The DOI matches its Crossref record; 60 of the 62 references it cites were found in a registry or an index.
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior
Open accessAbstract
Physical or mental stress leads to neuroplasticity in the brain and increases the risk of depression and anxiety. Stress exposure causes the dysfunction of peripheral T lymphocytes. However, the pathological role and underlying regulatory mechanism of peripheral T lymphocytes in mood disorders have not been well established. Here, we show that the lack of CD4+ T cells protects mice from stress-induced anxiety-like behavior. Physical stress-induced leukotriene B4 triggers severe mitochondrial fission in CD4+ T cells, which further leads to a variety of behavioral abnormalities including anxiety, depression, and social disorders. Metabolomic profiles and single-cell transcriptome reveal that CD4+ T cell-derived xanthine acts on oligodendrocytes in the left amygdala via adenosine receptor A1. Mitochondrial fission promotes the de novo synthesis of purine via interferon regulatory factor 1 accumulation in CD4+ T cells. Our study implicates a critical link between a purine metabolic disorder in CD4+ T cells and stress-driven anxiety-like behavior.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, peripheral CD4+ T cells have been reported as the major contributors to the occurrence of mental disorders [15, 16].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [15]
Citations
Cites
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
Naidoo, J., Page, D. B., Li, B. T., Connell, L. C., Schindler, K., Lacouture, M. E., Postow, M. A., & Wolchok, J. D. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv383 · Cited by 1,505
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Buck, M. D., O’Sullivan, D., Geltink, R. I. K., Curtis, J. D., Chang, C., Sanin, D. E., Qiu, J., Kretz, O., Braas, D., van der Windt, G. J. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.035 · Cited by 1,491
Mechanisms of stress in the brain
McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386
Stress, depression, the immune system, and cancer
Reiche, E. M. V., Nunes, S. O. V., & Morimoto, H. K. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01597-9 · Cited by 1,364
Mitochondrial Dynamics and Metabolic Regulation
Wai, T., & Langer, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.001 · Cited by 1,354
Metabolic regulation of mitochondrial dynamics
Mishra, P., & Chan, D. C. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201511036 · Cited by 1,143
Flagged first, then by citations
2 of the 62 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–312 of 312
Chen, Z., Lin, Y., Wang, B., & Wang, M. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106863 · Cited by 1
Tang, R., Xie, Z., Fan, Y., Zhang, J., Lu, L., Zhuang, Y., 郭存举, 舒宽勇, Li, S., Zhang, P., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.06.024
Self-citationYin, J., Lü, Z., Chen, C., Shen, X., Xie, Y. Q., Gao, G., Hao, J., Ye, Z., & Jiang, L. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117029
Tu, H., Hou, Y., Cui, W., Wang, X., Chen, M., Shi, M., Kang, T., Jiang, Y., Wu, Q., Li, W., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.07.024
Li, J., Wang, M., Liu, H., Dong, K., & Guo, R. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1828806
Keshky, M. E. S. E., & Samak, A. Y. (2026) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2026.152189
Yang, D., Wu, X., Luo, X., Teng, Y., Duan, X., Kang, T., & Wu, W. (2026) · Biomedical Chromatography · doi:10.1002/bmc.70560
Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction
Rivera-López, Y. A., Meléndez-Rodríguez, L. L., Torres-Rodríguez, O. I., Rivera-Pérez, L. M., Torres-Rosado, A. P., Tworoger, S. S., & Armaiz-Peña, G. N. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101322
Lin, K., Wang, P., Li, S., Ma, C., Wen, D., Wang, X., & Liao, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1712425
Sun, Y., Li, Y., Ren, M., Jin, Y., Zhang, M., & Wu, T. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c03771
Self-citationShi, M.-J., Hou, Z., Zheng, Z., Xing, J.-P., Bu, H., Liu, Z., Xu, Y., & Liu, S. (2026) · World Journal of Traditional Chinese Medicine · doi:10.4103/wjtcm.wjtcm_67_26
Wan, L., Chen, Z., Wan, N., Wang, C., Long, Z., Chen, D., Ouyang, R., Long, X., Du, K., Dong, X., et al. (2026) · Movement Disorders · doi:10.1002/mds.70541
Metadata
- Authors
- Fan, K.-Q., Li, Y.-Y., Wang, H.-L., Mao, X.-T., Guo, J.-X., Wang, F., Huang, L.-J., Li, Y.-N., Ma, X.-Y., Gao, Z.-J., Chen, W., Qian, D.-D., Xue, W.-J., Cao, Q., Zhang, L., Shen, L., Zhang, L., Tong, C., Zhong, J.-Y., Lu, W., Lu, L., Ren, K.-M., Zhong, G., Wang, Y., Tang, M., Feng, X.-H., Chai, R.-J., & Jin, J.
- Affiliations
- Zhejiang University (CN)
- Sir Run Run Shaw Hospital (CN)
- East China Normal University (CN)
- Southeast University (CN)
- ShanghaiTech University (CN)
- Corresponding author
- Jin, Jin
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 179
- Issue
- 4
- Pages
- 864-879.e19
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2983084556
- Cited by
- 312
- References
- 62
- Citations by year
- 2026: 30 · 2025: 43 · 2024: 57 · 2023: 45 · 2022: 54 · 2021: 41 · 2020: 39 · 2019: 3
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key R&D Program of China (2018YFA0800503, 2018YFD0500100)
- Excellent Young Scientist Fund of NSFC (31822017)
- Zhejiang Provincial Natural Science Foundation of China (LR19C080001)
- Strategic Priority Research Program of the Chinese Academy of Science (XDA16010302)
- National Natural Science Foundation of China (81572651, 81771675, 81622013, 81700913)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- stress-induced anxiety, CD4+ T cells, leukotriene B4, mitochondrial fission, purine metabolism, xanthine, adenosine A1 receptor, oligodendrocytes, amygdala, IRF1, depression, social behavior disorders, mood disorders, T cell dysfunction
- MeSH terms
- Amygdala, Animals, Anxiety, Behavior, Animal, Brain Diseases, Metabolic, Disease Models, Animal, Humans, Oligodendroglia, Stress, Psychological, CD4-Positive T-Lymphocytes, Xanthine, Mice, Single-Cell Analysis, Transcriptome, Mitochondrial Dynamics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
