Cited by 279Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchAntioxidant Activity and Oxidative Stress

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Antioxidative and prooxidative effects of quercetin on A549 cells

Robaszkiewicz, Agnieszka, Balcerczyk, Aneta, Bartosz, Grzegorz·2007·Cell Biology International

DOI 10.1016/j.cellbi.2007.04.009

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Abstract

Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase. Quercetin decreased production of reactive oxygen species in the cells but produced peroxides in the medium. The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium.

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Ogurlu, B., Hamelink, T. L., Tricht, I. M. V., Leuvenink, H. G. D., de Borst, M. H., Moers, C., & Pool, M. B. F. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.01.001 · Cited by 17
Biochemical, liver and renal toxicities of Melissa officinals hydroalcoholic extract on balb/C mice
Namjoo, A., MirVakili, M., Shirzad, H., & Faghani, M. (2013) · Journal of Herbmed Pharmacology · Cited by 17
Quercetin inhibits neutrophil extracellular traps release and their cytotoxic effects on A549 cells, as well the release and enzymatic activity of elastase and myeloperoxidase
Pereira, G. S., Percebom, I., Mendes, S. G., de Souza, P. S. S., Diniz, L. F. A., Costa, M. F., Lopes, B. R. P., & Toledo, K. A. (2022) · Brazilian Journal of Biology · doi:10.1590/1519-6984.252936 · Cited by 16
Long-term administration of Silymarin augments proinflammatory mediators in the hippocampus of rats: Evidence for antioxidant and pro-oxidant effects
Malekinejad, H., Rahmani, F., Valivande-Azar, S., Taheri‐Broujerdi, M., & Bazargani‐Gilani, B. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112436405 · Cited by 16
“For example, the antioxidant and pro-oxidant effects of green tea polyphenols and quercetin in a dose- and concentration-dependent manner have been reported.(7,8) Since oxidative stress is one of the main mechanisms in the pathogenesis of neurodegenerative diseases, the growing interest to use the antioxidant compound…”
Background
Chemical and cytological evaluation of honeybee pollen antioxidant ability
Yang, Y., Liu, M., Wang, K., Yang, Y., Su, N., Huang, W., & Wu, Y. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15047 · Cited by 16
N-Chloroamino acids mediate the action of hypochlorite on A549 lung cancer cells in culture
Robaszkiewicz, A., Bartosz, G., & Soszyński, M. (2010) · Toxicology · doi:10.1016/j.tox.2010.02.003 · Cited by 16
“Detection of apoptosis and necrosis Apoptotic, necrotic and living cells were quantified by double-staining with acridine orange and propidium iodide using flow cytometry (Benderitter et al., 2000; Robaszkiewicz et al., 2007).”
MethodSelf-citation
Protective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review
Raghav, A., Giri, R., Agarwal, S., Kala, S., & Jeong, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1040027 · Cited by 16
“QCT exhibits various biological properties, including antioxidant (2), immunoprotective (3), anti-inflammatory, and anti-viral (4).”
Background
Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: A promising therapeutic and prophylactic treatment for viral respiratory infections
Vaiss, D. P., Rodrigues, J. L., Yurgel, V. C., Guedes, F. D. C., da Matta, L. L. M., Barros, P. A. B., Vaz, G. R., dos Santos, R. N., Matte, B. F., Kupski, L., et al. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106766 · Cited by 15
A moderate protective effect of quercetin against γ-irradiation- and storage-induced oxidative damage in red blood cells for transfusion
Żbikowska, H. M., Antosik, A., Szejk, M., Bijak, M., & Nowak, P. (2013) · International Journal of Radiation Biology · doi:10.3109/09553002.2013.877173 · Cited by 15
Quercetin-Induced Lifespan Extension in Podospora anserina Requires Methylation of the Flavonoid by the O-Methyltransferase PaMTH1
Warnsmann, V., Hainbuch, S., & Osiewacz, H. D. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00160 · Cited by 15
“Beside the anti-oxidative capacity, studies with cell cultures and rats identified a pro-oxidative effect of quercetin (Laughton et al., 1989; Metodiewa et al., 1999; Robaszkiewicz et al., 2007).”
Background
Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
Zhou, S., Zhang, Y., Casals, E., Zeng, M., Morales‐Ruiz, M., Liu, Q., Zhang, B., & Casals, G. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s525411 · Cited by 14
Oxidative Stress: a Promising Target for Chemoprevention
John, A. M. S. P., Ankem, M. K., & Damodaran, C. (2016) · Current Pharmacology Reports · doi:10.1007/s40495-016-0052-3 · Cited by 14
“reduced GSH have been clearly demonstrated to possess both antioxidant (low) and pro-oxidant (high) properties [56].”
Background
Effects of Alternanthera sessilis Red leaf extracts on hydrogen peroxide-induced oxidative stress in HepG2 cells and identification of phytochemicals using HPLC-QToF-MS/MS
Hazli, U. H. A. M., Hwong, C. S., Aziz, A. A., Junit, S. M., Leong, K. H., & Kong, K. W. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2022.04.056 · Cited by 14
Hypoglycemic effect and toxicity of the dry extract of Eugenia biflora (L.) DC. leaves
Oliveira, E. S. C., Acho, L. D. R., da Silva, B. J. P., Morales-Gamba, R. D., Pontes, F. S. C., do Rosário, A. S., Bezerra, J. D. A., Campos, F. R., Barcellos, J. F. M., Lima, É. S., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115276 · Cited by 13
Design and evaluation of a novel flavonoid-based radioprotective agent utilizing monoglucosyl rutin
Aizawa, Y., Sunada, S., Hirakawa, H., Fujimori, A., Kato, T. A., & Uesaka, M. (2017) · Journal of Radiation Research · doi:10.1093/jrr/rrx090 · Cited by 13
“It is therefore desirable that flavonoids selected as radioprotective agents have high antioxidant activity; on the other hand, it is also necessary to consider the influence of the adverse pro-oxidant effect that oxidized flavonoids can have on cells [17].”
Background
Stimulation of phenolic compounds production in the in vitro cultivated Polyscias filicifolia Bailey shoots and evaluation of the antioxidant and cytotoxic potential of plant extracts
Śliwińska, A. A., Sykłowska-Baranek, K., Kośmider, A., Granica, S., Miszczak, K., Nowicka, G., Kasztelan, A., Podsadni, P., Turło, J., & Pietrosiuk, A. (2018) · Acta Societatis Botanicorum Poloniae · doi:10.5586/asbp.3586 · Cited by 13
“The SA extract was not well tolerated by normal cells, which could be related to its enhanced content of quercetin derivatives and have been reported to be associated with anticancer activity as, being easily oxidized, they acquire prooxidant properties [16,20,21,50,51].”
Background
Quercetin alleviated H2O2‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells
Li, M., Yang, X., Yu, H., & Mao, D. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22527 · Cited by 13
Quercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth
Kasi, P. B., Opoku, H., Novikova, L. N., Wiberg, M., Kingham, P. J., Wang, J., & Novikov, L. N. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114609 · Cited by 12
Quercetin protects the buffalo rat liver (BRL-3A) cells from aflatoxin B1-induced cytotoxicity via activation of Nrf2-ARE pathway
Wang, X., Li, L., & Zhang, G. (2019) · World Mycotoxin Journal · doi:10.3920/wmj2019.2465 · Cited by 12
Efficacy ofGinkgo bilobaon Vaginal Estrous and Ovarian Histological Alterations for Evaluating Anti‐Implantation and Abortifacient Potentials in Albino Female Mice
ElMazoudy, R. H., & Attia, A. A. (2012) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.21032 · Cited by 12
Erratum to: Differences among five amaranth varieties (Amaranthus spp.) regarding secondary metabolites and foliar herbivory by chewing insects in the field
Niveyro, S. L., Mortensen, A. G., Fomsgaard, I. S., & Salvo, A. (2012) · Arthropod-Plant Interactions · doi:10.1007/s11829-012-9245-9 · Cited by 12
Amino acids with basic amino side chain accelerate the pro-oxidant ability of polyphenolic compounds
Chen, T., Liou, S.-Y., Wu, H.-C., Tsai, F., Tsai, C.-H., Huang, C., & Chang, Y.-L. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.132 · Cited by 11
Interactions between macromolecule-bound antioxidants and Trolox during liposome autoxidation: A multivariate approach
Çelik, E. E., Amigo, J. M., Andersen, M. L., & Gökmen, V. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.06.034 · Cited by 11
Hypoxia induces an increase in intestinal permeability and pulmonary arterial pressures in neonatal Holstein calves despite feeding the flavonoid rutin
Shellenberger, N. W., Collinsworth, K. K., Subbiah, S., Klein, D., & Neary, J. M. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17289 · Cited by 11
Quercetin induces autophagy in myelodysplastic bone marrow including hematopoietic stem/progenitor compartment
Daw, S., & Law, S. (2020) · Environmental Toxicology · doi:10.1002/tox.23020 · Cited by 11
Molecular and cellular outcomes of quercetin actions on healthy and tumor osteoblasts
Lezcano, V., Morelli, S. R., & Pardo, V. G. (2022) · Biochimie · doi:10.1016/j.biochi.2022.04.003 · Cited by 10
The molecular basis of the anticancer properties of quercetin
Adorisio, S., Argentieri, M. P., Avato, P., Caderni, G., Chioccioli, S., Cirmi, S., Delfino, D. V., Greco, G., Hrelia, P., Iriti, M., et al. (2021) · doi:10.36118/pharmadvances.2021.10 · Cited by 10
“Antioxidant and pro-oxidant effects of quercetin depends on its cellular concentrations and on the cellular levels of reduced GSH: low concentrations of quercetin increase the antioxidant capacity of cells; higher concentrations of quercetin reduce antioxidant capacity and GSH content leading to cellular damage (119).”
Background
Antiproliferative and Apoptotic Activities of Natural Honey
Mumtaz, P. T., Bashir, S. M., Rather, M. A., Dar, K. B., Taban, Q., Sajood, S., Ali, A., Rather, Z. A., Amin, I., & Dar, M. A. (2020) · Springer eBooks · doi:10.1007/978-981-15-6799-5_18 · Cited by 9
RETRACTED: Efficient three-dimensional (3D) human bone differentiation on quercetin-functionalized isotropic nano-architecture chitinous patterns of cockroach wings
Mostofi, M., Mostofi, F., Hosseini, S., Alipour, A., Nourany, M., Hamidian, R., Vahidi, S., Farokhi, M., Shokrgozar, M. A., Homaeigohar, S., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.129155 · Cited by 9
Retracted
Cytotoxic and Apoptotic Effect of Structurally Similar Flavonoids on Parental and Drug-Resistant Cells of a Human Cervical Carcinoma
Durgo, K., Vukovic, L. D., Rusak, G., Osmak, M., & Čolić, J. F. (2009) · University of Zagreb University Computing Centre (SRCE) · Cited by 9
Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors
Szewczyk, K., Lewandowska, U., Owczarek, K., Sosnowska, D., Gorlach, S., Koziołkiewicz, M., Hrabec, Z., & Hrabec, E. (2014) · Polish Journal of Food and Nutrition Sciences · doi:10.2478/pjfns-2013-0003 · Cited by 9
Novel biodegradable and non-fouling systems for controlled-release based on poly(ε-caprolactone)/Quercetin blends and biomimetic bacterial S-layer coatings
Sanchez‐Rexach, E., Iturri, J. J., Fernández, J., Meaurio, E., Toca-Herrera, J. L., & Sarasua, J.-R. (2019) · RSC Advances · doi:10.1039/c9ra04398e · Cited by 9
Standardized Rhus verniciflua stokes extract and its major flavonoid fustin attenuate oxidative stress induced by tert-butyl hydroperoxide via activation of nuclear factor erythroid 2-related factor
Choi, Y. J., Min, G., Shin, J.-H., Kim, J. Y., & Kwon, O. (2014) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.1007/s13765-013-4201-7 · Cited by 9
“Physiologic doses of exogenous antioxidants are required to maintain redox homeostasis, and the pro-oxidant or antioxidant activity intimately depends on their concentration (Watjen et al., 2005; Robaszkiewicz et al., 2007; Valko et al., 2007).”
Background
Alteration of the aortic vascular reactivity associated to excessive consumption of Hibiscus sabdariffa Linnaeus: Preliminary findings
Manzano-Pech, L., Guarner‐Lans, V., Soto, M. E., Díaz‐Díaz, E., & Pérez-Torres, I. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20020 · Cited by 8
“Several studies have shown that cell survival and viability, thiol content, total antioxidant capacity (TAC), and activities of SOD isoforms, CAT, and glutathione-S-transferase (GST) are reduced by quercetin at 50 μ M [28].”
Background
Water leaves extracts of Cornus mas and Cornus kousa as aldose reductase inhibitors: the potential therapeutic agents
Miláčková, I., Meščanová, M., Ševčíková, V., & Mučaji, P. (2017) · Chemical Papers · doi:10.1007/s11696-017-0227-3 · Cited by 8
“…higher than cca 100 lM and its longer incubation, more than 6 h, could decrease the activities of intracellular antioxidant enzymes superoxide dismutase, catalase, and glutathione S-transferase and, therefore, can be included to cytotoxicity (Metodiewa et al. 1999; Robaszkiewicz et al. 2007).”
Background
THERMODYNAMICS OF QUERCETIN SOLVATION IN WATER-DIMETHYLSULFOXIDE SOLVENT
Kuranova, N. N., Нурмахмадович, К. Д., Kashina, O. V., & Усачева, Т. Р. (2020) · IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA · doi:10.6060/ivkkt.20206310.6285 · Cited by 8
“1), который проявляет противовоспалительное, антиоксидантное, противомикробное и противоопухолевое действие [3-7].”
Chronic effects of different quercetin doses in penicillin-induced focal seizure model
Sümbül, O., & Aygün, H. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135848 · Cited by 8

Authors: Robaszkiewicz, A., Balcerczyk, A., & Bartosz, G.
Affiliations: University of Łódź (PL)
Corresponding author: Robaszkiewicz, Agnieszka
ORCID: Robaszkiewicz, Agnieszka
Balcerczyk, Aneta
Bartosz, Grzegorz
Venue: Cell Biology International
Publisher: Wiley
Published: 2007-10
Volume: 31
Issue: 10
Pages: 1245-1250
ISSN: 1065-6995 (ISSN-L)
1095-8355
DOI: 10.1016/j.cellbi.2007.04.009
OpenAlex: W2086381409
Cited by: 279
References: 46
Citations by year: 2026: 3 · 2025: 4 · 2024: 11 · 2023: 16 · 2022: 31 · 2021: 25 · 2020: 23 · 2019: 9 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
FWCI: 7.64
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1920 d)
Locations: Cell Biology International (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: quercetin, flavonoids, plant polyphenols, A549 cells, lung epithelial cells, antioxidant capacity, pro-oxidant activity, oxidative stress, reactive oxygen species, superoxide dismutase, catalase, glutathione S-transferase, thiol content, cell proliferation, cell viability, peroxide formation
MeSH terms: Antioxidants, Carcinoma, Non-Small-Cell Lung, Catalase, Glutathione Transferase, Humans, Lung Neoplasms, Quercetin, Sulfhydryl Compounds, Superoxide Dismutase, Tumor Cells, Cultured, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation

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Antioxidative and prooxidative effects of quercetin on A549 cells

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