Antagonistic control of social versus repetitive self-grooming behaviors by separable amygdala neuronal subsets
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Animals display a range of innate social behaviors that play essential roles in survival and reproduction. While the medial amygdala (MeA) has been implicated in prototypic social behaviors such as aggression, the circuit-level mechanisms controlling such behaviors are not well understood. Using cell-type-specific functional manipulations, we find that distinct neuronal populations in the MeA control different social and asocial behaviors. A GABAergic subpopulation promotes aggression and two other social behaviors, while neighboring glutamatergic neurons promote repetitive self-grooming, an asocial behavior. Moreover, this glutamatergic subpopulation inhibits social interactions independently of its effect to promote self-grooming, while the GABAergic subpopulation inhibits self-grooming, even in a nonsocial context. These data suggest that social versus repetitive asocial behaviors are controlled in an antagonistic manner by inhibitory versus excitatory amygdala subpopulations, respectively. These findings provide a framework for understanding circuit-level mechanisms underlying opponency between innate behaviors, with implications for their perturbation in psychiatric disorders.
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Advanced circuit mapping tools have recently been effective at identifying specific nodes critical for sex-specific behaviors like mating, parenting, and aggression, but many rely on transgenic mice, which do not engage in tertiary social play.
“While advanced circuit mapping tools have recently been effective at identifying specific nodes critical for sex-specific behaviors like mating, parenting, and aggression (Hong et al., 2014; Wu et al., 2009), many of these techniques rely on the use of transgenic mice, which, in contrast to rats, do not engage in tertiary social play.”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Hong et al., 2014
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Experimental — accuracy not yet measuredActivation of GABAergic rather than glutamatergic neurons in the MeA is associated with onset of male aggression.
“previous work has demonstrated that activation of GABAergic rather than glutamatergic neurons in the MeA is associated with onset of male aggression [82].”
The medial amygdala posterodorsal (MeApd) is primarily involved in conspecific social behaviors such as mating and aggression.
“The MeA has been subdivided into distinct functional regions along the anterior-posterior and dorsal-ventral axes, with the medial amygdala posterodorsal (MeApd) primarily involved in conspecific social behaviors such as mating and aggression (Choi et al., 2005; Hong et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Hong et al., 2014
The MeApd comprises GABAergic and glutamatergic neurons at an approximate ratio of 2:1, with GABAergic neurons representing the major population of projection neurons driving social responses.
“The MeApd comprises GABAergic and glutamatergic neurons at an approximate ratio of 2:1, with GABAergic neurons representing the major population of projection neurons driving social responses (Choi et al., 2005; Hong et al., 2014; Keshavarzi et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Hong et al., 2014
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Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Neurodegenerative Disorders: Parkinson's Disease and Huntington's Disease
Hague, S., Klaffke, S., & Bandmann, O. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860948961_0007 · Cited by 2,767 · see citing works
Rowan, W., & Tinbergen, N. (1952) · Bird-Banding · doi:10.2307/4510368 · Cited by 2,715 · see citing works
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351 · see citing works
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works
NEWMAN, S. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09271.x · Cited by 1,189 · see citing works
Baron-Cohen, S., Ring, H. A., Bullmore, E. T., Wheelwright, S., Ashwin, C., & Williams, S. C. R. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00011-7 · Cited by 1,130 · see citing works
Neural mechanisms of aggression
Nelson, R. J., & Trainor, B. C. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2174 · Cited by 1,021 · see citing works
Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
Gradinaru, V., Zhang, F., Ramakrishnan, C., Mattis, J., Prakash, R., Diester, I., Goshen, I., Thompson, K. R., & Deisseroth, K. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.037 · Cited by 999 · see citing works
Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 996 · see citing works
Pitkänen, A., Savander, V., & LeDoux, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01125-9 · Cited by 980 · see citing works
Aravanis, A. M., Wang, L., Zhang, F., Meltzer, L. A., Mogri, M., Schneider, M. B., & Deisseroth, K. A. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/3/s02 · Cited by 960 · see citing works
Functional identification of an aggression locus in the mouse hypothalamus
Lin, D., Boyle, M. P., Dollar, P., Lee, H., Lein, E. S., Perona, P., & Anderson, D. J. (2011) · Nature · doi:10.1038/nature09736 · Cited by 914 · see citing works
Self-citationOrganization of projections from the medial nucleus of the amygdala: A PHAL study in the rat
Canteras, N. S., Simerly, R. B., & Swanson, L. W. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903600203 · Cited by 884 · see citing works
Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2
Stowers, L., Holy, T. E., Meister, M., Dulac, C. G., & Koentges, G. (2002) · Science · doi:10.1126/science.1069259 · Cited by 880 · see citing works
Amygdala inhibitory circuits and the control of fear memory
Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., & Lüthi, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.026 · Cited by 878 · see citing works
Cerebral hemisphere regulation of motivated behavior
Swanson, L. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02905-x · Cited by 846 · see citing works
New Vistas on Amygdala Networks in Conditioned Fear
Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841 · cited 1× · see citing works
“, 1997; Swanson and Petrovich, 1998) and is anatomically distinct from amygdala nuclei involved in conditioned fear (Duvarci and Pare, 2014; Ehrlich et al., 2009; Paré et al., 2004).”
BackgroundAmygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751 · see citing works
Topography of projections from amygdala to bed nuclei of the stria terminalis
Dong, H.-W., Petrovich, G. D., & Swanson, L. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00079-0 · Cited by 714 · see citing works
Yang, C. F., Chiang, M. C., Gray, D. C., Prabhakaran, M., Alvarado, M., Juntti, S. A., Unger, E. K., Wells, J. A., & Shah, N. M. (2013) · Cell · doi:10.1016/j.cell.2013.04.017 · Cited by 685 · see citing works
Molecular detection of pheromone signals in mammals: from genes to behaviour
Dulac, C. G., & Torello, A. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1140 · Cited by 662 · see citing works
Canteras, N. S., Simerly, R. B., & Swanson, L. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480103 · Cited by 547 · see citing works
Identification of protein pheromones that promote aggressive behaviour
Chamero, P., Marton, T. F., Logan, D. W., Flanagan, K. A., Cruz, J. R., Saghatelian, A., Cravatt, B. F., & Stowers, L. (2007) · Nature · doi:10.1038/nature05997 · Cited by 529 · see citing works
The Intense World Theory – A Unifying Theory of the Neurobiology of Autism
Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 521 · see citing works
Fatemi, S. H., Halt, A. R., Stary, J. M., Kanodia, R., Schulz, S. C., & Realmuto, G. R. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01430-0 · Cited by 500 · see citing works
Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus
Lee, H., Kim, D.-W., Remedios, R., Anthony, T. E., Chang, A., Madisen, L., Zeng, H., & Anderson, D. J. (2014) · Nature · doi:10.1038/nature13169 · Cited by 479 · see citing works
Self-citationChoi, G. B., Dong, H.-W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Swanson, L. W., & Anderson, D. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.011 · Cited by 462 · see citing works
Self-citationNeuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior
Blundell, J., Blaiss, C. A., Etherton, M. R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M. F., Südhof, T. C., & Powell, C. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4517-09.2010 · Cited by 450 · see citing works
Etherton, M. R., Blaiss, C. A., Powell, C. M., & Südhof, T. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910297106 · Cited by 447 · see citing works
Olfactory Inputs to Hypothalamic Neurons Controlling Reproduction and Fertility
Yoon, H., Enquist, L. W., & Dulac, C. G. (2005) · Cell · doi:10.1016/j.cell.2005.08.039 · Cited by 435 · see citing works
Neuropharmacology of brain-stimulation-evoked aggression
Siegel, A., Roeling, T. A. P., Gregg, T. R., & Kruk, M. R. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00040-2 · Cited by 381 · see citing works
Linkage and association of the glutamate receptor 6 gene with autism
Jamain, S., Betancur, C., Quach, H., Philippe, A., Fellous, M., Giros, B., Gillberg, C., Leboyer, M., & Bourgeron, T. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000979 · Cited by 332 · see citing works
Influence of amygdalectomy on social behavior in monkeys.
Rosvold, H. E., Mirsky, A. F., & Pribram, K. H. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058870 · Cited by 331 · see citing works
Kollack‐Walker, S., & Newman, S. W. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00563-k · Cited by 315 · see citing works
Medial Nucleus of the Amygdala Mediates Chemosensory Control of Male Hamster Sexual Behavior
Lehman, M. N., Winans, S. S., & Powers, J. B. (1980) · Science · doi:10.1126/science.7423209 · Cited by 282 · see citing works
Deficits in sexual and aggressive behaviors in Cnga2 mutant mice
Mandiyan, V. S., Coats, J., & Shah, N. M. (2005) · Nature Neuroscience · doi:10.1038/nn1589 · Cited by 270 · see citing works
Modular Genetic Control of Sexually Dimorphic Behaviors
Xu, X., Coats, J., Yang, C. F., Wang, A., Ahmed, O. M., Alvarado, M., Izumi, T., & Shah, N. M. (2012) · Cell · doi:10.1016/j.cell.2011.12.018 · Cited by 266 · see citing works
Sex-specific processing of social cues in the medial amygdala
Bergan, J. F., Ben-Shaul, Y., & Dulac, C. (2014) · eLife · doi:10.7554/elife.02743 · Cited by 237 · see citing works
Couture, S. M., Penn, D. L., Losh, M. C., Adolphs, R., Hurley, R. S. E., & Piven, J. (2009) · Psychological Medicine · doi:10.1017/s003329170999078x · Cited by 231 · see citing works
Behavioral abnormality and pharmacologic response in social isolation-reared mice
Koike, H., Ibi, D., Mizoguchi, H., Nagai, T., Nitta, A., Takuma, K., Nabeshima, T., Yoneda, Y., & Yamada, K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.028 · Cited by 221 · see citing works
Toward a Neural Basis for Social Behavior
Stanley, D. A., & Adolphs, R. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.038 · Cited by 213 · see citing works
Orienting to social stimuli differentiates social cognitive impairment in autism and schizophrenia
Sasson, N., Tsuchiya, N., Hurley, R., Couture, S. M., Penn, D. L., Adolphs, R., & Piven, J. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.03.009 · Cited by 201 · see citing works
Ethology and pharmacology of hypothalamic aggression in the rat
Kruk, M. R. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80144-7 · Cited by 166 · see citing works
Kondo, Y. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90074-c · Cited by 163 · see citing works
Problems in the study of rodent aggression
Blanchard, R. J., Wall, P. M., & Blanchard, D. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00127-2 · Cited by 160 · see citing works
Veening, J. G., Coolen, L. M., A, T. R. D. J., Joosten, H. W. J., de Boer, S. F., Koolhaas, J. M., & Olivier, B. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.041 · Cited by 156 · see citing works
Williams, J. H. G. (2008) · Autism Research · doi:10.1002/aur.15 · Cited by 140 · see citing works
Early social deprivation induces disturbed social communication and violent aggression in adulthood.
Tóth, M., Halász, J., Mikics, É., Barsy, B., & Haller, J. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.4.849 · Cited by 135 · see citing works
The hypothalamus: cross-roads of endocrine and behavioural regulation in grooming and aggression
Kruk, M. R., Westphal, K. G. C., van Erp, A. M. M., van Asperen, J., Cave, B. J., Slater, E., de Koning, J., & Haller, J. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00018-9 · Cited by 123 · see citing works
Medial amygdala lesions in male rats reduce aggressive behavior: interference with experience
Vochteloo, J. D., & Koolhaas, J. M. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90137-5 · Cited by 109 · see citing works
Kollack, S. S., & Newman, S. W. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90270-h · Cited by 102 · see citing works
Mating-induced increases in FOS protein in preoptic area and medial amygdala of cycling female rats
Erskine, M. S. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90289-n · Cited by 98 · see citing works
Brain mechanisms of aggressive behavior: an updated review.
Adams, D. B. (2006) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.09.004 · Cited by 97 · see citing works
Zufall, F., & Leinders‐Zufall, T. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.07.012 · Cited by 97 · see citing works
Kondo, Y., & Arai, Y. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00205-j · Cited by 92 · see citing works
Cortical-Like Functional Organization of the Pheromone-Processing Circuits in the Medial Amygdala
Bian, X., Yanagawa, Y., Chen, W. R., & Luo, M. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00902.2007 · Cited by 92 · see citing works
Taming in wild rats following medial amygdaloid lesions
Kemble, E. D., Blanchard, D. C., Blanchard, R. J., & Takushi, R. Y. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90084-2 · Cited by 70 · see citing works
Wang, Y., He, Z., Zhao, C., & Li, L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.002 · Cited by 59 · see citing works
A failure of amygdaloid lesions to alter agonistic behavior in the laboratory rat
Busch, D. E., & Barfield, R. J. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90027-4 · Cited by 58 · see citing works
Comparing social attention in autism and amygdala lesions: Effects of stimulus and task condition
Birmingham, E., Cerf, M., & Adolphs, R. (2011) · Social Neuroscience · doi:10.1080/17470919.2011.561547 · Cited by 49 · see citing works
Takahashi, L. K., & Gladstone, C. D. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.2.268 · Cited by 42 · see citing works
Takahashi, L. K., & Gladstone, C. D. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.2.268 · Cited by 35 · see citing works
Dhungel, S., Masaoka, M., Rai, D., Kondo, Y., & Sakuma, Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.051 · Cited by 32 · see citing works
Niimi, K., Horie, S., Yokosuka, M., Kawakami-Mori, F., Tanaka, K., Fukayama, H., & Sahara, Y. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.050 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ventromedial hypothalamic neurons control a defensive emotion state
Kunwar, P. S., Zelikowsky, M., Remedios, R., Cai, H., Balban, M. Y., Meister, M., & Anderson, D. J. (2015) · eLife · doi:10.7554/elife.06633 · Cited by 1,112 · see citing works
Self-citationNeurobiology of rodent self-grooming and its value for translational neuroscience
Kalueff, A. V., Stewart, A. M., Song, C., Berridge, K. C., Graybiel, A. M., & Fentress, J. C. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.8 · Cited by 852 · see citing works
Neural circuit mechanisms of social behavior
Chen, P., & Hong, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.026 · Cited by 527 · see citing works
Self-citationFunctional circuit architecture underlying parental behaviour
Kohl, J., Babayan, B. M., Rubinstein, N. D., Autry, A. E., Marin-Rodriguez, B., Kapoor, V., Miyamichi, K., Zweifel, L. S., Luo, L., Uchida, N., et al. (2018) · Nature · doi:10.1038/s41586-018-0027-0 · Cited by 459 · see citing works
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Fenster, R. J., Lebois, L. A. M., Ressler, K. J., & Suh, J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0039-7 · Cited by 456 · see citing works
Detecting Activated Cell Populations Using Single-Cell RNA-Seq
Wu, Y. E., Pan, L., Zuo, Y., Li, X., & Hong, W. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.026 · Cited by 438 · see citing works
Self-citationCombined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex
Murugan, M., Jang, H. J., Park, M., Miller, E. M., Cox, J., Taliaferro, J. P., Parker, N. F., Bhave, V., Hur, H., Liang, Y., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.002 · Cited by 311 · see citing works
Circuit modules linking internal states and social behaviour in flies and mice
Anderson, D. J. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.125 · Cited by 319 · see citing works
Self-citationHypothalamic CRH neurons orchestrate complex behaviours after stress
Füzesi, T., Daviu, N., Wamsteeker Cusulin, J. I., Bonin, R. P., & Bains, J. S. (2016) · Nature Communications · doi:10.1038/ncomms11937 · Cited by 316 · see citing works
Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala
Han, W., Téllez, L. A., Rangel, M. J., Motta, S. C., Zhang, X., Pérez-Martínez, I. O., Canteras, N. S., Shammah‐Lagnado, S. J., van den Pol, A. N., & de Araújo, I. E. (2017) · Cell · doi:10.1016/j.cell.2016.12.027 · Cited by 292 · see citing works
Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice
Li, Y., Mathis, A., Grewe, B. F., Osterhout, J. A., Ahanonu, B., Schnitzer, M. J., Murthy, V. N., & Dulac, C. (2017) · Cell · doi:10.1016/j.cell.2017.10.015 · Cited by 291 · see citing works
Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state
Padilla, S. L., Qiu, J., Soden, M. E., Sanz, E., Nestor, C. C., Barker, F. D., Quintana, A., Zweifel, L. S., Rønnekleiv, O. K., Kelly, M. J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4274 · Cited by 293 · see citing works
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress
Zelikowsky, M., Hui, M., Karigo, T., Choe, A., Yang, B., Blanco, M. R., Beadle, K., Gradinaru, V., Deverman, B. E., & Anderson, D. J. (2018) · Cell · doi:10.1016/j.cell.2018.03.037 · Cited by 282 · see citing works
Self-citationVanRyzin, J. W., Marquardt, A. E., Argue, K. J., Vecchiarelli, H. A., Ashton, S. E., Arambula, S. E., Hill, M. N., & McCarthy, M. M. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.006 · Cited by 272 · see citing works
Medial amygdalar aromatase neurons regulate aggression in both sexes
Unger, E. K., Burke, K. J., Yang, C. F., Bender, K. J., Fuller, P. M., & Shah, N. M. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.040 · Cited by 275 · see citing works
Neural mechanisms of aggression across species
Lischinsky, J. E., & Lin, D. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00715-2 · Cited by 267 · see citing works
The neuroanatomy of autism – a developmental perspective
Donovan, A. P. A., & Basson, M. A. (2016) · Journal of Anatomy · doi:10.1111/joa.12542 · Cited by 266 · see citing works
Multimodal analysis of cell types in a hypothalamic node controlling social behavior
Kim, D.-W., Yao, Z., Graybuck, L. T., Kim, T. K., Nguyen, T. N., Smith, K. A., Fong, O., Yi, L., Koulena, N., Pierson, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.09.020 · Cited by 259 · see citing works
Self-citationNeighborhood matters: divergent patterns of stress-induced plasticity across the brain
Chattarji, S., Tomar, A., Suvrathan, A., Ghosh, S., & Rahman, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4115 · Cited by 248 · see citing works
Segalin, C., Williams, J., Karigo, T., Hui, M., Zelikowsky, M., Sun, J. J., Perona, P., Anderson, D. J., & Kennedy, A. (2021) · eLife · doi:10.7554/elife.63720 · Cited by 244 · see citing works
Self-citationHypothalamic control of male aggression-seeking behavior
Falkner, A. L., Grosenick, L., Davidson, T. J., Deisseroth, K. A., & Lin, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4264 · Cited by 242 · see citing works
Prefrontal–amygdala circuits in social decision-making
Gangopadhyay, P., Chawla, M., Monte, O. D., & Chang, S. W. C. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00738-9 · Cited by 247 · see citing works
Hoopfer, E. D., Jung, Y., Inagaki, H., Rubin, G. M., & Anderson, D. J. (2015) · eLife · doi:10.7554/elife.11346 · Cited by 235 · see citing works
Self-citationNeurobiology of social behavior abnormalities in autism and Williams syndrome
Barak, B., & Feng, G. (2016) · Nature Neuroscience · doi:10.1038/nn.4276 · Cited by 224 · see citing works
Ko, J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00041 · Cited by 212 · see citing works
Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala
Chen, P. B., Hu, R. K., Wu, Y. E., Pan, L., Huang, S., Micevych, P. E., & Hong, W. (2019) · Cell · doi:10.1016/j.cell.2019.01.024 · Cited by 209 · see citing works
Self-citationThe role of GABAergic signalling in neurodevelopmental disorders
Tang, X., Jaenisch, R., & Sur, M. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00443-x · Cited by 206 · see citing works
Neural circuits of social behaviors: Innate yet flexible
Wei, D., Talwar, V., & Lin, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.012 · Cited by 185 · see citing works
An amygdala-to-hypothalamus circuit for social reward
Hu, R. K., Zuo, Y., Ly, T., Wang, J., Meera, P., Wu, Y. E., & Hong, W. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00828-2 · Cited by 174 · see citing works
Self-citationDistinct and Dynamic ON and OFF Neural Ensembles in the Prefrontal Cortex Code Social Exploration
Liang, B., Zhang, L., Barbera, G., Fang, W., Zhang, J., Chen, X., Chen, R., Li, Y., & Lin, D. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.043 · Cited by 170 · see citing works
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior
Knoedler, J. R., Inoue, S., Bayless, D. W., Yang, T., Tantry, A., Davis, C.-H. O., Leung, N. Y., Parthasarathy, S., Wang, G., Alvarado, M., et al. (2022) · Cell · doi:10.1016/j.cell.2021.12.031 · Cited by 165 · see citing works
The neural circuits of mating and fighting in male mice
Hashikawa, K., Hashikawa, Y., Falkner, A. L., & Lin, D. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.01.006 · Cited by 157 · see citing works
Neural control of affiliative touch in prosocial interaction
Wu, Y. E., Dang, J., Kingsbury, L., Zhang, M., Sun, F., Hu, R. K., & Hong, W. (2021) · Nature · doi:10.1038/s41586-021-03962-w · Cited by 153 · see citing works
Self-citationOxytocin signaling in the medial amygdala is required for sex discrimination of social cues
Yao, S., Bergan, J., Lanjuin, A., & Dulac, C. (2017) · eLife · doi:10.7554/elife.31373 · Cited by 151 · see citing works
Kim, H., Lim, C., & Kaang, B. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0087-y · Cited by 146 · see citing works
Correlated Neural Activity across the Brains of Socially Interacting Bats
Zhang, W., & Yartsev, M. M. (2019) · Cell · doi:10.1016/j.cell.2019.05.023 · Cited by 138 · see citing works
Neural and Hormonal Control of Sexual Behavior
Jennings, K. J., & de Lecea, L. (2020) · Endocrinology · doi:10.1210/endocr/bqaa150 · Cited by 143 · see citing works
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation
Lee, C. R., Chen, A., & Tye, K. M. (2021) · Cell · doi:10.1016/j.cell.2021.02.028 · Cited by 138 · see citing works
Ventromedial Hypothalamus and the Generation of Aggression
Hashikawa, Y., Hashikawa, K., Falkner, A. L., & Lin, D. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00094 · Cited by 141 · see citing works
So, N., Franks, B., Lim, S., & Curley, J. P. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134509 · Cited by 135 · see citing works
Organization of neural circuits underlying social behavior: A consideration of the medial amygdala
Raam, T., & Hong, W. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.02.008 · Cited by 134 · see citing works
Self-citationLimbic Neurons Shape Sex Recognition and Social Behavior in Sexually Naive Males
Bayless, D. W., Yang, T., Mason, M. M., Susanto, A. A. T., Lobdell, A., & Shah, N. M. (2019) · Cell · doi:10.1016/j.cell.2018.12.041 · Cited by 131 · see citing works
Dynamics of social representation in the mouse prefrontal cortex
Levy, D. R., Tamir, T., Kaufman, M., Parabucki, A., Weissbrod, A., Schneidman, E., & Yizhar, O. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0531-z · Cited by 127 · see citing works
An insular view of the social decision-making network
Rogers-Carter, M. M., & Christianson, J. P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.005 · Cited by 121 · see citing works
Molecular and neural basis of contagious itch behavior in mice
Yu, Y.-Q., Barry, D. M., Hao, Y., Liu, X., & Chen, Z. (2017) · Science · doi:10.1126/science.aak9748 · Cited by 127 · see citing works
Oxytocin mediates entrainment of sensory stimuli to social cues of opposing valence
Choe, H. K., Reed, M. D., Benavidez, N., Montgomery, D., Soares, N., Yim, Y. S., & Choi, G. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.022 · Cited by 124 · see citing works
Neural substrates underlying effort, time, and risk-based decision making in motivated behavior
Bailey, M. R., Simpson, E. H., & Balsam, P. D. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.015 · Cited by 119 · see citing works
Divergent medial amygdala projections regulate approach–avoidance conflict behavior
Miller, S. M., Marcotulli, D., Shen, A., & Zweifel, L. S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0337-z · Cited by 116 · see citing works
Neurobiology of rodent self-grooming and its value for translational neuroscience
Kalueff, A. V., Stewart, A., Song, C., Berridge, K. C., Fentress, J. C., & Graybiel, A. M. (2017) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 114 · see citing works
Valence coding in amygdala circuits
Pignatelli, M., & Beyeler, A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.10.010 · Cited by 120 · see citing works
Steinman, M. Q., Duque-Wilckens, N., & Trainor, B. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.10.008 · Cited by 105 · see citing works
A limbic circuitry involved in emotional stress-induced grooming
Mu, M., Geng, H.-Y., Rong, K., Peng, R., Shu-ting, W., Geng, L.-T., Qian, Z., Yung, W., & Ke, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-16203-x · Cited by 111 · see citing works
Tan, T., Wang, W., Liu, T., Zhong, P., Conrow‐Graham, M., Tian, X., & Yan, Z. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108874 · Cited by 103 · see citing works
Posterior amygdala regulates sexual and aggressive behaviors in male mice
Yamaguchi, T., Wei, D., Song, S. C., Lim, B. K., Tritsch, N. X., & Lin, D. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0675-x · Cited by 99 · see citing works
Estrogen receptor–α in medial amygdala neurons regulates body weight
Xu, P., Cao, X., He, Y., Zhu, L., Yang, Y., Saito, K., Wang, C., Yan, X., Hinton, A. O., Jr., Zou, F., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80941 · Cited by 98 · see citing works
Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders
Gandhi, T., & Lee, C. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592710 · Cited by 94 · see citing works
An intra-amygdala circuit specifically regulates social fear learning
Twining, R. C., Vantrease, J. E., Love, S., Padival, M., & Rosenkranz, J. A. (2017) · Nature Neuroscience · doi:10.1038/nn.4481 · Cited by 93 · see citing works
The Neural Mechanisms of Sexually Dimorphic Aggressive Behaviors
Hashikawa, K., Hashikawa, Y., Lischinsky, J. E., & Lin, D. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.07.001 · Cited by 89 · see citing works
Potentiation of Divergent Medial Amygdala Pathways Drives Experience-Dependent Aggression Escalation
Nordman, J. C., Ma, X., Gu, Q., Potegal, M., Li, H., Kravitz, A. V., & Li, Z. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0370-20.2020 · Cited by 87 · see citing works
Signatures of sex: Sex differences in gene expression in the vertebrate brain
Gegenhuber, B., & Tollkühn, J. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.348 · Cited by 85 · see citing works
Li, L., Lu, L., Ren, Y., Tang, G. Y., Zhao, Y., Cai, X., Shi, Z. H., Ding, H., Liu, C., Cheng, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28539-7 · Cited by 87 · see citing works
A projection specific logic to sampling visual inputs in mouse superior colliculus
Reinhard, K., Li, C., Do, Q. H., Burke, E. G., Heynderickx, S., & Farrow, K. (2019) · eLife · doi:10.7554/elife.50697 · Cited by 84 · see citing works
A neural circuit for male sexual behavior and reward
Bayless, D. W., Davis, C.-H. O., Yang, R., Wei, Y., Carvalho, V. M. D. A., Knoedler, J. R., Yang, T., Livingston, O., Lomvardas, A., Martins, G. J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.021 · Cited by 82 · see citing works
Aleyasin, H., Flanigan, M. E., & Russo, S. J. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.013 · Cited by 79 · see citing works
Dopaminergic Dynamics Contributing to Social BehaviorPreprint
Gunaydin, L. A., & Deisseroth, K. A. (2014) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2014.79.024711 · Cited by 79 · see citing works
Rogers-Carter, M. M., Djerdjaj, A., Gribbons, K. B., Varela, J. A., & Christianson, J. P. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0316-19.2019 · Cited by 79 · see citing works
Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression
Yamaguchi, T., & Lin, D. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.011 · Cited by 77 · see citing works
Cell-Type-SpecificShank2Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes
Kim, R., Kim, J., Chung, C., Ha, S., Lee, S., Lee, E., Yoo, Y.-E., Kim, W., Shin, W., & Kim, E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2684-17.2018 · Cited by 77 · see citing works
Internal States and Behavioral Decision-Making: Toward an Integration of Emotion and CognitionPreprint
Kennedy, A., Asahina, K., Hoopfer, E. D., Inagaki, H., Jung, Y., Lee, H., Remedios, R., & Anderson, D. J. (2014) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2014.79.024984 · Cited by 78 · see citing works
Self-citationTourette syndrome: a disorder of the social decision-making network
Albin, R. L. (2017) · Brain · doi:10.1093/brain/awx204 · Cited by 77 · see citing works
Popovitz, J., Mysore, S. P., & Adwanikar, H. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00006 · Cited by 76 · see citing works
Neural coding of sex-specific social information in the mouse brain
Li, Y., & Dulac, C. G. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.07.005 · Cited by 76 · see citing works
State-dependent responses to sex pheromones in mouse
Stowers, L., & Liberles, S. D. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.001 · Cited by 75 · see citing works
Trouillet, A., Keller, M., Weiss, J., Leinders‐Zufall, T., Birnbaumer, L., Zufall, F., & Chamero, P. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821492116 · Cited by 74 · see citing works
Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior
Soden, M. E., Miller, S. M., Burgeno, L. M., Phillips, P. E. M., Hnasko, T. S., & Zweifel, L. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.067 · Cited by 72 · see citing works
Coordination of social behaviors by the bed nucleus of the stria terminalis
Flanigan, M. E., & Kash, T. L. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.14991 · Cited by 71 · see citing works
Genetic dissection of neural circuits underlying sexually dimorphic social behaviours
Bayless, D. W., & Shah, N. M. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0109 · Cited by 69 · see citing works
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 101 · see citing works
The neurobiology of offensive aggression: Revealing a modular view
de Boer, S. F., Olivier, B., Veening, J., & Koolhaas, J. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.040 · Cited by 70 · see citing works
Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis
Beyeler, A., & Dabrowska, J. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-815134-1.00003-9 · Cited by 65 · see citing works
Salay, L. D., & Huberman, A. D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109792 · Cited by 65 · see citing works
Bíró, L., Sipos, E., Bruzsik, B., Farkas, I., Zelena, D., Balázsfi, D., Tóth, M., & Haller, J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3234-17.2018 · Cited by 66 · see citing works
Sano, K., Nakata, M., Musatov, S. A., Morishita, M., Sakamoto, T., Tsukahara, S., & Ogawa, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524907113 · Cited by 65 · see citing works
Animal models of excessive aggression: implications for human aggression and violence
de Boer, S. F. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.04.006 · Cited by 63 · see citing works
An amygdala circuit that suppresses social engagement
Kwon, J.-T., Ryu, C., Lee, H., Sheffield, A., Fan, J., Cho, D. H., Bigler, S., Sullivan, H. A., Choe, H. K., Wickersham, I. R., et al. (2021) · Nature · doi:10.1038/s41586-021-03413-6 · Cited by 61 · see citing works
Molecular and neural control of sexually dimorphic social behaviors
Yang, T., & Shah, N. M. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.015 · Cited by 61 · see citing works
Neural dynamics in the limbic system during male social behaviors
Guo, Z., Yin, L., Diaz, V. E., Dai, B., Osakada, T., Lischinsky, J. E., Chien, J. M., Yamaguchi, T., Urtecho, A., Tong, X., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.07.011 · Cited by 60 · see citing works
New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.
Stoop, R., Hegoburu, C., & van den Burg, E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033904 · Cited by 56 · see citing works
Onaolapo, A. Y., Aina, O. A., & Onaolapo, O. J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.094 · Cited by 58 · see citing works
Preemptive Stimulation of AgRP Neurons in Fed Mice Enables Conditioned Food Seeking under Threat
Jikomes, N., Ramesh, R. N., Mandelblat-Cerf, Y., & Andermann, M. L. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.019 · Cited by 57 · see citing works
Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
Kim, D. G., Gonzales, E. L., Kim, S., Kim, Y., Adil, K. J., Jeon, S. J., Cho, K. S., Kwon, K. J., & Shin, C. Y. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.2.247 · Cited by 57 · see citing works
Self-citationWu, M. V., & Tollkühn, J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.07.001 · Cited by 55 · see citing works
Ventral striatal islands of Calleja neurons control grooming in mice
Zhang, Y. F., Cifuentes, L. V., Wright, K. N., Bhattarai, J. P., Mohrhardt, J., Fleck, D., Janke, E., Jiang, C., Cranfill, S. L., Goldstein, N., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00952-z · Cited by 54 · see citing works
Rojas‐Carvajal, M., Fornaguera, J., Mora-Gallegos, A., & Brenes, J. C. (2018) · Animal Behaviour · doi:10.1016/j.anbehav.2018.01.018 · Cited by 54 · see citing works
Sun, J., Yuan, Y., Wu, X., Liu, A., Wang, J., Yang, S., Liu, B., Kong, Y., Wang, L., Zhang, K., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.010 · Cited by 53 · see citing works
Zilkha, N., Sofer, Y., Beny, Y., & Kimchi, T. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.014 · Cited by 51 · see citing works
VMHvl-Projecting Vglut1+ Neurons in the Posterior Amygdala Gate Territorial Aggression
Zha, X., Wang, L. A., Jiao, Z., Yang, R., Xu, C., & Xu, X. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.081 · Cited by 53 · see citing works
A brain-to-spinal sensorimotor loop for repetitive self-grooming
Xie, Z., Li, D., Cheng, X., Pei, Q., Gu, H., Tao, T., Huang, M., Shang, C., Geng, D., Zhao, M., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.028 · Cited by 52 · see citing works
Вячеславовна, Г. А., Svirin, E. P., Pavlov, D., Cespuglio, R., Proshin, A. T., Schroeter, C. A., Lesch, K., & Strekalova, T. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020915 · Cited by 54 · see citing works
Neural circuits regulating sexual behaviors via the olfactory system in mice
Ishii, K. K., & Touhara, K. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.10.009 · Cited by 53 · see citing works
- Authors
- Hong, W., Kim, D.-W., & Anderson, D. J.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Anderson, David J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 158
- Issue
- 6
- Pages
- 1348-1361
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4167378
- OpenAlex
- W2065254519
- Cited by
- 405
- References
- 68
- Citations by year
- 2026: 17 · 2025: 39 · 2024: 32 · 2023: 38 · 2022: 39 · 2021: 45 · 2020: 51 · 2019: 29 · 2018: 30 · 2017: 31 · 2016: 25 · 2015: 25 · 2014: 3
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Simons Foundation
- California Institute of Technology
- National Institutes of Health
- National Institute of Mental Health (MH085082, MH070053, R01MH085082, R01MH070053)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- medial amygdala, social behavior, aggression, GABAergic neurons, glutamatergic neurons, neuronal subpopulations, asocial behavior
- MeSH terms
- Aggression, Amygdala, Animals, Female, gamma-Aminobutyric Acid, Grooming, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Neurons, Social Behavior, Mice, In Vitro Techniques
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