Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

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Systemic Oxidative Stress and Oxidized Albumin Mediate the Pathogenic Kidney-to-Gut Crosstalk by Disrupting Intestinal Barrier Integrity

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FKBP51 mediates mitochondrial function via NF-κB pathway during sleep fragmentation-induced cognitive impairment

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Sleep Deprivation, Endothelial Dysfunction and Hypertension: A Narrative Review

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Melatonin Alleviates Sleep Disturbance‐Induced Ovarian Reserve Decline by Suppressing NLRP3‐Mediated Pyroptosis in Granulosa Cells

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Engineering food systems for microbiome stability and metabolic health in deep-space missions

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Artificial light pollution disrupts sleep and neuronal genomic stability in wild reef fish

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Sleep deficiency and mortality: is the solution in the gut?

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Dynamic molecular choreography of circadian rhythm disorders (DMCRD): a prospective cohort study protocol

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Direct Determination of the Gas-Solid Interface Reaction Products of Melatonin with Ozone by Laser-Induced Acoustic Desorption – Mass Spectrometry (LIAD-MS)

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Sleep regulation: The gut sets the threshold

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Basics of sleep–wake physiology for athletes and sports professionals

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Association between dietary total antioxidant capacity and sleep problems and depressive symptoms among U.S. adults

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Neuronal Progenitors Suffer Genotoxic Stress in the Drosophila Clock Mutant per0

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Pentose phosphate pathway of glucose-6-phosphate oxidation in the liver of rats with alloxan diabetes on the background of melatonin administrations and variable photoperiod

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Enhancing Employee Health Through an Experimental Diet: Insights from Machine Learning Analysis

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Impact of Sleep Deprivation on the Central Nervous System Neurotransmitters and Immune Function in Male Albino Rats

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Viscera affectum anno: the gut beyond eating behaviours

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Sleep Disturbance–Induced Free Radical Formation in the Gut May Be Blocked by Melatonin

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Pinpointing the genetic and cellular links between sleep and metabolism

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Facile synthesis of Cu/Ls MOF for laccase-like oxidative decomposition of phenols and identification of toxicity effects for C. elegansPreprint

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How Do People with Late Bedtimes use Social Media?Preprint

Wang, S., Xu, Y., Tian, X., Song, Y., Luo, Y., & Zhu, M. (2022) · Research Square · doi:10.21203/rs.3.rs-1133832/v1 · Cited by 1

Molecular Signatures of Post-Traumatic Stress Disorder in War-Zone Exposed Veteran and Active Duty SoldiersPreprint

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Elevated sleep need in a stress-resilient Drosophila speciesPreprint

Yano, J. M., Nave, C., Larratt, K., Honey, P., Jingco, C., Roberts, M., Trotter, D., He, X., Elezi, G., Whitelegge, J. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.27.542279 · Cited by 1

Opposing implications of co-evolutionary lineages and traits of gut microbiome on human health statusPreprint

Li, H., He, J., Liang, J., Liang, Y., Zheng, W. H., Qu, Q., & Guo, F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.30.542569 · Cited by 1

A familial natural short sleep mutation promotes healthy aging and extends lifespan in DrosophilaPreprint

Pandey, P., Wall, P. K., Lopez, S. R., Dubuisson, O. S., Zunica, E. R. M., Dantas, W. S., Kirwan, J. P., Axelrod, C. L., & Johnson, A. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.25.538137 · Cited by 1

Improving Quality of Life in Chronic Fatigue Syndrome using Antioxidant Complex Twendee M®.Preprint

You, F., Harakawa, Y., Yoshikawa, T., & Inufusa, H. (2024) · Preprints.org · doi:10.20944/preprints202402.0373.v1

Molecular basis for the co-evolution of thermophysiology and pigmentation in Habrobracon hebetor (Hymenoptera: Braconidae)Preprint

Yan, S., Lyu, B., Lu, H., Tang, J., Zhang, Q.-K., Jiao, B., & Wu, Y.-X. (2024) · Research Square · doi:10.21203/rs.3.rs-4897874/v1 · Cited by 1

Information, Geometry, and Chaos: Revealing Latent Cysteine Butterflies on Fractal Redox Shapes in the Proteomic SpectraPreprint

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Sleep Deprivation Primes Synaptic Vulnerability Without Inducing Oxidative Damage: A Mechanistic ReappraisalPreprint

Guo, L., Ferretti, V., & Gilestro, G. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.05.674430 · Cited by 1

Integrated respirometry and metabolomics unveil circadian metabolic dynamics in DrosophilaPreprint

Akhtar, F., Malik, D. M., Sengupta, A., Haynes, P. R., Nguyen, A. D., Klok, J., Sehgal, A., & Weljie, A. M. (2025) · eLife · doi:10.7554/elife.108681 · Cited by 1

Early life sleep is associated with longevity in DrosophilaPreprint

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A molecular integrator of sleep duration and interruptionPreprint

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Can You Die from Lack of Sleep

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Sleep modulates alcohol toxicity in DrosophilaPreprint

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Insomnia Symptoms in Chronic Pain : Clinical presentation, risk and treatment

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Moving beyond sleep stage scoring epoch-by-epoch (other PSG/EEG characteristics and parameters)

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An omics analysis of genetic sleep loss in C. elegans

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Sleep medicine is more than just obstructive sleep apnoea

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A role for caveolar proteins in regulation of the circadian clockPreprint

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Integrated analysis of the microbiota-gut-brain axis in response to sleep deprivation in a diet-induced obesity mouse modelPreprint

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Intestinal redox regulation and inflammatory bowel disease

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Dihydromyricetin improves rhythm by anti-oxidative stress damage in sleep deprivation Drosophila

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Environmental and genetic influence of circadian rhythm over cardiac metabolism and disease

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The Effects of Sleep on Human Physiology and Its Regulation

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Seed-Induced Accumulation of β-Amyloid Exacerbates Oxidative Stress in Drosophila

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Ketamine induces insomnia‐like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse

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Exercise attenuates the association between pyrethroid exposure and sleep disorders in male adults

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Utx Improves Hypoxic-Ischemic Neuronal Injury in Neonatal Mice by Upregulating Scd1 to Inhibit FerroptosisPreprint

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Sleep Arousal Identification Based on Generative Adversarial Network and Multi-Head Attention Convolutional NetworkPreprint

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Cognitive hyperplasticity drives insomniaPreprint

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Investigating the antimicrobial and immunomodulatory effects of honeybee venom peptide apamin in the Drosophila genetic platformPreprint

Wei, Y., Jia, W., Sun, Y., Zhang, T., Miao, H., Wu, Z., Dong, R., Ning, F., & Kim, W. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.25.605111

eLife Assessment: Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish

Bene, F. D. (2024) · eLife · doi:10.7554/elife.99191.1.sa3

Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish

Lloyd, E., Xia, F., Moore, K., Zertuche Mery, C., Rastogi, A., Kozol, R. A., Kenzor, O., Warren, W., Appelbaum, L., Moran, R. L., et al. (2025) · eLife · doi:10.7554/elife.99191

Reviewer #2 (Public Review): Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish

Lloyd, E., Xia, F., Moore, K., et al. (2024) · eLife · doi:10.7554/elife.99191.1.sa1

Elevated DNA Damage without signs of aging in the short-sleeping Mexican CavefishPreprint

Lloyd, E., Xia, F., Moore, K., Zertuche-Mery, C., Rastogi, A., Kozol, R. A., Kenzior, O., Warren, W. C., Appelbaum, L., Moran, R. L., et al. (2024) · eLife · doi:10.7554/elife.99191.1

Reviewer #1 (Public Review): Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish

Lloyd, E., Xia, F., Moore, K., et al. (2024) · eLife · doi:10.7554/elife.99191.1.sa2

Reviewer #3 (Public Review): Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish

Lloyd, E., Xia, F., Moore, K., et al. (2024) · eLife · doi:10.7554/elife.99191.1.sa0

Pengaruh Ekstrak Biji Kopi Robusta Terhadap Histopatologi Duodenum Yang Diinduksi Monosodium Glutamat Pada Tikus Sprague-dawley

Yahmal, P. N. (2024) · Jurnal Kesehatan Holistic · doi:10.33377/jkh.v8i2.189

Melatonin intervention to prevent nanomaterial exposure‐induced damages: A systematic review and meta‐analysis of in vitro and in vivo studies

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Effects of coffee on gut microbiota in health and diseases

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Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stressPreprint

Tener, S. J., Kim, C., Lee, J., Oraedu, K., Gatto, J. A., Chang, T. Y., Lam, C., Schanta, R., Jankowski, M. S., Park, S. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.01.626207

Elevated DNA Damage without signs of aging in the short-sleeping Mexican CavefishPreprint

Lloyd, E., Xia, F., Moore, K., Zertuche-Mery, C., Rastogi, A., Kozol, R. A., Kenzior, O., Warren, W. C., Appelbaum, L., Moran, R. L., et al. (2025) · eLife · doi:10.7554/elife.99191.2

Skin Transcriptomic Analysis Reveals Altered Fatty Acid Metabolism Pathways in Mice Subjected to Sleep Fragmentation

Lee, D.-B., Yoo, S.-L., Heo, J. S., Lim, J.-Y., Pyo, S. S., Moon, J. S., Lee, M.-R., Kim, J., Kim, S. W., & Yoon, D. W. (2025) · Skin Pharmacology and Physiology · doi:10.1159/000544736

Exploring the evolving frontiers of sleep deprivation research in the post-COVID-19 era

Abdelwahab, S. İ., Taha, M. M. E., Aldhahi, M. I., Jerah, A. A., Farasani, A. M., Abdullah, S. M., Aljahdali, I. A., Ibrahim, R., Oraibi, O., Oraibi, B., et al. (2025) · Medicine · doi:10.1097/md.0000000000041806

Distinct Hepatic Metabolic Reprogramming in Acute and Chronic Sleep Deprivation and the Protective Effects of the Chalcone Analogue TAK

Wang, Y., Hu, Y., Wang, P., Hu, R., Chen, Z. Q., Zhang, T., Liu, J., Noda, M., Long, J., & Peng, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083485

Balancing Between Too Little and Too Much Sleep

Juginović, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-92060-8_16

Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammationPreprint

Malita, A., Skakkebaek, A. H., Kubrak, O. I., Chen, X., Koyama, T., Connolly, E. C., Ahrentløv, N., Andersen, D. S., Texada, M. J., Halberg, K. A., et al. (2025) · eLife · doi:10.7554/elife.99999.2

The effects of sleep disruption, sex, and mating status on susceptibility to fungal ( Metarhizium anisopliae ) infections in Drosophila melanogasterPreprint

Nan, M., & Leger, R. J. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.21.665781

Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila

Akhtar, F., Malik, D. M., Sengupta, A., Haynes, P. R., Nguyen, A. D., Klok, J., Sehgal, A., & Weljie, A. M. (2026) · eLife · doi:10.7554/elife.108681.3

Information, Geometry, and Chaos: Revealing Latent Cysteine Butterflies on Fractal Redox Shapes in the Proteomic SpectraPreprint

Cobley, J. N. (2025) · Preprints.org · doi:10.20944/preprints202507.2120.v2

ROS elevation in early development extends Aleuroglyphus ovatus lifespan

Ai, H., Chen, Y., Miao, G., Zhong, S., Hu, Y., Xin, T., Xia, B., & Zou, Z. (2025) · Journal of Stored Products Research · doi:10.1016/j.jspr.2025.102788

Ultrasmall Gold Nanoparticles Boost Radiotherapy and Protect against Radiation Damage

Piacenti‐Silva, M., Zaparoli, H. H., Isikawa, M. M., Guidelli, É. J., Crampon, E., & Vieira, C. L. Z. (2025) · ACS Omega · doi:10.1021/acsomega.5c05201

Relationship between sleep duration and hearing loss among adults aged 20–69: exploration of the U–shaped curve pattern

Yang, X., Ju, K., Wu, R., Liu, B., Zhao, Q., & Jiang, T. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1621044

Ambient effects on neural stem cells: Insights from Drosophila

Ren, X., Zhang, Q., Zhang, H., Zhang, L., Yu, Y., Chen, Q., & An, H. (2025) · World Journal of Meta-Analysis · doi:10.13105/wjma.v13.i3.107588

Mutations in antimicrobial peptides differently affect sleep and plasticityPreprint

Kumar, R., Madhav, G., Balasubramanian, P., Lakhiani, R., Joshi, M., Jaggi, V., Pal, A., Khan, I., & Melnattur, K. V. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.28.679065

Cornelian Cherry (Cornus mas) Fruit Extract Administration in Sleep Deprived Wistar Rats—Friend or Foe?

Neculicioiu, V. S., Chiş, I. C., Colosi, I. A., Sevastre-Berghian, A., David, L., Muntean, M., Vlase, A.-M., Moldovan, R., Decea, R. M., Costache, C. A., et al. (2025) · Biology · doi:10.3390/biology14101341

Medicine on the menu: When illness informs appetite

Han, J. H., & Ja, W. W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2524005122

Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in DrosophilaPreprint

Akhtar, F., Malik, D. M., Sengupta, A., Haynes, P. R., Klok, J., Sehgal, A., & Weljie, A. M. (2025) · eLife · doi:10.7554/elife.108681.1

Azadirachtin inhibits RSV accumulation by disrupting the proliferation–apoptosis balance in Laodelphax striatellus

Huang, Z., Gao, J., Tan, Y. Y., Hu, W., Wang, K., Zuo, S., Liu, F., & Zhang, L. (2025) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2025.106828

L-Citrulline Ameliorates Sleep Deprivation-Induced Oxidative Stress, Inflammation and Haematological Alterations in Adult Female Wistar Rats

Isa, A. I., Khan, S., Metwally, A., O’haj, M., Adam, M. I. E., & Mohammed, N. A. (2025) · Biology Bulletin · doi:10.1134/s1062359025602009

Sleep controls peroxisomal abundance to reduce wake-induced brain oxidationPreprint

Guevara, C., Li, Y., Pyfrom, E. S., Killiany, S. L., Yue, Z., & Sehgal, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.28.691144 · Cited by 1

Additional file 1 of Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis

Liang, B., Zhong, Y., Huang, Y., Lin, X., Liu, J., Lin, L., Hu, M., Jiang, J., Dai, M., Wang, B., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14746315

Additional file 2 of Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1

Wang, Y., Wang, Q., Dou, S., Zhou, Q., & Xie, L. (2024) · Figshare · doi:10.6084/m9.figshare.26082705

AMPK targets PDZD8 to trigger carbon source shift to glutaminePreprint

Li, M., Wang, Y., 魏晓妍, Cai, W.-F., Zhu, M., Yao, L., Wang, Y., Liu, Y.-H., Wu, J., Xiong, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.548338

Additional file 4 of Metabolic fingerprints of fear memory consolidation during sleep

Koyanagi, I., Sonomura, K., Naoi, T., Ohnishi, T., Kaneko, N., Sawamoto, K., Sato, T.-A., & Sakaguchi, M. (2021) · Figshare · doi:10.6084/m9.figshare.13889481

Additional file 1 of Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1

Wang, Y., Wang, Q., Dou, S., Zhou, Q., & Xie, L. (2024) · Figshare · doi:10.6084/m9.figshare.26082643

Dual trajectories of nighttime sleep duration and frailty in relation to cardiovascular disease risk in middle-aged and older Chinese adults: a longitudinal study

Wu, Q., Zhang, J. J., Liu, J., Huang, H., Zhang, Z., Yue, S., Su, M., Chen, J., Zhao, S., & Ma, J. (2026) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2026.106149

A genetically encoded ionic-stress sensor reveals protons as a sleep driverPreprint

Ji, Z., Liu, J., Wang, B., Wei, S., Bian, Y., Zeng, W., Chung, C.-I., Ma, Z., Zhang, J., Shu, X., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.27.702131

Acetylcholine-binding protein 5 regulates extracellular apoptosis in the wolf spider as a sacrificial ROS scavenger

Zhang, H., Wang, J., Tan, Y., Zhang, J., Shi, C., Hu, T., Wang, K., & Liu, Z. (2026) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2026.107001

TFR-GANNet: Multi-channel time–frequency ridge fusion and CWGAN-GP for sleep arousal identification

Lu, W., Liu, Z., Chen, Y., & Wang, J. (2026) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2026.109846

Sleep Disorders and Male Infertility: Integrated Mechanisms and Precision Therapeutic Strategies

Rong, J., & Dong, M. (2026) · Andrology · doi:10.1111/andr.70191 · Cited by 1

Sleep, Insomnia, and Immune Responses to Influenza Vaccine: State of the Art and Implications for Health Psychology

Ballesio, A. (2026) · Current Sleep Medicine Reports · doi:10.1007/s40675-026-00353-3

Dietary EPA shows superior efficacy over DHA in chronic sleep deprivation-induced cognitive decline by disrupting the crosstalk between intestinal ferroptosis and gut-derived Aβ production

Chen, L., Wang, X., Yang, Y., Shi, H., Zhang, N., Wang, Z., Han, J., & Wen, M. (2026) · Food & Function · doi:10.1039/d5fo03915k

Komagataella phaffii KM71H Attenuates Sleep Deprivation–Induced Anxiety and Cognitive Dysfunction via Neuroimmune–Metabolic and Stress-Related PathwaysPreprint

Xavier, R., de Oliveira, R. L., Pujol, L. N., Rodrigues, R. R., Sousa, F. S. S., Lanius, S. L., Collares, T. V., Seixas, F. K., Conceição, F. R., & Savegnago, L. (2026) · Research Square · doi:10.21203/rs.3.rs-8960800/v1

Peripheral modulation of Pumilio in intestinal stem cells and the corpus allatum affects sleep latency in Drosophila

Rodríguez-Cordero, J. A., Avilés, M. D., Rodriguez‐Fernandez, I. A., Ghezzi, A., Lizardi-Ortiz, J. E., & Agosto, J. L. (2026) · PLoS ONE · doi:10.1371/journal.pone.0337303

Les phéromones sexuelles redéfinissent les rythmes quotidiens d'activité et de repos des insectes

Ghosh, S. (2025) · theses.fr (ABES) · doi:10.70675/aa2d51b1zf20dz4abdz8160ze3c91dd95623

Sleep loss lethality is caused by gut ROS in mice and flies

Hindson, J. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0340-6 · Cited by 5

Sleepless with ROS

Wong, W. (2020) · Science Signaling · doi:10.1126/scisignal.abd4214 · Cited by 2

Sleep deficiency and mortality: is the solution in the gut?

Nakada, Y., & Sadoshima, J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa309 · Cited by 1

Sleep and the Gut

Juginović, A., Li, Z., Laureano, A., Mlinar, A., & Rogulja, D. (2025) · doi:10.46793/iccbikg25.002j

A bidirectional relationship between sleep and oxidative stress in Drosophila

Hill, V. M., O'Connor, R. M., Sissoko, G. B., Irobunda, I., Leong, S., Canman, J. C., Stavropoulos, N., & Shirasu‐Hiza, M. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005206 · Cited by 200