, M. E., Nasr, J., Nasr, D., Yaghi, M., Bouferraa, Y., & Nagarajan, A. (2022) · Current Alzheimer Research · doi:10.2174/1567205020666221227090125 · Cited by 20 · see citing works
Shi, J., Zhang, X., Chen, J., Shen, R.-S., Cui, H., & Wu, H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1275860 · Cited by 20 · see citing works
Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?
Zhang, S., Lu, J., Jin, Z., Xu, H., Zhang, D., Chen, J., & Wang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1459655 · Cited by 24 · see citing works
Bidirectional regulation of the brain–gut–microbiota axis following traumatic brain injury
You, X., Niu, L., Fu, J., Ge, S., Shi, J., Zhang, Y., & Zhuang, P. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00088 · Cited by 19 · see citing works
Unraveling the Vicious Cycle: Oxidative Stress and Neurotoxicity in Neurodegenerative Diseases
Wang, X., Dong, B., Gan, Q., Li, J., Wu, P., Guan, Y., & Wang, J. (2025) · FASEB BioAdvances · doi:10.1096/fba.2025-00093 · Cited by 23 · see citing works
Cutuli, D., Giacovazzo, G., Decandia, D., & Coccurello, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1010169 · Cited by 18 · see citing works
The Role of the Microbiome in First Episode of Psychosis
Nuncio-Mora, L., Lanzagorta, N., Nicolini, H., Sarmiento, E., Ortiz, G., Sosa, F., & Mendoza, A. D. G. (2023) · Biomedicines · doi:10.3390/biomedicines11061770 · Cited by 18 · see citing works
Kumar, U., Kumar, A., Singh, S., Arya, P., Singh, S. K., Chaurasia, R. N., Singh, A. K., & Kumar, D. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00700-z · Cited by 18 · see citing works
Long, J., Zhang, J., Zeng, X., Wang, M., & Wang, N. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70101 · Cited by 17 · see citing works
Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090724 · Cited by 20 · see citing works
Huang, W., Wang, Z., Wang, G., Li, K., Jin, Y., & Zhao, F. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119813 · Cited by 17 · see citing works
Imarisio, A., Yahyavi, I., Gasparri, C., Hassan, A., Avenali, M., Maio, A. D., Buongarzone, G., Galandra, C., Picascia, M., Filosa, A., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02991-z · Cited by 17 · see citing works
Favero, F., Barberis, E., Gagliardi, M., Espinoza, S., Contu, L., Gustincich, S., Boccafoschi, F., Borsotti, C., Lim, D., Rubino, V., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273036 · Cited by 16 · see citing works
Fu, L., Zhu, W., Tian, D., Tang, Y., Ye, Y., Wei, Q., Zhang, C., Qiu, W., Qin, D., Yang, X., et al. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s356934 · Cited by 16 · see citing works
Xi, Y., Li, W., Wang, J., Yu, M., Zeng, X., Li, H., & Li, J. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250141 · Cited by 17 · see citing works
Gupta, S., Dinesh, S., & Sharma, S. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249271548231115071021 · Cited by 16 · see citing works
Oral Health and Cognitive Decline: A Systematic Review of the Periodontitis–Alzheimer’s Connection
Inchingolo, A. M., Inchingolo, A. D., Piras, F., Avantario, P., Ferrante, L., Paduanelli, G., Inchingolo, F., Palermo, A., Dipalma, G., & Corsalini, M. (2025) · Applied Sciences · doi:10.3390/app15126728 · Cited by 15 · see citing works
Lin, C., & Lane, H. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac027 · Cited by 15 · see citing works
Self-citation
- Authors
- Chang, C.-H., Lin, C.-H., & Lane, H.-Y.
- Affiliations
- China Medical University (TW)
- Chang Gung University (TW)
- Asia University (TW)
- Corresponding author
- Lin, Chieh-Hsin
- Lane, Hsien-Yuan
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-04-11
- Volume
- 21
- Issue
- 8
- Pages
- 2676
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7215955
- OpenAlex
- W3015756776
- Cited by
- 191
- References
- 132
- Citations by year
- 2026: 14 · 2025: 40 · 2024: 47 · 2023: 31 · 2022: 32 · 2021: 19 · 2020: 8
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- China Medical University Hospital (DMR‐108‐BC2)
- Chang Gung Medical Foundation
- Ministry of Science and Technology, Taiwan (MOST108-2628-B182A-002, MOST108-2314-B039-002, MOST107-2628-B182A-002, MOST107-2632-B039-001)
- National Health Research Institutes (NHRI-EX108-10731NI)
- China Medical University
- Division of Materials Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- D-glutamic acid, gut microbiota, Alzheimer's disease, dementia, brain-gut-microbiota axis, glutamate metabolism, NMDA receptor, glutamate racemase, Bacteroides vulgatus, Campylobacter jejuni, Corynebacterium glutamicum, Brevibacterium lactofermentum, cognitive function, neurodegenerative diseases, Parkinson's disease
- MeSH terms
- Gastrointestinal Microbiome, Alzheimer Disease, Animals, Blood-Brain Barrier, Brain, Diet, Disease Susceptibility, Humans, Synaptic Transmission, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Glutamic Acid, Metabolic Networks and Pathways
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