Massively parallel assessment of human variants with base editor screens

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

Szklarczyk, D., Gable, A. L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., Simonovic, M., Doncheva, N. T., Morris, J. H., Bork, P., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1131 · Cited by 17,749

The Ensembl Variant Effect Predictor

McLaren, W., Gil, L., Hunt, S. E., Riat, H. S., Ritchie, G. R. S., Thormann, A., Flicek, P., & Cunningham, F. (2016) · Genome Biology · doi:10.1186/s13059-016-0974-4 · Cited by 8,099

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A., & Liu, D. R. (2016) · Nature · doi:10.1038/nature17946 · Cited by 5,437

Improved vectors and genome-wide libraries for CRISPR screening

Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239

Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., Smith, I., Tothova, Z., Wilen, C., Orchard, R., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3437 · Cited by 4,637

ClinVar: improving access to variant interpretations and supporting evidence

Landrum, M. J., Lee, J. M., Benson, M., Brown, G. R., Chao, C., Chitipiralla, S., Gu, B., Hart, J., Hoffman, D., Jang, W., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1153 · Cited by 4,196

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Gaudelli, N. M., Komor, A. C., Rees, H. A., Packer, M. S., Badran, A. H., Bryson, D. I., & Liu, D. R. (2017) · Nature · doi:10.1038/nature24644 · Cited by 4,184

Next-generation characterization of the Cancer Cell Line Encyclopedia

Ghandi, M., Huang, F. W., Jané-Valbuena, J., Kryukov, G. V., Lo, C. C., McDonald, E. R., Barretina, J., Gelfand, E. T., Bielski, C. M., Li, H., et al. (2019) · Nature · doi:10.1038/s41586-019-1186-3 · Cited by 3,394

Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput

Kennedy, P. H., Sheikh, A. A. D., Balakar, M., Jones, A. C., Olive, M. E., Hegde, M., Matias, M. I., Pirete, N., Burt, R. A., Levy, J. M., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02256-z · Cited by 30

CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

Cabré-Romans, J.-J., & Cuella-Martin, R. (2025) · Frontiers in Genome Editing · doi:10.3389/fgeed.2025.1553590 · Cited by 33

Targeted manipulation of m6A RNA modification through CRISPR-Cas-based strategies

Sun, X., Wang, D. O., & Wang, J. (2022) · Methods · doi:10.1016/j.ymeth.2022.03.006 · Cited by 26

Base editor enables rational genome-scale functional screening for enhanced industrial phenotypes in Corynebacterium glutamicum

Liu, Y., Wang, R., Liu, J., Lu, H., Li, H., Wang, Y., Ni, X., Li, J., Guo, Y., Ma, H., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq2157 · Cited by 25

High-throughput screening of human genetic variants by pooled prime editing

Herger, M., Kajba, C. M., Buckley, M., Cunha, A., Strom, M., & Findlay, G. M. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100814 · Cited by 26

Integration of Organoids With CRISPR Screens: A Narrative Review

Mukhare, R., Gandhi, K., Kadam, A., Raja, A., Singh, A., Madhav, M., Chaubal, R., Pandey, S., & Gupta, S. (2025) · Biology of the Cell · doi:10.1111/boc.70006 · Cited by 26

Discovering new biology with drug-resistance alleles

Freedy, A. M., & Liau, B. B. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00865-9 · Cited by 25

Emerging technologies for prenatal diagnosis: The application of whole genome and RNA sequencing

Liu, P., & Vossaert, L. (2022) · Prenatal Diagnosis · doi:10.1002/pd.6146 · Cited by 25

Genome-wide base editor screen identifies regulators of protein abundance in yeast

Schubert, O. T., Bloom, J. S., Sadhu, M. J., & Kruglyak, L. (2022) · eLife · doi:10.7554/elife.79525 · Cited by 21

Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing

Ang, R. M. L., Chen, S.-A. A., Kern, A., Xie, Y., & Fraser, H. B. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100260 · Cited by 23

Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease

Islam, M. M., Tamlander, M., Hlushchenko, I., Ripatti, S., & Pfisterer, S. G. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.10.006 · Cited by 21

Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants

Sahu, S., Sullivan, T. L., Mitrophanov, A. Y., Galloux, M., Nousome, D., Southon, E. A., Caylor, D., Mishra, A. P., Evans, C. N., Clapp, M. E., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010940 · Cited by 24

An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing

Waterbury, A. L., Kwok, H. S., Lee, C., Narducci, D. N., Freedy, A. M., Su, C., Raval, S., Reiter, A. H., Hawkins, W., Lee, K., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.05.017 · Cited by 22

Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells

Spahn, P. N., Zhang, X., Hu, Q., Lu, H., Hamaker, N. K., Hefzi, H., Li, S., Kuo, C., Huang, Y., Lee, J. C., et al. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.28016 · Cited by 22

A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

Wei, C. T., Popp, N. A., Peleg, O., Powell, R. L., Borenstein, E., Maly, D. J., & Fowler, D. M. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01278-6 · Cited by 21

Functional profiling of serine, threonine and tyrosine sites

Li, Y., Xu, T., Ma, H., Yue, D., Lamao, Q., Liu, Y., Zhou, Z. L., & Wei, W. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01731-0 · Cited by 22

Mechanistic insights into genetic susceptibility to prostate cancer

Tian, P. W., Zhong, M., & Wei, G. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.025 · Cited by 22

Unbiased interrogation of functional lysine residues in human proteome

Bao, Y., Pan, Q., Xu, P., Liu, Z., Zhang, Z., Liu, Y., Xu, Y., Yu, Y., Zhou, Z. L., & Wei, W. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.10.033 · Cited by 19

CRISPR Technology and Its Emerging Applications

Zhang, X. E., Ma, D., & Liu, F. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf034 · Cited by 21

Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens

Cheng, W., Liu, F., Ren, Z., Chen, W., Chen, Y., Liu, T., Ma, Y., Cao, N., & Wang, J. (2022) · Nature Communications · doi:10.1038/s41467-022-28106-0 · Cited by 17

Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR‐Mediated Base Editors

Li, J., Lin, J., Huang, S., Li, M., Yu, W., Zhao, Y., Guo, J., Zhang, P., Huang, X., & Qiao, Y. (2022) · Advanced Science · doi:10.1002/advs.202200717 · Cited by 16

Emerging maps of allosteric regulation in cellular networks

Mathy, C. J. P., & Kortemme, T. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102602 · Cited by 20

A temperature-tolerant CRISPR base editor mediates highly efficient and precise gene editing in Drosophila

Doll, R. M., Boutros, M., & Port, F. (2023) · Science Advances · doi:10.1126/sciadv.adj1568 · Cited by 18

Health research in the era of artificial intelligence: Advances in gene-editing study

Dai, M., Li, X., Zhang, Q., Liang, T., Huang, X., & Fu, Q. (2024) · Medicine Plus · doi:10.1016/j.medp.2024.100027 · Cited by 19

Robust and inducible genome editing via an all-in-one prime editor in human pluripotent stem cells

Wu, Y., Zhong, A., Sidharta, M., Kim, T. W., Ramirez, B., Persily, B., Studer, L., & Zhou, T. (2024) · Nature Communications · doi:10.1038/s41467-024-55104-1 · Cited by 22

A multiplex, prime editing framework for identifying drug resistance variants at scalePreprint

Chardon, F. M., Suiter, C. C., Daza, R. M., Smith, N. T., Parrish, P. C. R., McDiarmid, T. A., Lalanne, J., Martin, B., Calderon, D., Ellison, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.27.550902 · Cited by 17

Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment

Walsh, Z. H., Frangieh, C. J., Kothapalli, N., Levy, J. A., Heck, C., Melms, J. C., Gejman, R. S., Shah, P., Pollard, J. M., Naik, A., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.037 · Cited by 16

Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs

Zhang, H., McCarroll, A., Peyton, L., de León‐Guerrero, S. D., Zhang, S., Gowda, P., Sirkin, D., ElAchwah, M., Duhe, A., Wood, W., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.08.003 · Cited by 15

Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery

(2023) · doi:10.7554/elife.80640 · Cited by 16

CRISPR base editing applications for identifying cancer-driving mutations

Pál, M., & Herold, M. J. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200550 · Cited by 17

Prime editor-based high-throughput screening reveals functional synonymous mutations in human cells

Niu, X., Tang, W., Liu, Y., Mo, B., Liu, Y., Liu, Y., & Wei, W. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02710-z · Cited by 18

A streamlined base editor engineering strategy to reduce bystander editing

Valdez, I., O’Connor, I., Patel, D., Gierer, K., Harrington, J., Ellis, E., Caponetti, S. A., Sebra, R., Valley, H. C., Coote, K. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63609-6 · Cited by 17

Neuromuscular disorders: finding the missing genetic diagnoses

Koczwara, K. E., Lake, N. J., DeSimone, A. M., & Lek, M. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.07.001 · Cited by 16

Integrative dissection of gene regulatory elements at base resolution

Chen, Z., Javed, N. M., Moore, M. M., Wu, J., Sun, G., Vinyard, M. E., Collins, A., Pinello, L., Najm, F. J., & Bernstein, B. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100318 · Cited by 17

Manipulating and studying gene function in human pluripotent stem cell models

Balmas, E., Sozza, F., Bottini, S., Ratto, M. L., Savoré, G., Becca, S., Snijders, K. E., & Bertero, A. (2023) · FEBS Letters · doi:10.1002/1873-3468.14709 · Cited by 18

Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells

Li, H., Bartke, R., Zhao, L., Verma, Y., Horacek, A., Ben-Natan, A. R., Pangilinan, G. R., Krishnappa, N., Nielsen, R., & Hockemeyer, D. F. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01065-7 · Cited by 16

Development of a base editor for convenient and multiplex genome editing in cyanobacteria

Li, X.-D., Liu, L.-M., Xi, Y.-C., Sun, Q.-W., Luo, Z., Huang, H.-L., Wang, X.-W., Jiang, H.-B., & Chen, W. (2024) · Communications Biology · doi:10.1038/s42003-024-06696-3 · Cited by 14

Preclinical Anticipation of On- and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review

Dziubańska-Kusibab, P. J., Nevedomskaya, E., & Haendler, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020705 · Cited by 14

scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics

Cooper, S., Coelho, M. A., Strauß, M. E., Gontarczyk, A. M., Wu, Q., Garnett, M. J., Marioni, J. C., & Bassett, A. R. (2024) · Genome biology · doi:10.1186/s13059-024-03169-y · Cited by 12

Understanding genetic variants in context

Sinnott-Armstrong, N., Fields, S., Roth, F. P., Starita, L. M., Trapnell, C., Villén, J., Fowler, D. M., & Queitsch, C. (2024) · eLife · doi:10.7554/elife.88231 · Cited by 14

CRISPR Screens to Identify Regulators of Tumor Immunity

LaFleur, M. W., & Sharpe, A. H. (2021) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070120-094725 · Cited by 16

Analyzing the functional effects of DNA variants with gene editing

Cooper, S., Obolenski, S., Waters, A. J., Bassett, A. R., & Coelho, M. A. (2024) · Cell Reports Methods · doi:10.1016/j.crmeth.2024.100776 · Cited by 14

Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC)

Viswanatha, R., Entwisle, S., Hu, Y.-H., Kim, A.-R., Reap, K., Butnaru, M., Qadiri, M., Mohr, S. E., & Perrimon, N. (2025) · Nature Communications · doi:10.1038/s41467-025-61692-3 · Cited by 7

Massively parallel CRISPR-assisted homologous recombination enables saturation editing of full-length endogenous genes in yeast

Deng, L., Zhou, Y., Cai, Z., Zhu, J., Li, Z., & Bao, Z. (2024) · Science Advances · doi:10.1126/sciadv.adj9382 · Cited by 16

Trans-eQTL hotspots shape complex traits by modulating cellular states

Renganaath, K., & Albert, F. W. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100873 · Cited by 11

Engineering of cytosine base editors with DNA damage minimization and editing scope diversification

Yuan, B., Zhang, S., Song, L., Chen, J., Cao, J., Qiu, Z., Qiu, Z., Chen, J., Zhao, X., & Cheng, T.-L. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad855 · Cited by 13

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

Potts, M. A., McDonald, J. A., Sutherland, K. D., & Herold, M. J. (2020) · European Journal of Immunology · doi:10.1002/eji.202048712 · Cited by 11

A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites

Pihlajamaa, P., Kauko, O., Sahu, B., Kivioja, T., & Taipale, J. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01444-6 · Cited by 11

CRISPR/Cas-Based Approaches to Study Schizophrenia and Other Neurodevelopmental Disorders

Kurishev, A. O., Karpov, D. S., Nadolinskaia, N. I., Гончаренко, А. В., & Голимбет, В. Е. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010241 · Cited by 13

Bcl-x short-isoform is essential for maintaining homeostasis of multiple tissues

Keller, M. A., Huang, C.-Y., Ivessa, A., Singh, S., Romanienko, P. J., & Nakamura, M. (2023) · iScience · doi:10.1016/j.isci.2023.106409 · Cited by 11

CRISPR/Cas-based Human T cell Engineering: Basic Research and Clinical Application

Bernard, B. E., Landmann, E., Jeker, L. T., & Schumann, K. (2022) · Immunology Letters · doi:10.1016/j.imlet.2022.03.005 · Cited by 12

Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells

Muhtaseb, A. W., & Duan, J. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.04.003 · Cited by 11

CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue

Gu, J., Iyer, A., Wesley, B., Taglialatela, A., Leuzzi, G., Hangai, S., Decker, A., Gu, R., Klickstein, N., Shuai, Y., et al. (2023) · doi:10.1101/2023.12.26.572587 · Cited by 10

Deconstructing cancer with precision genome editing

Johnson, G. A., Gould, S. I., & Rivera, F. J. S. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230984 · Cited by 11

Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform

Dorighi, K. M., Zhu, A., Fortin, J., Lo, J. H.-H., Sudhamsu, J., Wendorff, T. J., Durinck, S., Callow, M. G., Foster, S. A., & Haley, B. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114313 · Cited by 11

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

Wichroski, M. J., Liu, S.-Q., Zasadil, L. M., Benci, J. L., Gedeon, P. C., Condon, K. J., Joshi, S., Posy, S., Carlson, P., Maier, A., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-25-0156 · Cited by 10

Evaluation and prediction of guide RNA activities in genome-editing tools

Kim, H. K., & Kim, S. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00352-z · Cited by 12

The Current Situation and Development Prospect of Whole-Genome Screening

Yang, C., Lei, Y., Ren, T., & Yao, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010658 · Cited by 12

CRISPR/Cas9 genetic screens in hepatocellular carcinoma gene discovery

Chiu, C. H. (2023) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2023.100127 · Cited by 10

High-throughput CRISPR technology: a novel horizon for solid organ transplantation

Li, X., Chen, Z., Ye, W., Yu, J., Zhang, X., Li, Y., Niu, Y., Ran, S., Wang, S., Luo, Z., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295523 · Cited by 10

Expanding the flexibility of base editing for high-throughput genetic screens in bacteria

Gawlitt, S., Collins, S. P., Yu, Y., Blackman, S. A., Barquist, L., & Beisel, C. L. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae174 · Cited by 9

CRISPR beyond: harnessing compact RNA-guided endonucleases for enhanced genome editing

Wang, F., Ma, S., Zhang, S., Ji, Q., & Hu, C. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2566-8 · Cited by 10

Activity-based selection for enhanced base editor mutational scanning

Kaplan, E. L., Steger, R. J., Shah, S. T., Drepanos, L. M., Griffith, A. L., Reint, G., & Doench, J. G. (2025) · Nature Genetics · doi:10.1038/s41588-025-02366-0 · Cited by 9

Towards a CRISPeR understanding of homologous recombination with high-throughput functional genomics

Hayward, S. B., & Ciccia, A. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.08.006 · Cited by 9

Efficient multitool/multiplex gene engineering with TALE-BE

Boyne, A. R., Yang, M., Pulicani, S., Feola, M., Tkach, D., Hong, R., Duclert, A., Duchateau, P. N., & Juillerat, A. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1033669 · Cited by 9

Generation of PCBP1-deficient pigs using CRISPR/Cas9-mediated gene editing

Qi, C., Pang, D., Yang, K., Jiao, S., Wu, H., Zhao, C., Hu, L., Li, F., Zhou, J., Yang, L., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105268 · Cited by 9

Base Editor Scanning Reveals Activating Mutations of DNMT3A

Garcia, E. M., Lue, N. Z., Liang, J. K., Lieberman, W. K., Hwang, D. D., Woods, J. C., & Liau, B. B. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00257 · Cited by 9

Human genetics implicates a BACH2-NRF2 axis in fetal heamoglobin activationPreprint

Guo, C., Arora, U. P., Cheng, X., Xu, W., Cato, L. D., Li, R., Lu, H. Y., Lee, A., Yu, F., Agarwal, G., et al. (2023) · medRxiv · doi:10.1101/2023.03.24.23287659 · Cited by 9

Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Zhou, X., Gao, J., Luo, L., Huang, C., Wu, J., & Wang, X. (2024) · Communications Biology · doi:10.1038/s42003-024-07078-5 · Cited by 11

Using omics data and genome editing methods to decipher GWAS loci associated with coronary artery disease

Chignon, A., & Lettre, G. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118621 · Cited by 9

Massively parallel interrogation of human functional variants modulating cancer immunosurveillance

Liu, Y., Liu, Y., Niu, X., Chen, A., Li, Y., Yu, Y., Mo, B., Liu, Z., Xu, T., Cheng, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02171-5 · Cited by 8

CRISPR-based genetic screens advance cancer immunology

Cao, Y., Li, X., Pan, Y., Wang, H., Yang, S., Hong, L., & Ye, L. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2571-0 · Cited by 8

The use of base editing technology to characterize single nucleotide variants

McDaniel, S., Komor, A. C., & Goren, A. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.031 · Cited by 7

CRISPR-based genome editing in disease treatment

Qin, H., Xu, W., & Yao, K. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.05.003 · Cited by 8

Massively parallel approaches for characterizing noncoding functional variation in human evolution

Rong, S., Root, E., & Reilly, S. K. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102256 · Cited by 9

High-throughput screening for optimizing adoptive T cell therapies

Zhang, Y., Xu, Q., Gao, Z., Zhang, H., Xie, X., & Li, M. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00580-w · Cited by 8

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

Huang, K., Tian, J., Zhao, W., Zhang, S., Xiang, L., Yang, M., Ls, L., Huang, Y., Zhang, N., Sun, L., et al. (2026) · iMetaOmics. · doi:10.1002/imo2.70115 · Cited by 8

Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics

Leng, K., & Kampmann, M. (2022) · Genome Medicine · doi:10.1186/s13073-022-01134-7 · Cited by 7

Decoding molecular mechanisms for loss-of-function variants in the human proteomePreprint

Cagiada, M., Jonsson, N., & Lindorff‐Larsen, K. (2025) · eLife · doi:10.7554/elife.108160.1 · Cited by 9

Genome editing with programmable base editors in human cells

Osgood, N. R. B., Zawalick, N. M., Sawyer, C. B., Cowan, Q. T., Gu, S., Mawson, S. J., Ranzau, B. L., Li, L., Gymrek, M., Goren, A., et al. (2025) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2025.01.001 · Cited by 6

A side-by-side comparison of variant function measurements using deep mutational scanning and base editing

Sokirniy, I., Inam, H., Tomaszkiewicz, M., Reynolds, J., McCandlish, D. M., & Pritchard, J. R. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf738 · Cited by 6

RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

Behera, A. K., Kim, J. J., Kordale, S., Pekovic, F., Damodaran, A. P., Kumari, B., Vidak, S., Dickson, E., Xiao, M.-S., Duncan, G., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2025.12.003 · Cited by 6

Triple base editor catalyzes saturation mutation of adenine, cytidine, and guanine

Wu, Y., Wang, J., Zhang, Z., Shang, M., Wang, S. W., Li, Y., Li, G., lu, S., Ji, K., Wang, X., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1423 · Cited by 6

A proteome-wide dependency map of protein interaction motifs

Ambjørn, S. M., Meeusen, B., Kliche, J., Wang, J., Garvanska, D. H., Kruse, T., Mendez, B. L., Mann, M., Mailand, N., Hertz, E. P. T., et al. (2026) · Nature Structural & Molecular Biology · doi:10.1038/s41594-026-01762-2 · Cited by 8

Single-cell and spatial profiling in cancer biology and clinical oncology

Frangieh, C. J., Fan, J. L., Melms, J. C., Shah, P., Azizi, E., & Izar, B. (2026) · Nature Cancer · doi:10.1038/s43018-026-01142-1 · Cited by 8

Large-Scale CRISPR Screen of LDLR Pathogenic Variants

Li, M., Ma, L., Chen, Y., Li, J., Wang, Y., You, W., Yuan, H., Tang, X., Ouyang, H., & Pang, D. (2023) · Research · doi:10.34133/research.0203 · Cited by 6

SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution

Yao, Y., Zhou, Z., Wang, X., Liu, Z., Zhai, Y., Chi, X., Du, J., Luo, L., Zhao, Z., Wang, X., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100583 · Cited by 6

Development of a universal antibiotic resistance screening reporter for improving efficiency of cytosine and adenine base editing

Ma, L., Xing, J., Li, Q., Zhang, Z., & Xu, K. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102103 · Cited by 6

CRISPR‐Suppressor Scanning for Systematic Discovery of Drug‐Resistance Mutations

Ngan, K. C.-H., Lue, N. Z., Lee, C., & Liau, B. B. (2022) · Current Protocols · doi:10.1002/cpz1.614 · Cited by 7

CRISPR-Mediated Base Editing: Promises and Challenges for a Viable Oncotherapy Strategy

Huang, L., Yang, C., Chen, Y., Deng, H., Liao, Z., & Xiao, H. (2023) · Human Gene Therapy · doi:10.1089/hum.2023.045 · Cited by 7

CRISPR base editor screens identify variant function at scale

Parrish, P. C. R., & Berger, A. H. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.036 · Cited by 6

Tools for Decoding Ubiquitin Signaling in DNA Repair

Foster, B., Attwood, M., & Gibbs‐Seymour, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.760226 · Cited by 5

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR ‐based screens

Wilson, J., & Loizou, J. I. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13272 · Cited by 6

Dual guide RNA-mediated concurrent C&G-to-T&A and A&T-to-G&C conversions using CRISPR base editors

Zhao, Y., Li, M., Liu, J., Xue, X., Zhong, J., Lin, J., Ye, B., Chen, J., & Qiao, Y. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.12.055 · Cited by 6

TDP1 splice-site mutation causes HAP1 cell hypersensitivity to topoisomerase I inhibition

Goh, C. G., Bader, A. S., Tran, T.-A., Belotserkovskaya, R., D’Alessandro, G., & Jackson, S. P. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkae1163 · Cited by 5

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex

Yuan, L., Ji, W., Dwyer, B. G., Lu, J., Bian, J. T., Colombo, G. M., Martinez, M. J., Fernández, D., Phillips, N. A., Tang, M. T., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0271 · Cited by 6

Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing

Jung, Y. J., Yu, G., Oh, H.-C., Lee, J.-H., Jeon, E., Bae, J., Sim, T., & Kim, S. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01531-4 · Cited by 7

Precision genome editing with DNA base editors

Mawson, S. J., Dunne-Dombrink, K., Pollak, B. R., & Komor, A. C. (2026) · Nature Reviews Methods Primers · doi:10.1038/s43586-026-00478-3 · Cited by 8

Drug screening approaches for small-molecule compounds in cancer-targeted therapy

Zhao, Y., Yuan, C., Shi, Y., Liu, X., Luo, L., Zhang, L., Pešić, M., Yao, H.-J., & Li, L. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2427185 · Cited by 5

Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants

Vasquez, C. A., Osgood, N. R. B., Zepeda, M. L., Sandel, D. K., Cowan, Q. T., Peiris, M. N., Donoghue, D. J., & Komor, A. C. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf037 · Cited by 7

CRISPR base editor screens identify variant function at scale

Parrish, P. C. R., & Berger, A. H. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.036 · Cited by 6

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

Sangree, A. K., Griffith, A. L., Szegletes, Z. M., Roy, P., DeWeirdt, P. C., Hegde, M., McGee, A. V., Hanna, R. E., & Doench, J. G. (2022) · Nature Communications · doi:10.1038/s41467-022-28884-7 · Cited by 64

Abstract SY05-02: Applications of base editor technology in small molecule: Target validation

Griffith, A. L., Sangree, A. K., Roy, P., Hanna, R. E., & Doench, J. G. (2022) · Cancer Research · doi:10.1158/1538-7445.am2022-sy05-02

A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants

Kweon, J., Jang, A.-H., Shin, H. R., See, J.-E., Lee, W., Lee, J. W., Chang, S., Kim, K., & Kim, Y. (2019) · Oncogene · doi:10.1038/s41388-019-0968-2 · Cited by 93

Decoding disease-relevant variants with base and prime editors at scale

Liu, Y., Niu, X., & Wei, W. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.02.001 · Cited by 2