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Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment
Open accessAbstract
Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received chemotherapy. Developing a mouse model of methotrexate chemotherapy-induced neurological dysfunction, we find a similar depletion of white matter OPCs, increased but incomplete OPC differentiation, and a persistent deficit in myelination. OPCs from chemotherapy-naive mice similarly exhibit increased differentiation when transplanted into the microenvironment of previously methotrexate-exposed brains, indicating an underlying microenvironmental perturbation. Methotrexate results in persistent activation of microglia and subsequent astrocyte activation that is dependent on inflammatory microglia. Microglial depletion normalizes oligodendroglial lineage dynamics, myelin microstructure, and cognitive behavior after methotrexate chemotherapy. These findings indicate that methotrexate chemotherapy exposure is associated with persistent tri-glial dysregulation and identify inflammatory microglia as a therapeutic target to abrogate chemotherapy-related cognitive impairment. VIDEO ABSTRACT.
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“Reactive microglia and brain-infiltrating macrophages impair mechanisms of cellular homeostasis and plasticity such as the ongoing generation of myelin-forming oligodendrocytes (Gibson et al., 2019), myelin plasticity (Geraghty et al., 2019), and new neuron generation in the hippocampus (Monje et al., 2002, 2003, 2007).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Microglia, brain-resident macrophages, become persistently reactive following exposure to certain chemotherapy drugs, after cranial radiation, or after systemic inflammatory challenge with low-dose lipopolysaccharide (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2002, 2003, 2007).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“A distinct subpopulation of microglia that reside in white matter (Hammond et al., 2019) are selectively activated by systemic insults such as exposure to the chemotherapy drug methotrexate (Gibson et al., 2019).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“This complex cellular dysregulation is thought to contribute importantly to cognitive impairment, and anti-inflammatory strategies correct this multicellular dysregulation and rescue cognition in disease states such as those occurring after exposure to neurotoxic cancer therapies (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003) and in aging (Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“This complex cellular dysregulation is thought to contribute importantly to cognitive impairment, and anti-inflammatory strategies correct this multicellular dysregulation and rescue cognition in disease states such as those occurring after exposure to neurotoxic cancer therapies (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003) and in aging (Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“In contrast to methotrexate chemotherapy exposure (Geraghty et al., 2019; Gibson et al., 2019), changes in myelin sheath thickness relative to axon diameter (g ratio) were not conclusively identified in the remaining myelin sheaths after mild respiratory COVID (Figures S7C–S7F).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Such neuroinflammatory changes—particularly white-matter-selective/enriched microglial reactivity—are associated with impaired hippocampal neurogenesis, dysregulation of the oligodendroglial lineage, and myelin loss in other disease contexts (Geraghty et al., 2019; Gibson et al., 2019; Guttenplan et al., 2021; Liddelow et al., 2017; Monje et al., 2003; Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“As occurs after cancer therapies and in other disease states, the microglial reactivity present after mild respiratory SARS-CoV-2 infection may also induce neurotoxic astrocyte reactivity (Liddelow et al., 2017; Gibson et al., 2019; Guttenplan et al., 2021), as well as aberrant microglial pruning of synapses (Hinkle et al., 2019; Hosseini et al., 2018; Vasek et al., 2016).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“While methotrexate directly stimulates reactivity of microglia (Gibson et al., 2019),”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“For example, microglial depletion strategies can restore similar multicellular deficits and rescue impaired cognitive performance in mouse models of CRCI (Acharya et al., 2016; Gibson et al., 2019),”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Preclinical studies in disease models that share numerous features with the cellular dysregulation observed here after mild respiratory COVID have identified anti-inflammatory and neuro-regenerative strategies that restore neural plasticity and rescue cognition (Ayoub et al., 2020; Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003; Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
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1 retracted
Bialas, A. R., & Stevens, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3560 · Cited by 519
RetractedNeurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Self-citationGenomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
(1967) · Medical Entomology and Zoology · Cited by 1,713
Flagged first, then by citations
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Items 101–200 of 372
The multifaceted mechanisms of malignant glioblastoma progression and clinical implications
Sun, R., & Kim, A. H. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10051-5 · Cited by 40
Grant, C. V., Sullivan, K. A., Wentworth, K. M., Otto, L., Strehle, L. D., Otero, J. J., & Pyter, L. M. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.004 · Cited by 35
Long-term clinically relevant rodent model of methotrexate-induced cognitive impairment
Berlin, C., Lange, K. R., Lekaye, C., Hopland, K., Phillips, S. M., Piao, J., & Tabar, V. S. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa086 · Cited by 36
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Parmigiani, E., Scalera, M., Mori, E., Tantillo, E., & Vannini, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.709917 · Cited by 34
Burfeind, K. G., Zhu, X., Norgard, M. A., Levasseur, P. R., Huisman, C., Michaelis, K. A., Olson, B. G., & Marks, D. L. (2020) · Glia · doi:10.1002/glia.23796 · Cited by 33
Kao, J., & Frankland, P. W. (2022) · Cell · doi:10.1016/j.cell.2022.06.020 · Cited by 34
Chen, J., Wang, J., Li, C., Ding, H., Ye, J., & Xia, Z. (2021) · Aging · doi:10.18632/aging.202626 · Cited by 33
Senolytic treatment alleviates doxorubicin‐induced chemobrain
Budamagunta, V., Kumar, A., Rani, A., Sindhu, S. M., Yang, Y., Zhou, D., & Foster, T. C. (2024) · Aging Cell · doi:10.1111/acel.14037 · Cited by 35
Peptidomimetic‐based identification of FDA‐approved compounds inhibiting IRE1 activity
Doultsinos, D., Carlesso, A., Chintha, C., Paton, J. C., Paton, A. W., Samali, A., Chevet, É., & Eriksson, L. A. (2020) · FEBS Journal · doi:10.1111/febs.15372 · Cited by 31
Brain network mapping and glioma pathophysiology
Mandal, A. S., Brem, S. S., & Suckling, J. (2023) · Brain Communications · doi:10.1093/braincomms/fcad040 · Cited by 33
Wang, X., Fan, Y., Wang, Q., Shu, X., Lin, J., Guo, J., Li, Z., & Xu, J. (2025) · Discover Oncology · doi:10.1007/s12672-025-02827-2 · Cited by 31
Tan, Y., Pan, J., Deng, B., Ling, Z., Song, W., Xu, J., Duan, J., Wang, Z., Yu, X., Chang, A. H., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02829-9 · Cited by 30
Neuropathological Effects of Chemotherapeutic Drugs
Umfress, A., Speed, H. E., Tan, C., Ramezani, S., Birnbaum, S. G., Brekken, R. A., Sun, X., Plattner, F., Powell, C. M., & Bibb, J. A. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00338 · Cited by 29
Nevins, S., McLoughlin, C. D., Oliveros, A., Stein, J. B., Rashid, M. A., Hou, Y., Jang, M., & Lee, K. (2023) · Small · doi:10.1002/smll.202300744 · Cited by 31
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Kadowaki, A., Wheeler, M. A., Li, Z., Andersen, B. M., Lee, H., Illouz, T., Lee, J.-H., Ndayisaba, A., Zandee, S., Basu, H., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01875-9 · Cited by 30
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Torre, M., Dey, A., Woods, J. K., & Feany, M. Β. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab074 · Cited by 28
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Lee, J., Jeong, M. I., Kim, H.-R., Park, H., Moon, W.-K., & Kim, B. (2020) · Antioxidants · doi:10.3390/antiox9090836 · Cited by 26
Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity
Karschnia, P., Nelson, T. A., & Dietrich, J. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00863-2 · Cited by 34
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Zhou, F., Wen, Y., Jin, R., & Chen, H. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09827-z · Cited by 25
Mzayek, Y., de Ruiter, M. B., Oldenburg, H. S. A., Reneman, L., & Schagen, S. B. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00319-1 · Cited by 25
George, R. P., Semendric, I., Hutchinson, M. R., & Whittaker, A. L. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.021 · Cited by 24
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Ambady, P., Hu, L., Politi, L. S., Anzalone, N., & Barajas, R. (2021) · Annals of Lymphoma · doi:10.21037/aol-20-53 · Cited by 25
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Ho, J., Chaiswing, L., & Clair, D. K. S. (2022) · Antioxidants · doi:10.3390/antiox11061194 · Cited by 26
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Aslankoç, R., Özmen, Ö., & Yalçın, A. (2021) · Biotechnic & Histochemistry · doi:10.1080/10520295.2021.2004616 · Cited by 22
Scholz, S., Lewis, K. L., Saulich, F., Endres, M., Boehmerle, W., & Huehnchen, P. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1006497 · Cited by 21
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Kim, H., Rashid, M. A., Poleschuk, M., Ullah, F., Lee, S., Kim, S., Qin, B., Zheng, X., & Jang, M.-H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118581 · Cited by 25
Moretti, R. L., Dias, E. N., Kiel, S. G., Augusto, M. C. M., Rodrigues, P., Sampaio, A. C., de Medeiros, L. I. P., Martins, M. D. F. M., Suffredini, I. B., Cardoso, C. V., et al. (2021) · Research in Veterinary Science · doi:10.1016/j.rvsc.2021.09.009 · Cited by 23
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Wen, J., Patel, C., Diglio, F., Baker, K., Marshall, G., Li, S., & Cole, P. D. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108939 · Cited by 22
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Parment, R., Dubois, M., Desrues, L., Mutel, A., Dembélé, K.-P., Belin, N., Tron, L., Guérin, C., Coëffier, M., Compère, V., et al. (2022) · Cancers · doi:10.3390/cancers14184403 · Cited by 20
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de la Hoz-Camacho, R., Rivera-Lazarín, A. L., Vázquez-Guillén, J. M., Caballero-Hernández, D. E., Mendoza-Gamboa, E., Martínez‐Torres, A. C., & Rodrı́guez-Padilla, C. (2021) · EXCLI journal · doi:10.17179/excli2021-4160 · Cited by 19
Rabaiotti, P., Ciracì, C., Donelli, D., Oggioni, C., Rizzi, B., Savi, F., Antonelli, M., Rizzato, M., Moderato, L., Brambilla, V., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13050791 · Cited by 18
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Tolba, M. F., Sedky, N. K., Ali, M. A., & Abdollah, M. R. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89833-1.00049-5 · Cited by 17
Hong, Y., Wang, Y., Shu, W., Li, J., Mi, Y., Chen, H., & Chen, C. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102835 · Cited by 17
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Davies, M. R., Greenberg, Z., van Vuurden, D. G., Cross, C., Zannettino, A. C. W., Bardy, C., & Wardill, H. R. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.013 · Cited by 17
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Bansal, R., Bhojwani, D., Sun, B. F., Sawardekar, S., Wayne, A. S., Ouassil, H., Gupte, C., Marcelino, C., Anaya, M. J. G., Luna, N., et al. (2024) · Pediatric Research · doi:10.1038/s41390-024-03351-9 · Cited by 15
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He, Y., Zhou, C., Jiang, S., Lan, W.-Q., Zhang, F., Tao, X., & Chen, W. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1292807 · Cited by 14
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Subramaniam, C. B., Wardill, H. R., Davies, M. R., Heng, V., Gladman, M. A., & Bowen, J. M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03136-3 · Cited by 13
Klein, I., Boenert, J., Lange, F., Christensen, B., Wassermann, M. K., Wiesen, M. H. J., Olschewski, D. N., Rabenstein, M., Müller, C., Lehmann, H. C., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1038285 · Cited by 14
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Yu, S., Zhao, J., Wang, M., Cheng, G., Li, W., Tang, L., Yao, S., Pang, L., Yin, X., Jing, Y., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.945433 · Cited by 12
Liu, Y., Reiken, S. R., Dridi, H., Yuan, Q., Mohammad, K. S., Trivedi, T., Miotto, M., Wedderburn-Pugh, K., Sittenfeld, L. R., Kerley, Y., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf8977 · Cited by 13
Rashid, M. A., Tang, J. J., Yoo, K.-H., Corujo-Ramirez, A. M., Oliveros, A., Kim, S., Ullah, F., Altawell, R., Hawse, J. R., Cole, P. D., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1295991 · Cited by 12
Estephan, F., Ye, X., Dzaye, O. D. A., Wagner‐Johnston, N. D., Swinnen, L. J., Gladstone, D. E., Ambinder, R., Kamson, D. O., Lambrecht, S., Grossman, S. A., et al. (2019) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03279-9 · Cited by 12
Nie, E. H., Ahmadian, S. S., Bharadwaj, S., Acosta-Alvarez, L., Threlkeld, Z. D., Frank, M. J., Miklos, D. B., Monje, M., Scott, B. J., & Vogel, H. S. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac121 · Cited by 11
Cao, Y., Zhang, Y., Jia, Z., Jia, H., Sun, Y., Yuan, H., Bian, Y., Xu, B., Fu, J., & Qin, F. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114077 · Cited by 12
Morowitz, J. M., Pogson, K., Roque, D., & Church, F. (2022) · Brain Sciences · doi:10.3390/brainsci12050536 · Cited by 11
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Hervey‐Jumper, S. L., & Berger, M. S. (2020) · Neurosurgery · doi:10.1093/neuros/nyaa358 · Cited by 13
Palakshappa, J. A., Batt, J. A. E., Bodine, S. C., Connolly, B. A., Doles, J. D., Falvey, J. R., Ferrante, L. E., Files, D. C., Harhay, M. O., Harrell, K., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202311-2130ws · Cited by 10
Liu, C., Zhang, C., Chen, L., Liu, X., Wu, J., Sun, Y., Liu, J., & Chen, C. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.98376 · Cited by 10
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Sinha, S., Fleck, M., Ayushman, M., Tong, X., Mikos, G., Jones, S., Soto, L. A. C., & Yang, F. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c16993 · Cited by 11
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Song, Y., & Yang, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30005 · Cited by 11
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Segawa, K., Blumenthal, Y., Yamawaki, Y., & Ohtsuki, G. (2021) · Biology · doi:10.3390/biology10010034 · Cited by 11
Klimkiewicz, J., Pankowski, D., Wytrychiewicz‐Pankowska, K., Klimkiewicz, A., Siwik, P., Klimczuk, J., & Lubas, A. (2022) · Nutrients · doi:10.3390/nu14081580 · Cited by 11
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Moore, B., Sheets, G., Doss, J., Umrigar, A., Norman, M., Fang, Z., Prasad, P. K., Musso, A., Clay, S., & Tsien, F. (2023) · American Journal of Audiology · doi:10.1044/2023_aja-22-00157 · Cited by 9
Mayburd, A. L., Koivogui, M., & Baranova, A. V. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224315 · Cited by 9
Gan, C., Yao, S., Zhao, J., Shi, H., Xu, J., Zhang, M., & Cheng, H. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03674-7 · Cited by 8
Chemoradiation induced multiple sclerosis-like demyelination
Borges, A., Garcez, D., Pedro, C., & Passos, J. (2021) · eNeurologicalSci · doi:10.1016/j.ensci.2021.100315 · Cited by 8
van Lint, J. A., Bakker, T., ten Klooster, P. M., van Puijenbroek, E., Vonkeman, H. E., & Jessurun, N. T. (2021) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2003328 · Cited by 8
Aires, V., Ziegler‐Waldkirch, S., Friesen, M., Reichardt, W., Erny, D., Loreth, D., Harborne, A. C., Kretz, O., von Elverfeldt, D., & Meyer‐Luehmann, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.862918 · Cited by 8
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Dietrich, J., Parsons, M. W., & Santarnecchi, E. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-1342 · Cited by 8
The Sociobiology of Brain Tumors
Gutmann, D. H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-35727-6_8 · Cited by 8
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Gibson, E. M., & Monje, M. (2020) · Nature Medicine · doi:10.1038/s41591-020-1014-1 · Cited by 8
DeSantis, D. F., & Smith, C. J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.734938 · Cited by 8
Konsman, J. P., Laaker, C. J., Lloyd, K. R., Hiltz, A. R., Smith, B. L., Smail, M. A., & Reyes, T. M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.003 · Cited by 8
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Wang, J., Zhang, H., Augenreich, M. A., Luis Martinez‐Lemus, A., Liu, Z., Kang, X., Lu, B., Chang, H., Yeh, E. T. H., Cata, J. P., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70024 · Cited by 7
Kuil, L. E., Coppola, N., Dietrich, J., & Castel, H. (2025) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2025.2539199 · Cited by 7
Butt, A. M., Niu, J., Yi, C., & Verkhratsky, A. (2026) · Physiological Reviews · doi:10.1152/physrev.00023.2025 · Cited by 7
Hutterer, M., & Oberndorfer, S. (2021) · memo - Magazine of European Medical Oncology · doi:10.1007/s12254-021-00690-9 · Cited by 7
Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment
Ng, D. Q., Chan, D., Acharya, M. M., Grill, J. D., & Chan, A. (2023) · Cancers · doi:10.3390/cancers15133409 · Cited by 7
Metadata
- Authors
- Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., Woo, P. J., Barres, B. A., Liddelow, S., Vogel, H., & Monje, M.
- Affiliations
- Stanford University (US)
- New York University (US)
- Institute for Stem Cell Biology and Regenerative Medicine (US)
- Corresponding author
- Monje, Michelle
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 176
- Issue
- 1-2
- Pages
- 43-55.e13
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6329664
- OpenAlex
- W2903050755
- Cited by
- 372
- References
- 71
- Citations by year
- 2026: 39 · 2025: 65 · 2024: 38 · 2023: 47 · 2022: 60 · 2021: 52 · 2020: 41 · 2019: 28
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- California Institute for Regenerative Medicine (RB4-06093, RN3-06510)
- Unravel Pediatric Cancer
- McKenna Claire Foundation
- Virginia and D.K. Ludwig Fund for Cancer Research
- National Institutes of Neurological Disorders and Stroke (R01NS092597)
- Stanford Medical Scientist Training Program
- Stanford Neuroscience Institute
- Stanford Maternal and Child Health Research Institute
- Anne T. and Robert M. Bass Endowed Faculty Scholarship in Pediatric Cancer and Blood Diseases
- Stanford CTSA (UL1 RR025744)
- BioX Institute
- McCormick Fellowship
- Stanford MedScholars Program
- Christopher and Dana Reeve Foundation
- Novartis Institute for Biomedical Research
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- JPB Foundation
- Cure Alzheimer's Fund
- Glenn Foundation
- Esther B. O’Keeffe Charitable Foundation
- Australian National Health and Medical Research Council (GNT1052961)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- methotrexate, chemotherapy-induced cognitive impairment, oligodendrocyte precursor cells, myelination, microglial activation, astrocyte activation, neuroinflammation, cognitive behavior
- MeSH terms
- Animals, Brain, Cell Differentiation, Disease Models, Animal, Drug Therapy, Humans, Methotrexate, Myelin Sheath, Nerve Fibers, Myelinated, Neuroglia, Neurons, Oligodendroglia, Microglia, Cell Lineage, Mice, Neurogenesis, Cognitive Dysfunction, Drug-Related Side Effects and Adverse Reactions, White Matter
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