Cited by 279Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchAntioxidant Activity and Oxidative Stress

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Antioxidative and prooxidative effects of quercetin on A549 cells

Robaszkiewicz, Agnieszka, Balcerczyk, Aneta, Bartosz, Grzegorz·2007·Cell Biology International

DOI 10.1016/j.cellbi.2007.04.009

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Abstract

Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase. Quercetin decreased production of reactive oxygen species in the cells but produced peroxides in the medium. The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium.

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Authors: Robaszkiewicz, A., Balcerczyk, A., & Bartosz, G.
Affiliations: University of Łódź (PL)
Corresponding author: Robaszkiewicz, Agnieszka
ORCID: Robaszkiewicz, Agnieszka
Balcerczyk, Aneta
Bartosz, Grzegorz
Venue: Cell Biology International
Publisher: Wiley
Published: 2007-10
Volume: 31
Issue: 10
Pages: 1245-1250
ISSN: 1065-6995 (ISSN-L)
1095-8355
DOI: 10.1016/j.cellbi.2007.04.009
OpenAlex: W2086381409
Cited by: 279
References: 46
Citations by year: 2026: 3 · 2025: 4 · 2024: 11 · 2023: 16 · 2022: 31 · 2021: 25 · 2020: 23 · 2019: 9 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
FWCI: 7.64
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1920 d)
Locations: Cell Biology International (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: quercetin, flavonoids, plant polyphenols, A549 cells, lung epithelial cells, antioxidant capacity, pro-oxidant activity, oxidative stress, reactive oxygen species, superoxide dismutase, catalase, glutathione S-transferase, thiol content, cell proliferation, cell viability, peroxide formation
MeSH terms: Antioxidants, Carcinoma, Non-Small-Cell Lung, Catalase, Glutathione Transferase, Humans, Lung Neoplasms, Quercetin, Sulfhydryl Compounds, Superoxide Dismutase, Tumor Cells, Cultured, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation

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Antioxidative and prooxidative effects of quercetin on A549 cells

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