Cited by 147SARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studiesCOVID-19 Prevention and Impact

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Public health actions to control new SARS-CoV-2 variants

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Grubaugh, Nathan D., Hodcroft, Emma B., Fauver, Joseph R., Phelan, Alexandra L., Cevik, Muge·2021·Cell

DOI 10.1016/j.cell.2021.01.044PMC PMC7846239

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Abstract

Recent reports suggest that some SARS-CoV-2 genetic variants, such as B.1.1.7, might be more transmissible and are quickly spreading around the world. As the emergence of more transmissible variants could exacerbate the pandemic, we provide public health guidance for increased surveillance and measures to reduce community transmission.

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“In late 2020, genomic surveillance in South Africa revealed a new SARSCoV-2 variant (designated B.1.351 or 501Y.V2) associated with a concerning rise in local COVID-19 cases (Tegally et al., 2020).”
BackgroundInfluential
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“…estimated that B.1.1.7 is approximately 50% more transmissible (Davies et al., 2020), which could increase the average number of people that one infected person will pass the virus to (effective reproductive rate) by between 0.4 and 0.7 people (Volz et al., 2021).”
BackgroundInfluential
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England
The COVID-19 Genomics UK (COG-UK) consortium, Volz, E., Mishra, S., Chand, M., Barrett, J. C., Johnson, R., Geidelberg, L., Hinsley, W. R., Laydon, D. J., Dabrera, G., et al. (2021) · Nature · doi:10.1038/s41586-021-03470-x · Cited by 1,611
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“One of the mutations in this variant, N501Y, is located in the important receptor-binding domain (RBD) of spike protein, and is predicted to increase binding to human cells and reduce viral neutralization by the monoclonal antibody LY-CoV016 (Greaney et al., 2021; Starr et al., 2020).”
Background
Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies
Greaney, A. J., Loes, A. N., Crawford, K. H. D., Starr, T. N., Malone, K. D., Chu, H. Y., & Bloom, J. D. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.003 · Cited by 1,178

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Davies, 2020, Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England, medRxiv

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Authors: Grubaugh, N. D., Hodcroft, E. B., Fauver, J. R., Phelan, A. L., & Cevik, M.
Affiliations: Yale University (US)
University of Bern (CH)
Georgetown University (US)
Corresponding author: Hodcroft, Emma B.
Fauver, Joseph R.
Phelan, Alexandra L.
ORCID: Grubaugh, Nathan D.
Hodcroft, Emma B.
Fauver, Joseph R.
Phelan, Alexandra L.
Venue: Cell
Publisher: Elsevier BV
Published: 2021-03
Volume: 184
Issue: 5
Pages: 1127-1132
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2021.01.044
PMC: PMC7846239
OpenAlex: W3127798546
Cited by: 147
References: 20
Citations by year: 2026: 5 · 2025: 6 · 2024: 11 · 2023: 21 · 2022: 48 · 2021: 56
FWCI: 10.85
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: George Mason University
Centers for Disease Control and Prevention (75D30120C09570)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
Social Sciences › Sociology and Political Science › COVID-19 Prevention and Impact
Keywords: SARS-CoV-2 variants, B.1.1.7 variant, Omicron variant, transmissibility, variant surveillance, public health measures, COVID-19 pandemic
MeSH terms: COVID-19, SARS-CoV-2, Age Factors, Communicable Disease Control, United Kingdom, Humans, Travel, Global Health, Vulnerable Populations, Mandatory Programs, Pandemics, Epidemiological Monitoring

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