Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

Ioannou, Maria S., Jackson, Jesse, Sheu, Shu-Hsien, Chang, Chi-Lun, Weigel, Aubrey V., Liu, Hui, Pasolli, H. Amalia, Xu, C. Shan, Pang, Song, Matthies, Doreen, Hess, Harald F., Lippincott-Schwartz, Jennifer, Liu, Zhe·2019·Cell

DOI 10.1016/j.cell.2019.04.001

Cited by (761)

Items 201–300 of 761

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Zhao, Jing, Ikezu, Tadafumi C., Lu, Wenyan, Macyczko, Jesse R., Li, Yonghe, Lewis-Tuffin, Laura J., Martens, Yuka A., Ren, Yingxue, Zhu, Yiyang, Asmann, Yan W. et al. · 2023 · Stem Cell Research & Therapy
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Zhuoqing Lan, Shukai Lv, Ziyi Ge, Bing Zhao, Leilei Li, Caixia Li · 2024 · Journal of Lipid Research
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Lijie Zhang, Qiuru Yao, Jinjing Hu, Baizhi Qiu, Yupeng Xiao, Qi Zhang, Yuting Zeng, Shuqi Zheng, Youao Zhang, Yantong Wan et al. · 2024 · European journal of medical research
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Xuewen Cheng, Miao Zhao, Lei Chen, Chen‐Wei Huang, Qiwu Xu, Jia Shao, Hongtao Wang, Yuxian Zhang, Xuequan Li, Xuan Xu et al. · 2024 · Neuron
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke
Shuai Wang, Yi Guo, Rui-qi Cao, Yongming Zhu, Shigang Qiao, Huaping Du, Yuan Liu, Yuan Xu, Xian-yong Zhou, Lei Sun et al. · 2024 · Acta Pharmacologica Sinica
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Ji Liu, Man Luo, Weijie Gao, Kunyuan Duan, Haojun Bian, Zhiyuan Jin, Yuhan Pan, Shiya Wang, Yueqing Gu, Jinrong Zheng et al. · 2024 · Biosensors and Bioelectronics
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Baoman Li, Qian Sun, Fengfei Ding, Qiwu Xu, Ning Kang, Yang Xue, Antonio Ladrón-de-Guevara, Hajime Hirase, Pia Weikop, Sheng Gong et al. · 2024 · Cell Metabolism