The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment
Open accessAbstract
Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received chemotherapy. Developing a mouse model of methotrexate chemotherapy-induced neurological dysfunction, we find a similar depletion of white matter OPCs, increased but incomplete OPC differentiation, and a persistent deficit in myelination. OPCs from chemotherapy-naive mice similarly exhibit increased differentiation when transplanted into the microenvironment of previously methotrexate-exposed brains, indicating an underlying microenvironmental perturbation. Methotrexate results in persistent activation of microglia and subsequent astrocyte activation that is dependent on inflammatory microglia. Microglial depletion normalizes oligodendroglial lineage dynamics, myelin microstructure, and cognitive behavior after methotrexate chemotherapy. These findings indicate that methotrexate chemotherapy exposure is associated with persistent tri-glial dysregulation and identify inflammatory microglia as a therapeutic target to abrogate chemotherapy-related cognitive impairment. VIDEO ABSTRACT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reactive microglia and brain-infiltrating macrophages impair mechanisms of cellular homeostasis and plasticity such as the ongoing generation of myelin-forming oligodendrocytes (Gibson et al., 2019), myelin plasticity (Geraghty et al., 2019), and new neuron generation in the hippocampus (Monje et al., 2002, 2003, 2007).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Microglia, brain-resident macrophages, become persistently reactive following exposure to certain chemotherapy drugs, after cranial radiation, or after systemic inflammatory challenge with low-dose lipopolysaccharide (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2002, 2003, 2007).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“A distinct subpopulation of microglia that reside in white matter (Hammond et al., 2019) are selectively activated by systemic insults such as exposure to the chemotherapy drug methotrexate (Gibson et al., 2019).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“This complex cellular dysregulation is thought to contribute importantly to cognitive impairment, and anti-inflammatory strategies correct this multicellular dysregulation and rescue cognition in disease states such as those occurring after exposure to neurotoxic cancer therapies (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003) and in aging (Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“This complex cellular dysregulation is thought to contribute importantly to cognitive impairment, and anti-inflammatory strategies correct this multicellular dysregulation and rescue cognition in disease states such as those occurring after exposure to neurotoxic cancer therapies (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003) and in aging (Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“In contrast to methotrexate chemotherapy exposure (Geraghty et al., 2019; Gibson et al., 2019), changes in myelin sheath thickness relative to axon diameter (g ratio) were not conclusively identified in the remaining myelin sheaths after mild respiratory COVID (Figures S7C–S7F).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Such neuroinflammatory changes—particularly white-matter-selective/enriched microglial reactivity—are associated with impaired hippocampal neurogenesis, dysregulation of the oligodendroglial lineage, and myelin loss in other disease contexts (Geraghty et al., 2019; Gibson et al., 2019; Guttenplan et al., 2021; Liddelow et al., 2017; Monje et al., 2003; Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“As occurs after cancer therapies and in other disease states, the microglial reactivity present after mild respiratory SARS-CoV-2 infection may also induce neurotoxic astrocyte reactivity (Liddelow et al., 2017; Gibson et al., 2019; Guttenplan et al., 2021), as well as aberrant microglial pruning of synapses (Hinkle et al., 2019; Hosseini et al., 2018; Vasek et al., 2016).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“While methotrexate directly stimulates reactivity of microglia (Gibson et al., 2019),”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“For example, microglial depletion strategies can restore similar multicellular deficits and rescue impaired cognitive performance in mouse models of CRCI (Acharya et al., 2016; Gibson et al., 2019),”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Preclinical studies in disease models that share numerous features with the cellular dysregulation observed here after mild respiratory COVID have identified anti-inflammatory and neuro-regenerative strategies that restore neural plasticity and rescue cognition (Ayoub et al., 2020; Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003; Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Bialas, A. R., & Stevens, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3560 · Cited by 519
RetractedNeurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Self-citationGenomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
(1967) · Medical Entomology and Zoology · Cited by 1,713
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
Chung, W.-S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12776 · Cited by 1,377
Object recognition test in mice
Leger, M., Quiedeville, A., Bouet, V., Haelewyn, B., Boulouard, M., Schumann-Bard, P., & Freret, T. (2013) · Nature Protocols · doi:10.1038/nprot.2013.155 · Cited by 1,357
Irradiation induces neural precursor-cell dysfunction
Monje, M. L., Mizumatsu, S., Fike, J. R., & Palmer, T. D. (2002) · Nature Medicine · doi:10.1038/nm749 · Cited by 1,271
Self-citationMotor skill learning requires active central myelination
McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177
Microglial brain region-dependent diversity and selective regional sensitivities to aging
Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4222 · Cited by 1,151
Diffusion tensor imaging of white matter tract evolution over the lifespan
Lebel, C., Gee, M., Camicioli, R., Wieler, M., Martin, W., & Beaulieu, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.094 · Cited by 1,100
Oligodendrocytes: Myelination and Axonal SupportPreprint
Simons, M., & Nave, K. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020479 · Cited by 929
Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927
Hughes, E. G., Kang, S. H., Fukaya, M., & Bergles, D. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3390 · Cited by 808
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
Quail, D. F., Bowman, R. L., Akkari, L., Quick, M. L., Schuhmacher, A. J., Huse, J. T., Holland, E. C., Sutton, J. C., & Joyce, J. A. (2016) · Science · doi:10.1126/science.aad3018 · Cited by 684
Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
Zrzavy, T., Hametner, S., Wimmer, I., Butovsky, O., Weiner, H. L., & Lassmann, H. (2017) · Brain · doi:10.1093/brain/awx113 · Cited by 684
Bohlen, C. J., Bennett, F. C., Tucker, A. F., Collins, H. Y., Mulinyawe, S. B., & Barres, B. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.043 · Cited by 658
Self-citationErblich, B., Zhu, L., Etgen, A. M., Dobrenis, K., & Pollard, J. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026317 · Cited by 649
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement
Adamsky, A., Kol, A., Kreisel, T., Doron, A., Ozeri-Engelhard, N., Melcer, T., Refaeli, R., Horn, H., Regev, L., Groysman, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.002 · Cited by 631
Hagemeyer, N., Hanft, K.-M., Akriditou, M.-A., Unger, N., Park, E. S., Stanley, E. R., Staszewski, O., Dimou, L., & Prinz, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1747-1 · Cited by 558
Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex
Hughes, E. G., Orthmann-Murphy, J. L., Langseth, A. J., & Bergles, D. E. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0121-5 · Cited by 540
Dietrich, J., Han, R., Yang, Y. M., Mayer‐Pröschel, M., & Noble, M. (2006) · Journal of Biology · doi:10.1186/jbiol50 · Cited by 520
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
Xiao, L., Ohayon, D., McKenzie, I. A., Sinclair-Wilson, A., Wright, J. L., Fudge, A. D., Emery, B., Li, H., & Richardson, W. D. (2016) · Nature Neuroscience · doi:10.1038/nn.4351 · Cited by 507
Dagher, N. N., Najafi, A. R., Kayala, K. M. N., Elmore, M. R. P., White, T. E., Medeiros, R., West, B. L., & Green, K. N. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0366-9 · Cited by 505
Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain
Hill, R. A., Li, A. M., & Grutzendler, J. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0120-6 · Cited by 467
Myelination of Cortical-hippocampal Relays During Late Adolescence
Benes, F. M. (1989) · Schizophrenia Bulletin · doi:10.1093/schbul/15.4.585 · Cited by 448
Development of a Method for the Purification and Culture of Rodent Astrocytes
Foo, L. C., Allen, N. J., Bushong, E. A., Ventura, P. B., Chung, W.-S., Zhou, L., Cahoy, J. D., Daneman, R., Zong, H., Ellisman, M. H., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.022 · Cited by 433
Chemotherapy-Related Cognitive Dysfunction
Wefel, J. S., & Schagen, S. B. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0264-9 · Cited by 417
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
Mitew, S., Gobius, I., Fenlon, L. R., McDougall, S. J., Hawkes, D. J., Xing, Y. L., Bujalka, H., Gundlach, A. L., Richards, L. J., Kilpatrick, T. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02719-2 · Cited by 353
Ellenberg, L., Liu, Q., Gioia, G. A., Yasui, Y., Packer, R. J., Mertens, A. C., Donaldson, S. S., Stovall, M., Kadan‐Lottick, N. S., Armstrong, G. T., et al. (2009) · Neuropsychology · doi:10.1037/a0016674 · Cited by 334
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
Monje, M., Mitra, S., Freret, M., Raveh, T., Kim, J., Masek, M., Attema, J., Li, G., Haddix, T., Edwards, M. S., et al. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1101657108 · Cited by 316
Han, R., Yang, Y. M., Dietrich, J., Luebke, A., Mayer-Pröschel, M., & Noble, M. (2008) · Journal of Biology · doi:10.1186/jbiol69 · Cited by 316
Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies
Monje, M., Vogel, H. S., Masek, M., Ligon, K. L., Fisher, P. G., & Palmer, T. D. (2007) · Annals of Neurology · doi:10.1002/ana.21214 · Cited by 308
Parent, J. M., Tada, E., Fike, J. R., & Lowenstein, D. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04508.1999 · Cited by 291
Molecular comparison of GLT1 + and ALDH1L1 + astrocytes in vivo in astroglial reporter mice
Yang, Y., Vidensky, S., Jin, L., Jie, C., Lorenzini, I., Frankl, M., & Rothstein, J. D. (2010) · Glia · doi:10.1002/glia.21089 · Cited by 264
Wrapped to Adapt: Experience-Dependent Myelination
Mount, C., & Monje, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.009 · Cited by 262
Cells of the oligodendroglial lineage, myelination, and remyelination
Miron, V. E., Kuhlmann, T., & Antel, J. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.09.010 · Cited by 249
Robinson, G. W., Rudneva, V. A., Buchhalter, I., Billups, C. A., Waszak, S. M., Smith, K. S., Bowers, D. C., Bendel, A. E., Fisher, P. G., Partap, S., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30204-3 · Cited by 238
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain
Viganò, F., Möbius, W., Götz, M., & Dimou, L. (2013) · Nature Neuroscience · doi:10.1038/nn.3503 · Cited by 230
Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma
Lin, G. L., Nagaraja, S., Filbin, M. G., Suvà, M. L., Vogel, H. S., & Monje, M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0553-x · Cited by 202
Anderson, V. A., Godber, T., Smibert, E., Weiskop, S., & EKERT, H. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.0912 · Cited by 198
The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice
Winocur, G., Vardy, J. L., Binns, M. A., KERR, L., & Tannock, I. F. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.010 · Cited by 196
Bray, V. J., Dhillon, H. M., Bell, M. L., Kabourakis, M., Fiero, M. H., Yip, D., Boyle, F., Price, M. A., & Vardy, J. L. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.67.8201 · Cited by 182
Remarkable Stability of Myelinating Oligodendrocytes in Mice
Tripathi, R. B., Jackiewicz, M., McKenzie, I. A., Kougioumtzidou, E., Grist, M., & Richardson, W. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.050 · Cited by 176
Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice
Zhou, W., Kavelaars, A., & Heijnen, C. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151890 · Cited by 170
Aukema, E. J., Caan, M. W. A., Oudhuis, N., Majoie, C. B. L. M., Vos, F. M., Reneman, L., Last, B. F., Grootenhuis, M. A., & Meeteren, A. Y. N. S. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.08.060 · Cited by 153
Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1
Garber, C., Vasek, M. J., Vollmer, L. L., Sun, T., Jiang, X., & Klein, R. S. (2017) · Nature Immunology · doi:10.1038/s41590-017-0021-y · Cited by 152
Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats
Seigers, R., Schagen, S. B., Coppens, C. M., van der Most, P. J., van Dam, F. S. A. M., Koolhaas, J. M., & Buwalda, B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.025 · Cited by 150
NG2+/Olig2+ Cells are the Major Cycle‐Related Cell Population of the Adult Human Normal Brain
Geha, S., Pallud, J., Junier, M., Devaux, B. C., Léonard, N., Chassoux, F., Chneiweiss, H., Daumas‐Duport, C., & Varlet, P. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00295.x · Cited by 145
A Call for a Neuroscience Approach to Cancer-Related Cognitive Impairment
Horowitz, T. S., Suls, J. M., & Treviño, M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.001 · Cited by 130
Seigers, R., Timmermans, J., van der Horn, H. J., de Vries, E. F. J., Dierckx, R., Visser, L., Schagen, S. B., van Dam, F. S. A. M., Koolhaas, J. M., & Buwalda, B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.009 · Cited by 119
Briones, T. L., & Woods, J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.07.175 · Cited by 114
Microglia ablation alleviates myelin-associated catatonic signs in mice
Janova, H., Arinrad, S., Balmuth, E., Mitjans, M., Hertel, J., Habes, M., Bittner, R. A., Pan, H., Goebbels, S., Begemann, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci97032 · Cited by 107
Stem Cell Transplantation Reverses Chemotherapy-Induced Cognitive Dysfunction
Acharya, M. M., Martirosian, V., Chmielewski, N. N., Hanna, N. M., Tran, K. K., Liao, A. C., Christie, L., Parihar, V. K., & Limoli, C. L. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2237 · Cited by 104
Baxi, E. G., DeBruin, J., Jin, J., Strasburger, H. J., Smith, M. D., Orthmann‐Murphy, J. L., Schott, J. T., Fairchild, A. N., Bergles, D. E., & Calabresi, P. A. (2017) · Glia · doi:10.1002/glia.23229 · Cited by 97
Neurophysiological Basis of Cognitive Deficits in Long-term Survivors of Childhood Cancer
Moore, B. D., Copeland, D. R., & Ried, H. L. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530320033009 · Cited by 95
Effect of cancer therapy on neural stem cells
Gibson, E. M., & Monje, M. (2012) · Current Opinion in Oncology · doi:10.1097/cco.0b013e3283571a8e · Cited by 50
Green, J. L., Knight, S., McCarthy, M., & Luca, C. R. D. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24537 · Cited by 49
Pierson, C., Waite, E. N., & Pyykkonen, B. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26117 · Cited by 48
Pharmacokinetics of high-dose methotrexate treatment in children
Bratlid, D., & Moe, P. J. (1978) · European Journal of Clinical Pharmacology · doi:10.1007/bf00607446 · Cited by 38
Hyrien, O., Dietrich, J., & Noble, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1400 · Cited by 38
Morioka, S., Morimoto, M., Yamada, K., Hasegawa, T., Morita, T., Moroto, M., Isoda, K., Chiyonobu, T., Imamura, T., Nishimura, A., et al. (2013) · Neuroradiology · doi:10.1007/s00234-013-1245-7 · Cited by 36
Bisen-Hersh, E. B., Hineline, P., & Walker, E. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3764 · Cited by 25
Morris, G. M., Hopewell, J. W., & Morris, A. D. (1995) · British Journal of Radiology · doi:10.1259/0007-1285-68-808-406 · Cited by 19
Cited by
Sorted by citations
Astrocyte Crosstalk in CNS Inflammation
Linnerbauer, M., Wheeler, M. A., & Quintana, F. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.012 · Cited by 989
Cancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 602
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Patani, R., Hardingham, G. E., & Liddelow, S. A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00822-1 · Cited by 531
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., O’Dea, M. R., Dutton, S., Shamardani, K., Nwangwu, K., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.008 · Cited by 521
Self-citationMicroglia regulate central nervous system myelin growth and integrity
McNamara, N. B., Munro, D. A. D., Bestard-Cuche, N., Uyeda, A., Bogie, J. F. J., Hoffmann, A., Holloway, R. K., Molina-Gonzalez, I., Askew, K. E., Mitchell, S., et al. (2023) · Nature · doi:10.1038/s41586-022-05534-y · Cited by 507
Metadata
- Authors
- Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., Woo, P. J., Barres, B. A., Liddelow, S., Vogel, H., & Monje, M.
- Affiliations
- Stanford University (US)
- New York University (US)
- Institute for Stem Cell Biology and Regenerative Medicine (US)
- Corresponding author
- Monje, Michelle
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 176
- Issue
- 1-2
- Pages
- 43-55.e13
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6329664
- OpenAlex
- W2903050755
- Cited by
- 372
- References
- 71
- Citations by year
- 2026: 39 · 2025: 65 · 2024: 38 · 2023: 47 · 2022: 60 · 2021: 52 · 2020: 41 · 2019: 28
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- California Institute for Regenerative Medicine (RB4-06093, RN3-06510)
- Unravel Pediatric Cancer
- McKenna Claire Foundation
- Virginia and D.K. Ludwig Fund for Cancer Research
- National Institutes of Neurological Disorders and Stroke (R01NS092597)
- Stanford Medical Scientist Training Program
- Stanford Neuroscience Institute
- Stanford Maternal and Child Health Research Institute
- Anne T. and Robert M. Bass Endowed Faculty Scholarship in Pediatric Cancer and Blood Diseases
- Stanford CTSA (UL1 RR025744)
- BioX Institute
- McCormick Fellowship
- Stanford MedScholars Program
- Christopher and Dana Reeve Foundation
- Novartis Institute for Biomedical Research
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- JPB Foundation
- Cure Alzheimer's Fund
- Glenn Foundation
- Esther B. O’Keeffe Charitable Foundation
- Australian National Health and Medical Research Council (GNT1052961)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- methotrexate, chemotherapy-induced cognitive impairment, oligodendrocyte precursor cells, myelination, microglial activation, astrocyte activation, neuroinflammation, cognitive behavior
- MeSH terms
- Animals, Brain, Cell Differentiation, Disease Models, Animal, Drug Therapy, Humans, Methotrexate, Myelin Sheath, Nerve Fibers, Myelinated, Neuroglia, Neurons, Oligodendroglia, Microglia, Cell Lineage, Mice, Neurogenesis, Cognitive Dysfunction, Drug-Related Side Effects and Adverse Reactions, White Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
