The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior
Open accessAbstract
The ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) contains ∼4,000 neurons that project to multiple targets and control innate social behaviors including aggression and mounting. However, the number of cell types in VMHvl and their relationship to connectivity and behavioral function are unknown. We performed single-cell RNA sequencing using two independent platforms-SMART-seq (∼4,500 neurons) and 10x (∼78,000 neurons)-and investigated correspondence between transcriptomic identity and axonal projections or behavioral activation, respectively. Canonical correlation analysis (CCA) identified 17 transcriptomic types (T-types), including several sexually dimorphic clusters, the majority of which were validated by seqFISH. Immediate early gene analysis identified T-types exhibiting preferential responses to intruder males versus females but only rare examples of behavior-specific activation. Unexpectedly, many VMHvl T-types comprise a mixed population of neurons with different projection target preferences. Overall our analysis revealed that, surprisingly, few VMHvl T-types exhibit a clear correspondence with behavior-specific activation and connectivity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In hypothalamus, several studies using either of the two approaches in mice demonstrate that activated neurons during a specific behavioral state are often distributed across a range of transcriptomic cell types (Kim et al., 2019; Moffitt et al., 2018; Xu et al., 2020).”
From What is a cell type and how to define it? (2022) · cites this paper as Kim et al., 2019
In the citing paper
“Indeed, in the ventromedial hypothalamus, few transcriptionally defined cell types exhibited a clear correspondence with behavior-specific activation or connectivity.”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [99]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Hierarchical Grouping to Optimize an Objective Function
Ward, J. H. (1963) · Journal of the American Statistical Association · doi:10.1080/01621459.1963.10500845 · Cited by 21,341
The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Massively parallel digital transcriptional profiling of single cells
Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.
Macosko, E. Z., Basu, A., Satija, R., Nemesh, J., Shekhar, K., Goldman, M., Tirosh, I., Bialas, A. R., Kamitaki, N., Martersteck, E. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.002 · Cited by 7,110
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Self-citationSoftware for Computing and Annotating Genomic Ranges
Lawrence, M. F., Huber, W. K., Pagès, H., Aboyoun, P., Carlson, M. R. J., Gentleman, R. C., Morgan, M. T., & Carey, V. J. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003118 · Cited by 4,475
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Greenberg, M. E., & Ziff, E. B. (1984) · Nature · doi:10.1038/311433a0 · Cited by 2,992
A mesoscale connectome of the mouse brain
Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612
Self-citationMolecular Architecture of the Mouse Nervous System
Zeisel, A., Hochgerner, H., Lönnerberg, P., Johnsson, A., Memic, F., van der Zwan, J., Häring, M., Braun, E., Borm, L. E., La Manno, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.021 · Cited by 2,552
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,786
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH
Eng, C.-H. L., Lawson, M., Zhu, Q., Dries, R., Koulena, N., Takei, Y., Yun, J., Cronin, C., Karp, C., Yuan, G.-C., et al. (2019) · Nature · doi:10.1038/s41586-019-1049-y · Cited by 1,754
Self-citationShared and distinct transcriptomic cell types across neocortical areas
Tasic, B., Yao, Z., Graybuck, L. T., Smith, K. A., Nguyen, T. N., Bertagnolli, D., Goldy, J., Garren, E., Economo, M. N., Viswanathan, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0654-5 · Cited by 1,746
Self-citationAdult mouse cortical cell taxonomy revealed by single cell transcriptomics
Tasic, B., Menon, V., Nguyen, T. N., Kim, T. K., Jarsky, T., Yao, Z., Levi, B., Gray, L. T., Sorensen, S. A., Dolbeare, T., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4216 · Cited by 1,714
Self-citationMolecular diversity and specializations among the cells of the adult mouse brain
Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,531 · cited 1×
“Using single-cell RNA sequencing (scRNA-seq), recent surveys have estimated up to ~600 different transcriptomic cell types (T-types) in the mouse brain (Saunders et al., 2018; Zeisel et al., 2018).”
Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region
Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365
A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons
Tervo, D. G. R., Hwang, B., Viswanathan, S., Gaj, T., Lavzin, M., Ritola, K., Lindo, S. E., Michael, S. C., Кулешова, Е. П., Ojala, D. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.021 · Cited by 1,220
Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity
Welch, J. D., Kozareva, V., Ferreira, A., Vanderburg, C., Martin, C., & Macosko, E. Z. (2019) · Cell · doi:10.1016/j.cell.2019.05.006 · Cited by 1,193
Ilastik: Interactive learning and segmentation toolkit
Sommer, C., Straehle, C., Köthe, U., & Hamprecht, F. A. (2011) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi.2011.5872394 · Cited by 1,145
Ventromedial hypothalamic neurons control a defensive emotion state
Kunwar, P. S., Zelikowsky, M., Remedios, R., Cai, H., Balban, M. Y., Meister, M., & Anderson, D. J. (2015) · eLife · doi:10.7554/elife.06633 · Cited by 1,130
Self-citationFunctional identification of an aggression locus in the mouse hypothalamus
Lin, D., Boyle, M. P., Dollar, P., Lee, H., Lein, E. S., Perona, P., & Anderson, D. J. (2011) · Nature · doi:10.1038/nature09736 · Cited by 914
Self-citationNeuronal cell-type classification: challenges, opportunities and the path forward
Zeng, H., & Sanes, J. R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.85 · Cited by 841
Self-citationA molecular census of arcuate hypothalamus and median eminence cell types
Campbell, J. N., Macosko, E. Z., Fenselau, H., Pers, T. H., Lyubetskaya, A., Tenen, D., Goldman, M., Verstegen, A. M. J., Resch, J. M., McCarroll, S. A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4495 · Cited by 817
Daigle, T. L., Madisen, L., Hage, T. A., Valley, M. T., Knoblich, U., Larsen, R. S., Takeno, M. M., Huang, L., Gu, H., Larsen, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.035 · Cited by 817
Self-citationDhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791
Midbrain circuits for defensive behaviour
Tovote, P., Esposito, M. S., Botta, P., Chaudun, F., Fadok, J. P., Marković, M., Wolff, S. B. E., Ramakrishnan, C., Fenno, L. E., Deisseroth, K. A., et al. (2016) · Nature · doi:10.1038/nature17996 · Cited by 766
Simerly, R. B. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142745 · Cited by 723
Yang, C. F., Chiang, M. C., Gray, D. C., Prabhakaran, M., Alvarado, M., Juntti, S. A., Unger, E. K., Wells, J. A., & Shah, N. M. (2013) · Cell · doi:10.1016/j.cell.2013.04.017 · Cited by 694
Shah, S., Lubeck, E., Zhou, W., & Cai, L. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.001 · Cited by 671
Self-citationGalanin neurons in the medial preoptic area govern parental behaviour
Wu, Z., Autry, A. E., Bergan, J. F., Watabe‐Uchida, M., & Dulac, C. G. (2014) · Nature · doi:10.1038/nature13307 · Cited by 610
Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction
Xu, Y., Nedungadi, T. P., Zhu, L., Sobhani, N., Irani, B. G., Davis, K. E., Zhang, X., Zou, F., Gent, L. M., Hahner, L. D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.009 · Cited by 597
Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity
Chen, R., Wu, X., Jiang, L., & Zhang, Y. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.004 · Cited by 592
Moffitt, J. R., Hao, J., Wang, G., Chen, K. H., Babcock, H. P., & Zhuang, X. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612826113 · Cited by 568
Canteras, N. S., Simerly, R. B., & Swanson, L. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480103 · Cited by 565
Neural circuit mechanisms of social behavior
Chen, P., & Hong, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.026 · Cited by 527
Musatov, S. A., Chen, W. W., Pfaff, D. W., Mobbs, C. V., Yang, X.-J., Clegg, D. J., Kaplitt, M. G., & Ogawa, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610787104 · Cited by 521
The efferent connections of the ventromedial nucleus of the hypothalamus of the rat,
Saper, C. B., Swanson, L. W., & Cowan, W. M. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901690403 · Cited by 516
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov, R. A., Zeisel, A., Bakker, J., Girach, F., Hellysaz, A., Tomer, R., Alpár, A., Mulder, J., Clotman, F., Keimpema, E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4462 · Cited by 502
Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex
Hrvatin, S., Hochbaum, D. R., Nagy, M. A., Cicconet, M., Robertson, K., Cheadle, L., Zilionis, R., Ratner, A., Borges-Monroy, R., Klein, A. M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0029-5 · Cited by 497
Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus
Lee, H., Kim, D.-W., Remedios, R., Anthony, T. E., Chang, A., Madisen, L., Zeng, H., & Anderson, D. J. (2014) · Nature · doi:10.1038/nature13169 · Cited by 479
Self-citationMice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity
Moon, Y. S., Smas, C. M., Lee, K., Villena, J. A., Kim, K., Yun, E. J., & Sul, H. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5585-5592.2002 · Cited by 473
Functional circuit architecture underlying parental behaviour
Kohl, J., Babayan, B. M., Rubinstein, N. D., Autry, A. E., Marin-Rodriguez, B., Kapoor, V., Miyamichi, K., Zweifel, L. S., Luo, L., Uchida, N., et al. (2018) · Nature · doi:10.1038/s41586-018-0027-0 · Cited by 470
Choi, G. B., Dong, H.-W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Swanson, L. W., & Anderson, D. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.011 · Cited by 462
Self-citationPfaff, D. W., & Sakuma, Y. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012690 · Cited by 461
Detecting Activated Cell Populations Using Single-Cell RNA-Seq
Wu, Y. E., Pan, L., Zuo, Y., Li, X., & Hong, W. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.026 · Cited by 438
Saper, C. B., & Lowell, B. B. (2014) · Current Biology · doi:10.1016/j.cub.2014.10.023 · Cited by 423
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity
Paul, A., Crow, M., Raudales, R., He, M., Gillis, J., & Huang, Z. J. (2017) · Cell · doi:10.1016/j.cell.2017.08.032 · Cited by 421
Distinct descending motor cortex pathways and their roles in movement
Economo, M. N., Viswanathan, S., Tasic, B., Bas, E., Winnubst, J., Menon, V., Graybuck, L. T., Nguyen, T. N., Smith, K. A., Yao, Z., et al. (2018) · Nature · doi:10.1038/s41586-018-0642-9 · Cited by 415
Self-citationHong, W., Kim, D.-W., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.07.049 · Cited by 405
Self-citationData exploration, quality control and testing in single-cell qPCR-based gene expression experiments
McDavid, A., Finak, G., Chattopadyay, P. K., Dominguez, M., Lamoreaux, L., Ma, S. S., Roederer, M., & Gottardo, R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts714 · Cited by 395
Luiten, P. G. M., Horst, G. J. T., & Steffens, A. B. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90004-9 · Cited by 391
Crow, M., Paul, A., Ballouz, S., Huang, Z. J., & Gillis, J. (2018) · Nature Communications · doi:10.1038/s41467-018-03282-0 · Cited by 365
Pfaff, D. W., & Sakuma, Y. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012691 · Cited by 351
Cellular Organization of the Neural Circuit that Drives Drosophila Courtship Behavior
Yu, J. Y., Kanai, M. I., Demir, E., Jefferis, G. S. X. E., & Dickson, B. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.08.025 · Cited by 349
Sensory regulation of male mating behavior in caenorhabditis elegans
Liu, K. S., & Sternberg, P. W. (1995) · Neuron · doi:10.1016/0896-6273(95)90242-2 · Cited by 334
Collateral Pathways from the Ventromedial Hypothalamus Mediate Defensive Behaviors
Wang, L., Chen, I. Z., & Lin, D. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.025 · Cited by 329
Sexual Dimorphism in the Fly Brain
Cachero, S., Ostrovsky, A. D., Yu, J. Y., Dickson, B. J., & Jefferis, G. S. X. E. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.045 · Cited by 325
Mickelsen, L. E., Bolisetty, M. T., Chimileski, B. R., Fujita, A., Beltrami, E. J., Costanzo, J., Naparstek, J., Robson, P., & Jackson, A. C. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0349-8 · Cited by 324
Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH
Shah, S., Takei, Y., Zhou, W., Lubeck, E., Yun, J., Eng, C.-H. L., Koulena, N., Cronin, C. J., Karp, C., Liaw, E. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.035 · Cited by 322
Self-citationHormonal gain control of a medial preoptic area social reward circuit
McHenry, J. A., Otis, J. M., Rossi, M. A., Robinson, J. E., Kosyk, O., Miller, N. W., McElligott, Z. A., Budygin, E. A., Rubinow, D. R., & Stuber, G. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4487 · Cited by 319
Hypothalamic Survival Circuits: Blueprints for Purposive Behaviors
Sternson, S. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.018 · Cited by 313
Esr1+ cells in the ventromedial hypothalamus control female aggression
Hashikawa, K., Hashikawa, Y., Tremblay, R., Zhang, J., Feng, J. E., Sabol, A., Piper, W. T., Lee, H., Rudy, B., & Lin, D. (2017) · Nature Neuroscience · doi:10.1038/nn.4644 · Cited by 278
Modular Genetic Control of Sexually Dimorphic Behaviors
Xu, X., Coats, J., Yang, C. F., Wang, A., Ahmed, O. M., Alvarado, M., Izumi, T., & Shah, N. M. (2012) · Cell · doi:10.1016/j.cell.2011.12.018 · Cited by 273
Independent hypothalamic circuits for social and predator fear
Silva, B. A., Mattucci, C., Krzywkowski, P., Murana, E., Illarionova, A., Grinevich, V., Canteras, N. S., Ragozzino, D., & Gross, C. T. (2013) · Nature Neuroscience · doi:10.1038/nn.3573 · Cited by 271
Classifying Drosophila Olfactory Projection Neuron Subtypes by Single-Cell RNA Sequencing
Li, H., Horns, F., Wu, B., Xie, Q., Li, J., Li, T., Luginbuhl, D. J., Quake, S. R., & Luo, L. (2017) · Cell · doi:10.1016/j.cell.2017.10.019 · Cited by 261
Wei, Y., Wang, S.-R., Jiao, Z., Zhang, W., Lin, J.-K., Li, X., Li, S., Zhang, X., & Xu, X. (2018) · Nature Communications · doi:10.1038/s41467-017-02648-0 · Cited by 259
The BRAIN Initiative: developing technology to catalyse neuroscience discovery
Jorgenson, L. A., Newsome, W. T., Anderson, D. J., Bargmann, C. I., Brown, E. N., Deisseroth, K. A., Donoghue, J. P., Hudson, K., Ling, G. S. F., MacLeish, P. R., et al. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0164 · Cited by 249
Self-citationSocial behaviour shapes hypothalamic neural ensemble representations of conspecific sex
Remedios, R., Kennedy, A., Zelikowsky, M., Grewe, B. F., Schnitzer, M. J., & Anderson, D. J. (2017) · Nature · doi:10.1038/nature23885 · Cited by 219
Self-citationAncestral Circuits for the Coordinated Modulation of Brain State
Lovett-Barron, M., Andalman, A. S., Allen, W. E., Vesuna, S., Kauvar, I., Burns, V. M., & Deisseroth, K. (2017) · Cell · doi:10.1016/j.cell.2017.10.021 · Cited by 212
Representing Sex in the Brain, One Module at a Time
Yang, C. F., & Shah, N. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.029 · Cited by 203
The organization of the ventromedial hypothalamic nucleus
Millhouse, O. E. (1973) · Brain Research · doi:10.1016/0006-8993(73)90489-7 · Cited by 190
A labeled-line neural circuit for pheromone-mediated sexual behaviors in mice
Ishii, K. K., Osakada, T., Mori, H., Miyasaka, N., Yoshihara, Y., Miyamichi, K., & Touhara, K. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.038 · Cited by 185
Sakurai, K., Zhao, S., Takatoh, J., Rodriguez, E., Lu, J., Leavitt, A. D., Fu, M., Han, B.-X., & Wang, F. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.015 · Cited by 180
Multicut brings automated neurite segmentation closer to human performance
Beier, T., Pape, C., Rahaman, N., Prange, T., Berg, S., Bock, D. D., Cardona, A., Knott, G. W., Plaza, S. M., Scheffer, L. K., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4151 · Cited by 161
Social Control of Hypothalamus-Mediated Male Aggression
Yang, T., Yang, C. F., Chizari, M., Maheswaranathan, N., Burke, K. J., Borius, M., Inoue, S., Chiang, M. C., Bender, K. J., Ganguli, S., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.046 · Cited by 161
Correa, S. M., Newstrom, D. W., Warne, J. P., Flandin, P., Cheung, C. C., Lin-Moore, A. T., Pierce, A. A., Xu, A. W., Rubenstein, J. L. R., & Ingraham, H. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.011 · Cited by 158
Kurrasch, D. M., Cheung, C. C., Lee, F. Y., Tran, P. V., Hata, K., & Ingraham, H. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2858-07.2007 · Cited by 157
Sano, K., Tsuda, M. C., Musatov, S. A., Sakamoto, T., & Ogawa, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12131 · Cited by 148
Ventromedial Hypothalamus and the Generation of Aggression
Hashikawa, Y., Hashikawa, K., Falkner, A. L., & Lin, D. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00094 · Cited by 146
Neuronal Cell Types and Connectivity: Lessons from the Retina
Seung, H. S., & Sümbül, U. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.054 · Cited by 143
Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
Lo, L., Yao, S., Kim, D., Cetin, A. H., Harris, J. A., Zeng, H., Anderson, D. J., & Weissbourd, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817503116 · Cited by 141
Self-citationCharacterization of Estrogen-Concentrating Hypothalamic Neurons by Their Axonal Projections
Morrell, J. I., & Pfaff, D. W. (1982) · Science · doi:10.1126/science.7112131 · Cited by 128
Efferent connections of the hypothalamic “aggression area” in the rat
Roeling, T. A. P., Veening, J. G., Kruk, M. R., Peters, J. P. W., Vermelis, M. E. J., & Nieuwenhuys, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90302-6 · Cited by 126
Decoding Ventromedial Hypothalamic Neural Activity during Male Mouse Aggression
Falkner, A. L., Dollár, P., Perona, P., Anderson, D. J., & Lin, D. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5109-13.2014 · Cited by 119
Self-citationCertain ventromedial hypothalamic afferents
Millhouse, O. E. (1973) · Brain Research · doi:10.1016/0006-8993(73)90490-3 · Cited by 105
Cheung, C. C., Kurrasch, D. M., Liang, J. K., & Ingraham, H. A. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23226 · Cited by 90
Macroscale intrinsic network architecture of the hypothalamus
Hahn, J. D., Sporns, O., Watts, A. G., & Swanson, L. W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819448116 · Cited by 87
Growth factor-responsive genes in fibroblasts.
Bravo, R. (1990) · PubMed · Cited by 86
Single cell transcriptomics in neuroscience: cell classification and beyond
Tasic, B. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.04.021 · Cited by 83
Self-citationInternal States and Behavioral Decision-Making: Toward an Integration of Emotion and CognitionPreprint
Kennedy, A., Asahina, K., Hoopfer, E. D., Inagaki, H., Jung, Y., Lee, H., Remedios, R., & Anderson, D. J. (2014) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2014.79.024984 · Cited by 75
Self-citationHypothalamic Control of Conspecific Self-Defense
Wang, L., Talwar, V., Osakada, T., Kuang, A., Guo, Z., Yamaguchi, T., & Lin, D. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.078 · Cited by 72
Tsuneoka, Y., Tsukahara, S., Yoshida, S., Takase, K., Oda, S., Kuroda, M., & Funato, H. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00026 · Cited by 58
Wermter, A., Scherag, A., Meyre, D., Reichwald, K., Durand, E., Nguyen, T. T., Koberwitz, K., Lichtner, P., Meitinger, T., Schäfer, H., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.64 · Cited by 54
Self-citationKrause, W. C., & Ingraham, H. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_10 · Cited by 32
Persson-Augner, D., Lee, Y.-W., Tovar, S. A., Diéguez, C., & Meister, B. (2014) · Neuroendocrinology · doi:10.1159/000369069 · Cited by 21
How the Vertebrate Brain Regulates Behavior: Direct from the Lab
Pfaff, D. W. (2017) · Cited by 10
Flagged first, then by citations
Cited by
Sorted by citations
Confronting false discoveries in single-cell differential expression
Squair, J. W., Gautier, M., Kathe, C., Anderson, M. A., James, N. D., Hutson, T. H., Hudelle, R., Qaiser, T., Matson, K. J. E., Barraud, Q., et al. (2021) · doi:10.1101/2021.03.12.435024 · Cited by 1,086
What is a cell type and how to define it?
Zeng, H. (2022) · Cell · doi:10.1016/j.cell.2022.06.031 · Cited by 439
Self-citationThe emerging landscape of spatial profiling technologies
Moffitt, J. R., Lundberg, E., & Heyn, H. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00515-3 · Cited by 419
The Specious Art of Single-Cell Genomics
Chari, T., & Pachter, L. (2021) · doi:10.1101/2021.08.25.457696 · Cited by 379
Self-citationSingle-cell and spatial transcriptomics: deciphering brain complexity in health and disease
Piwecka, M., Rajewsky, N., & Rybak-Wolf, A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00809-y · Cited by 320
Metadata
- Authors
- Kim, D.-W., Yao, Z., Graybuck, L. T., Kim, T. K., Nguyen, T. N., Smith, K. A., Fong, O., Yi, L., Koulena, N., Pierson, N., Shah, S., Lo, L., Pool, A.-H., Oka, Y., Pachter, L., Cai, L., Tasic, B., Zeng, H., & Anderson, D. J.
- Affiliations
- California Institute of Technology (US)
- Allen Institute for Brain Science (US)
- Corresponding author
- Anderson, David J.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 179
- Issue
- 3
- Pages
- 713-728.e17
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7534821
- OpenAlex
- W2981201615
- Cited by
- 259
- References
- 102
- Citations by year
- 2026: 25 · 2025: 40 · 2024: 33 · 2023: 42 · 2022: 43 · 2021: 32 · 2020: 41 · 2019: 3
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- California Institute of Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- ventromedial hypothalamus, hypothalamic neurons, social behavior, aggression, mounting behavior, neuronal cell types, axonal projections, sexual dimorphism, intruder response, immediate early genes, single-cell transcriptomics, canonical correlation analysis, seqFISH
- MeSH terms
- Animals, Female, Hypothalamus, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Neurons, Sexual Behavior, Animal, Social Behavior, Estrogen Receptor alpha, Mice, Single-Cell Analysis, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
