The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment
Open accessAbstract
Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received chemotherapy. Developing a mouse model of methotrexate chemotherapy-induced neurological dysfunction, we find a similar depletion of white matter OPCs, increased but incomplete OPC differentiation, and a persistent deficit in myelination. OPCs from chemotherapy-naive mice similarly exhibit increased differentiation when transplanted into the microenvironment of previously methotrexate-exposed brains, indicating an underlying microenvironmental perturbation. Methotrexate results in persistent activation of microglia and subsequent astrocyte activation that is dependent on inflammatory microglia. Microglial depletion normalizes oligodendroglial lineage dynamics, myelin microstructure, and cognitive behavior after methotrexate chemotherapy. These findings indicate that methotrexate chemotherapy exposure is associated with persistent tri-glial dysregulation and identify inflammatory microglia as a therapeutic target to abrogate chemotherapy-related cognitive impairment. VIDEO ABSTRACT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reactive microglia and brain-infiltrating macrophages impair mechanisms of cellular homeostasis and plasticity such as the ongoing generation of myelin-forming oligodendrocytes (Gibson et al., 2019), myelin plasticity (Geraghty et al., 2019), and new neuron generation in the hippocampus (Monje et al., 2002, 2003, 2007).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Microglia, brain-resident macrophages, become persistently reactive following exposure to certain chemotherapy drugs, after cranial radiation, or after systemic inflammatory challenge with low-dose lipopolysaccharide (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2002, 2003, 2007).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“A distinct subpopulation of microglia that reside in white matter (Hammond et al., 2019) are selectively activated by systemic insults such as exposure to the chemotherapy drug methotrexate (Gibson et al., 2019).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“This complex cellular dysregulation is thought to contribute importantly to cognitive impairment, and anti-inflammatory strategies correct this multicellular dysregulation and rescue cognition in disease states such as those occurring after exposure to neurotoxic cancer therapies (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003) and in aging (Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“This complex cellular dysregulation is thought to contribute importantly to cognitive impairment, and anti-inflammatory strategies correct this multicellular dysregulation and rescue cognition in disease states such as those occurring after exposure to neurotoxic cancer therapies (Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003) and in aging (Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“In contrast to methotrexate chemotherapy exposure (Geraghty et al., 2019; Gibson et al., 2019), changes in myelin sheath thickness relative to axon diameter (g ratio) were not conclusively identified in the remaining myelin sheaths after mild respiratory COVID (Figures S7C–S7F).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Such neuroinflammatory changes—particularly white-matter-selective/enriched microglial reactivity—are associated with impaired hippocampal neurogenesis, dysregulation of the oligodendroglial lineage, and myelin loss in other disease contexts (Geraghty et al., 2019; Gibson et al., 2019; Guttenplan et al., 2021; Liddelow et al., 2017; Monje et al., 2003; Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“As occurs after cancer therapies and in other disease states, the microglial reactivity present after mild respiratory SARS-CoV-2 infection may also induce neurotoxic astrocyte reactivity (Liddelow et al., 2017; Gibson et al., 2019; Guttenplan et al., 2021), as well as aberrant microglial pruning of synapses (Hinkle et al., 2019; Hosseini et al., 2018; Vasek et al., 2016).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“While methotrexate directly stimulates reactivity of microglia (Gibson et al., 2019),”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“For example, microglial depletion strategies can restore similar multicellular deficits and rescue impaired cognitive performance in mouse models of CRCI (Acharya et al., 2016; Gibson et al., 2019),”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
In the citing paper
“Preclinical studies in disease models that share numerous features with the cellular dysregulation observed here after mild respiratory COVID have identified anti-inflammatory and neuro-regenerative strategies that restore neural plasticity and rescue cognition (Ayoub et al., 2020; Geraghty et al., 2019; Gibson et al., 2019; Monje et al., 2003; Villeda et al., 2011).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Gibson et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Bialas, A. R., & Stevens, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3560 · Cited by 519
RetractedNeurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Self-citationGenomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
(1967) · Medical Entomology and Zoology · Cited by 1,713
Cited by
Sorted by citations
Astrocyte Crosstalk in CNS Inflammation
Linnerbauer, M., Wheeler, M. A., & Quintana, F. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.012 · Cited by 989
Cancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 602
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Patani, R., Hardingham, G. E., & Liddelow, S. A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00822-1 · Cited by 531
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., O’Dea, M. R., Dutton, S., Shamardani, K., Nwangwu, K., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.008 · Cited by 521
Self-citationMicroglia regulate central nervous system myelin growth and integrity
McNamara, N. B., Munro, D. A. D., Bestard-Cuche, N., Uyeda, A., Bogie, J. F. J., Hoffmann, A., Holloway, R. K., Molina-Gonzalez, I., Askew, K. E., Mitchell, S., et al. (2023) · Nature · doi:10.1038/s41586-022-05534-y · Cited by 507
Molecular and spatial signatures of mouse brain aging at single-cell resolution
Allen, W. E., Blosser, T. R., Sullivan, Z. A., Dulac, C., & Zhuang, X. (2023) · Cell · doi:10.1016/j.cell.2022.12.010 · Cited by 423
“Activated astrocytes and microglia may in turn exacerbate oligodendrocyte and myelin degeneration.(40,56) Our result further showed that microglia and astrocyte activation induced by aging exhibited both similarities to and notable differences from those induced by systemic inflammatory challenge.”
ResultThe neurobiology of long COVID
Monje, M., & Iwasaki, A. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.006 · Cited by 415
Self-citationImmune cell regulation of glia during CNS injury and disease
Greenhalgh, A. D., David, S., & Bennett, F. C. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0263-9 · Cited by 411
Roadmap for the Emerging Field of Cancer Neuroscience
Monje, M., Borniger, J. C., D’Silva, N. J., Deneen, B., Dirks, P. B., Fattahi, F., Frenette, P. S., Garzia, L., Gutmann, D. H., Hanahan, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.034 · Cited by 402
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 354
Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology
Gutmann, D. H., & Kettenmann, H. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.028 · Cited by 301
Mechanisms of Chemotherapy-Induced Neurotoxicity
Waś, H., Borkowska, A., Bagüés, A., Tu, L., Liu, J. Y. H., Lu, Z., Rudd, J. A., Nurgali, K., & Abalo, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.750507 · Cited by 307
Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment
Geraghty, A. C., Gibson, E. M., Ghanem, R. A., Greene, J. J., Ocampo, A., Goldstein, A. K., Ni, L., Yang, T., Marton, R. M., Paşca, S. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.032 · Cited by 288
Questions and (some) answers on reactive astrocytes
Escartin, C., Guillemaud, O., & Carrillo‐de Sauvage, M. (2019) · Glia · doi:10.1002/glia.23687 · Cited by 275
Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?
Liddelow, S. A., Marsh, S. E., & Stevens, B. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.006 · Cited by 226
Developmental origins and emerging therapeutic opportunities for childhood cancer
Filbin, M. G., & Monje, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0383-9 · Cited by 258
Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis
Schulz, M., Salamero‐Boix, A., Niesel, K., Alekseeva, T., & Sevenich, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01713 · Cited by 226
Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue
Theoharides, T. C., Cholevas, C., Polyzoidis, K. S., & Politis, A. M. (2021) · BioFactors · doi:10.1002/biof.1726 · Cited by 227
Glial and myeloid heterogeneity in the brain tumour microenvironment
Andersen, B. M., Akl, C. F., Wheeler, M. A., Chiocca, E. A., Reardon, D. A., & Quintana, F. J. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00397-3 · Cited by 216
Microglia as Dynamic Cellular Mediators of Brain Function
Wright-Jin, E. C., & Gutmann, D. H. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.08.013 · Cited by 197
Guo, X., Pan, Y., Xiong, M., Sanapala, S., Anastasaki, C., Cobb, O. M., Dahiya, S. M., & Gutmann, D. H. (2020) · Nature Communications · doi:10.1038/s41467-020-15770-3 · Cited by 175
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration
Molina-Gonzalez, I., Holloway, R. K., Jiwaji, Z., Dando, O., Kent, S. A., Emelianova, K., Lloyd, A. F., Forbes, L. H., Mahmood, A., Skripuletz, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39046-8 · Cited by 176
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
Nguyen, L. D., & Ehrlich, B. E. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012075 · Cited by 181
Long-Term Cognitive Dysfunction in Cancer Survivors
Országhová, Z., Mego, M., & Chovanec, M. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.770413 · Cited by 196
Microglia as hackers of the matrix: sculpting synapses and the extracellular space
Crapser, J. D., Arreola, M. A., Tsourmas, K. I., & Green, K. N. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00751-3 · Cited by 178
Crapser, J. D., Ochaba, J., Soni, N., Reidling, J. C., Thompson, L. M., & Green, K. N. (2020) · Brain · doi:10.1093/brain/awz363 · Cited by 157
Microglia regulation of central nervous system myelin health and regeneration
Kent, S. A., & Miron, V. E. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-023-00907-4 · Cited by 183
Molecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 149
Mayo, S. J., Lustberg, M. B., Dhillon, H. M., Nakamura, Z. M., Allen, D. H., Ah, D. M. V., Janelsins, M. C., Chan, A., Olson, K. L., Tan, C. J., et al. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05860-9 · Cited by 149
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia
Wang, J., He, X., Meng, H., Li, Y., Dmitriev, P., Tian, F., Page, J. C., Lu, Q. R., & He, Z. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.016 · Cited by 141
Maladaptive myelination promotes generalized epilepsy progression
Knowles, J. K., Xu, H., Soane, C., Batra, A., Saucedo, T., Frost, E., Tam, L. T., Fraga, D. A., Ni, L., Villar, K., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01052-2 · Cited by 130
The influence of environment and origin on brain resident macrophages and implications for therapy
Bennett, M. L., & Bennett, F. C. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0545-6 · Cited by 136
The neural addiction of cancer
Magnon, C., & Hondermarck, H. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00556-8 · Cited by 128
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.03.019 · Cited by 114
Microglia in Cancer Therapy-Related Cognitive Impairment
Gibson, E. M., & Monje, M. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.02.003 · Cited by 101
Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis
Kleffman, K., Levinson, G., Rose, I. V. L., Blumenberg, L. M., Shadaloey, S. A. A., Dhabaria, A., Wong, E., Galán-Echevarría, F., Karz, A., Argibay, D., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1006 · Cited by 101
Neuron–oligodendroglial interactions in health and malignant disease
Taylor, K. R., & Monje, M. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00744-3 · Cited by 106
Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., Yalçın, B., Taylor, K. R., Dutton, S., Acosta-Alvarez, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.07.475453 · Cited by 104
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
Chadarevian, J. P., Lombroso, S. I., Peet, G. C., Hasselmann, J., Tu, C. H., Marzan, D. E., Capocchi, J. K., Purnell, F. S., Nemec, K. M., Lahian, A., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220857 · Cited by 101
Adaptive and maladaptive myelination in health and disease
Knowles, J. K., Batra, A., Xu, H., & Monje, M. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00737-3 · Cited by 97
A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
Flury, A. G., Aljayousi, L., Park, H.-J., Khakpour, M., Mechler, J., Aziz, S., McGrath, J. D., Deme, P., Sandberg, C., Ibáñez, F. G., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.11.018 · Cited by 102
Cognitive adverse effects of chemotherapy and immunotherapy: are interventions within reach?
Schagen, S. B., Tsvetkov, A. S., Compter, A., & Wefel, J. S. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00617-2 · Cited by 101
Endothelin signalling mediates experience-dependent myelination in the CNS
Swire, M., Kotelevtsev, Y. V., Webb, D. J., Lyons, D. A., & ffrench‐Constant, C. (2019) · eLife · doi:10.7554/elife.49493 · Cited by 88
White matter microglia heterogeneity in the CNS
Amor, S., McNamara, N. B., Gerrits, E., Marzin, M. C., Kooistra, S. M., Miron, V. E., & Nutma, E. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02389-x · Cited by 89
Cognitive Deficits in Long Covid-19
Venkataramani, V., & Winkler, F. (2022) · New England Journal of Medicine · doi:10.1056/nejmcibr2210069 · Cited by 90
An Overview on Chemotherapy-induced Cognitive Impairment and Potential Role of Antidepressants
Das, A., Ranadive, N., Kinra, M., Nampoothiri, M., Arora, D. S., & Mudgal, J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200221113842 · Cited by 87
Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease
Yang, Y., & Zhang, Z. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00110 · Cited by 76
Peng, A. Y. T., Agrawal, I., Ho, W. Y., Yen, Y.-C., Pinter, A. J., Liu, J., Phua, Q. X. C., Koh, K. B., Chang, J., Sanford, E., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007806117 · Cited by 77
Liu, X., Xin, D. E., Zhong, X., Zhao, C., Li, Z., Zhang, L., Dourson, A. J., Lee, L., Mishra, S. V., Bayat, A. E., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.005 · Cited by 80
Schroyen, G., Blommaert, J., Weehaeghe, D. V., Sleurs, C., Vandenbulcke, M., Dedoncker, N., Hatse, S., Goris, A., Koole, M. J. B., Smeets, A., et al. (2021) · Cancers · doi:10.3390/cancers13164198 · Cited by 80
Sex‐specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury
Fiore, N. T., Yin, Z., Güneykaya, D., Gauthier, C. D., Hayes, J. P., D’Hary, A., Butovsky, O., & Moalem‐Taylor, G. (2022) · Glia · doi:10.1002/glia.24133 · Cited by 73
Animal models of chemotherapy-induced cognitive decline in preclinical drug development
John, J., Kinra, M., Mudgal, J., Viswanatha, G. L., & Nandakumar, K. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05977-7 · Cited by 73
Comprehensive Analysis to Identify SPP1 as a Prognostic Biomarker in Cervical Cancer
Zhao, K.-D., Ma, Z., & Zhang, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.732822 · Cited by 65
Zhao, J., Bang, S., Furutani, K., McGinnis, A., Jiang, C., Roberts, A., Donnelly, C. R., He, Q., James, M. L., Berger, M., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.05.022 · Cited by 64
Correa, D. D., Braun, E., Kryza‐Lacombe, M., Ho, K.-W., Reiner, A. S., Panageas, K. S., Yahalom, J., Sauter, C. S., Abrey, L. E., DeAngelis, L. M., et al. (2019) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03257-1 · Cited by 65
Schmahmann, J. D. (2019) · Child s Nervous System · doi:10.1007/s00381-019-04253-6 · Cited by 64
Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity
Gupta, P., Makkar, T. K., Goel, L., & Pahuja, M. (2022) · Immunologic Research · doi:10.1007/s12026-022-09307-7 · Cited by 71
Salama, A., Elgohary, R., Amin, M. M., & Elwahab, S. A. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175217 · Cited by 60
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice
Geraghty, A. C., Acosta-Alvarez, L., Rotiroti, M. C., Dutton, S., O’Dea, M. R., Kim, W., Trivedi, V., Mancusi, R. A., Shamardani, K., Malacon, K. E., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.041 · Cited by 64
Gibson, E. M., & Monje, M. (2019) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000578 · Cited by 60
Fernandez, H. R., Varma, A., Flowers, S. A., & Rebeck, G. W. (2020) · Cancers · doi:10.3390/cancers12123842 · Cited by 65
Neuroinflammation in HIV-Related Neuropathic Pain
Lu, H.-J., Fu, Y.-Y., Wei, Q.-Q., & Zhang, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653852 · Cited by 61
Glial Cells Promote Myelin Formation and Elimination
Hughes, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661486 · Cited by 64
Bashiri, H., Enayati, M., Bashiri, A., & Salari, A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113003 · Cited by 57
Peng, F., Zhao, F., Shan, L., Li, R., Jiang, S., & Zhang, P. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111467 · Cited by 57
Subramaniam, C. B., Bowen, J. M., Gladman, M. A., Lustberg, M. B., Mayo, S. J., & Wardill, H. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.002 · Cited by 59
Neuron-oligodendroglia interactions: Activity-dependent regulation of cellular signaling
Thornton, M. A., & Hughes, E. G. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134916 · Cited by 57
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders
Liddelow, S. A., Olsen, M. L., & Sofroniew, M. V. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041356 · Cited by 55
Dias-Carvalho, A., Ferreira, M., Ferreira, R. M., Bastos, M. D. L., Sá, S. I., Capela, J. P., Carvalho, F. D., & Costa, V. M. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03171-4 · Cited by 59
A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head
Lee, E. J., Han, J. C., Park, D. Y., & Kee, C. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100840 · Cited by 54
Astrocytes usurp neurons as a disease focus
Liddelow, S. A., & Sofroniew, M. V. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0367-6 · Cited by 50
McAlpin, B. R., Mahalingam, R., Singh, A. K., Dharmaraj, S., Chrisikos, T. T., Boukelmoune, N., Kavelaars, A., & Heijnen, C. J. (2021) · Theranostics · doi:10.7150/thno.67410 · Cited by 52
Jang, A., Petrova, B., Cheong, T.-C., Zawadzki, M. E., Jones, J. K., Culhane, A. J., Shipley, F. B., Chiarle, R., Wong, E. T., Kanarek, N., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.009 · Cited by 51
BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep
Rojo, D., Cengio, L. D., Badner, A., Kim, S., Sakai, N., Greene, J. J., Dierckx, T., Mehl, L. C., Eisinger, E. C., Ransom, J., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.002 · Cited by 53
Nicotinamide mononucleotide prevents cisplatin-induced cognitive impairments
Yoo, K., Tang, J. J., Rashid, M., Chang, H.-C., Corujo-Ramirez, A., Choi, J., Bae, M. G., Brogren, D., Hawse, J., Hou, X., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3290 · Cited by 38
Brain Tumor Networks in Diffuse Glioma
Yang, Y., Schubert, M. C., Kuner, T., Wick, W., Winkler, F., & Venkataramani, V. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01320-w · Cited by 49
Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology
Barrientos, R. M., Brunton, P. J., Lenz, K. M., Pyter, L. M., & Spencer, S. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.010 · Cited by 50
Chemobrain in Breast Cancer: Mechanisms, Clinical Manifestations, and Potential Interventions
Onzi, G. R., D’Agustini, N., García, S. C., Guterres, S. S., Pohlmann, P. R., Rosa, D. D., & Pohlmann, A. R. (2022) · Drug Safety · doi:10.1007/s40264-022-01182-3 · Cited by 48
Basilico, B., Ferrucci, L., Khan, A., Angelantonio, S. D., Ragozzino, D., & Reverte, I. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1022431 · Cited by 52
Liu, Q., Zhang, K., Kang, Y., Li, Y., Deng, P., Li, Y., Tian, Y., Sun, Q., Tang, Y., Xu, K., et al. (2022) · Science Advances · doi:10.1126/sciadv.add6391 · Cited by 48
Safaei, M., & Shishehbore, M. R. (2021) · Talanta · doi:10.1016/j.talanta.2021.122247 · Cited by 48
Reorganization and Plasticity of the Language Network in Patients with Cerebral Gliomas
Nieberlein, L., Rampp, S., Gussew, A., Prell, J., & Hartwigsen, G. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103326 · Cited by 47
Complex neural-immune interactions shape glioma immunotherapy
Song, K.-W., Lim, M. K., & Monje, M. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.017 · Cited by 50
Duffau, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.855587 · Cited by 52
Neuron–Glial Interactions in Health and Brain Cancer
Pan, Y., & Monje, M. (2022) · Advanced Biology · doi:10.1002/adbi.202200122 · Cited by 46
Murillo, L. C., Sutachan, J. J., & Albarracín, S. L. (2023) · Toxicology Reports · doi:10.1016/j.toxrep.2023.04.015 · Cited by 42
Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities
Huang, Z., Zhang, Y., Zou, P., Zong, X., & Zhang, Q. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00861-w · Cited by 49
Microenvironmental interactions of oligodendroglial cells
Yalçın, B., & Monje, M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.06.006 · Cited by 45
Labib, D., Wang, Z., Prakash, P. S., Zimmer, M., Smith, M. D., Frazel, P. W., Barbar, L., Sapar, M. L., Calabresi, P. A., Peng, J., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.870085 · Cited by 45
Investigating Microglia in Health and Disease: Challenges and Opportunities
Miron, V. E., & Priller, J. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.002 · Cited by 43
El-Derany, M. O., & Noureldein, M. H. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02384-9 · Cited by 41
Taha, M., Eldemerdash, O. M., Elshaffei, I. M., Yousef, E. M., Soliman, A. S., & Senousy, M. A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03299-7 · Cited by 42
Kim, T., James, B. T., Kahn, M. C., Blanco‐Duque, C., Abdurrob, F., Islam, R., Lavoie, N., Kellis, M., & Tsai, L. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adf4601 · Cited by 43
Chen, D., Wang, C., Chen, X., Li, J., Chen, S., Li, Y., Ma, F., Li, T., Zou, M., Li, X., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.ads6111 · Cited by 42
Signaling Regulatory Protein (SIRP)α-CD47 Blockade Joins the Ranks of Immune Checkpoint Inhibition
Veillette, A., & Tang, Z.-H. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.00121 · Cited by 39
Myelin Plasticity and Repair: Neuro-Glial Choir Sets the Tuning
Ronzano, R., Thétiot, M., Lubetzki, C., & Desmazières, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00042 · Cited by 42
Central Nervous System Plasticity Influences Language and Cognitive Recovery in Adult Glioma
Krishna, S., Kakaizada, S., Almeida, N. C., Brang, D., & Hervey‐Jumper, S. L. (2020) · Neurosurgery · doi:10.1093/neuros/nyaa456 · Cited by 41
Clearing the Fog surrounding Chemobrain
Gutmann, D. H. (2019) · Cell · doi:10.1016/j.cell.2018.12.027 · Cited by 38
(Re)building the nervous system: A review of neuron–glia interactions from development to disease
Demmings, M. D., Chagas, L. D. S., Traetta, M. E., Rodrigues, R. S., Acutain, M. F., Barykin, E. P., Datusalia, A. K., German‐Castelan, L., Mattera, V. S., Mazengenya, P., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16258 · Cited by 44
Zhu, L., Retana, D., García‐Gómez, P., Álvaro‐Espinosa, L., Priego, N., Masmudi‐Martín, M., Yebra, N., Miarka, L., Hernández-Encinas, E., Blanco‐Aparicio, C., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114552 · Cited by 38
Metadata
- Authors
- Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., Woo, P. J., Barres, B. A., Liddelow, S., Vogel, H., & Monje, M.
- Affiliations
- Stanford University (US)
- New York University (US)
- Institute for Stem Cell Biology and Regenerative Medicine (US)
- Corresponding author
- Monje, Michelle
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 176
- Issue
- 1-2
- Pages
- 43-55.e13
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6329664
- OpenAlex
- W2903050755
- Cited by
- 372
- References
- 71
- Citations by year
- 2026: 39 · 2025: 65 · 2024: 38 · 2023: 47 · 2022: 60 · 2021: 52 · 2020: 41 · 2019: 28
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- California Institute for Regenerative Medicine (RB4-06093, RN3-06510)
- Unravel Pediatric Cancer
- McKenna Claire Foundation
- Virginia and D.K. Ludwig Fund for Cancer Research
- National Institutes of Neurological Disorders and Stroke (R01NS092597)
- Stanford Medical Scientist Training Program
- Stanford Neuroscience Institute
- Stanford Maternal and Child Health Research Institute
- Anne T. and Robert M. Bass Endowed Faculty Scholarship in Pediatric Cancer and Blood Diseases
- Stanford CTSA (UL1 RR025744)
- BioX Institute
- McCormick Fellowship
- Stanford MedScholars Program
- Christopher and Dana Reeve Foundation
- Novartis Institute for Biomedical Research
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- JPB Foundation
- Cure Alzheimer's Fund
- Glenn Foundation
- Esther B. O’Keeffe Charitable Foundation
- Australian National Health and Medical Research Council (GNT1052961)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- methotrexate, chemotherapy-induced cognitive impairment, oligodendrocyte precursor cells, myelination, microglial activation, astrocyte activation, neuroinflammation, cognitive behavior
- MeSH terms
- Animals, Brain, Cell Differentiation, Disease Models, Animal, Drug Therapy, Humans, Methotrexate, Myelin Sheath, Nerve Fibers, Myelinated, Neuroglia, Neurons, Oligodendroglia, Microglia, Cell Lineage, Mice, Neurogenesis, Cognitive Dysfunction, Drug-Related Side Effects and Adverse Reactions, White Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
