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Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
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Abstract
Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are transferred to astrocytic lipid droplets by ApoE-positive lipid particles. Astrocytes consume the FAs stored in lipid droplets via mitochondrial β-oxidation in response to neuronal activity and turn on a detoxification gene expression program. Our findings reveal that FA metabolism is coupled in neurons and astrocytes to protect neurons from FA toxicity during periods of enhanced activity. This coordinated mechanism for metabolizing FAs could underlie both homeostasis and a variety of disease states of the brain.
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“Reactive astrocytes can upregulate VLCFA-rich phosphatidylcholines, which drive the death of neurons and OLs, probably via lipoparticle secretion [415].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [415]
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“Injured neurons and oligodendrocytes have a low capacity for consuming FFAs and sequestering them into LDs61, making them more vulnerable to lipid-induced cytotoxicity in chronic inflammation62,63.”
From Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease (2025) · cites this paper as [63]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This neuron–astrocyte metabolic coupling, mediated by apoE, plays an essential role in preventing activity‐induced lipotoxicity in neurons. 1”
From Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes (2025) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ischemia is correlated with both increased lipid peroxidation and neutral lipid accumulation in the brain (Yoshida et al., 1982; Gasparovic et al., 2001; Ioannou et al., 2019).”
From APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size (2024) · cites this paper as Ioannou et al., 2019
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“recent reports revealed a role of ApoE in transporting peroxidized FAs from neuron to astrocyte upon neuronal stimulation (Ioannou et al., 2019)”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Ioannou et al., 2019
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“Because LDL receptors are involved in neuron-to-astrocyte FA transfer (Ioannou et al., 2019), the lower ability of E4 astrocytes in uptaking LDL (Figure S3E) is consistent with a reduced capacity of E4 astrocytes in internalizing FAs.”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Ioannou et al., 2019
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In the citing paper
“Strikingly, we observed substantial accumulation of LD-like lipid structures in neurons (Figure 1A; days in vitro 8 [DIV8]) under culture conditions without extra NMDA stimulation or oxidative challenge used previously (Ioannou et al., 2019).”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Ioannou et al., 2019
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“while autophagy contributes to LD formation in NMDA-stimulated neurons (Ioannou et al., 2019)”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Ioannou et al., 2019
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“Other studies demonstrated that lipid peroxides formed in neurons under oxidative or excitotoxic stress can be transported by APOE-lipoproteins to astrocytes; astrocytes store these neuron-derived lipids in LDs, which protect against neurotoxicity and may play a role in detoxifying these deleterious lipid species (Walker et al., 2006; Liu et al., 2015, 2017; Ioannou et al., 2019; Moulton et al., 2”
From APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size (2024) · cites this paper as Ioannou et al., 2019
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In the citing paper
“Other studies demonstrated that lipid peroxides formed in neurons under oxidative or excitotoxic stress can be transported by APOE-lipoproteins to astrocytes; astrocytes store these neuron-derived lipids in LDs, which protect against neurotoxicity and may play a role in detoxifying these deleterious lipid species (Walker et al., 2006; Liu et al., 2015, 2017; Ioannou et al., 2019; Moulton et al., 2”
From APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size (2024) · cites this paper as Ioannou et al., 2019
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“Various studies have shown that lipid droplets influence intercellular communication13,17,61.”
From APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics (2026) · cites this paper as [61]
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“In the brain, ApoE contributes to a bidirectional metabolic network that couples astrocytes and neurons (Ioannou et al., 2019;Liu et al., 2017;Qi et al., 2021).”
From Isoform- and cell-state-specific lipidation of ApoE in astrocytes (2022) · cites this paper as Ioannou et al., 2019
In the citing paper
“cell culture models have demonstrated that hyperactive neurons can release APOE-associated fatty acids which are taken up by astrocytes and buffer lipotoxic stress35.”
From APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia (2024) · cites this paper as [35]
In the citing paper
“ApoE-mediated transport of lipids from neurons to glia in flies61 and mammalian cells is neuroprotective62.”
From Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes (2025) · cites this paper as [62]
In the citing paper
“In the CNS, apoE facilitates the transport of cholesterol and FAs between cells, maintaining lipid homeostasis.”
From Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes (2025) · cites this paper as [1]
In the citing paper
“Astrocytes are critical for maintaining central nervous system (CNS) homeostasis, playing essential roles in lipid metabolism and the clearance of toxic protein aggregates.”
From Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes (2025) · cites this paper as [1]
In the citing paper
“Upon oxidative stress or hyperactivity, neurons transfer peroxidized FAs to glia via ApoE-positive lipid particles (Ioannou et al., 2019).”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Ioannou et al., 2019
In the citing paper
“Collectively, these genes have been implicated in the coordination of lipid and oxidative metabolism between neurons and astrocytes30.”
From Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease (2020) · cites this paper as [30]
In the citing paper
“these results and those of others demonstrate that astrocytes and microglia secrete and degrade a huge array and quantity of lipids”
From Neurotoxic reactive astrocytes induce cell death via saturated lipids (2021) · cites this paper as [21]
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“Besides, researchers have noted that astrocytes can protect the brain by endocytosing the toxic fatty acids released from neurons through ApoE-positive lipoparticles, which implies that lipoparticles are involved in astrocyte– neuron interactions [8, 9].”
Backgroundda Costa, E. R., Henrique, E. P., da Silva, J. B., Pereira, P. D. C., de Abreu, C. C., Fernandes, T. N., Magalhães, N. G. D. M., da Silva, A. D. J. F., Guerreiro, L. C. F., Diniz, C. G., et al. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101805 · Cited by 3
Yamashita, A., Ignatenko, O., Nguyen, M., Lambert, R., Watt, K., Daneault, C., Robillard-Frayne, I., Topisirovic, I., Rosiers, C. D., & McBride, H. M. (2023) · Biology Direct · doi:10.1186/s13062-023-00416-3 · Cited by 3
“In the brain, peroxisomal factors are enriched in astrocytes compared to neurons, and cultured astrocytes but not neurons demonstrate beta-oxidation activity (Eraso-Pichot et al., 2018; Ioannou et al., 2019; McGee et al., 1992; Russo et al., 2021).”
BackgroundJiang, H., Qi, H., Tang, A., Hu, S., & Lai, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102808 · Cited by 2
Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance
Yin, J., Chen, H.-L., Grigsby-Brown, A., He, Y., Cotten, M. L., Short, J., Dermady, A., Lei, J., Gibbs, M., Cheng, E. S., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv2902 · Cited by 8
“…play key roles in these processes, serving as primary sources of lipid binding proteins and transporters that shuttle essential lipids and metabolites between neuron and glia ( 10 – 15 ), thus contributing to the establishment and maintenance of the brain’s unique lipid environment ( 10 , 16 ).”
Tomiyama, H., Yamasaki, M., Isagawa, T., Takeda, N., Hashimoto, T., Hirata, H., & Matsumoto, S. (2025) · Discover Nano · doi:10.1186/s11671-025-04304-9 · Cited by 2
“Unused fatty acids in neurons are transferred as lipid droplets to antioxidant-rich astrocytes and used as fuel for mitochondrial oxidative phosphorylation [20, 21].”
Cui, J., Liu, J., Cui, Y. R., & Xie, K. (2025) · Shock · doi:10.1097/shk.0000000000002709 · Cited by 2
Huang, B., Yu, H., Wen, Z., Dong, J., Jin, S., & Li, H. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02746-9 · Cited by 2
“The levels of ROS are reduced, likely because of the activation of converging pathways that counteract the generation of ROS by increased β-oxidation and mitochondrial activity [119].”
Zheng, H., Zhang, X., Li, M., Wang, Y., Guo, S., Jiang, M., Xu, R., Huang, Y.-L., & Ma, Z. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114801 · Cited by 2
Fu, Y., Zhang, X.-Y., Li, L.-L., Jiang, H., Ren, Q., Yi, T., Zhang, Y., & Lu, Y. (2025) · Antioxidants · doi:10.3390/antiox14111321 · Cited by 2
“Available studies [5] suggest that the brain is heavily dependent on astrocyte mitochondrial β -oxidation to degrade fatty acids (FAs) and maintain lipid homeostasis [7], and that aberrant lipid metabolism induces the accumulation of lipid droplets (LDs) [8] and subsequent neurodegeneration [9].”
A Lipid Road to Neuroimmunology: Fatty Acids Linking Immune and Nervous Systems
Moraes-de-Souza, I., de Moraes, B. P. T., Muniz‐Santos, R., Gomes-Reis, G. L. D. S., dos Santos, F. D. S., Saraiva, J. S. G., Ferreira-Costa, M., da Cunha, C. M. C., Carpinter, B. A., Silva, A. R., et al. (2025) · NeuroImmunoModulation · doi:10.1159/000550168 · Cited by 2
Pancreas-brain axis: exploring the pathogenic mechanisms of pancreatic encephalopathy
Dai, N., Geng, Z., Wang, J., Bu, X., Gong, M.-Y., Qin, C., Zhang, Y., Fu, X.-Y., & Fu, B. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116332 · Cited by 3
Shirolapov, I. V., Zakharov, A. V., Pavlova, O. N., Borisova, O. V., Bulgakova, S. V., & Kurmaev, D. P. (2025) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-235-3-44-54 · Cited by 2
Wu, W., Chen, Z., Xu, Y., Xie, X., Tan, A., Hu, M., Xu, D., Lv, X., Chen, W., Zhou, J., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.03.024 · Cited by 2
Baumart, G. J., Rodrigues, M. S., Sholl, J. N., de Sousa, A. C., Weber, A. F., Costa‐Beber, L. C., Farias, H. R., Costa, M. V., Peres, A. M., de Camargo, P. R., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70403 · Cited by 2
Liu, W., Wang, Y., Zhao, Y., Song, B., Luo, L., Zahir, K. M., Song, M., Wang, Y., Zhang, L., Zuo, Z., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104137 · Cited by 2
“Mitochondrial homeostasis impairment and increased reactive oxygen species (ROS) levels will induce neuronal death by inhibiting synaptogenesis, reducing phagocytosis and secreting inflammatory factors [7].”
Robinson, L., Do-Ha, D., Cheng, F., Stevens, C. H., Porto, R. R., Coles, M., Subachandran, J., Kalajdzic, P., Lui, J., Balez, R., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03827-x · Cited by 2
“More broadly, astrocytes are increasingly recognised as active metabolic partners of neurons that couple neuronal activity to local energy supply [89, 90].”
An optimized method to visualize lipid droplets in mouse brain tissue
Rey, A., Petrelli, F., Panfilova, D., Madsen, S., Héritier, N., & Knobloch, M. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101455 · Cited by 5
“18 This process may serve as a physiological mechanism for detoxification, and its functioning might be impaired in disease contexts.”
Liao, W., Yin, R., Zuo, F., Li, Y., Deng, J., Li, Y., Li, X., 陶德定, Luo, X. P., 季维克, et al. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03754-y · Cited by 2
“Using the lipid peroxidation sensor BODIPY C11 [47], we detected pronounced peroxidized lipid accumulation within LDs of dormant cells (Fig.”
Chen, C. F., Zhao, Y., Lian, Y., Hou, Y., Gong, L., Wu, T., Yang, Y., ZHU, J., Wang, X., 张凯华, et al. (2026) · Advanced Science · doi:10.1002/advs.76377 · Cited by 2
“Indeed, neuron-astrocyte metabolic coupling has been shown to protect against activity-induced fatty acid toxicity by enabling astrocytes to buffer excess neuronal lipids and prevent lipotoxic damage [ 59 ].”
Metabolic Plasticity of Astrocytes
Gorina, Y. V., Salmina, A. B., Erofeev, A. I., Can, Z., Bolshakova, A. V., Balaban, P. M., Борисович, Б. И., & Власова, О. Л. (2021) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093021060016 · Cited by 2
Lamin A/C mediates microglial activation by modulating cell proliferation and immune response
Liu, H., Liu, X., Luo, S., Ma, R., Ge, W., Meng, S., & Gao, Y. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25263 · Cited by 2
Self-citationYeo, X. Y., Dao, T., Jo, Y., Kim, J. E., Ryu, D., Chan, J. P., & Jung, S. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300883 · Cited by 2
den Hoedt, S., Crivelli, S. M., Dorst‐Lagerwerf, K. Y., Leijten, F. P. J., Losen, M. H., de Vries, H. E., Sijbrands, E. J. G., Verhoeven, A. J. M., Martínez‐Martínez, P., & Mulder, M. T. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16176 · Cited by 2
“However, to prevent these from becoming toxic they may need to be transferred to astrocytes via ApoE-containing lipid particles for detoxification (Ioannou et al., 2019).”
Neuron-Astrocyte Interactions: A Human Perspective
Pio, T., Hill, E. J., Kebede, N., Andersen, J., & Sloan, S. A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_4 · Cited by 2
Challenges and Frontiers in Computational Metabolic Psychiatry
Chesebro, A. G., Antal, B. B., Weistuch, C., & Mujica-Parodi, L. R. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.10.011 · Cited by 2
Rosiglitazone-induced white adipocyte browning is regulated by actin and Myh9
Chen, L., Hao, J., Zhang, J., Wu, J., & Ren, Z. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123217 · Cited by 2
Bai, L., Guan, Z., Zhang, J., Lv, Z., Duan, Y., & Tian, S. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00846 · Cited by 2
APOE4 Regulates Synaptic Function by Directly Modulating the SNARE Complex AssemblyPreprint
Chen, F., Chen, Y., Chen, H., Wang, Y., Wei, W., Cai, Y., Liang, C., Cao, H., Chen, X., Ji, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-380304/v1 · Cited by 3
Editorial: Molecular Role of Lipids in Aging
Skowronska‐Krawczyk, D., Narayan, P. S., & Tessarz, P. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.946884 · Cited by 2
“Multiple studies have revealed that APOE4 alter cellular lipid state, and that alterations to lipid state can have changes to cell autonomous or non-autonomous functions (Lin et al., 2018; Farmer et al., 2019; Ioannou et al., 2019; Blanchard et al., 2020; Sienski et al., 2021; Victor et al., 2022).”
BackgroundContextual guidance: An integrated theory for astrocytes function in brain circuits and behaviorPreprint
Murphy‐Royal, C., Ching, S., & Papouin, T. (2022) · arXiv (Cornell University) · doi:10.48550/arxiv.2211.09906 · Cited by 3
Cold induces brain region-selective cell activity-dependent lipid metabolismPreprint
Min, H., Yang, Y. Y., & Yang, Y. (2024) · eLife · doi:10.7554/elife.98353 · Cited by 2
“…the BODIPY 493 (BD493), an LD probe which has been well developed and widely applied to measure LD number and area in fixed tissues and live cells, respectively ( Spangenburg et al., 2011 ; Long et al., 2012 ; Liu et al., 2015 ; Geller et al., 2019 ; Ioannou et al., 2019 ; Smoli č et al., 2021 ).”
InfluentialZhao, X., Li, Y., Zhang, S., Sudwarts, A., Zhang, H., Kozlova, A., Moulton, M. J., Goodman, L. D., Pang, Z. P., Sanders, A. R., et al. (2024) · medRxiv · doi:10.1101/2024.08.14.24312009 · Cited by 2
Blumenreich, S., Ben‐Yashar, D. P., Shalit, T., Kupervaser, M., Milenković, I., Joseph, T., & Futerman, A. H. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16024 · Cited by 1
“…), a list of lipid droplet-associated proteins was manually generated (Blumenreich, Yaacobi, et al., 2020 ; Chapman et al., 2019 ; Häsler et al., 2014; Ioannou et al., 2019 ; Jarc & Petan, 2019 ; Kassan et al., 2013 ; Liu et al., 2015 ; Liu et al., 2017; Marschallinger et al., 2020 ; Olzmann &…”
BackgroundSong, J., Kang, J., Zhang, Y., Wang, Y., Yang, R. X., & Ning, B. (2025) · Medicinal Research Reviews · doi:10.1002/med.22103 · Cited by 1
“FAs serve as crucial components of lipids and are the primary focus of lipid metabolism in astrocytes [94].”
Selective Antiproliferative Effects of Marine Oils on Neuroblastoma Cells in 3D Cultures
Freiría‐Martínez, L., Oliva, J. M., Rodríguez-Tébar, A., Hermanson, O., Aubourg, S. P., Spuch, C., & Medina, I. (2025) · Marine Drugs · doi:10.3390/md23070268 · Cited by 1
“Fatty acid metabolism is coupled between neurons and astrocytes so that fatty acids can then be consumed by oxidative phosphorylation in astrocyte mitochondria to protect neurons from their toxicity during periods of enhanced activity [65].”
Dai, Y., Bi, M., Jiao, Q., Du, X., Chen, X., Yan, C., & Jiang, H. F. (2025) · Movement Disorders · doi:10.1002/mds.30294 · Cited by 2
“43,44 Impairments in this metabolic exchange have been implicated in lipid dyshomeostasis, which is suggested to play a signi fi cant role in PD pathology according to genome-wide association studies.”
Chen, B. K., Hunsberger, H. C., Whye, A., Matthews, L. C., Yook, A., Willner, M. J., Logan, R., Johns, S., Weisblum, E., & Denny, C. (2025) · Alzheimer's Research & Therapy · doi:10.1186/s13195-025-01804-9 · Cited by 2
“Astrocytes are known to support neuronal metabolic processes [85–87] as well as enhance and facilitate neurotransmitter release [88, 89]; thus, overactive astrocyte and elevated GFAP levels could impair normal synaptic communication, and normalization of GFAP may thus improve and normalize synaptic…”
Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain
Berg, A. P., Tariq, S. H., Flores, C. C., Lefton, M., Owada, Y., Davis, C. J., Ferraro, T. N., Jacobs, J., Gritsenko, M. A., Lee, Y., et al. (2025) · Neuroglia · doi:10.3390/neuroglia6030033 · Cited by 2
“We are beginning to appreciate how astrocytes play a crucial protective role by the uptake of fatty acids and glutamate during extended activity/ wake periods, particularly at the tripartite synapse, thereby mitigating fatty acid-mediated excitotoxicity [76,78,79].”
Wang, J., Dai, C., Yuan, H., Tian, Q., Xiao, Q., Li, X., Shi, X., & Dong, Z. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102869 · Cited by 1
Garrahy, J. P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251404970 · Cited by 1
“158,159 (cid:129) In the adult CNS, neurons rely largely on astrocyte-derived cholesterol, exported in ApoE-lipoproteins, for synapse formation and membrane maintenance.”
Advances in Astrocyte Research on Neuronal Death and Regeneration
Yuan, C. N., Cao, W.-X. N., Liu, M.-R. N., Wu, H. N., Cui, L.-Y. N., & Liu, Y.-J. N. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin42985 · Cited by 1
Hector, A., Leduc, T., Caiado, M. J. D. C., Delignat‐Lavaud, B., Dufort‐Gervais, J., Daneault, C., Rosiers, C. D., Bourguignon, C., Lina, J., Fernandes, K. J. L., et al. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110835 · Cited by 5
Wang, X., Tan, S., Mou, Z., Zheng, Y., Yuan, J., Zeng, L., Wei, M., Ouyang, R., Fan, X., Huo, Y., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.02.038 · Cited by 1
A NIR fluorescence probe for dynamic profiling of lipid droplets in iron overload cardiomyopathy
Zhao, Y., Zheng, D., Wu, J., Ye, Y., Meng, X., Xu, L., Zeng, L., Qin, X., & Yang, X. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.139819 · Cited by 1
Metadata
- Authors
- Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., Hess, H. F., Lippincott-Schwartz, J., & Liu, Z.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Alberta (CA)
- Corresponding author
- Ioannou, Maria S.
- Liu, Zhe
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 177
- Issue
- 6
- Pages
- 1522-1535.e14
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2946373463
- Cited by
- 760
- References
- 72
- Citations by year
- 2026: 129 · 2025: 150 · 2024: 133 · 2023: 117 · 2022: 74 · 2021: 92 · 2020: 47 · 2019: 15
- FWCI
- 23.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- fatty acid toxicity, lipid droplets, apolipoprotein E, mitochondrial beta-oxidation, fatty acid metabolism, neuronal hyperactivity, astrocytes, lipid metabolism, neuroprotection
- MeSH terms
- Animals, Apolipoproteins E, Astrocytes, Brain, Fatty Acids, Homeostasis, Male, Mice, Inbred C57BL, Mitochondria, Neurons, Oxidation-Reduction, Rats, Sprague-Dawley, Mice, Knockout, Lipid Metabolism, Mice, Rats, Lipid Droplets
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