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Variant interpretation: functional assays to the rescue

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Optical Pooled Screens in Human Cells

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Mapping the Genetic Landscape of Human Cells

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Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing

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In vivo base editing of post-mitotic sensory cells

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A framework for exhaustively mapping functional missense variants

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Sequence-specific prediction of the efficiencies of adenine and cytosine base editors

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Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

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Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor

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Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens

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CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

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A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants

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miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

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Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotidesPreprint

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Single-cell analysis of a mutant library generated using CRISPR-guided deaminase in human melanoma cells

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High-content CRISPR screening

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A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants

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Decoding disease-relevant variants with base and prime editors at scale

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