Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

Stress and the brain: from adaptation to disease

de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621

The molecular neurobiology of depression

Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889

The role of the amygdala in fear and anxiety

Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357

Stress-induced immune dysfunction: implications for health

Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190

Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies

Naidoo, J., Page, D. B., Li, B. T., Connell, L. C., Schindler, K., Lacouture, M. E., Postow, M. A., & Wolchok, J. D. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv383 · Cited by 1,505

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Buck, M. D., O’Sullivan, D., Geltink, R. I. K., Curtis, J. D., Chang, C., Sanin, D. E., Qiu, J., Kretz, O., Braas, D., van der Windt, G. J. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.035 · Cited by 1,491

Mechanisms of stress in the brain

McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386

Stress, depression, the immune system, and cancer

Reiche, E. M. V., Nunes, S. O. V., & Morimoto, H. K. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01597-9 · Cited by 1,364

Mitochondrial Dynamics and Metabolic Regulation

Wai, T., & Langer, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.001 · Cited by 1,354

Metabolic regulation of mitochondrial dynamics

Mishra, P., & Chan, D. C. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201511036 · Cited by 1,143

DAMPs cross-talk interpretation of MDD mechanisms

Peng, Y., Chen, Z., Xu, Y., & Ren, B. (2025) · Science Advances · doi:10.1126/sciadv.adx3698 · Cited by 5

Targeting xanthine oxidoreductase reverses resistance to EGFR tyrosine kinase inhibitors in intrahepatic cholangiocarcinoma

He, J., Zhang, M., Shi, Y., Ji, Z., Lu, Y., Yu, W., Wang, F., Guan, Q., Yan, H., Chen, G., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.07.016 · Cited by 5

Chronic stress-induced depression-like behaviors through Th1-lymphocytes and microglia-mediated neuroinflammation in the mouse

Zhang, C., Liu, B., Li, X., Charlier, T. D., Kunikullaya, K. U., Steinbusch, H. W. M., & Song, C. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178710 · Cited by 4

Lactational retrorsine exposure changes maternal milk components and disturbs metabolism homeostasis of offspring rats

Dai, Y., Guo, Q., Xu, K., Gong, Z., Qiu, S., Sun, X., Liu, J., Wang, D., Yang, Z., Wang, H., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164929 · Cited by 5

Protective Effect of Hop Ethyl Acetate Extract on Corticosterone-Induced PC12 and Improvement of Depression-like Behavior in Mice

Ma, Z., Yu, Y., Gao, M., Chen, P., Hong, H., Yu, D., Liang, Z., Bai, Y., Ye, Q., Wang, Y., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00081 · Cited by 5

Perioperative stroke deteriorates white matter integrity by enhancing cytotoxic CD8 + T‐cell activation

Zhou, Y., Wang, X., Yin, W., Li, N., Guo, Y., Chen, C., Boltze, J., Liesz, A., Sparwasser, T. D., Wen, D., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14747 · Cited by 5

Glycolytic metabolism: Food for immune cells, fuel for depression?

Bekhbat, M. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100843 · Cited by 7

High urea promotes mitochondrial fission and functional impairments in astrocytes inducing anxiety-like behavior in chronic kidney disease mice

Zhao, X., Zhang, S., Wu, M., Zhang, B., Wan, G., Zhang, M., Li, J., Fei, Z., Zhu, G., Jiang, S., et al. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01612-y · Cited by 6

Clinical characteristics of subjective idiopathic tinnitus and preliminarily analyses for the effect of tinnitus multielement integration sound therapy

Yan, L., Wang, W., Wu, X., Fang, Q., & Yang, J. (2021) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-020-06501-x · Cited by 5

A road map for happiness: The psychological factors related cell types in various parts of human body from single cell RNA-seq data analysis

Wang, Z., Zhang, Y., Li, Q., Zou, Q., & Liu, Q. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105286 · Cited by 5

Inversely Regulated Inflammation-Related Processes Mediate Anxiety–Obesity Links in Zebrafish Larvae and Adults

Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., & Meerson, A. (2023) · Cells · doi:10.3390/cells12131794 · Cited by 5

Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility

Jiao, F., Hu, X., Yin, H., Yuan, F., Zhou, Z., Wu, W. H., Chen, S., Liu, Z., & Guo, F. (2023) · Communications Biology · doi:10.1038/s42003-023-04425-w · Cited by 4

Causal associations between immune cells and psychiatric disorders: a bidirectional mendelian randomization analysis

Li, Y., Sun, G., Cui, Y., Ji, S., & Kan, T. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03818-4 · Cited by 6

Lycopene regulates intestinal dysmotility and behavioral disorders by regulating enteric neurons and the cholinergic system

Wang, D., Jiao, S., Guo, Q., Zhou, M., Ren, W., Zhao, Y., Li, D., Yang, W., Dai, S., Pei, Y., et al. (2025) · Food & Function · doi:10.1039/d5fo00039d · Cited by 5

Contrasting Risk Profiles for Suicide Attempt and Suicide Using Danish Registers and Genetic Data

Ge, F., Wang, Y., Agerbo, E., Köhler‐Forsberg, O., Bulik, C. M., Petersen, L. V., & Vilhjálmsson, B. J. (2025) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.3444 · Cited by 4

Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

Chivite, Í., Monelli, E., Munar-Gelabert, M., Gómez-Valadés, A. G., Alvarado-Diaz, A., Pozo, M., Varela, L. C., Ramírez, S., Haddad-Tóvolli, R., Toledo, M., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.01.012 · Cited by 6

Brain mitochondria as key drivers of cognition and behaviour

Sandi, C., Lobo, M. K., Hollis, F., Hirabayashi, Y., de Juan‐Sanz, J., & Bolaños, J. P. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01061-1 · Cited by 5

Linkage of blood cell division cycle 42 with T helper cells, and their correlation with anxiety, depression, and cognitive impairment in stroke patients

Ma, H., Chang, Q., Jia, J., Zhang, Y., Wang, G., & Li, Y. (2023) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2023e12855 · Cited by 5

Diminished salivary cortisol response to mental stress predict all-cause mortality in general population

Yin, H., Gao, Z., Jia, M., Jiang, C. S., Wang, Y., Xue, D., Huang, J., Feng, H., Jin, N., Liu, J., et al. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.112031 · Cited by 4

The Immune-Mind Connection

Hang, S., & Huh, J. R. (2019) · Cell · doi:10.1016/j.cell.2019.10.012 · Cited by 4

Nanomedicine-mediated prevention of inflammatory monocytes infiltration ameliorate ovalbumin-induced allergic rhinitis in mouse model

Gu, X., Xiao, F., Lu, W., Xu, Y., Li, X., Yu, C., & Cui, X. (2020) · Autoimmunity · doi:10.1080/08916934.2020.1750009 · Cited by 4

Neonatal immune challenge induces female-specific changes in social behavior and somatostatin cell number, independent of microglial inflammatory signalingPreprint

Smith, C. J. W., Kingsbury, M. A., Dziabis, J. E., Hanamsagar, R. M., Malacon, K. E., Tran, J. N., Norris, H. A., Gulino, M., & Bilbo, S. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.30.068924 · Cited by 4

Ginsenoside Rg1 mitigates the prolonged isoflurane anesthesia-induced neuroimmune disruptions

Meng, X., Gong, S., Jia, X., Zheng, A., Jia, M., Fu, T., & Wu, K. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120327 · Cited by 4

A 3-hit metabolic signaling model for the core symptoms of autism spectrum disorder

Naviaux, R. K. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102096 · Cited by 3

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Gai, W., Wu, M., Wu, A., Jing, Z., Ye, Z., Jin, J., Zhang, Y., Zhao, M. Y., Liu, G., Wang, X., et al. (2026) · Advanced Science · doi:10.1002/advs.202505906 · Cited by 3

Depression-related chronic stress promotes ovarian cancer progression via metabolic dysfunction and IRF1-mediated immune suppression

Zheng, Y., Cheng, Q., Wu, S., Li, B., Zhang, L., & Cheng, W. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106471 · Cited by 3

Anti-inflammatory Drugs in the Treatment of Depression

Cavanagh, J. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_459 · Cited by 6

Polypeptide N-Acetylgalactosaminyl transferase 14 is a novel mediator in pancreatic β-cell function and growth

Shu, T., Zhang, Y., Sun, T., & Zhu, Y. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112269 · Cited by 3

The correlation between systemic immune-inflammation index and major depression in patients with depression

Bai, Y., Fang, Z., Dai, H., Zhang, Q., & You, P. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1580151 · Cited by 5

Increasing Aspartoacylase in the Central Amygdala: The Common Mechanism of Gastroprotective Effects of Monoamine-Based Antidepressants Against Stress

Yao, K., Cao, L., Ding, H., Gao, Y., Li, T., Wang, G., & Zhang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.823291 · Cited by 3

Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxietyPreprint

Ilanges, A., Xia, M., Lü, J., Chen, L., Shiao, R., Wang, C., Jin, Z., Feng, R., Qi, Q., Han, Y., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.16.508224 · Cited by 3

Gut know-how: IL-22 from T cells boosts stress resilience

Yang, R., & He, D. (2025) · Immunity · doi:10.1016/j.immuni.2024.11.022 · Cited by 2

Mitochondrial mass and low mitochondrial membrane potential percentage of CD8+ T cell subsets are implicated with therapeutic effect in depressive disorder

Huang, Y., Chen, Z., Yang, X., & Ren, B. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1550958 · Cited by 2

ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk

Fuqiang, S., Lu, G., Li, N., Dai, K., Ren, Z., Ma, R., Feng, Y., Zong, S., & Cheng, B. (2025) · Brain and Behavior · doi:10.1002/brb3.70818 · Cited by 3

High dietary phosphate intake induces anxiety in normal male mice

Yanev, P. G., Ujas, T. A., Kim, H., Fujikawa, T., Isozumi, N., Mori, E., Turchan-Cholewo, J. T., Stuart, C., Sturgill, R. G., Birnbaum, S. G., et al. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101112 · Cited by 2

Integrating cellular and soluble immune signatures of major depression with and without recent suicide attempts

Lengvenytė, A., Blaquière, M., Dubois, J., Bonnin, M., Bourret, J., Hamzeh‐Cognasse, H., Olié, É., Cognasse, F., Marchi, N., & Courtet, P. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03601-2 · Cited by 3

Blood cell biomarker trajectories and depression risk in a sex-stratified 10-year longitudinal cohort analysis

Wang, L., Lin, Y., Fu, T., Xie, Y., Yang, Y., Xiang, N., Su, S., Song, H., Lu, D., & Huang, J. (2025) · Nature Mental Health · doi:10.1038/s44220-025-00517-0 · Cited by 3

Anxiety symptom remission is associated with genetic variation of PTPRZ1 among patients with major depressive disorder treated with escitalopram

Su, Y., Bousman, C., Liu, Q., Lv, X., Li, J., Lin, J., Yu, X., Tian, L., & Si, T. (2021) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000437 · Cited by 3

Linkage of CDC42 And T-helper Cell Ratio With Anxiety, Depression And Quality of Life in ST-Elevation Myocardial Infarction

Wang, X., Feng, J., Luan, S., Zhou, Y., Zhang, S., Su, H., & Wang, Z. (2024) · Biomarkers in Medicine · doi:10.2217/bmm-2023-0712 · Cited by 2

Mitochondrial Protein TAMM41 Modulates Depressive-like Behaviors

Guo, L., Liu, Z., Jia, X., Wang, Q., Ji, J., Lv, N., Liu, Z., Zhou, Q., Sun, C., & Wang, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04233-1 · Cited by 2

Study of the immune disorder and metabolic dysregulation underlying mental abnormalities caused by exposure to narrow confined spaces

Zhang, X., Qiao, Y., Wang, M., Liang, X., Wei, L., Zhang, M., Bi, H., & Gao, T. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149101 · Cited by 2

Theaflavins ameliorate insulin resistance and anxiety-like behavior induced by propionate combined with high-fat diet

Bai, H., Yang, Q., Zuo, X., Yu, Q., Zhao, Q., Tian, Y., Xu, Y., Du, J., Zhao, X. J., & Feng, X. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250231 · Cited by 2

The immune regulatory mechanism of ketamine-induced psychiatric disorders: A new perspective on drug-induced psychiatric symptoms

Wang, P., Hu, J., Chen, C., Jiang, Z., Zhang, Y., Lin, K., Liao, L., & Wang, X. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111194 · Cited by 2

Ubiquitination in the T Cell Metabolism-Based Immunotherapy in Diseases

Fan, K.-Q., Li, Y., & Jin, J. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-97-7288-9_2 · Cited by 2

Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice

Escudero-Lara, A., Cabañero, D., & Maldonado, R. J. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.946975 · Cited by 2

Metabolic Modulation of the Immune-Neuro Axis: Insights into Psychoneuroimmunology

Leite, J. A., Vieira, R. D. S., da Silva, J. V. H., Gonçalves, L. E. D., & Câmara, N. O. S. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_6 · Cited by 1

Migration of CD8 + TSCM cells into intestine via PPBP–CXCR2 axis increases host stress susceptibility by inhibiting gut microbiome-derived homovanillic acid

Zhang, Y., Ju, M., Chen, S., Yang, W., Cai, Y., Yu, X., Chen, G., Shen, Z., Bai, Y., Ren, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65112-4 · Cited by 1

Betulinic acid-loaded carboxymethyl chitosan/sodium alginate microspheres ameliorate dextran sodium sulfate-induced colitis and anxiety-like behaviors in mice

Zhuang, B., Zhuang, J., Wang, Y., & Zeng, J. (2025) · Journal of Bioactive and Compatible Polymers · doi:10.1177/08839115251356266 · Cited by 1

Genetically determined causality between immune cells and anxiety disorders: A Mendelian randomization study

Liu, J., Liang, P., Wang, Y., Huang, H. M., Zhang, S., Li, G., & Wu, H. (2026) · Medicine · doi:10.1097/md.0000000000048110 · Cited by 1

Revealing the enhancing mechanism and material basis of bile-processed Coptidis Rhizoma in anti-anxiety from perspective of cross organ regulation

Chen, L., Yuan, S.-M., Wang, R., Chen, L., Zhang, B., Zhang, Z., Zhao, Y., Weisheng, F. E. N. G., Zheng, X., Li, K., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121969 · Cited by 1

Oral Chinese patent medicine alleviates atopic dermatitis by regulating ALOX15-derived oxylipins disorder

Ru, N., Guo, M.-Z., Xu, H., Wu, Y. J., Li, Z.-X., Wang, R., Ouyang, S., Cao, Y., Sun, W., Tan, H.-L., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158524 · Cited by 1

Food restriction in adolescence increases emotional disorder-like behaviors in adult rats

Xu, L., & Wang, J. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.101731 · Cited by 1

Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell

Liu, X., Xu, X., Liao, Y., Yao, W., Geng, X., Zeng, X., Sun, X., Tang, A., & Yang, P. (2024) · Immunology · doi:10.1111/imm.13767 · Cited by 1

Jiannao pills mitigate chronic restraint stress-induced anxiety in mice through the regulation of intestinal microflora

Pan, J. (2024) · American Journal of Translational Research · doi:10.62347/geew4432 · Cited by 1

Xathine unveiled: Bridging CD4+ T cell and stress-induced disorders through purine metabolism

Zhang, L., Dong, J.-X., Li, Y., & Jin, J. (2025) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2025.100113 · Cited by 1

PD-1 deficiency disrupts in vivo neural activity in mouse Hippocampus and cortex

Hu, M., Lv, C., Zhu, J., Zhang, H., Wang, X., You, L., Xie, J., Liu, W., Wei, X., Chen, K., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107002 · Cited by 2

Mitochondrial and Purinergic Dysregulation Promote Abnormal Behavior in Mice

Fang, P., & Hsiao, E. Y. (2020) · Trends in Immunology · doi:10.1016/j.it.2019.12.007 · Cited by 1

Enhancement of Bioavailability and Bioequivalence of Drug Delivery in Sensory Neural Hearing Loss

Bhatt, P. R., Shah, D. A., Sorathia, K. R., & Patel, T. B. (2023) · Bioequivalence & Bioavailability International Journal · doi:10.23880/beba-16000215 · Cited by 1

T cells with fragmented mitochondria frazzle the mind

Bordon, Y. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0246-0

Stressed-Out T Cells Fragment the Mind

Bordt, E. A., & Bilbo, S. D. (2020) · Trends in Immunology · doi:10.1016/j.it.2019.12.008

Insulin Secretory Granules Release Exosomal miR-503 to Promote Insulin Resistance and β-Cell SenescencePreprint

Han, X., Zhou, Y., Liu, K., Sun, Y., Zhang, Y., Wu, Y., Shi, Y., Yao, Z., Li, Y., Bai, R., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-58542/v1

Dynamics and Correlation of Multiplex Immune Profiling Reveal Persistent Immune Inflammation In Drug Users After WithdrawalPreprint

Re, G.-F., Jia, J., Xu, Y., Zhang, Z., Xie, Z., Kong, D., Lu, D., Li, Y., Yu, J., Wang, K., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3896351

Oxygen - Mitochondrial fuel as a missing link in depressive pathophysiologyPreprint

Mavioğlu, R. N., Mack, M., Behnke, A., & Kolassa, I. (2021) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/m5t3h

Characterizing behavior changes in mice receiving splenectomyPreprint

Guan, J., Zhang, P.-S., Zhang, W.-C., Zhang, B.-Q., Wu, H.-T., Lan, Y., & Yuan, T. (2022) · Research Square · doi:10.21203/rs.3.rs-1401302/v1

Inhibition of c-Jun in AgRP neurons mediates chronic stress-induced anxiety-like behaviors and colitis susceptibilityPreprint

Jiao, F., Hu, X., Yin, H., Yuan, F., Zhou, Z., Wu, W., Chen, S., Liu, Z., & Guo, F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.02.490271

Metabolic and Behavioral Features of Acute Hyperpurinergia and the Connection to Autism Spectrum DisorderPreprint

Zolkipli‐Cunningham, Z., Naviaux, J. C., Nakayama, T., Hirsch, C. M., Monk, J. M., Li, K., Wang, L., Le, T. P., Meinardi, S., Blake, D. R., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-63567/v1

Dynamics and Correlation of Multiplex Immune Profiling Reveal Persistent Immune Inflammation in Drug Users After WithdrawalPreprint

Re, G.-F., Jia, J., Xu, Y., Zhang, Z., Xie, Z., Kong, D., Lu, D., Li, Y., Yu, J., Wang, K., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3910131

Relationship between anxiety and abnormal behavior in children with asthma in Lanzhou, ChinaPreprint

Shi, D., Li, G., Li, Y., Zhang, R., Na, F., & Gao, W. (2020) · doi:10.21203/rs.3.rs-70894/v1

Sex Differences in Behaviors and Related Lymphocyte and Inflammatory Mechanisms in a Depression Model of Rats Induced by Chronic StressPreprint

Zhang, C., Liu, B., Pawluski, J. L., Steinbusch, H. W. M., Kunikullaya, K. U., & Song, C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4145422

Effects of Hops Ethyl Acetate Extract on Lipopolysaccharide-induced Depression-like Behavior and the Underlying MechanismPreprint

Ma, Z., Yu, Y., Gao, M., Chen, P., Hong, H., Yu, D., Liang, Z., Ye, Q., Wang, Y., Huang, G., et al. (2022) · doi:10.22541/au.167061219.95188925/v1

Immunotherapy

Zhang, C. (2023) · Research Publications (Maastricht University) · doi:10.26481/dis.20230705cz

Clinical correlation and prognostic value of xanthine and inflammatory factors in postpartum depression

Zhang, L., Zhou, B., Wang, P., & Shu, L. (2024) · Ginekologia Polska · doi:10.5603/gpl.96837

The miR-203/ZBTB20/MAFA axis orchestrates pancreatic β-cell maturation and identity during weaning and diabetes

Li, Y., Yang, Y., Sun, Y., He, L., Zhao, L., Sun, H., Chang, X., Liang, R., Wang, S., Han, X., et al. (2024) · doi:10.2337/figshare.26364349

The miR-203/ZBTB20/MAFA axis orchestrates pancreatic β-cell maturation and identity during weaning and diabetes

Li, Y., Yang, Y., Sun, Y., He, L., Zhao, L., Sun, H., Chang, X., Liang, R., Wang, S., Han, X., et al. (2024) · doi:10.2337/figshare.26364349.v1

Dysfunction in neuro-mesenchymal units impairs the development of bone marrow B cells in mice with anxiety

Li, H., Yi, J., Xu, X., Ma, Y., Xiang, J., Shu, Y. L., Ye, W., Wang, T., Jiang, H., Zhang, X., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.12.008 · Cited by 1

The Role of the Immune System in the Onset and Regulation of Anxiety Disorders

Dai, B., Xiao, C., & Wei, J. (2024) · Integrated science · doi:10.1007/978-3-031-72079-6_9

Psychedelics reduce fear by targeting immune cells that modulate brain cells

Chen, Y., & Colonna, M. (2025) · Nature · doi:10.1038/d41586-025-01133-9

Increased peripheral CD4+ lymphocytes promote ketamine-induced abnormal behaviors in mice

Hu, J., Wang, P., Lin, Y., Jiang, Z., Zhang, Y., Shi, K., Wen, D., Ma, C., Liao, L., & Wang, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115337 · Cited by 1

The amino acid metabolism pathway of peripheral T lymphocytes and ketamine-induced schizophrenia-like phenotype

Wang, P., Jiang, L., Hu, J., Jiang, Z., Zhang, Y., Chen, C., Lin, Y., Su, M., Wang, X., & Liao, L. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.240038

Inactivation of LHAVglut2 neurons relieves stress-induced intestine inflammation by sympathetic nerve- intestinal epithelial cell Cxcl1 communication.

Liu, K., Tan, X.-Y., Fu, L.-G., & Mo, F.-F. (2025) · Cytokine · doi:10.1016/j.cyto.2025.157024

Bone marrow immune remodeling in depression: TNF/NF-κB mediated leukocyte redistribution and construction of an interpretable predictive model

Zhu, W., Shi, R., Li, X., Cong, J., An, Y., He, M., Zhang, G., Wang, Y., Li, S., Shi, W., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115487

Additional file 1 of Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice

Li, S., Liao, Y., Dong, Y., Li, X., Li, J., Cheng, Y., Cheng, J., & Yuan, Z. (2021) · Figshare · doi:10.6084/m9.figshare.13525292

Additional file 5 of Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory

Jeon, Y., Lim, Y., Yeom, J., & Kim, E.-K. (2021) · Figshare · doi:10.6084/m9.figshare.16755926

Additional file 1 of Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

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Additional file 1 of Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory

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Additional file 4 of Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory

Jeon, Y., Lim, Y., Yeom, J., & Kim, E.-K. (2021) · Figshare · doi:10.6084/m9.figshare.16755923

Additional file 2 of Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

Dong, Y., Li, S., Lu, Y., Li, X., Liao, Y., Peng, Z., Li, Y., Hou, L., Yuan, Z., & Cheng, J. (2020) · Figshare · doi:10.6084/m9.figshare.12623192

Additional file 2 of Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

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