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Cell Membranes Resist Flow
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Abstract
The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs quickly in cell-attached blebs but is largely suppressed in intact cells. The failure of tension to propagate in cells is explained by a fluid dynamical model that incorporates the flow resistance from cytoskeleton-bound transmembrane proteins. Perturbations to tension propagate diffusively, with a diffusion coefficient D σ ∼0.024 μm 2/s in HeLa cells. In primary endothelial cells, local increases in membrane tension lead only to local activation of mechanosensitive ion channels and to local vesicle fusion. Thus, membrane tension is not a mediator of long-range intracellular signaling, but local variations in tension mediate distinct processes in sub-cellular domains.
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“Indeed, a substantial spatial gradient of membrane tension is thought to persist due to attachment of cytoskeleton to the membrane28.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [28]
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Cites
The Fluid Mosaic Model of the Structure of Cell Membranes
Singer, S. J., & Nicolson, G. L. (1972) · Science · doi:10.1126/science.175.4023.720 · Cited by 9,158
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Brownian motion in biological membranes
Saffman, P. G., & Delbrück, M. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.3111 · Cited by 1,773
Micropipette aspiration of living cells
Hochmuth, R. M. (2000) · Journal of Biomechanics · doi:10.1016/s0021-9290(99)00175-x · Cited by 1,428
Piezo1 integration of vascular architecture with physiological force
Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,250
Phases and phase transitions of the phosphatidylcholines
Koynova, R. D., & Caffrey, M. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00006-9 · Cited by 1,155
Entropy-driven tension and bending elasticity in condensed-fluid membranes
Evans, E., & Rawicz, W. (1990) · Physical Review Letters · doi:10.1103/physrevlett.64.2094 · Cited by 1,129
Kusumi, A., Nakada, C., Ritchie, K. P., Murase, K., Suzuki, K. G. N., Murakoshi, H., Kasai, R. S., Kondo, J., & Fujiwara, T. K. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144637 · Cited by 1,122
Improving the photostability of bright monomeric orange and red fluorescent proteins
Shaner, N. C., Lin, M. Z., McKeown, M. R., Steinbach, P. A., Hazelwood, K. L., Davidson, M. W., & Tsien, R. Y. (2008) · Nature Methods · doi:10.1038/nmeth.1209 · Cited by 994
Emerging roles for lipids in shaping membrane-protein function
Phillips, R., Ursell, T. S., Wiggins, P. A., & Sens, P. (2009) · Nature · doi:10.1038/nature08147 · Cited by 988
Flagged first, then by citations
3 of the 95 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Ellefsen, 2018, Piezo1 calcium flickers localize to hotspots of cellular traction forces, bioRxiv
- Thottacherry, 2017, Mechanochemical feedback and control of endocytosis and membrane tension, bioRxiv
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Janmey, P. A., Fletcher, D. A., & Reinhart‐King, C. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 425
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Interplay between mechanics and signalling in regulating cell fate
Belly, H. D., Paluch, E. K., & Chalut, K. J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00472-z · Cited by 295
The Lateral Organization and Mobility of Plasma Membrane Components
Jacobson, K., Liu, P., & Lagerholm, B. C. (2019) · Cell · doi:10.1016/j.cell.2019.04.018 · Cited by 276
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
Cox, C. D., Bavi, N., & Martinac, B. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.075 · Cited by 240
Structural and functional consequences of reversible lipid asymmetry in living membranes
Doktorova, M., Symons, J. L., & Levental, I. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-00688-0 · Cited by 241
Wang, J., Jiang, J., Yang, X., Zhou, G., Wang, L., & Xiao, B. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110342 · Cited by 235
Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers
Ellefsen, K. L., Holt, J. R., Chang, A. C., Nourse, J. L., Arulmoli, J., Mekhdjian, A. H., Abuwarda, H., Tombola, F., Flanagan, L. A., Dunn, A. R., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0514-3 · Cited by 217
Pay attention to membrane tension: Mechanobiology of the cell surface
Sitarska, E., & Diz-Muñoz, A. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.04.001 · Cited by 203
The plasma membrane as a mechanochemical transducer
Roux, A. L., Quiroga, X., Walani, N., Arroyo, M., & Roca‐Cusachs, P. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0221 · Cited by 196
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels
Jiang, Y., Yang, X., Jiang, J., & Xiao, B. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.01.008 · Cited by 198
An atlas of nano-enabled neural interfaces
Ledesma, H. A., Li, X., Carvalho-de-Souza, J. L., Wei, W., Bezanilla, F., & Tian, B. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0487-x · Cited by 188
Steinkühler, J., Sezgin, E., Urbančič, I., Eggeling, C., & Dimova, R. (2019) · Communications Biology · doi:10.1038/s42003-019-0583-3 · Cited by 176
Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration
Bisaria, A., Hayer, A., Garbett, D., Cohen, D. J., & Meyer, T. (2020) · Science · doi:10.1126/science.aay7794 · Cited by 174
Yao, M., Tijore, A., Cheng, D., Li, J. V., Hariharan, A., Martinac, B., Nhieu, G. T. V., Cox, C. D., & Sheetz, M. P. (2022) · Science Advances · doi:10.1126/sciadv.abo1461 · Cited by 177
Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration
Hetmanski, J. H. R., Belly, H. D., Busnelli, I., Waring, T., Nair, R. V., Sokleva, V., Dobre, O., Cameron, A. J. M., Gauthier, N. C., Lamaze, C., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.09.006 · Cited by 171
Akamatsu, M., Vasan, R., Serwas, D., Ferrin, M. A., Rangamani, P., & Drubin, D. G. (2020) · eLife · doi:10.7554/elife.49840 · Cited by 148
Cell protrusions and contractions generate long-range membrane tension propagation
Belly, H. D., Yan, S., da Rocha, H. B., Ichbiah, S., Town, J. P., Zager, P. J., Estrada, D. C., Meyer, K., Turlier, H., Bustamante, C., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.014 · Cited by 138
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Kopf, A., Renkawitz, J., Hauschild, R., Girkontaite, I., Tedford, K., Merrin, J., Thorn-Seshold, O., Trauner, D., Häcker, H., Fischer, K.-D., et al. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201907154 · Cited by 125
Surface tension and viscosity of protein condensates quantified by micropipette aspiration
Wang, H., Kelley, F. M., Milovanović, D., Schuster, B. S., & Shi, Z. (2021) · Biophysical Reports · doi:10.1016/j.bpr.2021.100011 · Cited by 132
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Kameritsch, P., & Renkawitz, J. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.06.007 · Cited by 132
Osmani, N., Follain, G., García-León, M. J., Lefèbvre, O., Busnelli, I., Larnicol, A., Harlepp, S., & Goetz, J. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.102 · Cited by 122
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Wang, S., Wang, B., Shi, Y. X., Möller, T., Stegmeyer, R. I., Strilić, B., Li, T., Yuan, Z., Wang, C., Wettschureck, N., et al. (2022) · Blood · doi:10.1182/blood.2021014614 · Cited by 128
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Buyan, A., Cox, C. D., Barnoud, J., Li, J., Chan, H. S. M., Martinac, B., Marrink, . J., & Corry, B. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.07.043 · Cited by 111
Membrane curvature governs the distribution of Piezo1 in live cells
Yang, S., Miao, X., Arnold, S., Li, B., Ly, A. T., Wang, H., Wang, M., Guo, X., Pathak, M. M., Zhao, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35034-6 · Cited by 106
Self-citationTsujita, K., Satow, R., Asada, S., Nakamura, Y., Arnes, L., Sako, K., Fujita, Y., Fukami, K., & Itoh, T. (2021) · Nature Communications · doi:10.1038/s41467-021-26156-4 · Cited by 101
The importance of water and hydraulic pressure in cell dynamics
Li, Y., Konstantopoulos, K., Zhao, R., Mori, Y., & Sun, S. X. (2020) · Journal of Cell Science · doi:10.1242/jcs.240341 · Cited by 98
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Alimohamadi, H., & Rangamani, P. (2018) · Biomolecules · doi:10.3390/biom8040120 · Cited by 87
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Niethammer, P. (2021) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120319-030049 · Cited by 83
Verkest, C., Schaefer, I., Nees, T. A., Wang, N., Jegelka, J. M., Taberner, F. J., & Lechner, S. G. (2022) · Nature Communications · doi:10.1038/s41467-022-28974-6 · Cited by 79
Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis
Stassen, O. M. J. A., Ristori, T., & Sahlgren, C. (2020) · Journal of Cell Science · doi:10.1242/jcs.250738 · Cited by 75
Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling
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Graziano, B. R., Town, J. P., Sitarska, E., Nagy, T. L., Fošnarič, M., Penič, S., Iglič, A., Kralj‐Iglič, V., Gov, N. S., Diz-Muñoz, A., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000457 · Cited by 74
PIEZO1-Mediated Currents Are Modulated by Substrate Mechanics
Bavi, N., Richardson, J., Heu, C., Martinac, B., & Poole, K. (2019) · ACS Nano · doi:10.1021/acsnano.9b07499 · Cited by 77
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Lolo, F., Walani, N., Seemann, E. A., Zalvidea, D., Pavón, D. M., Cojoc, G., Zamai, M., de Lesegno, C. V., Martínez, F., Sánchez‐Álvarez, M., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-01034-3 · Cited by 72
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Sochacki, K. A., & Taraska, J. W. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.12.002 · Cited by 67
Cell membrane mechanics and mechanosensory transduction
Martinac, B., Nikolaev, Y. A., Silvani, G., Bavi, N., Romanov, V., Nakayama, Y., Martinac, A. D., Rohde, P. R., Bavi, O., & Cox, C. D. (2020) · Current topics in membranes · doi:10.1016/bs.ctm.2020.08.002 · Cited by 71
Dynamic interplay between cell membrane tension and clathrin‐mediated endocytosis
Djakbarova, U., Madraki, Y., Chan, E. T., & Kural, C. (2021) · Biology of the Cell · doi:10.1111/boc.202000110 · Cited by 66
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Cohen, A. E., & Shi, Z. (2019) · BioEssays · doi:10.1002/bies.201900142 · Cited by 70
Self-citationMechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling
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Lüchtefeld, I., Pivkin, I. V., Gardini, L., Zare‐Eelanjegh, E., Gäbelein, C. G., Ihle, S. J., Reichmuth, A. M., Capitanio, M., Martinac, B., Zambelli, T., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02277-8 · Cited by 68
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Bolado‐Carrancio, A., Rukhlenko, O. S., Nikonova, E. V., Tsyganov, M. A., Wheeler, A. P., García-Muñoz, A., Kölch, W., von Kriegsheim, A., & Kholodenko, B. Ν. (2020) · eLife · doi:10.7554/elife.58165 · Cited by 56
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Shi, Z., Innes-Gold, S. N., & Cohen, A. E. (2022) · Science Advances · doi:10.1126/sciadv.abo1297 · Cited by 55
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Lee, I., Imanaka, M. Y., Modahl, E. H., & Torres‐Ocampo, A. P. (2019) · ACS Omega · doi:10.1021/acsomega.9b00327 · Cited by 57
Multifunctional Biomedical Materials Derived from Biological Membranes
Wang, Y., Xu, X., Chen, X., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202107406 · Cited by 56
Chuang, Y.-C., & Chen, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886048 · Cited by 59
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Patterning and polarization of cells by intracellular flows
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Young, M. N., Lewis, A. H., & Grandl, J. M. (2022) · The Journal of General Physiology · doi:10.1085/jgp.202113044 · Cited by 57
Zhang, Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107677 · Cited by 56
Early events in endothelial flow sensing
Tanaka, K., Joshi, D., Timalsina, S., & Schwartz, M. A. (2021) · Cytoskeleton · doi:10.1002/cm.21652 · Cited by 55
Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis
Ogunmowo, T. H., Jing, H., Raychaudhuri, S., Kusick, G. F., Imoto, Y., Li, S., Itoh, K., Ma, Y., Jafri, H., Dalva, M. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38595-2 · Cited by 51
Mechanical Forces Orchestrate Brain Development
Javier‐Torrent, M., Zimmer‐Bensch, G., & Nguyen, L. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.012 · Cited by 51
SNARE-Mediated Exocytosis in Neuronal Development
Urbina, F. L., & Gupton, S. L. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00133 · Cited by 48
Biomimetic Nanomembranes: An Overview
Jakšić, Z., & Jaksic, O. M. (2020) · Biomimetics · doi:10.3390/biomimetics5020024 · Cited by 48
Alimohamadi, H., Smith, A. S., Nowak, R. B., Fowler, V. M., & Rangamani, P. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007890 · Cited by 48
Huebner, R. J., Malmi-Kakkada, A. N., Sarıkaya, S., Weng, S., Thirumalai, D., & Wallingford, J. B. (2021) · eLife · doi:10.7554/elife.65390 · Cited by 45
Kassianidou, E., Probst, D., Jäger, J., Lee, S., Roguet, A.-L., Schwarz, U. S., & Kumar, S. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.035 · Cited by 47
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Raote, I., Chabanon, M., Walani, N., Arroyo, M., Parajo, M. F. G., Malhotra, V., & Campelo, F. (2020) · eLife · doi:10.7554/elife.59426 · Cited by 46
Chataigner, L. M. P., Leloup, N. O. L., & Janssen, B. J. C. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00129 · Cited by 48
Plant cell polarity as the nexus of tissue mechanics and morphogenesis
Gorelova, V., Sprakel, J. H. B., & Weijers, D. (2021) · Nature Plants · doi:10.1038/s41477-021-01021-w · Cited by 47
Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals
Gomis Perez, C., Dudzinski, N. R., Rouches, M., Landajuela, A., Machta, B., Zenisek, D., & Karatekin, E. (2022) · Science Advances · doi:10.1126/sciadv.abl4411 · Cited by 43
Active probing of the mechanical properties of biological and synthetic vesicles
Piontek, M. C., Lira, R. B., & Roos, W. H. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.129486 · Cited by 42
Zuo, J., Zhu, E., Yin, W., Yao, C., Liao, J., Ping, X., Zhu, Y., Cai, X., Rao, Y., Feng, H. X., et al. (2023) · Chemical Science · doi:10.1039/d2sc05727a · Cited by 40
Annexin A4 trimers are recruited by high membrane curvatures in giant plasma membrane vesicles
Florentsen, C. D., Sonne, A., Moreno-Pescador, G., Pezeshkian, W., Zanjani, A. A. H., Khandelia, H., Nylandsted, J., & Bendix, P. M. (2020) · Soft Matter · doi:10.1039/d0sm00241k · Cited by 40
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Andrade, V., & Échard, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1046617 · Cited by 38
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Zhu, C., Chen, Y., & Ju, L. A. (2019) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2019.08.005 · Cited by 38
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Frey, F., & Idema, T. (2021) · Soft Matter · doi:10.1039/d0sm01758b · Cited by 35
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Kasuba, K. C., Buccino, A. P., Bartram, J., Gaub, B. M., Fauser, F. J., Ronchi, S., Kumar, S. S., Geissler, S. A., Nava, M. M., Hierlemann, A. R., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01609-1 · Cited by 35
Ion channel mediated mechanotransduction in immune cells
Atcha, H., Jairaman, A., Evans, E. L., Pathak, M. M., Cahalan, M. D., & Liu, W. F. (2021) · Current Opinion in Solid State and Materials Science · doi:10.1016/j.cossms.2021.100951 · Cited by 34
Liang, C., Huang, M. L., Li, T., Li, L., Sussman, H., Dai, Y., Siemann, D. W., Xie, M., & Tang, X. (2022) · Soft Matter · doi:10.1039/d1sm01618k · Cited by 34
Orientation of Cell Polarity by Chemical Gradients
Ghose, D., Elston, T. C., & Lew, D. J. (2022) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-110821-071250 · Cited by 33
The role of traction in membrane curvature generation
Alimohamadi, H., Vasan, R., Hassinger, J., Stachowiak, J. C., & Rangamani, P. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-02-0087 · Cited by 32
Moving through a changing world: Single cell migration in 2D vs. 3D
Pawluchin, A., & Galic, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1080995 · Cited by 31
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Metadata
- Authors
- Shi, Z., Graber, Z. T., Baumgart, T., Stone, H. A., & Cohen, A. E.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Pennsylvania (US)
- Princeton University (US)
- Corresponding author
- Cohen, Adam E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 175
- Issue
- 7
- Pages
- 1769-1779.e13
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6541487
- OpenAlex
- W2795033146
- Cited by
- 355
- References
- 95
- Citations by year
- 2026: 32 · 2025: 48 · 2024: 43 · 2023: 41 · 2022: 56 · 2021: 38 · 2020: 49 · 2019: 41 · 2018: 6
- FWCI
- 18.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Gordon and Betty Moore Foundation
- Howard Hughes Medical Institute
- NIH (R01 GM 09755, U54CA193417)
- NSF (CBET-1509347, DMS 1614907)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- membrane tension, cell membrane mechanics, mechanosensitive ion channels, vesicle fusion, endothelial cells, HeLa cells, intracellular signaling
- MeSH terms
- Animals, Cell Membrane, Cytoskeleton, Dogs, HeLa Cells, Humans, Ion Channels, Models, Biological, Signal Transduction, NIH 3T3 Cells, Mice, Rats, Madin Darby Canine Kidney Cells
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