The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
A Species-Wide Inventory of NLR Genes and Alleles in Arabidopsis thaliana
Open accessAbstract
Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consistent with extensive balancing and positive selection, NLRs are encoded by one of the most variable gene families in plants, but the true extent of intraspecific NLR diversity has been unclear. Here, we define a nearly complete species-wide pan-NLRome in Arabidopsis thaliana based on sequence enrichment and long-read sequencing. The pan-NLRome largely saturates with approximately 40 well-chosen wild strains, with half of the pan-NLRome being present in most accessions. We chart NLR architectural diversity, identify new architectures, and quantify selective forces that act on specific NLRs and NLR domains. Our study provides a blueprint for defining pan-NLRomes.
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Cites
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Cytoscape: A software Environment for integrated models of biomolecular interaction networks
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Self-citationNear-optimal probabilistic RNA-seq quantification
Bray, N. L., Pimentel, H., Melsted, P., & Pachter, L. (2016) · Nature Biotechnology · doi:10.1038/nbt.3519 · Cited by 9,723
Predicting coiled coils from protein sequences.
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Cited by
De novo assembly, annotation, and comparative analysis of 26 diverse maize genomes
Hufford, M. B., Seetharam, A. S., Woodhouse, M. R., Chougule, K. M., Ou, S., Liu, J., Ricci, W. A., Guo, T., Olson, A., Qiu, Y., et al. (2021) · Science · doi:10.1126/science.abg5289 · Cited by 747
Li, L., & Weigel, D. (2021) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-020620-114826 · Cited by 48
Self-citationA Truncated Singleton NLR Causes Hybrid Necrosis in Arabidopsis thaliana
Barragan, A. C., Collenberg, M., Wang, J., Lee, R. R. Q., Cher, W. Y., Rabanal, F. A., Ashkenazy, H., Weigel, D., & Chae, E. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa245 · Cited by 46
Self-citation(2022) · doi:10.1002/tpg2.20249 · Cited by 17
Prigozhin, D. M., Sutherland, C. A., Rangavajjhala, S., & Krasileva, K. V. (2025) · Molecular Plant-Microbe Interactions® · doi:10.1094/mpmi-05-24-0047-fi · Cited by 13
Differential expansion and retention patterns of LRR‐RLK genes across plant evolution
Kileeg, Z., Haldar, A., Khan, H., Qamar, A., & Mott, G. A. (2023) · Plant Direct · doi:10.1002/pld3.556 · Cited by 13
Metadata
- Authors
- Van de Weyer, A.-L., Monteiro, F., Furzer, O. J., Nishimura, M. T., Cevik, V., Witek, K., Jones, J. D. G., Dangl, J. L., Weigel, D., & Bemm, F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 178
- Issue
- 5
- Pages
- 1260-1272.e14
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2969924257
- Cited by
- 387
- References
- 13
- FWCI
- 32.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
