Cited by 228Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

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5-HT1A receptor-regulated signal transduction pathways in brain

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Polter, Abigail M., Li, Xiaohua·2010·Cellular Signalling

DOI 10.1016/j.cellsig.2010.03.019PMC PMC2903656

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Abstract

Serotonin is an influential monoamine neurotransmitter that signals through a number of receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A (5-HT1A) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. 5-HT1A receptors couple not only to the classical inhibitory G protein-regulated signaling pathway, but also to signaling pathways traditionally regulated by growth factors. Despite the importance of 5-HT1A receptors in brain function, little is known about how these signaling mechanisms link 5-HT1A receptors to regulation of brain physiology and behavior. Following a brief summary of the known physiological and behavioral effects of 5-HT1A receptors, this article will review the signaling pathways regulated by 5-HT1A receptors, and discuss the potential implication of these signaling pathways in 5-HT1A receptor-regulated physiological processes and behaviors.

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Authors: Polter, A. M., & Li, X.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Li, Xiaohua
ORCID: Polter, Abigail M.
Li, Xiaohua
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2010-10
Volume: 22
Issue: 10
Pages: 1406-1412
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/j.cellsig.2010.03.019
PMC: PMC2903656
OpenAlex: W2056800045
Cited by: 225
References: 181
Citations by year: 2026: 10 · 2025: 16 · 2024: 10 · 2023: 21 · 2022: 9 · 2021: 18 · 2020: 9 · 2019: 23 · 2018: 15 · 2017: 9 · 2016: 12 · 2015: 15 · 2014: 20 · 2013: 12 · 2012: 15
FWCI: 1.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (MH073723, MH086622, NS061788)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: 5-HT1A receptor, serotonin receptors, signal transduction, G protein-coupled receptor signaling, growth factor signaling, anxiety, mood, cognition, brain physiology, behavior
MeSH terms: Behavior, Brain, Neurons, Signal Transduction, Receptor, Serotonin, 5-HT1A

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5-HT1A receptor-regulated signal transduction pathways in brain

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