Cited by 312Tryptophan and brain disordersStress Responses and CortisolAdenosine and Purinergic Signaling

The DOI matches its Crossref record; 60 of the 62 references it cites were found in a registry or an index.

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

Open access

Fan, Ke-qi, Li, Yi-yuan, Wang, Hao-li, Mao, Xin-tao, Guo, Jin-xin, Wang, Fei, Huang, Ling-jie, Li, Yi-ning, Ma, Xiang-yu, Gao, Zheng-jun, Chen, Wei, Qian, Dan-dan, Xue, Wen-jin, Cao, Qian, Zhang, Lei, Shen, Li, Zhang, Long, Tong, Chao, Zhong, Jiang-yan, Lu, Wei, Lu, Ling, Ren, Ke-ming, Zhong, Guisheng, Wang, Yuan, Tang, Mingliang, Feng, Xin-Hua, Chai, Ren-jie, Jin, Jin·2019·Cell

DOI 10.1016/j.cell.2019.10.001

Open this paper in CoChat — free account Open PDF

Abstract

Physical or mental stress leads to neuroplasticity in the brain and increases the risk of depression and anxiety. Stress exposure causes the dysfunction of peripheral T lymphocytes. However, the pathological role and underlying regulatory mechanism of peripheral T lymphocytes in mood disorders have not been well established. Here, we show that the lack of CD4+ T cells protects mice from stress-induced anxiety-like behavior. Physical stress-induced leukotriene B4 triggers severe mitochondrial fission in CD4+ T cells, which further leads to a variety of behavioral abnormalities including anxiety, depression, and social disorders. Metabolomic profiles and single-cell transcriptome reveal that CD4+ T cell-derived xanthine acts on oligodendrocytes in the left amygdala via adenosine receptor A1. Mitochondrial fission promotes the de novo synthesis of purine via interferon regulatory factor 1 accumulation in CD4+ T cells. Our study implicates a critical link between a purine metabolic disorder in CD4+ T cells and stress-driven anxiety-like behavior.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2019.10.001

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
Naidoo, J., Page, D. B., Li, B. T., Connell, L. C., Schindler, K., Lacouture, M. E., Postow, M. A., & Wolchok, J. D. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv383 · Cited by 1,505
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Buck, M. D., O’Sullivan, D., Geltink, R. I. K., Curtis, J. D., Chang, C., Sanin, D. E., Qiu, J., Kretz, O., Braas, D., van der Windt, G. J. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.035 · Cited by 1,491
Mechanisms of stress in the brain
McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386
Stress, depression, the immune system, and cancer
Reiche, E. M. V., Nunes, S. O. V., & Morimoto, H. K. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01597-9 · Cited by 1,364
Mitochondrial Dynamics and Metabolic Regulation
Wai, T., & Langer, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.001 · Cited by 1,354
Metabolic regulation of mitochondrial dynamics
Mishra, P., & Chan, D. C. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201511036 · Cited by 1,143

Flagged first, then by citations

Show all 62 references

2 of the 62 references couldn’t be matched to a known paper.

Sorted by citations

Hallmarks of T cell aging
Mittelbrunn, M., & Kroemer, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00927-z · Cited by 702
Function and therapeutic value of astrocytes in neurological diseases
Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662
The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders
Knezevic, E., Nenic, K., Milanovic, V., & Knezevic, N. N. (2023) · Cells · doi:10.3390/cells12232726 · Cited by 564
“Peripheral CD4+ T cells appear to be major contributors to the occurrence of mental disorders [118,119] (see Table 1).”
Background
Immune cell regulation of glia during CNS injury and disease
Greenhalgh, A. D., David, S., & Bennett, F. C. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0263-9 · Cited by 411
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.026 · Cited by 368
The role of T cells in age-related diseases
Carrasco, E., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Desdín-Micó, G., Aranda, J. F., & Mittelbrunn, M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00557-4 · Cited by 250
Bacteroides species differentially modulate depression-like behavior via gut-brain metabolic signaling
Zhang, Y., Fan, Q., Hou, Y., Zhang, X., Yin, Z., Cai, X., Wei, W., Wang, J., He, D., Wang, G., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.02.007 · Cited by 226
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
Chamoto, K., Yaguchi, T., Tajima, M., & Honjo, T. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00867-9 · Cited by 185
International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update
IJzerman, A. P., Jacobson, K. A., Müller, C. E., Cronstein, B. N., & Cunha, R. A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000445 · Cited by 169
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
Dong, Y., Li, S., Lu, Y., Li, X., Liao, Y., Peng, Z., Li, Y., Hou, L., Yuan, Z., & Cheng, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01842-0 · Cited by 148
Self-citation
Systemic Immunometabolism: Challenges and Opportunities
Lercher, A., Baazim, H., & Bergthaler, A. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.012 · Cited by 144
The essential functions of mitochondrial dynamics in immune cells
Xie, J.-H., Li, Y., & Jin, J. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0480-1 · Cited by 135
Self-citation
Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications
Pu, T., Sun, J., Ren, G., & Li, H. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02241-8 · Cited by 155
Stress and cancer: The mechanisms of immune dysregulation and management
Liu, Y.-X., Tian, S., Ning, B., Huang, T., Li, Y., & Wei, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1032294 · Cited by 137
Self-citation
The role of the LTB4-BLT1 axis in health and disease
He, R., Chen, Y., & Cai, Q. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104857 · Cited by 115
Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice
Li, S., Liao, Y., Dong, Y., Li, X., Li, J., Cheng, Y., Cheng, J., & Yuan, Z. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02069-9 · Cited by 118
Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: The potential involvement of gut-brain axis
Wang, D., Wu, J., Zhu, P., Xie, H., Lu, L., Bai, W., Pan, W., Shi, R., Ye, J., Xia, B., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111289 · Cited by 118
Self-citation
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment
Wei, W., Liu, Y., Hou, Y., Cao, S., Chen, Z., Zhang, Y., Cai, X., Yan, Q., Li, Z., Yuan, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.026 · Cited by 120
The cancer-immune dialogue in the context of stress
Ma, Y., & Kroemer, G. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00949-8 · Cited by 121
Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression
Bauer, M. E. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00178-w · Cited by 107
Emerging targetome and signalome landscape of gut microbial metabolites
Zheng, X., Cai, X., & Hao, H. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.011 · Cited by 100
Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress
Ye, L., Hou, Y., Hu, W., Wang, H., Yang, R., Zhang, Q., Feng, Q., Zheng, X., Yao, G., & Hao, H. (2023) · Nature Communications · doi:10.1038/s41467-023-41817-2 · Cited by 106
Self-citation
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
Zhu, X., Sakamoto, S., Ishii, C., Smith, M. D., Ito, K., Obayashi, M., Unger, L., Hasegawa, Y., Kurokawa, S., Kishimoto, T., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01447-8 · Cited by 99
Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases
Simmons, E. C., Scholpa, N. E., & Schnellmann, R. G. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113309 · Cited by 100
GABA transporter sustains IL-1β production in macrophages
Xia, Y., He, F., Wu, X., Tan, B., Chen, S., Liao, Y., Qi, M., Chen, S., Peng, Y., Yin, Y., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe9274 · Cited by 102
Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment.
Zhang, L., Pan, J., Chen, W., Jiang, J., & Huang, J. (2020) · PubMed · Cited by 107
Self-citation
FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
González-Loyola, A., Bovay, E., Kim, J., Lozano, T. W., Sabine, A., Renevey, F., Arroz-Madeira, S., Rapin, A., Wypych, T. P., Rota, G., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf4335 · Cited by 94
Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
Peng, Z., Peng, S., Lin, K., Zhao, B., Wei, L., Tuo, Q., Liao, D., Yuan, T., & Shi, Z. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02543-6 · Cited by 95
Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
Tian, W., Liu, Y., Cao, C., Zeng, Y., Pan, Y., Liu, X., Peng, Y., & Wu, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.777018 · Cited by 94
Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen
Zhu, X., Huang, J.-Y., Dong, W., Tang, H.-D., Xu, S., Wu, Q., Zhang, H., Cheng, P., Jin, Y., Zhu, M., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01561-8 · Cited by 88
Self-citation
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety
Huang, S., Dong, W., Lin, X., Xu, K., Li, K., Xiong, S., Wang, Z., Nie, X., & Bian, J.-S. (2024) · Immunity · doi:10.1016/j.immuni.2024.01.018 · Cited by 83
Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
Wu, Y., Dong, J.-H., Dai, Y.-F., Zhu, M.-Z., Wang, M.-Y., Zhang, Y., Pan, Y.-D., Yuan, X.-R., Guo, Z.-X., Wang, C.-X., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.002 · Cited by 84
Self-citation
Defensive responses: behaviour, the brain and the body
Tseng, Y.-T., Schaefke, B., Wei, P., & Wang, L. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00736-3 · Cited by 84
Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s disease
Li, Z., Zhu, H., Guo, Y., Du, X., & Qin, C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15031 · Cited by 76
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
Golubnitschaja, O., Polívka, J., Potužník, P., Pešta, M., Štětkářová, I., Mazuráková, A., Lacková, L., Kubatka, P., Kropp, M., Thumann, G., et al. (2024) · The EPMA Journal · doi:10.1007/s13167-024-00356-6 · Cited by 76
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 72
Effects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial
Kaushik, D., Shah, P., Mukherjee, N. Z., Ji, N., Dursun, F., Kumar, A. P., Thompson, I. M., Mansour, A. M., Jha, R., Yang, X., et al. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00470-w · Cited by 68
Self-citation
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination
Zhu, Q., Yu, T., Gan, S., Wang, Y., Pei, Y., Zhao, Q., Pei, S., Hao, S., Yuan, J., Xu, J., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192083 · Cited by 66
Self-citation
Lactobacillus paracasei CCFM1229 and Lactobacillus rhamnosus CCFM1228 Alleviated Depression- and Anxiety-Related Symptoms of Chronic Stress-Induced Depression in Mice by Regulating Xanthine Oxidase Activity in the Brain
Xu, M., Tian, P., Zhu, H., Zou, R., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14061294 · Cited by 71
Self-citation
Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis
Pan, J., Zhang, L., Wang, X., Li, L., Yang, C., Wang, Z., Su, K., Hu, X., Zhang, Y., Ren, G., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02836-5 · Cited by 64
Self-citation
The neuroimmune connectome in health and disease
Wheeler, M. A., & Quintana, F. J. (2025) · Nature · doi:10.1038/s41586-024-08474-x · Cited by 71
Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells
Beurel, E., Medina-Rodriguez, E. M., & Jope, R. S. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000256 · Cited by 60
Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction
Zhao, Y., Chang, Y., Ren, H.-R., Lou, M., Jiang, F., Wang, J.-X., Chen, M., Liu, S., Shi, Y.-S., Zhu, H., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07752 · Cited by 62
Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?
Kunz, N., & Kemper, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629986 · Cited by 63
The impact of stress on immune systems and its relevance to mental illness
Ishikawa, Y., & Furuyashiki, T. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.09.005 · Cited by 73
Psychological distress and eustress in cancer and cancer treatment: Advances and perspectives
Wu, Y., Zhou, L., Zhang, X., Yang, X., Niedermann, G., & Xue, J. (2022) · Science Advances · doi:10.1126/sciadv.abq7982 · Cited by 69
IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke
Wu, W., Luo, Z., Shen, D., Lan, T., Xiao, Z., Liu, M., Hu, L., Sun, T., Wang, Y., Zhang, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102982 · Cited by 60
Self-citation
The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity
Huang, X., Hao, S., Liu, J., Huang, Y., Liu, M., Xiao, C., Wang, Y., Pei, S., Yu, T., Xu, J., et al. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00660-5 · Cited by 56
Self-citation
Mitochondria during T cell aging
Escrig-Larena, J. I., Delgado-Pulido, S., & Mittelbrunn, M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101808 · Cited by 60
Gut microbiota modulates stress-induced hypertension through the HPA axis
Wu, Q. J., Xu, Z., Song, S., Zhang, H., Zhang, W., Liu, L., Chen, Y., & Sun, J. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.05.014 · Cited by 56
Immunotherapy for depression: Recent insights and future targets
Bai, Y., Cai, Y., Chang, D., Li, D., Huo, X., & Zhu, T. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108624 · Cited by 56
Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis
Xu, L., Wang, X., Zhou, J., Qiu, Y., Shang, W., Liu, J., Wang, L., & Tong, C. (2020) · eLife · doi:10.7554/elife.56584 · Cited by 55
Self-citation
Links between thrombosis and inflammation in traumatic brain injury
Hubbard, W. B., Dong, J., Crúz, M. A., & Rumbaut, R. E. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.10.041 · Cited by 57
Inflamed brain: Targeting immune changes and inflammation for treatment of depression
Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13286 · Cited by 51
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution
Wu, Z., Wang, Y., Chen, W., Sun, H., Chen, X., Li, X., Wang, Z., Liang, W., Wang, S.-Y., Luan, X., et al. (2025) · Cell · doi:10.1016/j.cell.2025.02.007 · Cited by 57
Self-citation
Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice
Schumacher, F., Edwards, M. J., Mühle, C., Carpinteiro, A., Wilson, G. C., Wilker, B., Soddemann, M., Keitsch, S., Scherbaum, N., Müller, B. W., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102185 · Cited by 52
Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia
Chatterjee, J., Sanapala, S., Cobb, O. M., Bewley, A. F., Goldstein, A. K., Cordell, E., Ge, X., Garbow, J. R., Holtzman, M. J., & Gutmann, D. H. (2021) · Nature Communications · doi:10.1038/s41467-021-27455-6 · Cited by 50
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation
Saveljeva, S., Sewell, G. W., Ramshorn, K., Cader, M. Z., West, J. A., Clare, S., Haag, L.-M., Rodrigues, R. P. D. A., Unger, L. W., Iglesias-Romero, A. B., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.009 · Cited by 51
T Cell Subpopulations in the Physiopathology of Fibromyalgia: Evidence and Perspectives
Banfi, G., Diani, M., Pigatto, P. D., & Reali, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041186 · Cited by 46
Leucine-Restricted Diet Ameliorates Obesity-Linked Cognitive Deficits: Involvement of the Microbiota–Gut–Brain Axis
Wang, D., Wang, L., Han, L., Wang, B., Shi, R., Jin, Y., Xia, B., Zhao, Z., Zhao, B., & Liu, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01524 · Cited by 44
Inflammation, Autoimmunity, and Infection in Fibromyalgia: A Narrative Review
Paroli, M., Gioia, C., Accapezzato, D., & Caccavale, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115922 · Cited by 42
Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis
Xia, B., Liu, X., Li, X., Wang, Y., Wang, D., Kou, R.-W., Zhang, L., Shi, R., Ye, J., Bo, X., et al. (2022) · Food & Function · doi:10.1039/d1fo03888e · Cited by 41
Self-citation
Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon.
Zhang, L., Wang, H.-L., Zhang, Y.-F., Mao, X.-T., Wu, T., Huang, Z.-H., Jiang, W.-J., Fan, K.-Q., Liu, D.-D., Yang, B., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.002 · Cited by 40
Self-citation
Neonatal immune challenge induces female-specific changes in social behavior and somatostatin cell number
Smith, C. J. W., Kingsbury, M. A., Dziabis, J. E., Hanamsagar, R., Malacon, K. E., Tran, J. N., Norris, H. A., Gulino, M., Bordt, E. A., & Bilbo, S. D. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.013 · Cited by 47
Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence
Mocking, R. J. T., Naviaux, J. C., Li, K., Wang, L., Monk, J. M., Bright, A. T., Figueroa, C. A., Schene, A. H., Ruhé, H. G., Assies, J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01182-w · Cited by 40
Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study
Liu, X., Bai, X., Ren, R., Tan, L., Zhang, Y., Lan, H., Yang, Q., He, J., & Tang, X. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.985823 · Cited by 39
Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms
Fang, M., Li, Y., Liao, Z., Gan, W., Cao, Q., Li, Y., Duan, Y., Han, Y., Deng, X., Wu, F., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.02.002 · Cited by 40
Self-citation
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior
Xia, M., Lü, J., Lan, J., Teng, T., Shiao, R., Sun, H., Jin, Z., Liu, X., Wang, J., Wu, H., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.11.008 · Cited by 41
Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
Ramírez, S., Haddad-Tóvolli, R., Radosevic, M., Toledo, M., Pané, A., Alcolea, D. A., Ribas, V., Milà‐Guasch, M., Pozo, M., Obri, A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.023 · Cited by 42
Plasma Metabolomics Profiling of Metabolic Pathways Affected by Major Depressive Disorder
Du, Y., Wei, J., Zhang, Z., Yang, X., Wang, M., Wang, Y., Qi, X., Zhao, L., Tian, Y., Guo, W., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.644555 · Cited by 39
Self-citation
The emerging roles of absent in melanoma 2 (AIM2) inflammasome in central nervous system disorders
Li, Y.-K., Chen, J., & Wang, F. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105122 · Cited by 36
Self-citation
Prevalence and Associated Factors of Complains on Depression, Anxiety, and Stress in University Students: An Extensive Population-Based Survey in China
Yu, Y., Yan, W., Yu, J., Xu, Y., Wang, D., & Wang, Y. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.842378 · Cited by 46
Self-citation
Function of a Psychological Nursing Intervention on Depression, Anxiety, and Quality of Life in Older Adult Patients With Osteoporotic Fracture.
Huang, L.-Y., Zhang, C.-Y., Xu, J., Wang, W., Yu, M., Jiang, F.-S., Yan, L., & Dong, F.-H. (2021) · Worldviews on Evidence-Based Nursing · doi:10.1111/wvn.12518 · Cited by 31
Self-citation
Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety
Chen, K., Yang, J. N., Li, F., Chen, J., Chen, M., Shao, H., He, C., Cai, D., Zhang, X., Wang, L., et al. (2024) · Human Brain Mapping · doi:10.1002/hbm.26657 · Cited by 37
Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels
Jiang, S., Zhang, X.-X., Hu, L.-P., Wang, X., Li, Q., Zhang, X., Li, J., Gu, J., & Zhang, Z. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.586757 · Cited by 34
Obeticholic Acid Inhibits Anxiety via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice
Wu, L. M., Han, Y., Zheng, Z., Zhu, S., Chen, J., Yao, Y., Yue, S., Teufel, A., Weng, H., Li, L., et al. (2021) · Nutrients · doi:10.3390/nu13030940 · Cited by 36
Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits
Haddad-Tóvolli, R., Ramírez, S., Muñoz‐Moreno, E., Milà‐Guasch, M., Miquel-Rio, L., Pozo, M., Chivite, Í., Altirriba, J., Obri, A., Gómez-Valadés, A. G., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00557-1 · Cited by 33
Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy
Lei, Y., Liao, F., Tian, Y., Wang, Y., Xia, F., & Wang, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1321176 · Cited by 35
Self-citation
T cells: an emerging cast of roles in bipolar disorder
Chen, Z., Huang, Y., Wang, B., Peng, H., Wang, X., Wu, H., Chen, W., & Wang, M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02445-y · Cited by 35
Self-citation
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing
Cole, J., McColl, A., Shaw, R., Lynall, M.-E., Cowen, P. J., de Boer, P., Drevets, W. C., Harrison, N. A., Pariante, C. M., Pointon, L. J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01506-4 · Cited by 34
T cell responses in depressed mice induced by chronic unpredictable mild stress
Shi, W., Zhang, S., Lu, Y., Wang, Y., Zhao, J., & Li, L. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.064 · Cited by 32
Self-citation
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
Schumacher, F., Carpinteiro, A., Edwards, M. J., Wilson, G. C., Keitsch, S., Soddemann, M., Wilker, B., Kleuser, B., Becker, K. A., Müller, C. P., et al. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02250-y · Cited by 32
Correlation between anxiety-depression symptoms and immune characteristics in inpatients with 2019 novel coronavirus in Wuhan, China
Wu, C., Zhou, Z., Ni, L., Cao, J., Tan, M., Wu, X., Xu, Y., & Hu, J. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.07.027 · Cited by 32
Effect of chronic stress on tumorigenesis and development
Wang, C., Shen, Y., Ni, J., Hu, W., & Yang, Y. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04455-3 · Cited by 29
Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity
Jayashankar, V., Selwan, E. M., Hancock, S. E., Verlande, A., Goodson, M. O., Eckenstein, K. H., Milinkeviciute, G., Hoover, B., Chen, B., Fleischman, A. G., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013086 · Cited by 31
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress
Li, Z., Chen, K., Shao, Q., Lu, H., Zhang, X., Pu, Y., Sun, X.-J., He, H., & Cao, L. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02696-y · Cited by 30
Tong-Xie-Yao-Fang promotes dendritic cells maturation and retards tumor growth in colorectal cancer mice with chronic restraint stress.
Jiang, Y., Hu, Y., Yang, Y., Yan, R., Zheng, L.-L., Fu, X., Xiao, C., & You, F.-M. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117069 · Cited by 32
Psychedelic control of neuroimmune interactions governing fear
Chung, E. N., Lee, J., Polonio, C. M., Choi, J., Akl, C. F., Kilian, M., Weiß, W. M., Gunner, G., Ye, M., Heo, T. H., et al. (2025) · Nature · doi:10.1038/s41586-025-08880-9 · Cited by 39
Reduced mitochondrial respiration in T cells of patients with major depressive disorder
Gamradt, S., Hasselmann, H., Taenzer, A., Brasanac, J., Stiglbauer, V., Sattler, A., Sajitz-Hermstein, M., Kierszniowska, S., Ramien, C., Nowacki, J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103312 · Cited by 33
Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation
Tian, P., Hou, Y., Wang, Z., Jiang, J., Qian, X., Qu, Z., Zhao, J., Wang, G., & Chen, W. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250162 · Cited by 29
Self-citation
Emerging roles of the unfolded protein response (UPR) in the nervous system: A link with adaptive behavior to environmental stress?
Díaz-Hung, M.-L., Martínez, G., & Hetz, C. A. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.01.004 · Cited by 28
Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models
Zhang, H., Geng, X., Li, Z., Li, Y., Xu, K., Wu, H., Xie, J., Sun, P., Wei, S., & Qiao, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00295 · Cited by 29
Self-citation
Cerebrospinal fluid and plasma metabolomics of acute endurance exercise
Li, K., Schön, M., Naviaux, J. C., Monk, J. M., Laiferová, N. A., Wang, L., Straka, I., Matejička, P., Valkovič, P., Ukropec, J., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200509r · Cited by 31
DEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism
Li, S., Ouyang, X., Sun, H., Jin, J., Chen, Y., Li, L., Wang, Q., He, Y., Wang, J., Chen, T., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00682-z · Cited by 28
Self-citation
Iron-deficiency and dopaminergic treatment effects on RLS-Like behaviors of an animal model with the brain iron deficiency pattern of the restless legs syndrome
Allen, R. P., Earley, C. J., Jones, B. C., & Unger, E. L. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.01.024 · Cited by 27
Dynamics and correlations in multiplex immune profiling reveal persistent immune inflammation in male drug users after withdrawal
Re, G.-F., Jia, J., Xu, Y., Zhang, Z., Xie, Z., Kong, D., Lu, D., Li, Y., Peng, Q., Yu, J., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108696 · Cited by 25
Self-citation
Characteristics of mental health implications and plasma metabolomics in patients recently recovered from COVID-19
Yang, L., Zhou, M. L., Li, L., Luo, P., Fan, W., Xu, J., Chen, Q., Pan, F., Lei, P., Zheng, C., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01426-3 · Cited by 27
Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder
Zolkipli‐Cunningham, Z., Naviaux, J. C., Nakayama, T., Hirsch, C. M., Monk, J. M., Li, K., Wang, L., Le, T. P., Meinardi, S., Blake, D. R., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248771 · Cited by 27
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
Yang, J., Zhang, S., Wu, Q., Chen, P., Dai, Y., Long, J., Wu, Y., & Lin, Y. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103176 · Cited by 25
Proteomic and metabolomic characterization of amygdala in chronic social defeat stress rats
Fan, L., Yang, L., Li, X., Teng, T., Xiang, Y., Liu, X., Jiang, Y., Zhu, Y., Zhou, X., & Xie, P. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113407 · Cited by 24

Authors: Fan, K.-Q., Li, Y.-Y., Wang, H.-L., Mao, X.-T., Guo, J.-X., Wang, F., Huang, L.-J., Li, Y.-N., Ma, X.-Y., Gao, Z.-J., Chen, W., Qian, D.-D., Xue, W.-J., Cao, Q., Zhang, L., Shen, L., Zhang, L., Tong, C., Zhong, J.-Y., Lu, W., Lu, L., Ren, K.-M., Zhong, G., Wang, Y., Tang, M., Feng, X.-H., Chai, R.-J., & Jin, J.
Affiliations: Zhejiang University (CN)
Sir Run Run Shaw Hospital (CN)
East China Normal University (CN)
Southeast University (CN)
ShanghaiTech University (CN)
Corresponding author: Jin, Jin
ORCID: Li, Yi-yuan
Wang, Fei
Chen, Wei
Cao, Qian
Zhang, Lei
Zhang, Long
Tong, Chao
Lu, Wei
Zhong, Guisheng
Wang, Yuan
Tang, Mingliang
Feng, Xin-Hua
Jin, Jin
Venue: Cell
Publisher: Elsevier BV
Published: 2019-10
Volume: 179
Issue: 4
Pages: 864-879.e19
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2019.10.001
OpenAlex: W2983084556
Cited by: 312
References: 62
Citations by year: 2026: 30 · 2025: 43 · 2024: 57 · 2023: 45 · 2022: 54 · 2021: 41 · 2020: 39 · 2019: 3
FWCI: 11.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 396 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Key R&D Program of China (2018YFA0800503, 2018YFD0500100)
Excellent Young Scientist Fund of NSFC (31822017)
Zhejiang Provincial Natural Science Foundation of China (LR19C080001)
Strategic Priority Research Program of the Chinese Academy of Science (XDA16010302)
National Natural Science Foundation of China (81572651, 81771675, 81622013, 81700913)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Keywords: stress-induced anxiety, CD4+ T cells, leukotriene B4, mitochondrial fission, purine metabolism, xanthine, adenosine A1 receptor, oligodendrocytes, amygdala, IRF1, depression, social behavior disorders, mood disorders, T cell dysfunction
MeSH terms: Amygdala, Animals, Anxiety, Behavior, Animal, Brain Diseases, Metabolic, Disease Models, Animal, Humans, Oligodendroglia, Stress, Psychological, CD4-Positive T-Lymphocytes, Xanthine, Mice, Single-Cell Analysis, Transcriptome, Mitochondrial Dynamics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks