Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

Stress and the brain: from adaptation to disease

de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621

The molecular neurobiology of depression

Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889

The role of the amygdala in fear and anxiety

Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357

Stress-induced immune dysfunction: implications for health

Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190

Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies

Naidoo, J., Page, D. B., Li, B. T., Connell, L. C., Schindler, K., Lacouture, M. E., Postow, M. A., & Wolchok, J. D. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv383 · Cited by 1,505

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Buck, M. D., O’Sullivan, D., Geltink, R. I. K., Curtis, J. D., Chang, C., Sanin, D. E., Qiu, J., Kretz, O., Braas, D., van der Windt, G. J. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.035 · Cited by 1,491

Mechanisms of stress in the brain

McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386

Stress, depression, the immune system, and cancer

Reiche, E. M. V., Nunes, S. O. V., & Morimoto, H. K. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01597-9 · Cited by 1,364

Mitochondrial Dynamics and Metabolic Regulation

Wai, T., & Langer, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.001 · Cited by 1,354

Metabolic regulation of mitochondrial dynamics

Mishra, P., & Chan, D. C. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201511036 · Cited by 1,143

HDAC3-Regulated PGE2 Production by Microglia Induces Phobic Anxiety Susceptibility After Stroke and Pointedly Exploiting a Signal-Targeted Gamma Visual Stimulation New Therapy

Zhu, H., Guo, Y., Huang, A., Shen, H., Chen, Y., Song, J., Guan, A., Wu, L., Wang, H., & Deng, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.845678 · Cited by 25

Basic principles of neuroimmunology

Yoshida, T. M., Wang, A., & Hafler, D. A. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00951-7 · Cited by 27

Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients

Zhou, Y., & Ke, Y. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.996680 · Cited by 29

Macrophage-mediated immune response aggravates hearing disfunction caused by the disorder of mitochondrial dynamics in cochlear hair cells

Zhang, Y., Fu, X., Li, Y., Li, W., Hong, G., Guo, S., Xiao, Y., Liu, Z., Ding, S., Bi, X., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac270 · Cited by 26

Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain

Zhang, Z., Han, P., Fu, J., Yu, H., Xu, H., Hu, J.-C., Lu, J., Yang, X., Zhang, H.-J., Bu, M.-M., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116555 · Cited by 27

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Chen, J., Li, T., Huang, D., Gong, W., Tian, J., Gao, X., Qin, X., Du, G., & Zhou, Y. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.08.008 · Cited by 24

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder

Lingampelly, S. S., Naviaux, J. C., Heuer, L. S., Monk, J. M., Li, K., Wang, L., Haapanen, L. A. D., Kelland, C., de Water, J. V., & Naviaux, R. K. (2024) · Communications Biology · doi:10.1038/s42003-024-06102-y · Cited by 28

Mitochondrial and metabolic features of salugenesis and the healing cycle

Naviaux, R. K. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.04.003 · Cited by 27

Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis

Kulminski, A. M., Loiko, E., Loika, Y., & Culminskaya, I. V. (2021) · GeroScience · doi:10.1007/s11357-021-00484-1 · Cited by 24

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Chen, J., Tian, L., Qin, X., Du, G., & Zhou, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.900459 · Cited by 22

ER-mitochondrial contact protein Miga regulates autophagy through Atg14 and Uvrag

Xu, L., Qiu, Y., Wang, X., Shang, W., Bai, J., Shi, K., Liu, H., Liu, J., Wang, L., & Tong, C. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111583 · Cited by 22

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López-Otín, C., & Kroemer, G. (2024) · Cell Stress · doi:10.15698/cst2024.03.294 · Cited by 27

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Yang, C., Ning, L., Zhou, F. H., Sun, Q., Meng, H. P., Han, Z., Liu, Y., Huang, W., Liu, S., Li, X. H., et al. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00234-9 · Cited by 22

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Grotle, A., Darling, A. M., Saunders, E. F. H., Fadel, P. J., Trott, D. W., & Greaney, J. L. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00019.2022 · Cited by 21

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Gao, X., Ma, K., Yang, H., Wang, K., Fu, B., Zhu, Y., She, X., & Cui, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.994001 · Cited by 23

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Qian, Q., Qiu, D., Wu, Z., Yang, H., Xie, Y., Li, S., Yin, Y., & Li, X. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102720 · Cited by 21

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Yang, C., Liang, R., Liu, Y., Meng, F., Zhou, F. H., Zhang, X., Ning, L., Wang, Z., Liu, S., & Zhou, X. (2023) · The FASEB Journal · doi:10.1096/fj.202301140rr · Cited by 23

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Zhang, Y., Cong, R., Lv, T., Liu, K., Chang, X., Li, Y., Han, X., & Zhu, Y. (2024) · iScience · doi:10.1016/j.isci.2024.109540 · Cited by 24

Integrated Single‐Cell RNA‐seq and ATAC‐seq Reveals Heterogeneous Differentiation of CD4 + Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder

Sun, Z., Zhang, B., Zhou, J., Luo, Y., Zhu, X., Wang, Y., He, Y., Zheng, P., Zhang, L., Yang, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202308393 · Cited by 20

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You, X., Yang, Q., Yan, K., Wang, S.-R., Huang, R., Wang, S., Gao, C., Li, L., & Lian, Z. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.790990 · Cited by 20

Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice

Yuan, F., Zhou, Z., Wu, S., Jiao, F., Chen, L., Fang, L., Yin, H., Hu, X., Jiang, X., Liu, K., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215590120 · Cited by 19

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Wu, D., Yang, S., Yuan, C., Zhang, K., Tan, J., Guan, K., Zeng, H., & Huang, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136828 · Cited by 21

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He, Y., Tian, Y., Xiong, H., Deng, Z., Zhang, H., Guo, F., & Sun, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03733 · Cited by 18

Immune-brain plasticity underpins stress and affective behaviors

Lee, J., & Wheeler, M. E. (2025) · Neuron · doi:10.1016/j.neuron.2025.11.020 · Cited by 21

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Zhao, J., Feng, C., Wang, W., Su, L., & Jiao, J. (2022) · Cell Discovery · doi:10.1038/s41421-022-00469-0 · Cited by 17

High urea induces anxiety disorders associated with chronic kidney disease by promoting abnormal proliferation of OPC in amygdala

Huang, B., Huang, Z., Wang, H., Zhu, G., Liao, H., Wang, Z., Yang, B., & Ran, J. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175905 · Cited by 18

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Bordt, E. A., Moya, H., Jo, Y. C., Ravichandran, C. T., Bankowski, I. M., Ceasrine, A. M., McDougle, C. J., Carlezon, W. A., & Bilbo, S. D. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.010 · Cited by 21

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Qu, Z., Wu, S., Zheng, Y., Bing, Y., Liu, X., Li, S., Li, W., & Zou, X. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115807 · Cited by 17

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Lin, J., Shi, J., Min, X., Chen, S., Zhao, Y., Zhang, Y., & Cheng, L. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.803052 · Cited by 18

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Zhou, Z., Zhang, B., & Yu, X. Y. (2022) · Infrared Physics & Technology · doi:10.1016/j.infrared.2022.104400 · Cited by 17

Metabolomics Based on Peripheral Blood Mononuclear Cells to Dissect the Mechanisms of Chaigui Granules for Treating Depression

Huang, D., Wang, L., Wu, Y., Qin, X., Du, G., & Zhou, Y. (2022) · ACS Omega · doi:10.1021/acsomega.1c06046 · Cited by 16

Abnormal microglial polarization induced by Arid1a deletion leads to neuronal differentiation deficits

Gong, M., Shi, R., Liu, Y., Ke, J.-P., Liu, X., Du, H., & Liu, C. (2022) · Cell Proliferation · doi:10.1111/cpr.13314 · Cited by 16

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

Li, J., Huang, D., Lei, B., Huang, J., Yang, L., Nie, M., Su, S., Zhao, Q., & Wang, Y. (2022) · eLife · doi:10.7554/elife.83272 · Cited by 15

Cardiovascular Disease, Genetic Susceptibility, and Risk of Psychiatric Disorders and Suicide Attempt: A Community‐Based Matched Cohort Study Based on the UK Biobank

Yang, J., Zeng, Y., Yang, H., Qu, Y., Han, X., Chen, W., Sun, Y., Hu, Y., Ying, Z., Liu, D., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031280 · Cited by 15

Non-nutritive Sweetener Aspartame Disrupts Circadian Behavior and Causes Memory Impairment in Mice

Bai, H., Zuo, X., Zhao, C., Zhang, S., & Feng, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c05394 · Cited by 15

Relevant Characteristics Analysis Using Natural Language Processing and Machine Learning Based on Phenotypes and T-Cell Subsets in Systemic Lupus Erythematosus Patients With Anxiety

Gu, X., Jin, Y., Fu, T., Zhang, X., Li, T., Yang, Y., Li, R., Zhou, W., Guo, J., Zhao, R. Z., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.793505 · Cited by 15

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Milaneschi, Y., Arnold, M., Kastenmüller, G., Dehkordi, S. M., Krishnan, R. R., Dunlop, B. W., Rush, A. J., Penninx, B. W. J. H., & Kaddurah‐Daouk, R. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.03.070 · Cited by 16

MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries

Ding, Y., Luo, H., & Qi, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1684-0 · Cited by 15

Mitochondria‐derived vesicles: A promising and potential target for tumour therapy

Peng, X. Y., Gao, Y., Liu, J., Shi, X., Li, W., Ma, Y., Li, X., & Li, H. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70320 · Cited by 14

Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer's disease by desorption electrospray ionization mass spectrometry imaging

Wang, X., Yang, X., Hou, Z., Tian, S., Xu, G., Li, J., Wen, L., Bi, D., Gao, F., Shen, Y., et al. (2022) · Talanta · doi:10.1016/j.talanta.2022.124046 · Cited by 15

Cellular specificity of mitochondrial and immunometabolic features in major depression

Brasanac, J., Gamradt, S., Otte, C., Milaneschi, Y., Monzel, A. S., Picard, M. A., & Gold, S. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01473-2 · Cited by 14

Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals

Waqas, M., Us-Salam, I., Bibi, Z., Wang, Y., Li, H., Zhu, Z., & He, S. (2020) · Neural Plasticity · doi:10.1155/2020/8829660 · Cited by 14

Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons

Yuan, F., Wu, S., Zhou, Z., Jiao, F., Yin, H., Niu, Y., Jiang, H., Chen, S., & Guo, F. (2023) · Life Metabolism · doi:10.1093/lifemeta/load004 · Cited by 14

CD4+ T-cell subsets are associated with chronic stress effects in newly diagnosed anxiety disorders

Dai, B., Li, T., Cao, J., Zhao, X., Jiang, Y., Shi, L., & Wei, J. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100661 · Cited by 13

Spinosin improves anxiety disorders in mice with chronic restraint stress via the ERK1/2-CREB-BDNF pathway

Guo, Y., Wei, F., Lv, Y. M., Wu, H., Li, Y., Tang, R., Zhao, M., Ge, W., & Du, W. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113517 · Cited by 13

Xanthine-induced deficits in hippocampal behavior and abnormal expression of hemoglobin genes

Kambe, J., Miyata, S., Li, C., Yamamoto, Y., & Nagaoka, K. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114476 · Cited by 13

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Sun, F., Zhou, K., Tian, K., Wang, J., Qiu, J., & Zha, D. (2020) · Neural Plasticity · doi:10.1155/2020/8831735 · Cited by 13

Chlorinated disinfection byproducts of diazepam perturb cell metabolism and induce behavioral toxicity in zebrafish larvae

Huang, X., Zhao, X., Zhang, X., Wang, P., Zhu, K., & Shao, B. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112416 · Cited by 12

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Zhang, J., Xie, J., Liang, Y., Li, Y., Zhang, Y., Wang, C., & Huang, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112913 · Cited by 12

Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice

Milà‐Guasch, M., Ramírez, S., Llana, S. R., Fos-Domènech, J., Dropmann, L. M., Pozo, M., Eyre, E., Gómez-Valadés, A. G., Obri, A., Haddad-Tóvolli, R., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002171 · Cited by 14

NEATmap: a high-efficiency deep learning approach for whole mouse brain neuronal activity trace mapping

Zheng, W., Mu, H., Chen, Z., Liu, J., Xia, D., Cheng, Y., Jing, Q., Lau, P.-M., Tang, J., Bi, G., et al. (2024) · National Science Review · doi:10.1093/nsr/nwae109 · Cited by 13

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Luo, R., Luo, C., Zhong, F., Shen, W., Li, H., Zhang, Y., & Dai, R. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02113-y · Cited by 12

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Galéra, C., Barbosa, S., Collet, O. A., Khalfallah, O., Aouizerate, B., Sutter‐Dallay, A., Koehl, M., Capuron, L., van der Waerden, J. E. B., Melchior, M., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.10.009 · Cited by 12

Stress induces behavioral disorders by promoting microglial phagocytosis via decreasing neuronal Dkk3

Chen, X., Zhang, K., Li, Y., Wang, C., Lou, H., & Yu, S. Y. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03314-4 · Cited by 15

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Jing, W., Bi, C., Fang, Z., Qian, C., Chen, J., Yu, J., Tian, G., Ye, M., & Liu, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114855 · Cited by 11

Quantitative imaging and semiotic phenotyping of mitochondrial network morphology in live human cells

Charrasse, S., Racine, V., Saint-Omer, C., Poquillon, T., Lionnard, L., Ledru, M., Gonindard, C., Delaunois, S., Kissa, K., Frye, R. E., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301372 · Cited by 11

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Chioino, A., & Sandi, C. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_537 · Cited by 12

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Zheng, L., Xin, J., Ye, H., Sun, N., Gan, B., Gong, X., Bao, S., Xiang, M., Wang, H., Ni, X., et al. (2025) · BMC Microbiology · doi:10.1186/s12866-025-03893-w · Cited by 12

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Chen, X., Chen, Y., Qi, D., & Cui, D. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110422 · Cited by 11

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Wang, Q., Zhong, Y., Chen, N., & Chen, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1078984 · Cited by 12

Low-dose IL-2 therapy compensates for metabolic shifts and reverses anxiety-like behavior in PD-1 deficiency-induced autoimmunity

Lv, C., Zhang, H., Li, Z., Zhang, H., Zhang, Y. X., Li, R., Wei, S., & Yu, D. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00562-y · Cited by 11

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Piletič, K., Kayvanjoo, A. H., Richter, F. C., Borsa, M., Lechuga‐Vieco, A. V., Popp, O., Grenet, S., Ko, J. K. L., Luo, L., Zec, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64266-5 · Cited by 10

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Wei, Q.-Q., Yin, Y., Qiao, Y.-X., Ni, H., Han, S.-Y., Yao, Y., Li, Y., Zhang, L., & Li, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176394 · Cited by 10

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Zhu, C., Xu, J., He, S., Niu, Q., Liu, Y., Guo, X., Hu, H., Sun, R., Chen, T., Liu, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202504414 · Cited by 10

SVM-Based Model Combining Patients’ Reported Outcomes and Lymphocyte Phenotypes of Depression in Systemic Lupus Erythematosus

Dong, C., Yang, N., Zhao, R. Z., Yang, Y., Gu, X., Fu, T., Sun, C. C., & Gu, Z. (2023) · Biomolecules · doi:10.3390/biom13050723 · Cited by 10

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Safari, H., & Mashayekhan, S. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128251883231031054700 · Cited by 11

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Qian, X., Jiang, J., Yang, B. K., Zhao, J., Wang, G., Tian, P., & Chen, W. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06422 · Cited by 10

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Zhang, C., Hu, Z., Wang, K., Yang, L., Li, Y., Schlüter, H., Yang, P., Hong, J., & Yu, H. (2020) · The Analyst · doi:10.1039/d0an00263a · Cited by 10

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Han, B., Yang, X., Hosseini, D. K., Luo, P., Liu, M., Xu, X., Zhang, Y., Su, H., Zhou, T., Sun, H., et al. (2020) · Aging · doi:10.18632/aging.103715 · Cited by 10

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Wang, Z., Xia, T., Jin, S., Liu, X., Pan, R., Yan, M., & Chang, Q. (2021) · Biomedicines · doi:10.3390/biomedicines9101321 · Cited by 10

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Darrigues, J., Almeida, V., Conti, E., & Ribot, J. C. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101657 · Cited by 10

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Lv, S., Zhang, G., Lu, Y., Zhong, X., Huang, Y., Ma, Y., Yan, W., Teng, J., & Wei, S. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155669 · Cited by 9

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Jeon, Y., Lim, Y., Yeom, J., & Kim, E. (2021) · Molecular Brain · doi:10.1186/s13041-021-00863-x · Cited by 9

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Huang, Z., Xie, Q., Li, S., Zhou, Y., He, Z., Lin, K., Yang, M., Song, P., & Chen, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.750185 · Cited by 9

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Shan, D., You, L., Wan, X., Yang, H., Zhao, M., Chen, S., Jiang, W., Xu, Q., & Yuan, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.004 · Cited by 9

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Dai, D., & Liu, H. (2022) · Journal of Immunology Research · doi:10.1155/2022/9595704 · Cited by 9

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Xue, H., Chen, J., & Fan, W. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.006 · Cited by 9

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Wang, D., Yang, Z., Wu, P., Li, Q., Yu, C., Yang, Y., Du, Y., Jiang, M., & Ma, J. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03229-2 · Cited by 8

Abnormal purine metabolism in nasal epithelial cells affects allergic rhinitis by regulating Th17/Treg cells

Xu, T., Xia, S., Zhang, X., & Yuan, Y. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00873.2024 · Cited by 8

Quercetin ameliorates chronic restraint stress- and LPS-induced anxiety-like behaviors by modulating neuroinflammation in the lateral hypothalamus

Wang, X., Weng, G., Gao, Y., Wang, Y., & Zhang, C. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06784-0 · Cited by 8

Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation

Wang, K., Hou, X., Lu, H., Han, N., Xie, M., Xi, A., & Xu, Z. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103199 · Cited by 9

Circulating T‐cell subsets discrepancy between bipolar disorder and major depressive disorder during mood episodes: A naturalistic, retrospective study of 1015 cases

Li, S., Lv, D., Qian, C., Jiang, J., Zhang, P., Xi, C., Wu, L., Gao, X., Fu, Y., Zhang, D., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14361 · Cited by 10

Dysregulation of Prefrontal Oligodendrocyte Lineage Cells Across Mouse Models of Adversity and Human Major Depressive DisorderPreprint

Sharma, S. K., Ma, W., Ressler, K. J., Anderson, T., Li, D. C., Jin, P., Gourley, S. L., & Qin, Z. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.09.531989 · Cited by 7

Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice

Hu, J., He, K., Yang, Y., Huang, C., Dou, Y., Wang, H., Zhang, G., Wang, J., Niu, C., Bi, G., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113817 · Cited by 7

The miR-203/ZBTB20/MAFA Axis Orchestrates Pancreatic β-Cell Maturation and Identity During Weaning and Diabetes

Li, Y., Yang, Y., Sun, Y., He, L., Liu, K., Zhang, Y., Zhou, Y., Chang, X., Liang, R., Wang, S., et al. (2024) · Diabetes · doi:10.2337/db23-0604 · Cited by 7

Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas

Tian, Y., Liu, S., Shi, H., Li, J., Wan, X., Sun, Y., Li, H., Cao, N., Feng, Z., Zhang, T., et al. (2025) · Advanced Science · doi:10.1002/advs.202413819 · Cited by 8

Peripheral CD4 + T cells mediate the destructive effects of maternal separation on prefrontal myelination and cognitive functions

Xiong, R., Hu, Y., Wang, M., Han, T., Hu, Y., Ma, C., & Li, B. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412995122 · Cited by 7

Molecular targets of endothelial phosphatidic acid regulating major depressive disorder

Edwards, M. J., Wilson, G. C., Keitsch, S., Soddemann, M., Wilker, B., Müller, C. P., Kornhuber, J., & Gulbins, E. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15708 · Cited by 7

Exploration of Lipid Metabolism Alterations in Children with Active Tuberculosis Using UHPLC-MS/MS

Sun, B., Liu, F., Yin, Q.-Q., Jiang, T., Fang, M., Duan, L., Quan, S., Tian, X., Shen, A., Mi, K., et al. (2023) · Journal of Immunology Research · doi:10.1155/2023/8111355 · Cited by 7

Analysis of the underlying mechanism of Ziziphi Spinosae Semen for treating anxiety disorder in a zebrafish sleep deprivation model

Zhang, J., Feng, J., & Feng, C. (2023) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2023.100019 · Cited by 7

Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety

Zhang, X., Kong, Y., He, G., & Zhou, Z. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108300 · Cited by 8

Combining Metabolomics and Quantitative Analysis to Investigate Purine Metabolism Disorders in Depression and the Therapeutic Effect of Chaigui Granules

Huang, D., Lv, J., Gong, W., Tian, J., Gao, X., Qin, X., Du, G., & Zhou, Y. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00804 · Cited by 6

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Gao, Z., Guo, M., Chen, K., Jiang, M., Zhang, L., Mannelli, L. D. C., & Zhang, C. (2025) · Medicine Bulletin · doi:10.1002/mdb2.70007 · Cited by 6

Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice

Hui, R., Xu, J., Ma, H., Feng, T., Hou, C., Wang, X., Jin, M., Feng, Y., Shi, Y., Xie, B., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03532-1 · Cited by 6

Association between systemic immune-inflammation index at admission and post-stroke depression in patients with acute ischemic stroke

Su, X., Chi, F., You, J., Zhao, J., Wang, S., Zhou, X., & Li, X. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1686621 · Cited by 6

Pregnant individuals with uncomplicated pregnancies display pro‐inflammatory immune changes when exposed to the COVID‐19 pandemic

Bernier, E., Brien, M., & Girard, S. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13828 · Cited by 6

Genes associated with cellular senescence as diagnostic markers of major depressive disorder and their correlations with immune infiltration

Chen, J., Xie, X., Lin, M., Han, H. R., Wang, T., Lei, Q., & He, R. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1372386 · Cited by 6

Peripheral immunity relate to disease progression and prognosis in amyotrophic lateral sclerosis

Jiang, Q., Wei, Q., Zhang, L., Yang, T., Lin, J., Xiao, Y., Li, C., Hou, Y., Ou, R., Liu, K., et al. (2024) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2024.2306969 · Cited by 6

Pathogenesis or a response to lithium? A novel perspective for mitochondrial mass fluctuation of naïve T cells in patients with bipolar disorder

Chen, Z., Wang, B., Huang, Y., Wang, X., Li, W., & Wang, M. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.095 · Cited by 6

Chronic mental stress and ischemic injury: Mechanisms and implications – A mini review

Zhu, Y., Simo, L., Geng, X., Li, F., & Ding, Y. (2025) · Brain Circulation · doi:10.4103/bc.bc_88_24 · Cited by 5

Xathine unveiled: Bridging CD4+ T cell and stress-induced disorders through purine metabolism

Zhang, L., Dong, J.-X., Li, Y., & Jin, J. (2025) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2025.100113 · Cited by 1

T cells with fragmented mitochondria frazzle the mind

Bordon, Y. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0246-0

The Immune-Mind Connection

Hang, S., & Huh, J. R. (2019) · Cell · doi:10.1016/j.cell.2019.10.012 · Cited by 4

Stressed-Out T Cells Fragment the Mind

Bordt, E. A., & Bilbo, S. D. (2020) · Trends in Immunology · doi:10.1016/j.it.2019.12.008

γδTreg/γδTh17 Cell Imbalance Drives Xanthine‐Mediated Metabolic Dysfunction in Restraint Stress‐Induced Anxiety‐Like Behavior

Xue, X., Tang, C., Yan, N., Lai, X., Li, Q., & Li, E. (2026) · Cell Biology International · doi:10.1002/cbin.70149