A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy

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Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

Stanzione, M., Zhong, J., Wong, E., LaSalle, T. J., Wise, J. F., Simoneau, A., Myers, D. T., Phat, S., Sade-Feldman, M., Lawrence, M. S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn1229 · Cited by 31 · see citing works

Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions

Zhu, H., Tian, Y., Chen, H., Qian, Y., Li, J., Niu, D., Zhao, W., Wu, Y., Zhang, X., Tang, T., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101287 · Cited by 30 · see citing works

Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors

Sakurai, Y., Ichinoe, M., Yoshida, K., Nakazato, Y., Saito, S., Satoh, M., Nakada, N., Sanoyama, I., Umezawa, A., Numata, Y., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.06.001 · Cited by 30 · see citing works

Role of Translesion DNA Synthesis in the Metabolism of Replication-associated Nascent Strand Gaps

Khatib, J. B., Nicolae, C. M., & Moldovan, G. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168275 · Cited by 28 · see citing works

REV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands, and its activity is regulated by the RanGTP/GDP switch

Wang, X., Pernicone, N., Pertz, L., Hua, D., Zhang, T., Listovsky, T., & Xie, W. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010123 · Cited by 29 · see citing works

Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response

Lin, S., Yu, L., Song, X., Bi, J., Jiang, L., Wang, Y., He, M., Xiao, Q., Sun, M., Olopade, O. I., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1871-z · Cited by 29 · see citing works

The in vivo role of Rev1 in mutagenesis and carcinogenesis

Sasatani, M., Zaharieva, E. K., & Kamiya, K. (2020) · Genes and Environment · doi:10.1186/s41021-020-0148-1 · Cited by 29 · see citing works

Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex

Xie, W., Wang, S., Wang, J., de la Cruz, M. J., Xu, G., Scaltriti, M., & Patel, D. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024512118 · Cited by 29 · see citing works

Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

Liptay, M., Barbosa, J. S., & Rottenberg, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00670 · Cited by 29 · see citing works

Structural basis for shieldin complex subunit 3–mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair

Dai, Y., Zhang, F., Wang, L., Shan, S., Gong, Z., & Zhou, Z. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011464 · Cited by 28 · see citing works

Drugging evolution of antibiotic resistance at a regulatory network hub

Zhai, Y., Pribis, J. P., Dooling, S. W., Garcı́a-Villada, L., Minnick, P. J., Xia, J., Liu, J., Mei, Q., Fitzgerald, D. M., Herman, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg0188 · Cited by 26 · see citing works

(Single-stranded DNA) gaps in understanding BRCAness

Schreuder, A., Wendel, T. J., Dorresteijn, C. G. V., & Noordermeer, S. M. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.04.013 · Cited by 25 · see citing works

MRN–CtIP, EXO1, and DNA2–WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavagePreprint

Seppa, I. M., Ceppi, I., Tennakoon, M., Reginato, G., Jackson, J., Rouault, C. D., Agashe, S., Sviderskiy, V. O., Limbu, M., Lantelme, E., et al. (2025) · Genes & Development · doi:10.1101/gad.352421.124 · Cited by 26 · see citing works

CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination

Brown, V. E., Moore, S. L., Chen, M., House, N. C. M., Ramsden, P., Wu, H., Ribich, S. A., Grassian, A. R., & Choi, Y. J. (2023) · NAR Cancer · doi:10.1093/narcan/zcad039 · Cited by 25 · see citing works

Aptamers against cancer drug resistance: Small fighters switching tactics in the face of defeat

Sanati, M., Afshari, A. R., Ahmadi, S. S., Kesharwani, P., & Sahebkar, A. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166720 · Cited by 26 · see citing works

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy

Nickoloff, J. A. (2022) · Molecules · doi:10.3390/molecules27154736 · Cited by 24 · see citing works

REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis

Chen, Y., Jie, X., Xing, B., Wu, Z., Yang, X., Rao, X., Xu, Y., Zhou, D., Dong, X., Zhang, T., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04567-5 · Cited by 23 · see citing works

Quaternary structural diversity in eukaryotic DNA polymerases: monomeric to multimeric form

Acharya, N., Khandagale, P., Thakur, S., Sahu, J. K., & Utkalaja, B. G. (2020) · Current Genetics · doi:10.1007/s00294-020-01071-1 · Cited by 22 · see citing works

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

Lahaye, X., Van, P. T., Chakraborty, C., Shmakova, A., Cao, N. T. B., Ferran, H., Aït-Mohamed, O., Maurin, M., Waterfall, J. J., Kaufer, B. B., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.008 · Cited by 21 · see citing works

Mechanisms used by cancer cells to tolerate drug-induced replication stress

Segeren, H. A., & Westendorp, B. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215804 · Cited by 22 · see citing works

Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor

Yuhas, S. C., Laverty, D. J., Lee, H., Majumdar, A. K., & Greenberg, M. M. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c02453 · Cited by 19 · see citing works

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine

Spanjaard, A., Shah, R., de Groot, D., Buoninfante, O. A., Morris, B., Lieftink, C., Pritchard, C. E. J., Zürcher, L. M., Ormel, S., Catsman, J. J. I., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac545 · Cited by 20 · see citing works

Targeting REV7 effectively reverses 5-FU and oxaliplatin resistance in colorectal cancer

Sun, X., Hou, W., Liu, X., Chai, J., Guo, H., & Yu, J. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01668-z · Cited by 21 · see citing works

Upregulation of REV7 correlates with progression of malignant melanoma

Hoshino, A., Nakayama, C., Jiang, S., Sakurai, Y., Kato, T., Numata, Y., Umezawa, A., Ichinoe, M., & Murakumo, Y. (2021) · Pathology International · doi:10.1111/pin.13174 · Cited by 19 · see citing works

REV1 Inhibition Enhances Radioresistance and Autophagy

Ikeh, K., Lamkin, E. N., Crompton, A., Deutsch, J., Fisher, K., Gray, M., Argyle, D. J., Lim, W. Y., Korzhnev, D. M., Hadden, M. K., et al. (2021) · Cancers · doi:10.3390/cancers13215290 · Cited by 19 · see citing works

Tolerating DNA damage by repriming: Gap filling in the spotlight

Jahjah, T., Singh, J. K., Gottifredi, V., & Quinet, A. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103758 · Cited by 22 · see citing works

Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers

Chen, G., Bao, Y., Weng, Q., Zhao, Y., Lu, X., Fu, L., Chen, L., Liu, Z., Zhang, X., & Liang, G. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01533 · Cited by 19 · see citing works

Disruption of DNA polymerase ζ engages an innate immune response

Martin, S. K., Tomida, J., & Wood, R. D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108775 · Cited by 20 · see citing works

Exploring nondegrading molecular glues for protein–protein interactions

Yu, S., Zhou, L., Yang, J., Zhang, J., & Lu, W. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.07.005 · Cited by 18 · see citing works

Translesion DNA Synthesis and Reinitiation of DNA Synthesis in Chemotherapy Resistance

Shilkin, E. S., Boldinova, E. O., Stolyarenko, A. D., Гончарова, Р. И., Chuprov‐Netochin, R. N., Smal, M. P., & Makarova, А. V. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920080039 · Cited by 18 · see citing works

REV1: A novel biomarker and potential therapeutic target for various cancers

Zhu, N., Zhao, Y., Mi, M., Lu, Y., Tan, Y., Fang, X., Weng, S., & Yuan, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.997970 · Cited by 18 · see citing works

Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis

Sellés‐Baiget, S., Ambjørn, S. M., Carli, A., Hendriks, I. A., Gallina, I., Davey, N. E., Benedict, B., Zarantonello, A., Gadi, S. A., Meeusen, B., et al. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01395-3 · Cited by 23 · see citing works

Visualizing Rev1 catalyze protein-template DNA synthesis

Weaver, T., Cortez, L. M., Khoang, T. H., Washington, M. T., Agarwal, P. K., & Freudenthal, B. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010484117 · Cited by 18 · see citing works

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

Tarantino, D., Walker, C., Weekes, D. B., Pemberton, H. N., Davidson, K., Torga, G., Frankum, J. R., Mendes‐Pereira, A. M., Prince, C., Ferro, R., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02369-9 · Cited by 17 · see citing works

Nanoparticle BAF312@CaP-NP Overcomes Sphingosine-1-Phosphate Receptor-1-Mediated Chemoresistance Through Inhibiting S1PR1/P-STAT3 Axis in Ovarian Carcinoma

Gong, K., Dong, Y., Wang, L., Duan, Y., Yu, J., Sun, Y., Bai, M., & Duan, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s248667 · Cited by 15 · see citing works

Investigating the cellular responses of osteosarcoma to cisplatin by confocal Raman microspectroscopy.

Wang, H., Li, J., Qin, J., Li, J., Chen, Y., Song, D., Zeng, H., & Wang, S. (2021) · Journal of Photochemistry and Photobiology. B: Biology · doi:10.1016/j.jphotobiol.2021.112366 · Cited by 11 · see citing works

REV7 in Cancer Biology and Management

Murakumo, Y., Sakurai, Y., Kato, T., Hashimoto, H., & Ichinoe, M. (2023) · Cancers · doi:10.3390/cancers15061721 · Cited by 14 · see citing works

Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells

Kim, S., Park, S. H., Kang, N., Ra, J. S., Myung, K., & Lee, K. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae785 · Cited by 14 · see citing works

DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions

Chen, T., Tongpeng, S., Lu, Z., Topatana, W., Juengpanich, S., Li, S., Hu, J., Cao, J., Lee, C., Tian, Y., et al. (2022) · Aging and Cancer · doi:10.1002/aac2.12047 · Cited by 13 · see citing works

The mutational impact of Illudin S on human cells

Casimir, L., Zimmer, S., Racine-Brassard, F., Jacques, P., & Maréchal, A. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103433 · Cited by 12 · see citing works

Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

Weaver, T., Click, T. H., Khoang, T. H., Washington, M. T., Agarwal, P. K., & Freudenthal, B. (2022) · Nature Communications · doi:10.1038/s41467-022-30577-0 · Cited by 13 · see citing works

Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations

Feltes, B. C., & Menck, C. F. M. (2022) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2022.108436 · Cited by 13 · see citing works

Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism

Gelova, S. P., Doherty, K. N., Alasmar, S., & Chan, K. (2022) · Genetics · doi:10.1093/genetics/iyac144 · Cited by 13 · see citing works

RAD51 is chromatin enriched and targetable in BRCA1-deficient cells

Peng, M., Lee, S., Nair, H. G., MacGilvary, N. J., Cong, K., Kraemer, M., Li, R., McConnell, J., Baer, C. E., Deng, B., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.08.017 · Cited by 12 · see citing works

REV1-POL ζ Inhibition and Cancer Therapy

Taniguchi, T. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.012 · Cited by 12 · see citing works

Cryo-EM reveals conformational flexibility in apo DNA polymerase ζ

Truong, C. D., Craig, T. A., Cui, G., Botuyan, M. V., Serkasevich, R. A., Chan, K.-Y., Mer, G., Chiu, P., & Kumar, R. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100912 · Cited by 12 · see citing works

Protein–Protein Interactions in Translesion Synthesis

Dash, R. C., & Hadden, M. K. (2021) · Molecules · doi:10.3390/molecules26185544 · Cited by 12 · see citing works

Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

Malik, R., Johnson, R. E., Ubarretxena‐Belandia, I., Prakash, L., Prakash, S., & Aggarwal, A. K. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01302-w · Cited by 12 · see citing works

Increased expression of REV7 in small cell lung carcinomas and its association with tumor cell survival and proliferation

Sanoyama, I., Sakurai, Y., Ichinoe, M., Hoshino, A., Kesen, Y., Kato, T., Numata, Y., Umezawa, A., Jiang, S., & Murakumo, Y. (2020) · Pathology International · doi:10.1111/pin.13040 · Cited by 12 · see citing works

Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapyPreprint

Yoon, J.-H., Johnson, R. E., Prakash, L., & Prakash, S. (2021) · Genes & Development · doi:10.1101/gad.348662.121 · Cited by 15 · see citing works

Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review)

Sui, L., Xie, X., Fu, P., Du, J., & Peng, C. Y. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5391 · Cited by 11 · see citing works

Cellular resistance mechanisms in cancer and the new approaches to overcome resistance mechanisms chemotherapy

AlSaihati, H., & Rabaan, A. A. (2023) · Saudi Medical Journal · doi:10.15537/smj.2023.44.4.20220600 · Cited by 11 · see citing works

Disrupting the MAD2L2-Rev1 Complex Enhances Cell Death upon DNA Damage

Pernicone, N., Elias, M., Onn, I., Tobi, D., & Listovsky, T. (2022) · Molecules · doi:10.3390/molecules27030636 · Cited by 11 · see citing works

Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

Yamanaka, K., Chatterjee, N., Hemann, M. T., & Walker, G. C. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006842 · Cited by 87 · see citing works

Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction

Sail, V., Rizzo, A. A., Chatterjee, N., Dash, R. C., Ozen, Z., Walker, G. C., Korzhnev, D. M., & Hadden, M. K. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.6b01144 · Cited by 52 · see citing works

Translesion Synthesis Inhibitors as Anti-Cancer Adjuvant Agents

Chan, K. A. (2018) · OpenCommons - UConn (University of Connecticut)

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

Chatterjee, N., Whitman, M. A., Harris, C. A., Min, S. M., Jonas, O. H., Lien, E. C., Luengo, A., Heiden, M. G. V., Hong, J., Zhou, P., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016064117 · Cited by 55 · see citing works

Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapyPreprint

Yoon, J.-H., Johnson, R. E., Prakash, L., & Prakash, S. (2021) · Genes & Development · doi:10.1101/gad.348662.121 · Cited by 15 · see citing works