The DOI matches its Crossref record; 181 of the 181 references it cites were found in a registry or an index.
5-HT1A receptor-regulated signal transduction pathways in brain
Open accessAbstract
Serotonin is an influential monoamine neurotransmitter that signals through a number of receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A (5-HT1A) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. 5-HT1A receptors couple not only to the classical inhibitory G protein-regulated signaling pathway, but also to signaling pathways traditionally regulated by growth factors. Despite the importance of 5-HT1A receptors in brain function, little is known about how these signaling mechanisms link 5-HT1A receptors to regulation of brain physiology and behavior. Following a brief summary of the known physiological and behavioral effects of 5-HT1A receptors, this article will review the signaling pathways regulated by 5-HT1A receptors, and discuss the potential implication of these signaling pathways in 5-HT1A receptor-regulated physiological processes and behaviors.
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“Some serotonergic receptors, beyond their traditional association with G proteins, modulate the activity of signaling pathways involved in neuronal plasticity such as extracellular-regulated kinase (ERK) or mitogen-activated protein kinase (MAPK, Cowen, 2007;Polter and Li, 2010).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Polter and Li, 2010
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Cites
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555
Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor
Yao, R., & Cooper, G. M. (1995) · Science · doi:10.1126/science.7701324 · Cited by 1,393
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
Xing, J. W., Ginty, D. D., & Greenberg, M. E. (1996) · Science · doi:10.1126/science.273.5277.959 · Cited by 1,246
Research works printed but not linked: 5
- Ahlemeyer, 1997, Brain Res., 777, 179
- Maier, 1995, Behav. Neurosci., 109, 404, 10.1037/0735-7044.109.3.404 · DOI · Paper page
- Cooper, 1982, Horiz. Biochem. Biophys., 6, 309
- Chuang, 1994, FEBS Lett., 346, 229
- Dizeyi, 2009, Urol Oncol
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Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 471
The neurobiology of aggression and violence
Rosell, D. R., & Siever, L. J. (2015) · CNS Spectrums · doi:10.1017/s109285291500019x · Cited by 472
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder
Valvezan, A. J., & Klein, P. S. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00001 · Cited by 390
Stress and the reproductive axis
Toufexis, D., Rivarola, M. A., Lara, H., & Viau, V. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12179 · Cited by 350
Metadata
- Authors
- Polter, A. M., & Li, X.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Li, Xiaohua
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 22
- Issue
- 10
- Pages
- 1406-1412
- ISSN
- 0898-6568 (ISSN-L)
- PMC
- PMC2903656
- OpenAlex
- W2056800045
- Cited by
- 225
- References
- 181
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 10 · 2023: 21 · 2022: 9 · 2021: 18 · 2020: 9 · 2019: 23 · 2018: 15 · 2017: 9 · 2016: 12 · 2015: 15 · 2014: 20 · 2013: 12 · 2012: 15
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (MH073723, MH086622, NS061788)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 5-HT1A receptor, serotonin receptors, signal transduction, G protein-coupled receptor signaling, growth factor signaling, anxiety, mood, cognition, brain physiology, behavior
- MeSH terms
- Behavior, Brain, Neurons, Signal Transduction, Receptor, Serotonin, 5-HT1A
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