The DOI matches its Crossref record; 126 of the 128 references it cites were found in a registry or an index.
Molecular Choreography of Acute Exercise
Open accessPublished version of a preprint
Abstract
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these pathways, the system-wide molecular response to an acute bout of exercise has not been fully characterized. We performed longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptome from 36 well-characterized volunteers, before and after a controlled bout of symptom-limited exercise. Time-series analysis revealed thousands of molecular changes and an orchestrated choreography of biological processes involving energy metabolism, oxidative stress, inflammation, tissue repair, and growth factor response, as well as regulatory pathways. Most of these processes were dampened and some were reversed in insulin-resistant participants. Finally, we discovered biological pathways involved in cardiopulmonary exercise response and developed prediction models revealing potential resting blood-based biomarkers of peak oxygen consumption.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the increases of acute inflammatory markers seen during exercise (e.g., IL-6, TNF-a, IL1-RA, and IGF-1) could be problematic to an already increased inflammatory pattern we measured in astronauts (Fig. 5B), even though these markers are reduced by regular exercise in low-grade systemic inflammation patients (Contrepois et al., 2020; Khazaei, 2012).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Contrepois et al., 2020
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A study on acute exercise in individuals with a spectrum of insulin resistance showed that acute physical activity triggers molecular responses on the metabolic and energy-producing pathways, increasing glycolysis, TCA cycle, and fatty acid oxidation (Contrepois et al., 2020).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Contrepois et al., 2020
In the citing paper
“A seminal work by Contrepois et al. [643] found that a simple amount of acute exercise (and up to 1 -h recovery after the training in individulas aged 40–75 years) induced substantial changes in more than half (n = 9,816 analytes) of the 17,662 analytes evaluated through a multi-omics approach.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [643]
In the citing paper
“A seminal work by Contrepois et al. [643] found that a simple amount of acute exercise (and up to 1 -h recovery after the training in individulas aged 40–75 years) induced substantial changes in more than half (n = 9,816 analytes) of the 17,662 analytes evaluated through a multi-omics approach.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [643]
In the citing paper
“Acute exercise creates a unique exerkine milieu that lasts several hours after exercise cessation, which provides a temporal window for immune function stimulation31.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
STRING v10: protein–protein interaction networks, integrated over the tree of life
Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K., Heller, D., Huerta-Cepas, J., Simonovic, M., Roth, A., Santos, A., Tsafou, K. P., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1003 · Cited by 10,436
Prediction of coronary heart disease using risk factor categories
Wilson, P. W. F., D’Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., & Kannel, W. B. (1998) · Circulation · doi:10.1161/01.cir.97.18.1837 · Cited by 9,581
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The Perseus computational platform for comprehensive analysis of (prote)omics data
Tyanova, S., Temu, T., Sinitcyn, P., Carlson, A., Hein, M. Y., Geiger, T., Mann, M., & Cox, J. (2016) · Nature Methods · doi:10.1038/nmeth.3901 · Cited by 8,803
Lang, R. M., Badano, L. P., Mor‐Avi, V., Afilalo, J., Armstrong, A. D. C., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jev014 · Cited by 8,630
Health benefits of physical activity: the evidence
Warburton, D. E. R. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051351 · Cited by 8,007
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
Prediabetes: a high-risk state for diabetes development
Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J., & Kivimäki, M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60283-9 · Cited by 2,958
Flagged first, then by citations
2 of the 128 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 499
Nieman, D. C., Sakaguchi, C. A., Pelleigrini, M., Thompson, M. J., Sumner, S., & Zhang, Q. (2023) · Scientific Reports · doi:10.1038/s41598-023-44068-9 · Cited by 13
Malsagova, K. A., Kopylov, A. T., Stepanov, A. A., Kulikova, L. I., Izotov, A., Yurku, K. A., Balakin, E. I., Pustovoyt, V. I., & Kaysheva, A. L. (2024) · Sports · doi:10.3390/sports12030072 · Cited by 15
Katz, D. H., Lindholm, M. E., & Ashley, E. A. (2024) · Physiology · doi:10.1152/physiol.00024.2024 · Cited by 12
Self-citationSingle-cell sequencing of immune cells after marathon and symptom-limited cardiopulmonary exercise
Yu, Y., Zhang, X., Chen, Y., Li, Y., Bian, S., Yang, Y., Song, H., Zhang, C., Dong, Z., Li, G., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106532 · Cited by 11
Cao, W., Liu, Y., Wei, H., Dong, Y., Sun, H., Zhang, X., & Qiu, J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1451429 · Cited by 10
Baraniuk, J. N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031282 · Cited by 10
Chang, H., Pan, K., Zhang, X., Lu, Z., Wang, Y., Liu, D., Lin, Y., Wu, Y., Lin, Y., Huang, Q., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138377 · Cited by 10
Effects of Compound Probiotics on Cecal Microbiome and Metabolome of Shaoxing Duck
Sun, H., Du, X., Zeng, T., Ruan, S., Li, G., Tao, Z., Xu, W., & Lu, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.813598 · Cited by 10
Proteomics Identifies Circulating TIMP-1 as a Prognostic Biomarker for Diffuse Large B-Cell Lymphoma
Lou, N., Wang, G., Wang, Y., Xu, M., Zhou, Y. L., Tan, Q., Zhong, Q., Zhang, L., Zhang, X., Liu, S., et al. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100625 · Cited by 10
Jin, A., Kan, Z., Tan, Q., Shao, J., Han, Q., Chang, Y., An, N., & Yi, M. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2254741 · Cited by 10
Wang, C., Gong, Y., Deng, F., Ding, E., Tang, J., Codling, G., Challis, J. K., Green, D., Wang, J., Chen, Q.-L., et al. (2021) · Global Change Biology · doi:10.1111/gcb.15638 · Cited by 9
Why is exercise good for you? Scientists are finding answers in our cells
Conroy, G. (2024) · Nature · doi:10.1038/d41586-024-01200-7 · Cited by 9
Rotondo, R., Padua, E., Annino, G., Guescini, M., Zeppa, S. D., Goffredo, M., Stocchi, V., Stocchi, F., & Pandis, M. F. D. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1412311 · Cited by 10
Association of blood cadmium and physical activity with mortality: A prospective cohort study
Chen, Y., Zhen, C., Zeng, L., Feng, H., Wang, J., Ai, Q. Y. H., Ai, S., Zhang, J., Liang, Y. Y., Xue, H., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117541 · Cited by 9
Acute exercise rewires the proteomic landscape of human immune cells
Walzik, D., Joisten, N., Metcalfe, A. J., Proschinger, S., Schenk, A., Wenzel, C., Henneberg, A., Schneider, M., Calderazzo, S., Groll, A., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-68101-9 · Cited by 11
Prediction of gestational age using urinary metabolites in term and preterm pregnancies
Contrepois, K., Chen, S., Ghaemi, M. S., Wong, R. J., Jehan, F., Sazawal, S., Baqui, A. H., Stringer, J. S. A., Rahman, A. M., Nisar, M. I., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11866-6 · Cited by 9
Self-citationStraat, M. E., Martínez‐Téllez, B., Janssen, L. G. M., van Veen, S., van Eenige, R., Kharagjitsing, A. V., van den Berg, S. A. A., de Rijke, Y. B., Haks, M. C., Rensen, P. C. N., et al. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103259 · Cited by 10
Impacts of glutamate, an exercise-responsive metabolite on insulin signaling
Xing, X., Sun, Q., Wang, R., Wang, R., & Wang, R. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122471 · Cited by 10
White, D., John, C. S., Kucera, A., Truver, B., Lepping, R. J., Kueck, P. J., Lee, P., Martin, L. E., Billinger, S. A., Burns, J. M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92177-0 · Cited by 10
Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?
Wang, H., Yang, Z., Zhang, X., Xie, J., Xie, Y., Gokulnath, P., Vulugundam, G., & Xiao, J. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10297-y · Cited by 9
Shah, R. V., Miller, P., Colangelo, L. A., Chernofsky, A., Houstis, N. E., Malhotra, R. K., Velagaleti, R. S., Jacobs, D. R., Gabriel, K. P., Reis, J. P., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026670 · Cited by 9
Landman, T. R. J., Uthman, L., Hofmans, I. A. H., Schoon, Y., de Leeuw, F., & Thijssen, D. H. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1026711 · Cited by 9
DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation
Zheng, X., Zhang, W., Hu, Y., Zhao, Z., Wu, J., Zhang, X., Hao, F., Han, J., Xu, J. B., Hao, W., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102634 · Cited by 10
Inflammation and Heart Failure: Friend or Foe?
Hajjar, R. J., & Leopold, J. A. (2021) · Circulation · doi:10.1161/circulationaha.121.056628 · Cited by 9
Daniels, M., Margolis, L. M., Rood, J. C., Lieberman, H. R., Pasiakos, S. M., & Karl, J. P. (2024) · Physiological Genomics · doi:10.1152/physiolgenomics.00008.2024 · Cited by 9
Møller, P. M., Kjøbsted, R., Petersen, M. H., de Almeida, M. E., Pedersen, A. J. T., Wojtaszewski, J. F. P., & Højlund, K. (2025) · Diabetologia · doi:10.1007/s00125-025-06454-y · Cited by 10
Ruple, B. A., Carlini, N. A., Kofoed, J. S., Rostamkhani, H., Hanson, B. E., Wilcox, I., Craig, J. C., Osburn, S. C., Drummond, M. J., Broxterman, R. M., et al. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00169.2025 · Cited by 8
Stec, M. J., Graham, Z., Su, Q., Adler, C., Ni, M., Rouzic, V. L., Golann, D. R., Ferrara, P. J., Halász, G., Sleeman, M. W., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113301 · Cited by 10
Evaluating untargeted metabolomics pipelines for sports nutrition research: a review
Liu, Y., Liu, X., Hu, Y., Gao, F., Yu, W., & Cheng, F. (2025) · Analytical Methods · doi:10.1039/d5ay01484k · Cited by 9
Roseburia inulinivorans increases muscle strength
Martínez‐Téllez, B., Schönke, M., Kovynev, A., García-Domínguez, E., Ortiz-Alvarez, L., Verhoeven, A., Gaćeša, R., Vila, A. V., Ducarmon, Q. R., Jiménez‐Pavón, D., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-336980 · Cited by 11
Metabolite and nutrient regulation of macrophages in obesity and metabolic disease
Sprenkle, N. T., & Mills, E. L. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01292-4 · Cited by 11
Holistic Rehabilitation: Biological Embedding of Social Adversity and Its Health Implications
Snyder‐Mackler, N., & Snyder‐Mackler, L. (2021) · Physical Therapy · doi:10.1093/ptj/pzab245 · Cited by 9
Global scientific trends in research of epigenetic response to exercise: A bibliometric analysis
Wu, H., Hu, Y., Jiang, C. H., & Chen, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25644 · Cited by 8
The HuMet Repository: Watching human metabolism at work
Weinisch, P., Raffler, J., Römisch‐Margl, W., Arnold, M., Mohney, R. P., Rist, M. J., Prehn, C. P., Skurk, T., Hauner, H., Daniel, H., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114416 · Cited by 8
Impacts of circulating microRNAs in exercise-induced vascular remodeling
Guilder, G. P. V., Preston, C. C., Munce, T. A., & Faustino, R. S. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00894.2020 · Cited by 8
Molecular transducers and the cardiometabolic benefits of exercise
Long, J. Z. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00609-8 · Cited by 8
Xiong, Q., Sun, L., Luo, Y., Yun, H., Shen, X., Yin, H., Chen, X., & Lin, X. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac006 · Cited by 8
Belhaj, M. R., Lawler, N. G., Hawley, J. A., Broadhurst, D., Hoffman, N. J., & Reinke, S. N. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.957549 · Cited by 7
Rao, Z., Geng, X. H., Huang, P., Wei, Q., Liu, S., Qu, C., & Zhao, J. (2024) · Experimental Physiology · doi:10.1113/ep092319 · Cited by 6
Prehabilitation and Inflammation
Kammerer, T., Mahú, I., & Schier, R. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000545181 · Cited by 7
The role of artificial intelligence in precision exercise nutrition: a shift from data to diets
Nasb, M., Zhang, Y., & Chen, N. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250623 · Cited by 7
Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α
Khetarpal, S. A., Li, H., Vitale, T., Rhee, J., Challa, S. P., Castro, C., Pabel, S., Sun, Y., Liu, J., Laznik-Bogoslavski, D., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00712-3 · Cited by 8
Mechanisms underlying phenotypic plasticity in response to environmental change
Seebacher, F., & Little, A. G. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.70100 · Cited by 9
Nemkov, T. G., Stauffer, É., Cendali, F. I., Stephenson, D., Nader, É., Robert, M., Skinner, S., Dzieciątkowska, M., Hansen, K. C., Robach, P., et al. (2026) · Blood Red Cells & Iron · doi:10.1016/j.brci.2026.100055 · Cited by 7
Zhou, Z., Liu, T., Kong, J., Zhao, Z., & Zhu, J. (2024) · Journal of Oceanology and Limnology · doi:10.1007/s00343-023-3137-y · Cited by 7
Kumar, J., Contrepois, K., Snyder, M. P., Grimm, P. C., Moudgil, A., Smith, J. M., Bobrowski, A. E., Verghese, P. S., Hooper, D. K., Ingulli, E., et al. (2021) · Transplantation Direct · doi:10.1097/txd.0000000000001244 · Cited by 7
Self-citationEffects of exercise on whole‐blood transcriptome profile in children with overweight/obesity
Altmäe, S., Plaza‐Florido, A., Esteban, F. J., Anguita‐Ruiz, A., Krjutškov, K., Katayama, S., Einarsdóttir, E., Kere, J., Radom‐Aizik, S., & Ortega, F. B. (2023) · American Journal of Human Biology · doi:10.1002/ajhb.23983 · Cited by 7
Sprenger, H., Mittenbühler, M. J., Sun, Y., Vranken, J. G. V., Schindler, S., Jayaraj, A., Khetarpal, S. A., Vargas‐Castillo, A., Puszynska, A. M., Spinelli, J. B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.10.588849 · Cited by 7
Kleuskens, M. T. A., Haasnoot, M. L., Garssen, J., Bredenoord, A. J., van Esch, B. C. A. M., & Redegeld, F. A. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.10.027 · Cited by 6
Zatloukal, J., Zylla, S., Markus, M. R. P., Ewert, R., Gläser, S., Völzke, H., Albrecht, D., Friedrich, N., Nauck, M. A., Peterson, L. R., et al. (2024) · Advanced Biology · doi:10.1002/adbi.202300633 · Cited by 6
Griffin, T. M., Komaravolu, R. K., Lopes, E. B. P., Mehta-D’souza, P., Conner, T., Kovats, T., Kovats, S., Allen, M. T., Harris, P., Humphrey, M. B., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-86726-0 · Cited by 6
Kalenta, H., Kilroe, S. P., Romsdahl, T. B., Marchant, E. D., Maroto, R., Linares, J. J., Russell, W. K., & Rasmussen, B. B. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00987.2024 · Cited by 6
Metabolome trajectories in male and female athletes
Schoeny, H., Stelzer, B., Hofbauer, T., Reisenbauer, F., Abiead, Y. E., Scharhag, J., & Koellensperger, G. (2025) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2025.101065 · Cited by 7
Intra- and inter-individual variation of the human lipidome
Anh, N. H., Beyene, H. B., Mocciaro, G., Hahnefeld, L., Lamichhane, S., Fabritius, M., Avela, H. F., Wang, Y., Dickens, A. M., Gurke, R., et al. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118368 · Cited by 7
Multi-omics signature of healthy versus unhealthy lifestyles reveals associations with diseases
Fu, G., Rushing, B. R., Graves, L. M., Nieman, D. C., Pellegrini, M. A., Soldano, M., Thompson, M. J., Sakaguchi, C. A., Pathmasiri, W., & Sumner, S. (2025) · Human Genomics · doi:10.1186/s40246-025-00817-7 · Cited by 7
Olvera‐Rojas, M., Plaza‐Florido, A., Solis‐Urra, P., Rodríguez‐Ayllón, M., Toval, Á., Esteban‐Cornejo, I., & Ortega, F. B. (2023) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14387 · Cited by 7
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth, B. J., Leiwe, M., Minogue, E., Cunha, P. P., Engman, V., Brombach, C., Asvestis, C., Sah‐Teli, S. K., Marklund, E., Koivunen, P., et al. (2023) · eLife · doi:10.7554/elife.92707 · Cited by 10
Bidzan-Wiącek, M., Błażek, M., & Antosiewicz, J. (2024) · Acta Psychologica · doi:10.1016/j.actpsy.2024.104145 · Cited by 9
Acute exercise promotes WAT browning by remodeling mRNA m6A methylation.
Chen, W., Liu, Y.-H., Liu, J., Chen, Y.-S., & Wang, X.-X. (2024) · Life Science · doi:10.1016/j.lfs.2024.123269 · Cited by 6
Qi, Z., Le, S., Cheng, R., Du, X., Zhao, C., Zhang, Z., Zhang, X., Feng, L., Schumann, M., Mao, L., et al. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003388 · Cited by 6
Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men
Vaara, J. P., Kyröläinen, H., Vasankari, T. J., Kainulainen, H., Raitanen, J. A., & Kujala, U. M. (2022) · Metabolites · doi:10.3390/metabo12080700 · Cited by 6
Qian, P., Wang, S., Zhang, T., & Wu, J. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02215-5 · Cited by 5
Exerkines: Benign adaptation for exercise and benefits for non-alcoholic fatty liver disease
Chen, Y., Zhang, Y., Jin, X., Hong, S., & Tian, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150305 · Cited by 5
The Metabolic Signature of Cardiorespiratory Fitness
Bork, J., Markus, M. R. P., Ewert, R., Nauck, M., Templin, C., Völzke, H., Kastenmüller, G., Artati, A., Adamski, J., Dörr, M., et al. (2025) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.70034 · Cited by 7
Janssens, G. E., Trętowicz, M. M., Grevendonk, L., Kotte, M., Scantlebery, A. M. L., Schomakers, B. V., van Weeghel, M., Hermans, J., Vervaart, M. A. T., Wever, E. J. M., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01150-x · Cited by 6
Tang, Z., Yang, J., Su, B., Xu, X., Luo, X., Wang, H., Zhang, K., Huan, T., Sinues, P., Fang, M., et al. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c00543 · Cited by 5
Germain, A., Glass, K. A., Eckert, M. A., Giloteaux, L., & Hanson, M. R. (2025) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2025.101467 · Cited by 5
A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques
Li, G., Zhu, X., Xiao, F., Zhao, X., Lv, L., Yin, F.-Q., Chang, L., Ge, M., Wang, Q., Zhao, J., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02912-y · Cited by 5
Obraitis, D., & Li, D. (2024) · Current Opinion in Virology · doi:10.1016/j.coviro.2024.101437 · Cited by 5
Xiao, Q., Qin, H.-Y., Chen, J., Fang, C., Wang, Q., Li, Q.-J., Zhu, S.-Y., & Xiong, L. (2025) · Biogerontology · doi:10.1007/s10522-025-10225-y · Cited by 6
Yang, Q., Zhang, L., Sun, D., Jie, S., Tao, X., Qing, M., & Luo, F. (2025) · Nutrition Journal · doi:10.1186/s12937-025-01103-x · Cited by 5
Zhao, H., Yang, Y., Hao, Y., Zhang, W., Cui, L., Wang, J., Chen, Y., Zuo, T., Yu, H., Zhang, Y., et al. (2025) · Clinical & Experimental Allergy · doi:10.1111/cea.70059 · Cited by 5
Wang, Z., Yao, C., Huang, L., Liang, J., Zhang, X., Shi, J., Wei, W., Zhou, J., Zhang, Y., & Wu, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1115494 · Cited by 5
Moneghetti, K. J., Carrick‐Ranson, G., & Howden, E. J. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2023.100669 · Cited by 5
Self-citationOsuna‐Prieto, F. J., Jurado‐Fasoli, L., Plaza‐Florido, A., Yang, W., Köhler, I., Di, X., Rubio‐López, J., Sánchez‐Delgado, G., Rensen, P. C. N., Ruiz, J. R., et al. (2023) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14405 · Cited by 5
Ruegsegger, G. N., Ekholm, E. R., Monroe, C. E., Rappaport, C. I., Huppert, R. D., Anton, C. R., & Ferguson, M. J. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114389 · Cited by 7
Lee-Ødegård, S., Hjorth, M., Olsén, T., Moen, G.-H., Daubney, E. R., Evans, D. M., Hevener, A. L., Lusis, A. J., Zhou, M., Seldin, M. M., et al. (2024) · eLife · doi:10.7554/elife.96535 · Cited by 13
Jonckheere–Terpstra–Kendall-based non-parametric analysis of temporal differential gene expression
Iuchi, H., & Hamada, M. (2021) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqab021 · Cited by 5
Personalizing treatments for patients based on cardiovascular phenotyping
Leopold, J. A. (2022) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2022.2028548 · Cited by 4
Hu, Y., Zheng, Y., Wang, Y., Yu, S., Li, M., Zhou, J., Wu, G., Xing, W., Dong, L., Liu, Y., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121284 · Cited by 5
Sexual dimorphism in the serum metabolome following acute exhaustive exercise
Wu, B., Tang, C., Ren, Z., Qian, J., Deng, Y., Fan, Z., Zhang, Y., & Shi, L. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00780-x · Cited by 6
Wang, T., Li, M., Ren, W., Meng, J., Yao, X., Chu, H., Yao, R., Zhai, M., & Zeng, Y. (2025) · Biology · doi:10.3390/biology14111609 · Cited by 4
Cheng, Y., Chen, R., Chen, F., Wu, C., Zhou, Y., Xia, T., Qian, D., & Xu, J. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2026.122657 · Cited by 4
Alizadeh, A., Graf, J. F., Misner, M. J., Burns, A., Ginty, F., O’Donovan, K. J., Wickiser, J. K., Barringer, N., Freisinger, G. M., Hermansen, N., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09663-2 · Cited by 4
Lipid remodeling during early development of rainbow trout (Oncorhynchus mykiss)
Wang, C., Gong, Y., Deng, F., Liu, X., Ding, E., Zhang, S., Ma, X., Raine, J. C., Jones, P. D., Tang, S., et al. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102005 · Cited by 4
Li, T., Shao, J., An, N., Chang, Y., Xia, Y., Han, Q., & Zhu, F. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.70030 · Cited by 4
Ttc39c is a potential target for the treatment of lung cancer
Rong, H., Peng, J., Ma, K., Zhu, J., & He, J. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02173-x · Cited by 4
Exercise blood-drop metabolic profiling links metabolism with perceived exertion
Opialla, T., Gollasch, B., Kuich, P. H. J. L., Klug, L., Rahn, G., Busjahn, A., Spuler, S., Boschmann, M., Kirwan, J., Luft, F. C., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1042231 · Cited by 4
TET3 Contributes to Exercise‐Induced Functional Axon Regeneration and Visual Restoration
Fang, S., Ji, Y., Shen, Y., Yang, S., Zhang, H., Xin, W., Shi, W., & Chen, W. (2024) · Advanced Biology · doi:10.1002/adbi.202400145 · Cited by 5
Hahnefeld, L., Hackel, J., Trautmann, S., Angioni, C., Schreiber, Y., Gurke, R., Thomas, D., Wicker, S., Geißlinger, G., & Tegeder, I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00630.2024 · Cited by 4
Sagini, K., Selvarajah, M., Romero, S., Bassols‐Citores, E., Martín-Gracia, B., Ramírez‐Garrastacho, M., Rise, F., Endzeliņš, E., Sadovska, L., Skorinkina, D., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202500678r · Cited by 4
Fukushima, T., Takata, M., Kato, A., Uchida, T., Nikawa, T., & Sakakibara, I. (2021) · Applied Sciences · doi:10.3390/app112110436 · Cited by 4
Tso, J., Liu, C., Turner, C. G., Uppal, K., Prabakaran, G., Ejaz, K., Baggish, A. L., Jones, D. P., Quyyumi, A. A., & Kim, J. H. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002960 · Cited by 5
Nie, M., Liu, Q., Jia, R., Li, Z., Li, X., & Meng, X. (2023) · Scientific Reports · doi:10.1038/s41598-023-38064-2 · Cited by 5
Considerations for exerkine research focusing on the response to exercise training
Darragh, I. A. J., & Egan, B. (2023) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.11.002 · Cited by 4
Nemkov, T. G., Cendali, F. I., Dzieciątkowska, M., Stephenson, D., Hansen, K. C., Jankowski, C. M., D’Alessandro, A., & Marker, R. J. (2024) · Pathophysiology · doi:10.3390/pathophysiology31010013 · Cited by 4
Neutralizing a Springboard for Inflammation: Physical Activity to Control the Immune Network
Kallen, V., Scherder, R. J., Cramer, M. J., Stam, J. V., Johnson, B. D., & Scherder, E. (2021) · Healthcare · doi:10.3390/healthcare9091196 · Cited by 4
Chen, S., Wang, G., Shen, X., Hornburg, D., Rego, S. M., Hoffman, R., Nevins, S. A., Cheng, X., & Snyder, M. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.28.446235 · Cited by 4
Self-citationAdvancing pediatric exercise research: A focus on immunomics and cutting-edge technologies
Plaza‐Florido, A., Lucía, A., & Radom‐Aizik, S. (2023) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.09.011 · Cited by 4
Metadata
- Authors
- Contrepois, K., Wu, S., Moneghetti, K. J., Hornburg, D., Ahadi, S., Tsai, M.-S., Metwally, A. A., Wei, E., Lee-McMullen, B., Quijada, J. V., Chen, S., Christle, J. W., Ellenberger, M., Balliu, B., Taylor, S., Durrant, M. G., Knowles, D. A., Choudhry, H., Ashland, M., Bahmani, A., Enslen, B., Amsallem, M., Kobayashi, Y., Avina, M., Perelman, D., Schüssler-Fiorenza Rose, S. M., Zhou, W., Ashley, E. A., Montgomery, S. B., Chaib, H., Haddad, F., & Snyder, M. P.
- Affiliations
- Stanford Medicine (US)
- The University of Melbourne (AU)
- King Abdulaziz University (SA)
- Corresponding author
- Snyder, Michael P.
- ORCID
- Contrepois, Kévin
- Wu, Si
- Moneghetti, Kegan J.
- Hornburg, Daniel
- Ahadi, Sara
- Metwally, Ahmed A.
- Chen, Songjie
- Christle, Jeffrey W.
- Ellenberger, Mathew
- Balliu, Brunilda
- Taylor, Shalina
- Durrant, Matthew G.
- Knowles, David A.
- Choudhry, Hani
- Ashland, Melanie
- Bahmani, Amir
- Amsallem, Myriam
- Kobayashi, Yukari
- Perelman, Dalia
- Zhou, Wenyu
- Ashley, Euan A.
- Montgomery, Stephen B.
- Snyder, Michael P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 181
- Issue
- 5
- Pages
- 1112-1130.e16
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7299174
- OpenAlex
- W3029490310
- Cited by
- 502
- References
- 128
- Citations by year
- 2026: 90 · 2025: 90 · 2024: 78 · 2023: 80 · 2022: 79 · 2021: 71 · 2020: 13
- FWCI
- 33.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Stanford Diabetes Research Center
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- acute exercise, multi-omics profiling, plasma metabolome, lipidome, peripheral blood mononuclear cells, immunome, proteome, transcriptome, energy metabolism, oxidative stress, inflammation, tissue repair, growth factor responsiveness, insulin resistance, peak oxygen uptake, blood-based biomarkers
- MeSH terms
- Aged, Energy Metabolism, Female, Humans, Insulin, Insulin Resistance, Leukocytes, Mononuclear, Longitudinal Studies, Male, Middle Aged, Oxygen, Oxygen Consumption, Biomarkers, Exercise, Proteome, Metabolome, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
