The DOI matches its Crossref record; 92 of the 95 references it cites were found in a registry or an index.
Cell Membranes Resist Flow
Open accessPublished version of a preprint
Abstract
The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs quickly in cell-attached blebs but is largely suppressed in intact cells. The failure of tension to propagate in cells is explained by a fluid dynamical model that incorporates the flow resistance from cytoskeleton-bound transmembrane proteins. Perturbations to tension propagate diffusively, with a diffusion coefficient D σ ∼0.024 μm 2/s in HeLa cells. In primary endothelial cells, local increases in membrane tension lead only to local activation of mechanosensitive ion channels and to local vesicle fusion. Thus, membrane tension is not a mediator of long-range intracellular signaling, but local variations in tension mediate distinct processes in sub-cellular domains.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Indeed, a substantial spatial gradient of membrane tension is thought to persist due to attachment of cytoskeleton to the membrane28.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Fluid Mosaic Model of the Structure of Cell Membranes
Singer, S. J., & Nicolson, G. L. (1972) · Science · doi:10.1126/science.175.4023.720 · Cited by 9,158
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Brownian motion in biological membranes
Saffman, P. G., & Delbrück, M. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.3111 · Cited by 1,773
Micropipette aspiration of living cells
Hochmuth, R. M. (2000) · Journal of Biomechanics · doi:10.1016/s0021-9290(99)00175-x · Cited by 1,428
Piezo1 integration of vascular architecture with physiological force
Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,250
Phases and phase transitions of the phosphatidylcholines
Koynova, R. D., & Caffrey, M. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00006-9 · Cited by 1,155
Entropy-driven tension and bending elasticity in condensed-fluid membranes
Evans, E., & Rawicz, W. (1990) · Physical Review Letters · doi:10.1103/physrevlett.64.2094 · Cited by 1,129
Kusumi, A., Nakada, C., Ritchie, K. P., Murase, K., Suzuki, K. G. N., Murakoshi, H., Kasai, R. S., Kondo, J., & Fujiwara, T. K. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144637 · Cited by 1,122
Improving the photostability of bright monomeric orange and red fluorescent proteins
Shaner, N. C., Lin, M. Z., McKeown, M. R., Steinbach, P. A., Hazelwood, K. L., Davidson, M. W., & Tsien, R. Y. (2008) · Nature Methods · doi:10.1038/nmeth.1209 · Cited by 994
Emerging roles for lipids in shaping membrane-protein function
Phillips, R., Ursell, T. S., Wiggins, P. A., & Sens, P. (2009) · Nature · doi:10.1038/nature08147 · Cited by 988
Nicolson, G. L. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.10.019 · Cited by 790
Mechanical stretch triggers rapid epithelial cell division through Piezo1
Gudipaty, S. A., Lindblom, J., Loftus, P. D., Redd, M. J., Edes, K., Davey, C. F., Krishnegowda, V., & Rosenblatt, J. (2017) · Nature · doi:10.1038/nature21407 · Cited by 786
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins
Hochbaum, D. R., Zhao, Y., Farhi, S. L., Klapoetke, N. C., Werley, C. A., Kapoor, V., Zou, P., Kralj, J. M., Maclaurin, D., Smedemark-Margulies, N., et al. (2014) · Nature Methods · doi:10.1038/nmeth.3000 · Cited by 782
Self-citationMechanism of shape determination in motile cells
Keren, K., Pincus, Z., Allen, G. M., Barnhart, E. L., Marriott, G., Mogilner, A., & Theriot, J. A. (2008) · Nature · doi:10.1038/nature06952 · Cited by 721
Bausch, A. R., Ziemann, F., Boulbitch, A., Jacobson, K., & Sackmann, E. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77646-5 · Cited by 714
Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding
Stewart, M. P., Helenius, J. H., Toyoda, Y., Ramanathan, S. P., Müller, D. J., & Hyman, A. A. (2010) · Nature · doi:10.1038/nature09642 · Cited by 679
Non-equilibration of hydrostatic pressure in blebbing cells
Charras, G., Yarrow, J. C., Horton, M. A., Mahadevan, L., & Mitchison, T. J. (2005) · Nature · doi:10.1038/nature03550 · Cited by 657
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
Structure of the mechanically activated ion channel Piezo1
Saotome, K., Murthy, S. E., Kefauver, J. M., Whitwam, T., Patapoutian, A., & Ward, A. B. (2018) · Nature · doi:10.1038/nature25453 · Cited by 649
Ultrafast endocytosis at mouse hippocampal synapses
Watanabe, S., Rost, B. R., Camacho-Pérez, M., Davis, M. W., Söhl-Kielczynski, B., Rosenmund, C., & Jorgensen, E. M. (2013) · Nature · doi:10.1038/nature12809 · Cited by 607
Shiga toxin induces tubular membrane invaginations for its uptake into cells
Römer, W., Berland, L., Chambon, V., Gaus, K., Windschiegl, B., Tenza, D., Aly, M., Fraisier, V., Florent, J., Perrais, D., et al. (2007) · Nature · doi:10.1038/nature05996 · Cited by 590
Use the force: membrane tension as an organizer of cell shape and motility
Diz-Muñoz, A., Fletcher, D. A., & Weiner, O. D. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.09.006 · Cited by 582
Houk, A. R., Jilkine, A., Mejean, C. O., Boltyanskiy, R., Dufresne, E. R., Angenent, S., Altschuler, S. J., Wu, L. F., & Weiner, O. D. (2012) · Cell · doi:10.1016/j.cell.2011.10.050 · Cited by 567
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
Bae, C., Sachs, F., & Gottlieb, P. A. (2011) · Biochemistry · doi:10.1021/bi200770q · Cited by 566
Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium
Ramanujan, S., Pluen, A., McKee, T. D., Brown, E. B., Boucher, Y., & Jain, R. K. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)73933-7 · Cited by 554
Actin dynamics counteract membrane tension during clathrin-mediated endocytosis
Boulant, S., Kural, C., Zeeh, J., Ubelmann, F., & Kirchhausen, T. L. (2011) · Nature Cell Biology · doi:10.1038/ncb2307 · Cited by 547
Cox, C. D., Bae, C., Ziegler, L., Hartley, S., Nikolova-Krstevski, V., Rohde, P. R., Ng, C.-A., Sachs, F., Gottlieb, P. A., & Martinac, B. (2016) · Nature Communications · doi:10.1038/ncomms10366 · Cited by 528
Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing
Basu, R., Whitlock, B. M., Husson, J., Floc’h, A. L., Jin, W., Oyler‐Yaniv, A., Dotiwala, F., Giannone, G., Hivroz, C., Biais, N., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.021 · Cited by 491
Formation and Interaction of Membrane Tubes
Derényi, I., Jülicher, F., & Prost, J. (2002) · Physical Review Letters · doi:10.1103/physrevlett.88.238101 · Cited by 484
Cell Surface Area Regulation and Membrane Tension
Morris, C. E., & Homann, U. (2001) · The Journal of Membrane Biology · doi:10.1007/s002320010040 · Cited by 483
Cell Spreading and Lamellipodial Extension Rate Is Regulated by Membrane Tension
Raucher, D., & Sheetz, M. P. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.1.127 · Cited by 461
Mechanical forces in the immune system
Huse, M. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.74 · Cited by 452
Membrane Tether Formation from Blebbing Cells
Dai, J., & Sheetz, M. P. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77168-7 · Cited by 447
Structure-based membrane dome mechanism for Piezo mechanosensitivity
Guo, Y. R., & MacKinnon, R. (2017) · eLife · doi:10.7554/elife.33660 · Cited by 446
Mechanical feedback between membrane tension and dynamics
Gauthier, N. C., Masters, T. A., & Sheetz, M. P. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.005 · Cited by 441
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
Lewis, A. H., & Grandl, J. M. (2015) · eLife · doi:10.7554/elife.12088 · Cited by 438
St-Pierre, F., Marshall, J. D., Yang, Y., Gong, Y., Schnitzer, M. J., & Lin, M. Z. (2014) · Nature Neuroscience · doi:10.1038/nn.3709 · Cited by 419
Characteristics of a Membrane Reservoir Buffering Membrane Tension
Raucher, D., & Sheetz, M. P. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77040-2 · Cited by 418
Photobleaching and photoactivation: following protein dynamics in living cells.
Lippincott‐Schwartz, J., Altan‐Bonnet, N., & Patterson, G. H. (2003) · PubMed · Cited by 415
Gauthier, N. C., Fardin, M.-A., Roca‐Cusachs, P., & Sheetz, M. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105845108 · Cited by 396
Tension-induced fusion of bilayer membranes and vesicles
Shillcock, J. C., & Lipowsky, R. (2005) · Nature Materials · doi:10.1038/nmat1333 · Cited by 392
Electrical Spiking in Escherichia coli Probed with a Fluorescent Voltage-Indicating Protein
Kralj, J. M., Hochbaum, D. R., Douglass, A. D., & Cohen, A. E. (2011) · Science · doi:10.1126/science.1204763 · Cited by 378
Self-citationFocal adhesion size uniquely predicts cell migration
Kim, D., & Wirtz, D. (2012) · The FASEB Journal · doi:10.1096/fj.12-220160 · Cited by 370
Membrane tension and cytoskeleton organization in cell motility
Sens, P., & Plastino, J. (2015) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/27/27/273103 · Cited by 312
Molecular mechanisms in signal transduction at the membrane
Groves, J. T., & Kuriyan, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1844 · Cited by 312
Measurement of the Elastic Modulus for Red Cell Membrane Using a Fluid Mechanical Technique
Hochmuth, R. M., Mohandas, N., & Blackshear, P. L. (1973) · Biophysical Journal · doi:10.1016/s0006-3495(73)86021-7 · Cited by 311
High Ca2+-phosphate transfection efficiency in low-density neuronal cultures
Jiang, M., & Chen, G. (2006) · Nature Protocols · doi:10.1038/nprot.2006.86 · Cited by 304
Howells, I. D. (1974) · Journal of Fluid Mechanics · doi:10.1017/s0022112074002503 · Cited by 271
Protein area occupancy at the center of the red blood cell membrane
Dupuy, A. D., & Engelman, D. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712379105 · Cited by 262
Rational design of a high-affinity, fast, red calcium indicator R-CaMP2
Inoue, M., Takeuchi, A., Horigane, S., Ohkura, M., Gengyo‐Ando, K., Fujii, H., Kamijo, S., Takemoto‐Kimura, S., Kano, M., Nakai, J., et al. (2014) · Nature Methods · doi:10.1038/nmeth.3185 · Cited by 260
Simplified Equation to Extract Diffusion Coefficients from Confocal FRAP Data
Kang, M., Day, C. A., Kenworthy, A. K., & DiBenedetto, E. (2012) · Traffic · doi:10.1111/tra.12008 · Cited by 258
Load Adaptation of Lamellipodial Actin Networks
Mueller, J. O., Szép, G., Némethová, M., de Vries, I., Lieber, A. D., Winkler, C., Kruse, K., Small, J. V., Schmeiser, C., Keren, K., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.051 · Cited by 245
Masters, T. A., Pontes, B., Viasnoff, V., Li, Y., & Gauthier, N. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301766110 · Cited by 228
Endothelial regulation of wall shear stress and blood flow in skeletal muscle microcirculation
Koller, Á., & Kaley, G. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.260.3.h862 · Cited by 225
Membrane tension and peripheral protein density mediate membrane shape transitions
Shi, Z., & Baumgart, T. (2015) · Nature Communications · doi:10.1038/ncomms6974 · Cited by 213
Self-citationShin, W., Ge, L., Arpino, G., Villarreal, S. A., Hamid, E., Liu, H., Zhao, W.-D., Wen, P. J., Chiang, H., & Wu, L. (2018) · Cell · doi:10.1016/j.cell.2018.02.062 · Cited by 211
Gating the mechanical channel Piezo1
Gottlieb, P. A., Bae, C., & Sachs, F. (2012) · Channels · doi:10.4161/chan.21064 · Cited by 195
Flow-induced calcium transients in single endothelial cells: spatial and temporal analysis
Geiger, R. V., Berk, B. C., Alexander, R. W., & Nerem, R. M. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.6.c1411 · Cited by 183
Membrane tension: A challenging but universal physical parameter in cell biology
Pontes, B., Monzo, P., & Gauthier, N. C. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.08.030 · Cited by 176
Cell motility: the integrating role of the plasma membrane
Keren, K. (2011) · European Biophysics Journal · doi:10.1007/s00249-011-0741-0 · Cited by 166
A sensitive measure of surface stress in the resting neutrophil
Needham, D., & Hochmuth, R. M. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81970-7 · Cited by 163
Thottacherry, J. J., Kosmalska, A. J., Kumar, A., Vishen, A. S., Elósegui-Artola, A., Pradhan, S., Sharma, S., Singh, P. P., Guadamillas, M. C., Chaudhary, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06738-5 · Cited by 153
Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane
Wen, P. J., Grenklo, S., Arpino, G., Tan, X., Liao, H.-S., Heureaux, J., Peng, S.-Y., Chiang, H., Hamid, E., Zhao, W.-D., et al. (2016) · Nature Communications · doi:10.1038/ncomms12604 · Cited by 151
Rhee, J. M., Pirity, M. K., Lackan, C. S., Long, J. Z., Kondoh, G., Takeda, J., & Hadjantonakis, A. (2006) · genesis · doi:10.1002/dvg.20203 · Cited by 148
Shear stress‐induced calcium transients in endothelial cells from human umbilical cord veins.
Schwarz, G., Callewaert, G., DROOGMANS, G., & Nilius, B. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019432 · Cited by 147
Dynamic sorting of lipids and proteins in membrane tubes with a moving phase boundary
Heinrich, M., Tian, A., Esposito, C., & Baumgart, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913997107 · Cited by 146
Self-citationHydrodynamic narrowing of tubes extruded from cells
Brochard‐Wyart, F., Borghi, N., Cuvelier, D., & Nassoy, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602012103 · Cited by 133
Plasma Membrane Area Increases with Spread Area by Exocytosis of a GPI-anchored Protein Compartment
Gauthier, N. C., Rossier, O., Mathur, A., Hone, J., & Sheetz, M. P. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0071 · Cited by 118
Model of Polarization and Bistability of Cell Fragments
Kozlov, M. M., & Mogilner, A. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.110411 · Cited by 115
Free diffusion coefficient of ionic calcium in cytoplasm
Donahue, B. S., & Abercrombie, R. F. (1987) · Cell Calcium · doi:10.1016/0143-4160(87)90027-3 · Cited by 112
Actin disassembly clock determines shape and speed of lamellipodial fragments
Ofer, N., Mogilner, A. J., & Keren, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105333108 · Cited by 109
Front-to-Rear Membrane Tension Gradient in Rapidly Moving Cells
Lieber, A. D., Schweitzer, Y., Kozlov, M. M., & Keren, K. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.02.007 · Cited by 108
Mobility in geometrically confined membranes
Domanov, Y. A., Aimon, S., Toombes, G. E. S., Renner, M., Quemeneur, F., Triller, A., Turner, M. S., & Bassereau, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102646108 · Cited by 105
Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells
Rosholm, K. R., Leijnse, N., Mantsiou, A., Tkach, V., Pedersen, S. L., Wirth, V. F., Oddershede, L. B., Jensen, K. J., Martinez, K. L., Hatzakis, N. S., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2372 · Cited by 104
Plasma Membrane is Compartmentalized by a Self-Similar Cortical Actin Meshwork
Sadegh, S., Higgins, J. L., Mannion, P. C., Tamkun, M. M., & Krapf, D. (2017) · Physical Review X · doi:10.1103/physrevx.7.011031 · Cited by 100
Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations
Wu, M., Wu, X., & Camilli, P. V. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221538110 · Cited by 99
Clausen, M. P., Colin‐York, H., Schneider, F., Eggeling, C., & Fritzsche, M. (2017) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/aa52a1 · Cited by 78
Bussell, S. J., Koch, D. L., & Hammer, D. A. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80360-7 · Cited by 76
A mechanosensitive ion channel regulating cell volume
Hua, S. Z., Gottlieb, P. A., Heo, J., & Sachs, F. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00503.2009 · Cited by 67
Coupling of exocytosis and endocytosis at the presynaptic active zone
Maritzen, T., & Haucke, V. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.09.013 · Cited by 64
Saha, S., Nagy, T. L., & Weiner, O. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0145 · Cited by 60
ORAI channels are critical for receptor-mediated endocytosis of albumin
Zeng, B., Chen, G.-L., Garcia‐Vaz, E., Bhandari, S., Daskoulidou, N., Berglund, L. M., Jiang, H., Hallett, T., Zhou, L.-P., Huang, L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02094-y · Cited by 58
Computational Estimates of Membrane Flow and Tension Gradient in Motile Cells
Fogelson, B., & Mogilner, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084524 · Cited by 54
SnapShot: Membrane Curvature Sensors and Generators
Shen, H., Pirruccello, M., & Camilli, P. V. D. (2012) · Cell · doi:10.1016/j.cell.2012.08.017 · Cited by 51
Role of membrane-tension gated Ca2+ flux in cell mechanosensation
He, L., Tao, J., Maity, D., Si, F., Wu, Y., Wu, T. C., Prasath, V., Wirtz, D., & Sun, S. X. (2018) · Journal of Cell Science · doi:10.1242/jcs.208470 · Cited by 51
Theoretical Analysis of Membrane Tension in Moving Cells
Schweitzer, Y., Lieber, A. D., Keren, K., & Kozlov, M. M. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2013.11.009 · Cited by 44
Mumtaz, S., Burdyga, G., Borisova, L., Wray, S., & Burdyga, T. V. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.11.010 · Cited by 34
Membrane tension feedback on shape and motility of eukaryotic cells
Winkler, B., Aranson, I. S., & Ziebert, F. (2015) · Physica D Nonlinear Phenomena · doi:10.1016/j.physd.2015.09.011 · Cited by 24
Zakharova, O. M., Rosenkranz, A. A., & Sobolev, A. S. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00047-7 · Cited by 24
Mechanical Detection of a Long-Range Actin Network Emanating from a Biomimetic Cortex
Bussonnier, M., Carvalho, K., Lemiere, J. P. C., Joanny, J., Sykes, C., & Betz, T. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.07.008 · Cited by 15
Myosin-II Mediated Traction Forces Evoke Localized Piezo1 Ca2+ Flickers
Ellefsen, K. L., Chang, A. C., Nourse, J. L., Holt, J. R., Arulmoli, J., Mekhdjian, A. H., Aburwarda, H., Tombola, F., Flanagan, L. A., Dunn, A. R., et al. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2018.11.2049 · Cited by 10
Structure of the mechanically activated ion channel Piezo1
Saotome, K., Kefauver, J. M., Patapoutian, A., & Ward, A. B. (2017) · Worldwide Protein Data Bank · doi:10.2210/pdb6bpz/pdb · Cited by 4
Flagged first, then by citations
3 of the 95 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Ellefsen, 2018, Piezo1 calcium flickers localize to hotspots of cellular traction forces, bioRxiv
- Thottacherry, 2017, Mechanochemical feedback and control of endocytosis and membrane tension, bioRxiv
Cited by
Sorted by citations
Janmey, P. A., Fletcher, D. A., & Reinhart‐King, C. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 425
Mechanisms of mechanotransduction and physiological roles of PIEZO channels
Xiao, B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00773-5 · Cited by 314
Interplay between mechanics and signalling in regulating cell fate
Belly, H. D., Paluch, E. K., & Chalut, K. J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00472-z · Cited by 295
The Lateral Organization and Mobility of Plasma Membrane Components
Jacobson, K., Liu, P., & Lagerholm, B. C. (2019) · Cell · doi:10.1016/j.cell.2019.04.018 · Cited by 276
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
Cox, C. D., Bavi, N., & Martinac, B. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.075 · Cited by 240
Metadata
- Authors
- Shi, Z., Graber, Z. T., Baumgart, T., Stone, H. A., & Cohen, A. E.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Pennsylvania (US)
- Princeton University (US)
- Corresponding author
- Cohen, Adam E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 175
- Issue
- 7
- Pages
- 1769-1779.e13
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6541487
- OpenAlex
- W2795033146
- Cited by
- 355
- References
- 95
- Citations by year
- 2026: 32 · 2025: 48 · 2024: 43 · 2023: 41 · 2022: 56 · 2021: 38 · 2020: 49 · 2019: 41 · 2018: 6
- FWCI
- 18.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Gordon and Betty Moore Foundation
- Howard Hughes Medical Institute
- NIH (R01 GM 09755, U54CA193417)
- NSF (CBET-1509347, DMS 1614907)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- membrane tension, cell membrane mechanics, mechanosensitive ion channels, vesicle fusion, endothelial cells, HeLa cells, intracellular signaling
- MeSH terms
- Animals, Cell Membrane, Cytoskeleton, Dogs, HeLa Cells, Humans, Ion Channels, Models, Biological, Signal Transduction, NIH 3T3 Cells, Mice, Rats, Madin Darby Canine Kidney Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
