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A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
Open accessAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of potential therapies and vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is the lack of susceptible small animals in large numbers. Commercially available laboratory strains of mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Here, we transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues. hACE2-transduced mice were productively infected with SARS-CoV-2, and this resulted in high viral titers in the lung, lung pathology, and weight loss. Passive transfer of a neutralizing monoclonal antibody reduced viral burden in the lung and mitigated inflammation and weight loss. The development of an accessible mouse model of SARS-CoV-2 infection and pathogenesis will expedite the testing and deployment of therapeutics and vaccines.
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Metadata
- Authors
- Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., Turner, J. S., Schmitz, A. J., Lei, T., Shrihari, S., Keeler, S. P., Fremont, D. H., Greco, S., McCray, P. B., Perlman, S., Holtzman, M. J., Ellebedy, A. H., & Diamond, M. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 182
- Issue
- 3
- Pages
- 744-753.e4
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3033015248
- Cited by
- 494
- References
- 14
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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